ATE223214T1 - Von milchsäure abgeleitete butyrat-prodrugs - Google Patents

Von milchsäure abgeleitete butyrat-prodrugs

Info

Publication number: ATE223214T1
Authority: AT; Austria
Prior art keywords: prodrugs; lactic acid; relates; methods; treating
Prior art date: 1997-03-10

Application number

AT98910204T

Other languages

English (en)

Inventor

Roger D Tung

Biqin Li

Michael Shin-San Su

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-10

Filing date

1998-03-10

Publication date

2002-09-15

1998-03-10 Application filed by Vertex Pharma filed Critical Vertex Pharma

2002-09-15 Application granted granted Critical

2002-09-15 Publication of ATE223214T1 publication Critical patent/ATE223214T1/de

Links

JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title abstract 4
239000000651 prodrug Substances 0.000 title abstract 4
229940002612 prodrug Drugs 0.000 title abstract 4
FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 title abstract 2
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 title abstract 2
239000004310 lactic acid Substances 0.000 title abstract 2
235000014655 lactic acid Nutrition 0.000 title abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 2
230000003211 malignant effect Effects 0.000 abstract 2
208000011580 syndromic disease Diseases 0.000 abstract 2
108010044495 Fetal Hemoglobin Proteins 0.000 abstract 1
108091005886 Hemoglobin subunit gamma Proteins 0.000 abstract 1
102100038617 Hemoglobin subunit gamma-2 Human genes 0.000 abstract 1
208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
208000005980 beta thalassemia Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
230000024245 cell differentiation Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000014951 hematologic disease Diseases 0.000 abstract 1
208000034737 hemoglobinopathy Diseases 0.000 abstract 1
208000018337 inherited hemoglobinopathy Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
- C07C69/68—Lactic acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Image Processing (AREA)

AT98910204T 1997-03-10 1998-03-10 Von milchsäure abgeleitete butyrat-prodrugs ATE223214T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/814,945 US5880152A (en)	1995-10-06	1997-03-10	Butyrate prodrugs derived from lactic acid
PCT/US1998/004413 WO1998040064A1 (en)	1997-03-10	1998-03-10	Butyrate prodrugs derived from lactic acid

Publications (1)

Publication Number	Publication Date
ATE223214T1 true ATE223214T1 (de)	2002-09-15

Family

ID=25216421

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98910204T ATE223214T1 (de)	1997-03-10	1998-03-10	Von milchsäure abgeleitete butyrat-prodrugs

Country Status (11)

Country	Link
US (1)	US5880152A (de)
EP (1)	EP0969828B1 (de)
JP (1)	JP2001513087A (de)
AT (1)	ATE223214T1 (de)
AU (1)	AU6450098A (de)
CA (1)	CA2283198C (de)
DE (1)	DE69807672T2 (de)
DK (1)	DK0969828T3 (de)
ES (1)	ES2182283T3 (de)
PT (1)	PT969828E (de)
WO (1)	WO1998040064A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6225350B1 (en)	1998-03-10	2001-05-01	Vertex Pharmaceuticals, Inc.	Butyrate prodrugs derived from lactic acid
WO2000056153A1 (en) *	1999-03-19	2000-09-28	Vertex Pharmaceuticals Incorporated	Oral low dose butyrate compositions
WO2002022133A1 (en) *	2000-09-12	2002-03-21	Virginia Commonwealth University	Promotion of adoptosis in cancer cells by co-administration of cyclin dependent kinase inhibitors and cellular differentiation agents
US6562995B1 (en)	2000-12-21	2003-05-13	Beacon Laboratories, Inc.	Delta dicarbonyl compounds and methods for using the same
AU2002325614A1 (en) *	2001-08-16	2003-03-03	Pharmacon-Forschung Und Beratung Gmbh	Compounds containing lactic acid elements, method for the production and use thereof as pharmaceutically active substances
US20070066512A1 (en) *	2005-09-12	2007-03-22	Dominique Verhelle	Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels
ITRM20080214A1 (it) *	2008-04-21	2009-10-22	Uni Degli Studi Di Napoli Federico Ii	Derivati dell'acido butirrico somministrabili per via orale, formulazioni che li contengono e loro uso clinico.
IT202000007423A1 (it) *	2020-04-07	2021-10-07	Caprika Srl	Composizione per supposte per il trattamento delle patologie prostatiche

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE824041C (de) *	1945-10-22	1951-12-10	Howards & Sons Ltd	Verfahren zur Herstellung von aliphatischen a -Acyloxymonocarbonsaeuren
US3526518A (en) *	1967-07-12	1970-09-01	Morton Kleiman	Control of apple storage scald using certain diphenylamine compositions
GB1197012A (en) *	1968-05-20	1970-07-01	Nat Starch Chem Corp	Acyl Derivatives of Alpha-Hydroxy Isobutyric Acid
US4479957A (en) *	1973-04-02	1984-10-30	Eli Lilly And Company	Use of vindesine in treating acute lymphatic leukemia and _other susceptible neoplasms
US5196136A (en) *	1991-06-20	1993-03-23	E. I. Du Pont De Nemours And Company	Cleaning composition of hydrocarbon component, surfactant and multibasic ester additive
US5454806A (en) *	1992-11-06	1995-10-03	Terumo Kabushiki Kaisha	Medical device
US5569675A (en) *	1994-03-07	1996-10-29	Bar Ilan University	Methods of using carboxylic acid esters to increase fetal-hemoglobin levels
WO1997012855A1 (en) *	1995-10-06	1997-04-10	Vertex Pharmaceuticals Incorporated	Butyrate prodrugs of lactic acid

1997
- 1997-03-10 US US08/814,945 patent/US5880152A/en not_active Expired - Lifetime
1998
- 1998-03-10 AU AU64500/98A patent/AU6450098A/en not_active Abandoned
- 1998-03-10 CA CA002283198A patent/CA2283198C/en not_active Expired - Fee Related
- 1998-03-10 DE DE69807672T patent/DE69807672T2/de not_active Expired - Lifetime
- 1998-03-10 PT PT98910204T patent/PT969828E/pt unknown
- 1998-03-10 EP EP98910204A patent/EP0969828B1/de not_active Expired - Lifetime
- 1998-03-10 AT AT98910204T patent/ATE223214T1/de not_active IP Right Cessation
- 1998-03-10 ES ES98910204T patent/ES2182283T3/es not_active Expired - Lifetime
- 1998-03-10 DK DK98910204T patent/DK0969828T3/da active
- 1998-03-10 WO PCT/US1998/004413 patent/WO1998040064A1/en not_active Ceased
- 1998-03-10 JP JP53705398A patent/JP2001513087A/ja active Pending

Also Published As

Publication number	Publication date
WO1998040064A1 (en)	1998-09-17
ES2182283T3 (es)	2003-03-01
EP0969828B1 (de)	2002-09-04
PT969828E (pt)	2003-01-31
JP2001513087A (ja)	2001-08-28
CA2283198C (en)	2007-07-17
EP0969828A1 (de)	2000-01-12
DE69807672D1 (de)	2002-10-10
US5880152A (en)	1999-03-09
AU6450098A (en)	1998-09-29
DE69807672T2 (de)	2003-09-18
DK0969828T3 (da)	2002-12-30
CA2283198A1 (en)	1998-09-17

Legal Events

Date	Code	Title	Description
2003-01-15	UEP	Publication of translation of european patent specification
2006-12-15	REN	Ceased due to non-payment of the annual fee

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PT809437E (pt)	2005-05-31	Tiois para promover crescimento de celulas progenitoras hematopoieticas
EA199900542A1 (ru)	2000-02-28	Соединения сульфоновой кислоты или сульфониламино-n-(гетероаралкил)-азагетероциклиламида
DE69807672D1 (de)	2002-10-10	Von milchsäure abgeleitete butyrat-prodrugs
DK0689586T3 (da)	2007-08-06	VPR-funktion og -aktivitet
IL126235A (en)	2003-02-12	Compounds with growth hormone releasing properties, pharmaceutical compositions comprising them and their use
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BR9610850A (pt)	1999-07-13	Pró-drogas de butirato de ácido láctico
IL113940A (en)	1999-12-31	Synthetic peptides which are elastase inhibitors and pharmaceutical compositions for the treatment of neutrophil associated inflammatory disease containing said inhibitors
EP0821969A3 (de)	2000-12-13	Arzneimittelzusammensetzung enthaltend TCF-II
TR199701605A2 (xx)	1998-07-21	S�lfonamid-substit�e edilmi� bile�ikler
TR200101425T2 (tr)	2002-02-21	IL-5 inhibe edici 6-azaurasil türevleri
PE61999A1 (es)	1999-06-19	Compuestos de tetrahidropiridina