ATE22297T1 - 17-spiroandrostene. - Google Patents

17-spiroandrostene.

Info

Publication number: ATE22297T1
Authority: AT; Austria
Prior art keywords: sub; hydrogen; fluorine; methyl; dehydro
Prior art date: 1982-05-28

Application number

AT83105275T

Other languages

English (en)

Inventor

Ravi K Varma

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-05-28

Filing date

1983-05-27

Publication date

1986-10-15

1983-05-27 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1986-10-15 Application granted granted Critical

1986-10-15 Publication of ATE22297T1 publication Critical patent/ATE22297T1/de

Links

229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 3
229910052731 fluorine Inorganic materials 0.000 abstract 3
239000011737 fluorine Substances 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Rheumatology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT83105275T 1982-05-28 1983-05-27 17-spiroandrostene. ATE22297T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/382,891 US4397782A (en)	1982-05-28	1982-05-28	Antiinflammatory 17-spiroandrostenes
EP83105275A EP0095749B1 (de)	1982-05-28	1983-05-27	17-Spiroandrostene

Publications (1)

Publication Number	Publication Date
ATE22297T1 true ATE22297T1 (de)	1986-10-15

Family

ID=23510846

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT83105275T ATE22297T1 (de)	1982-05-28	1983-05-27	17-spiroandrostene.

Country Status (6)

Country	Link
US (1)	US4397782A (de)
EP (1)	EP0095749B1 (de)
JP (1)	JPS58216200A (de)
AT (1)	ATE22297T1 (de)
CA (1)	CA1226277A (de)
DE (1)	DE3366231D1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4529548A (en) *	1984-05-07	1985-07-16	E. R. Squibb & Sons, Inc.	17β-(substituted thio)androstenes
SK286051B6 (sk) *	1993-01-19	2008-02-05	Endorecherche Inc.	Použitie prekurzora pohlavného steroidu na prípravu liečiva na prevenciu alebo liečenie znížených alebo nevyrovnaných koncentrácií pohlavných steroidov
EP1587818A4 (de) *	2003-01-21	2010-10-13	Merck Sharp & Dohme	17-carbomoyloxycortisolderivate als selektive modulatoren des glucocorticoidrezeptors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE642576A (de) *
US3274182A (en) *	1963-12-28	1966-09-20	Searle & Co	Process for reducing 19-methyl-1, 4-dien-3-ones to corresponding 19-nor-3-oxy-1, 3, 5(10)-trienes
US3338929A (en) *	1965-08-26	1967-08-29	Searle & Co	17-oxygenated 5alpha-estr-2-en-11beta-ols, 17-alkylated and esterified derivatives thereof
NL6617350A (de) *	1966-02-11	1967-08-14
CH559220A5 (de) *	1970-03-06	1975-02-28	Ciba Geigy Ag
US4094840A (en) *	1977-05-12	1978-06-13	E. R. Squibb & Sons, Inc.	17-Alkylthio (and arylthio) androsteno[16α,17α-b]benzodioxin-3-ones
US4091036A (en) *	1977-05-12	1978-05-23	E. R. Squibb & Sons, Inc.	17-Alkylthio (and arylthio)-1',2',3',4'-tetrahydroandrosteno [16 α, 17 α-b]naphthalenes and derivatives
US4133811A (en) *	1978-02-17	1979-01-09	E. R. Squibb & Sons, Inc.	13-Alkylthio (and arylthio)-11,17-epoxy-17-methyl-18-norandrostenes
US4146538A (en) *	1978-02-27	1979-03-27	E. R. Squibb & Sons, Inc.	17-Alkylthio (and arylthio) androsteno[17α,16α-b]benzopyran-3-ones and [16α,17α]naphthopyran-3-ones
US4243586A (en) *	1980-01-18	1981-01-06	E. R. Squibb & Sons, Inc.	Steroidal-17-spiro-dihydrofuranones

1982
- 1982-05-28 US US06/382,891 patent/US4397782A/en not_active Expired - Fee Related
1983
- 1983-04-29 CA CA000427070A patent/CA1226277A/en not_active Expired
- 1983-05-24 JP JP58092196A patent/JPS58216200A/ja active Pending
- 1983-05-27 DE DE8383105275T patent/DE3366231D1/de not_active Expired
- 1983-05-27 AT AT83105275T patent/ATE22297T1/de not_active IP Right Cessation
- 1983-05-27 EP EP83105275A patent/EP0095749B1/de not_active Expired

Also Published As

Publication number	Publication date
EP0095749A3 (en)	1985-01-09
US4397782A (en)	1983-08-09
DE3366231D1 (de)	1986-10-23
CA1226277A (en)	1987-09-01
JPS58216200A (ja)	1983-12-15
EP0095749B1 (de)	1986-09-17
EP0095749A2 (de)	1983-12-07

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Legal Events

Date	Code	Title	Description
1987-02-15	UEP	Publication of translation of european patent specification
1993-02-15	REN	Ceased due to non-payment of the annual fee