ATE222294T1 - Verbesserte verfahren zur enzymatischen synthese von oligosacchariden - Google Patents

Verbesserte verfahren zur enzymatischen synthese von oligosacchariden

Info

Publication number
ATE222294T1
ATE222294T1 AT96911628T AT96911628T ATE222294T1 AT E222294 T1 ATE222294 T1 AT E222294T1 AT 96911628 T AT96911628 T AT 96911628T AT 96911628 T AT96911628 T AT 96911628T AT E222294 T1 ATE222294 T1 AT E222294T1
Authority
AT
Austria
Prior art keywords
improved methods
oligosaccharides
enzymatic synthesis
sialyl
methods
Prior art date
Application number
AT96911628T
Other languages
English (en)
Inventor
Shawn Defrees
Robert J Bayer
Murray Ratcliffe
Original Assignee
Neose Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/419,659 external-priority patent/US5876980A/en
Application filed by Neose Technologies Inc filed Critical Neose Technologies Inc
Application granted granted Critical
Publication of ATE222294T1 publication Critical patent/ATE222294T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT96911628T 1995-04-11 1996-04-10 Verbesserte verfahren zur enzymatischen synthese von oligosacchariden ATE222294T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/419,659 US5876980A (en) 1995-04-11 1995-04-11 Enzymatic synthesis of oligosaccharides
US103595P 1995-07-11 1995-07-11
PCT/US1996/004790 WO1996032492A1 (en) 1995-04-11 1996-04-10 Improved enzymatic synthesis of oligosaccharides

Publications (1)

Publication Number Publication Date
ATE222294T1 true ATE222294T1 (de) 2002-08-15

Family

ID=26668454

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96911628T ATE222294T1 (de) 1995-04-11 1996-04-10 Verbesserte verfahren zur enzymatischen synthese von oligosacchariden

Country Status (8)

Country Link
EP (1) EP0820520B1 (de)
JP (1) JPH11503328A (de)
AT (1) ATE222294T1 (de)
AU (1) AU5445396A (de)
DE (1) DE69623005T2 (de)
DK (1) DK0820520T3 (de)
ES (1) ES2180757T3 (de)
WO (1) WO1996032492A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888984A (en) * 1994-05-12 1999-03-30 Dermal Research Laboratories, Inc. Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
US6030815A (en) * 1995-04-11 2000-02-29 Neose Technologies, Inc. Enzymatic synthesis of oligosaccharides
US5922577A (en) * 1995-04-11 1999-07-13 Cytel Corporation Enzymatic synthesis of glycosidic linkages
WO1997037682A1 (en) * 1996-04-10 1997-10-16 Cytel Corporation Nucleic acids encoding gdp-fucose pyrophosphorylase
JP2001507215A (ja) * 1997-01-16 2001-06-05 サイテル コーポレイション 組換え糖タンパク質のインビトロでの実用的なシアリル化
US6323008B1 (en) 1997-08-14 2001-11-27 Neose Technologies, Inc. Methods for producing sialyloligosaccharides in a dairy source
EP1165097B1 (de) 1999-02-01 2007-05-02 Dermal Research Laboratories, Inc. Pharmazeutische zusammensetzung aus komplexen kohlenhydraten deren anwendung
US20010051349A1 (en) 2000-02-17 2001-12-13 Glycominds Ltd. Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof
US7879824B2 (en) 2001-07-31 2011-02-01 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
CN1301330C (zh) 2002-07-18 2007-02-21 雅玛山酱油株式会社 Cmp－n－乙酰神经氨酸的制造方法
PL1615945T3 (pl) 2003-04-09 2012-03-30 Ratiopharm Gmbh Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
EP1669461A4 (de) * 2003-09-26 2011-06-29 Yamasa Corp Verfahren zur herstellung von cmp-n-acetylneuraminsäure
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
WO2006050247A2 (en) 2004-10-29 2006-05-11 Neose Technologies, Inc. Remodeling and glycopegylation of fibroblast growth factor (fgf)
US9029331B2 (en) 2005-01-10 2015-05-12 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
WO2006121569A2 (en) 2005-04-08 2006-11-16 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
EP2049144B8 (de) 2006-07-21 2015-02-18 ratiopharm GmbH Glycosylierung von peptiden über o-verbundene glycosylierungssequenzen
EP2054521A4 (de) 2006-10-03 2012-12-19 Novo Nordisk As Verfahren zur reinigung von polypeptid-konjugate
HRP20130382T1 (hr) 2007-04-03 2013-05-31 Biogenerix Ag Postupci lijeäśenja pomoä†u glikopegiliranog g-csf
CA2690611C (en) 2007-06-12 2015-12-08 Novo Nordisk A/S Improved process for the production of nucleotide sugars
PL2257311T3 (pl) 2008-02-27 2014-09-30 Novo Nordisk As Koniugaty cząsteczek czynnika VIII
AU2011278236A1 (en) * 2010-07-16 2013-02-07 Glycom A/S Derivatization of oligosaccharides
CN103443113A (zh) * 2011-03-18 2013-12-11 格力康公司 新型含岩藻糖的糖类衍生物的合成
CN103562401A (zh) 2011-05-13 2014-02-05 格力康公司 产生人乳寡糖(hmo)或其前体的方法
EP2522232A1 (de) 2011-05-13 2012-11-14 Nestec S.A. Nahrungsmittel mit menschlichen Milcholigosacchariden und Herstellungsverfahren dafür
CN103562214B9 (zh) 2011-05-13 2016-12-14 格力康公司 人乳寡糖(hmo)或其前体的多样化
WO2013190529A1 (en) * 2012-06-22 2013-12-27 Glycom A/S Glycosylated galactosyl disaccharddes, methods for their production and their use in consumable products
WO2013190531A1 (en) * 2012-06-22 2013-12-27 Glycom A/S Glycosylated galactosyl disaccharides, methods for their production and their use in consumable products
KR101525230B1 (ko) * 2013-05-31 2015-06-01 주식회사 진켐 시알산 유도체의 제조방법
ES2991621T3 (es) 2016-03-07 2024-12-04 Glycom As Separación de oligosacáridos de caldo de fermentación
WO2019003135A1 (en) 2017-06-30 2019-01-03 Glycom A/S PURIFICATION OF OLIGOSACCHARIDES
EP3456836A1 (de) 2017-09-13 2019-03-20 Glycom A/S Abtrennung von sialylierten oligosacchariden aus der fermentationsbrühe
DK181061B1 (en) 2021-03-12 2022-10-31 Glycom As Purification of sialooligosaccharides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409817A (en) * 1993-05-04 1995-04-25 Cytel, Inc. Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides
US5374541A (en) * 1993-05-04 1994-12-20 The Scripps Research Institute Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides

Also Published As

Publication number Publication date
DE69623005T2 (de) 2003-04-03
AU5445396A (en) 1996-10-30
ES2180757T3 (es) 2003-02-16
EP0820520B1 (de) 2002-08-14
EP0820520A1 (de) 1998-01-28
JPH11503328A (ja) 1999-03-26
DE69623005D1 (de) 2002-09-19
DK0820520T3 (da) 2002-12-02
WO1996032492A1 (en) 1996-10-17

Similar Documents

Publication Publication Date Title
ATE222294T1 (de) Verbesserte verfahren zur enzymatischen synthese von oligosacchariden
DE69611442D1 (de) Enzymatische synthese von glykosidischen verbindungen
ATE506450T1 (de) Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasen
ATE373672T1 (de) Synthese von methoxynukleoside und enzymatische nukleisäure moleküle
DE59608364D1 (de) Verfahren zur selektiven Synthese von Silylalkyldisulfiden
DE69928121D1 (de) Verwendungen von sulfatierten fuko-oligosacchariden zum pflanzenschutz
ATE229078T1 (de) Methode zur synthese von amino-deoxy- disacchariden und amino-deoxy-oligosacchariden
DE60018833D1 (de) Verfahren zur Synthese von Nukleosidanaloga
EP1062360A4 (de) Verbindungen und methoden zur vertäarkerrn nukleinsäuremolekül synthase
DK1303632T3 (da) Galactomannan-oligosaccharid og fremgangsmåde til fremstilling samt anvendelse heraf
EP1169466A4 (de) Synthese von 1,2,3,4-tetrahydroxybenzole und 1,2,3-trihydroxybenzolen durch myo-inositol-1-phosphatsynthase und myo-inositol-2-dehydrogenase
ATE355295T1 (de) Synthese von oligosacchariden, reagenzien und verfahren
ATE341541T1 (de) Synthese von 3,6-dialkyl-5,6-dihydro-4-hydroxy- pyran-2-one
WO1998032846A3 (en) Enzymatic nucleic acid treatment of diseases or conditions related to levels of c-fos
JO2249B1 (en) A compound of 6.3-dialkyl-6.5-dihydro-4-hydroxy-biran-2-one
ES2097103T1 (es) Metodo de producir almidon cationico.
DE69816642D1 (de) Verfahren zur stereoselektiven synthese von prostacyclin-derivaten
WO1997015678A3 (en) Modification of soluble solids using sucrose phosphate synthase encoding sequence
ATE285474T1 (de) Haemophilus adhäsionsproteinen
HN1998000091A (es) Inhibidores de la farnesil transferasa tratamiento del cancer.
DE69613984D1 (de) Für die protein-kinase a-spezifische modifizierte oligonukleotide und verfahren zur deren verwendung
ATE204023T1 (de) Enzymatische verfahren zur herstellung von (s)- cyanhydrinen
ATE227731T1 (de) Verfahren zur gezielten synthese von beta- glycosidisch verknüpften n- acetylglucosaminderivaten
DE59206765D1 (de) Verfahren zur enzymatischen Synthese von 2-Desoxy-beta-D-galactosiden
DE59900737D1 (de) Verfahren zur Synthese von Feststoffen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee