ATE222294T1 - Verbesserte verfahren zur enzymatischen synthese von oligosacchariden - Google Patents

Verbesserte verfahren zur enzymatischen synthese von oligosacchariden

Info

Publication number
ATE222294T1
ATE222294T1 AT96911628T AT96911628T ATE222294T1 AT E222294 T1 ATE222294 T1 AT E222294T1 AT 96911628 T AT96911628 T AT 96911628T AT 96911628 T AT96911628 T AT 96911628T AT E222294 T1 ATE222294 T1 AT E222294T1
Authority
AT
Austria
Prior art keywords
improved methods
oligosaccharides
enzymatic synthesis
sialyl
methods
Prior art date
Application number
AT96911628T
Other languages
English (en)
Inventor
Shawn Defrees
Robert J Bayer
Murray Ratcliffe
Original Assignee
Neose Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/419,659 external-priority patent/US5876980A/en
Application filed by Neose Technologies Inc filed Critical Neose Technologies Inc
Application granted granted Critical
Publication of ATE222294T1 publication Critical patent/ATE222294T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT96911628T 1995-04-11 1996-04-10 Verbesserte verfahren zur enzymatischen synthese von oligosacchariden ATE222294T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/419,659 US5876980A (en) 1995-04-11 1995-04-11 Enzymatic synthesis of oligosaccharides
US103595P 1995-07-11 1995-07-11
PCT/US1996/004790 WO1996032492A1 (en) 1995-04-11 1996-04-10 Improved enzymatic synthesis of oligosaccharides

Publications (1)

Publication Number Publication Date
ATE222294T1 true ATE222294T1 (de) 2002-08-15

Family

ID=26668454

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96911628T ATE222294T1 (de) 1995-04-11 1996-04-10 Verbesserte verfahren zur enzymatischen synthese von oligosacchariden

Country Status (8)

Country Link
EP (1) EP0820520B1 (de)
JP (1) JPH11503328A (de)
AT (1) ATE222294T1 (de)
AU (1) AU5445396A (de)
DE (1) DE69623005T2 (de)
DK (1) DK0820520T3 (de)
ES (1) ES2180757T3 (de)
WO (1) WO1996032492A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888984A (en) * 1994-05-12 1999-03-30 Dermal Research Laboratories, Inc. Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
US5922577A (en) * 1995-04-11 1999-07-13 Cytel Corporation Enzymatic synthesis of glycosidic linkages
US6030815A (en) * 1995-04-11 2000-02-29 Neose Technologies, Inc. Enzymatic synthesis of oligosaccharides
US6033663A (en) * 1996-04-10 2000-03-07 Neose Technologies, Inc. Nucleic acids encoding GDP-Fucose pyrophosphorylase
NZ336780A (en) * 1997-01-16 2000-12-22 Neose Technologies Inc In vitro sialylation of glycoproteins
US6323008B1 (en) 1997-08-14 2001-11-27 Neose Technologies, Inc. Methods for producing sialyloligosaccharides in a dairy source
AU2745700A (en) 1999-02-01 2000-08-18 Dermal Research Laboratories, Inc. A pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
US20010051349A1 (en) 2000-02-17 2001-12-13 Glycominds Ltd. Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof
US7879824B2 (en) 2001-07-31 2011-02-01 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
JPWO2004009830A1 (ja) 2002-07-18 2005-11-17 ヤマサ醤油株式会社 Ｃｍｐ−ｎ−アセチルノイラミン酸の製造法
NZ542586A (en) 2003-04-09 2009-11-27 Biogenerix Ag Method of forming a covalent conjugate between a G-CSF peptide and PEG
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US8450088B2 (en) 2003-09-26 2013-05-28 Yamasa Corporation Process for producing CMP-N-acetylneuraminic acid
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
EP3061461A1 (de) 2004-10-29 2016-08-31 ratiopharm GmbH Remodellierung und glykopegylierung von fibroblasten-wachstumsfaktor (fgf)
US9029331B2 (en) 2005-01-10 2015-05-12 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
EP1871795A4 (de) 2005-04-08 2010-03-31 Biogenerix Ag Zusammensetzungen und verfahren zur herstellung von glycosylierungsmutanten eines proteaseresistenten menschlichen wachstumshormons
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
US20080242607A1 (en) 2006-07-21 2008-10-02 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
US8969532B2 (en) 2006-10-03 2015-03-03 Novo Nordisk A/S Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
CN101796063B (zh) 2007-04-03 2017-03-22 拉蒂奥法姆有限责任公司 使用糖聚乙二醇化g‑csf的治疗方法
US9493499B2 (en) 2007-06-12 2016-11-15 Novo Nordisk A/S Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography
DK2257311T3 (da) 2008-02-27 2014-06-30 Novo Nordisk As Konjugerede Faktor VIII-Molekyler
US9102966B2 (en) 2010-07-16 2015-08-11 Glycom A/S Synthesis of sialooligosaccharide derivatives
AU2012232727A1 (en) * 2011-03-18 2013-09-26 Glycom A/S Synthesis of new fucose-containing carbohydrate derivatives
EP2522232A1 (de) 2011-05-13 2012-11-14 Nestec S.A. Nahrungsmittel mit menschlichen Milcholigosacchariden und Herstellungsverfahren dafür
KR20140036227A (ko) * 2011-05-13 2014-03-25 글리콤 에이/에스 모유 올리고사카라이드(hmo) 또는 그의 전구체의 생성 방법
CA2835989A1 (en) 2011-05-13 2012-11-22 Glycom A/S Diversification of human milk oligosaccharides (hmos) or precursors thereof
WO2013190531A1 (en) * 2012-06-22 2013-12-27 Glycom A/S Glycosylated galactosyl disaccharides, methods for their production and their use in consumable products
WO2013190529A1 (en) * 2012-06-22 2013-12-27 Glycom A/S Glycosylated galactosyl disaccharddes, methods for their production and their use in consumable products
KR101525230B1 (ko) * 2013-05-31 2015-06-01 주식회사 진켐 시알산 유도체의 제조방법
ES2991621T3 (es) 2016-03-07 2024-12-04 Glycom As Separación de oligosacáridos de caldo de fermentación
US11214588B2 (en) 2017-06-30 2022-01-04 Glycom A/S Synthesis of oligosaccharides
EP3456836A1 (de) 2017-09-13 2019-03-20 Glycom A/S Abtrennung von sialylierten oligosacchariden aus der fermentationsbrühe
DK181061B1 (en) 2021-03-12 2022-10-31 Glycom As Purification of sialooligosaccharides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374541A (en) * 1993-05-04 1994-12-20 The Scripps Research Institute Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides
US5409817A (en) * 1993-05-04 1995-04-25 Cytel, Inc. Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides

Also Published As

Publication number Publication date
WO1996032492A1 (en) 1996-10-17
DE69623005T2 (de) 2003-04-03
ES2180757T3 (es) 2003-02-16
AU5445396A (en) 1996-10-30
DE69623005D1 (de) 2002-09-19
EP0820520B1 (de) 2002-08-14
JPH11503328A (ja) 1999-03-26
EP0820520A1 (de) 1998-01-28
DK0820520T3 (da) 2002-12-02

Similar Documents

Publication Publication Date Title
DE69623005D1 (de) Verbesserte verfahren zur enzymatischen synthese von oligosacchariden
DE69611442D1 (de) Enzymatische synthese von glykosidischen verbindungen
DE69431839D1 (de) Methode zur synthese von amino-deoxy-disacchariden und amino-deoxy-oligosacchariden
ATE506450T1 (de) Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasen
DE69637256D1 (de) Synthese von Methoxynukleoside und enzymatische Nukleisäure Moleküle
DE59608364D1 (de) Verfahren zur selektiven Synthese von Silylalkyldisulfiden
DE69928121D1 (de) Verwendungen von sulfatierten fuko-oligosacchariden zum pflanzenschutz
DE60018833D1 (de) Verfahren zur Synthese von Nukleosidanaloga
EP1062360A4 (de) Verbindungen und methoden zur vertäarkerrn nukleinsäuremolekül synthase
PL321675A1 (en) Novel inhibitors of farnesil transferase, their production and pharmaceutic compositions containing them
DK1303632T3 (da) Galactomannan-oligosaccharid og fremgangsmåde til fremstilling samt anvendelse heraf
ATE215127T1 (de) Eintopfsynthese von oligosacchariden mittels multipler enzyme und cmp-sialiksäure bildendem system
AU6571700A (en) Enzymatic synthesis of deoxyribonucleosides
EP1169466A4 (de) Synthese von 1,2,3,4-tetrahydroxybenzole und 1,2,3-trihydroxybenzolen durch myo-inositol-1-phosphatsynthase und myo-inositol-2-dehydrogenase
ATE355295T1 (de) Synthese von oligosacchariden, reagenzien und verfahren
ES2097103T1 (es) Metodo de producir almidon cationico.
DE69816642D1 (de) Verfahren zur stereoselektiven synthese von prostacyclin-derivaten
WO1997015678A3 (en) Modification of soluble solids using sucrose phosphate synthase encoding sequence
HN1998000091A (es) Inhibidores de la farnesil transferasa tratamiento del cancer.
ATE203271T1 (de) Für die protein-kinase a-spezifische modifizierte oligonukleotide und verfahren zur deren verwendung
ATE189804T1 (de) Selektives verfahren zur deacylierung von acylverbindungen
ATE227731T1 (de) Verfahren zur gezielten synthese von beta- glycosidisch verknüpften n- acetylglucosaminderivaten
DE59206765D1 (de) Verfahren zur enzymatischen Synthese von 2-Desoxy-beta-D-galactosiden
DE59900737D1 (de) Verfahren zur Synthese von Feststoffen
ATE177151T1 (de) Nucleosideanaloge verfahren

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee