ATE223896T1 - 3-((5-substituierte benzyl)amino)-2- phenylpiperidine als substance-p-antagonisten - Google Patents

3-((5-substituierte benzyl)amino)-2- phenylpiperidine als substance-p-antagonisten

Info

Publication number: ATE223896T1
Authority: AT; Austria
Prior art keywords: alkyl; halo; disorders; cycloalkyl; hydrogen
Prior art date: 1995-12-21

Application number

AT96203560T

Other languages

English (en)

Inventor

Hiroaki Wakabayashi

Yuji Shishido

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-21

Filing date

1996-12-16

Publication date

2002-09-15

1996-12-16 Application filed by Pfizer filed Critical Pfizer

2002-09-15 Application granted granted Critical

2002-09-15 Publication of ATE223896T1 publication Critical patent/ATE223896T1/de

Links

-1 3-((5-SUBSTITUTED BENZYL)AMINO)-2-PHENYLPIPERIDINE Chemical class 0.000 title abstract 2
239000003890 substance P antagonist Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000035475 disorder Diseases 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
241000590002 Helicobacter pylori Species 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
206010042496 Sunburn Diseases 0.000 abstract 1
206010046543 Urinary incontinence Diseases 0.000 abstract 1
206010047700 Vomiting Diseases 0.000 abstract 1
230000002411 adverse Effects 0.000 abstract 1
230000000172 allergic effect Effects 0.000 abstract 1
230000033115 angiogenesis Effects 0.000 abstract 1
208000010668 atopic eczema Diseases 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
229940037467 helicobacter pylori Drugs 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT96203560T 1995-12-21 1996-12-16 3-((5-substituierte benzyl)amino)-2- phenylpiperidine als substance-p-antagonisten ATE223896T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IB9501148		1995-12-21

Publications (1)

Publication Number	Publication Date
ATE223896T1 true ATE223896T1 (de)	2002-09-15

Family

ID=11004393

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96203560T ATE223896T1 (de)	1995-12-21	1996-12-16	3-((5-substituierte benzyl)amino)-2- phenylpiperidine als substance-p-antagonisten

Country Status (8)

Country	Link
US (1)	US5789423A (de)
EP (1)	EP0780375B1 (de)
AT (1)	ATE223896T1 (de)
CA (1)	CA2193468C (de)
DE (1)	DE69623580T2 (de)
DK (1)	DK0780375T3 (de)
ES (1)	ES2180693T3 (de)
PT (1)	PT780375E (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW340842B (en) *	1995-08-24	1998-09-21	Pfizer	Substituted benzylaminopiperidine compounds
EP0991622A1 (de) *	1997-06-27	2000-04-12	MERCK SHARP & DOHME LTD.	Substituierte 3-(benzylamino)piperidin derivate und ihre verwendung als therapeutische wirkstoffe
AU3572800A (en) *	1999-05-06	2000-11-21	Pfizer Products Inc.	Substituted benzolactam compounds
AU9223601A (en) *	2000-09-26	2002-04-08	Tanabe Seiyaku Co	5-phenylbenzylamine compounds, process for their production and intermediates for their synthesis
JP6440625B2 (ja)	2012-11-14	2018-12-19	ザ・ジョンズ・ホプキンス・ユニバーシティー	精神分裂病を処置するための方法および組成物
US10227360B2 (en)	2014-02-19	2019-03-12	Piramal Enterprises Limited	Compounds for use as GPR120 agonists
US10273230B2 (en)	2014-07-25	2019-04-30	Piramal Enterprises Limited	Substituted phenyl alkanoic acid compounds as GPR120 agonists and uses thereof
WO2016038540A1 (en)	2014-09-11	2016-03-17	Piramal Enterprises Limited	Fused heterocyclic compounds as gpr120 agonists

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4680283A (en)	1984-09-26	1987-07-14	Merck & Co., Inc.	Analogs of substance P and eledoisin
DE3602169A1 (de)	1986-01-22	1987-07-23	Schering Ag	Neue alkan- und alkoxyalkanderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende insektizide und akarizide mittel
UA41251C2 (uk)	1990-01-04	2001-09-17	Пфайзер, Інк.	Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі
US5232929A (en) *	1990-11-28	1993-08-03	Pfizer Inc.	3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
US5364943A (en)	1991-11-27	1994-11-15	Pfizer Inc.	Preparation of substituted piperidines
BR9205807A (pt) *	1991-03-26	1994-06-28	Pfizer	Preparação estéreo-seletiva de piperidinas substituidas
BR9206161A (pt)	1991-06-20	1995-10-31	Pfizer	Derivados fluoroalcoxibenzilamino de heterociclos contendo nitrogénio
EP1114823A3 (de) *	1992-08-19	2001-07-18	Pfizer Inc.	Substituierte Benzylamin-Stickstoff enthaltende nichtaromatische Heterocyclen
GB9305718D0 (en) *	1993-03-19	1993-05-05	Glaxo Group Ltd	Medicaments
IL109646A0 (en)	1993-05-19	1994-08-26	Pfizer	Heteroatom substituted alkyl benzylamino-quinuclidines

1996
- 1996-12-16 ES ES96203560T patent/ES2180693T3/es not_active Expired - Lifetime
- 1996-12-16 DE DE69623580T patent/DE69623580T2/de not_active Expired - Fee Related
- 1996-12-16 DK DK96203560T patent/DK0780375T3/da active
- 1996-12-16 AT AT96203560T patent/ATE223896T1/de not_active IP Right Cessation
- 1996-12-16 EP EP96203560A patent/EP0780375B1/de not_active Expired - Lifetime
- 1996-12-16 PT PT96203560T patent/PT780375E/pt unknown
- 1996-12-17 US US08/767,985 patent/US5789423A/en not_active Expired - Fee Related
- 1996-12-19 CA CA002193468A patent/CA2193468C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2193468A1 (en)	1997-06-22
PT780375E (pt)	2002-12-31
US5789423A (en)	1998-08-04
EP0780375A1 (de)	1997-06-25
DE69623580T2 (de)	2003-01-09
CA2193468C (en)	2001-04-24
DK0780375T3 (da)	2002-10-07
EP0780375B1 (de)	2002-09-11
ES2180693T3 (es)	2003-02-16
DE69623580D1 (de)	2002-10-17

Legal Events

Date	Code	Title	Description
2009-09-15	REN	Ceased due to non-payment of the annual fee

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DE69206820D1 (de)	1996-01-25	1,3-Dihydro-2H-Imidano 4,5-b-quinolin-2-ein Derivate als Phosphodiestenase Hemmer
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NO884202D0 (no)	1988-09-22	Fremgangsmaate for fremstilling av terapeutisk aktive benzimidazolin-2-okso-1-karboksylsyrederivater.
TR200302047T4 (tr)	2004-01-21	Anti-iltihabik / analjezik maddeler olarak heteroaril fenil pirazol bileşikleri.
ATE180780T1 (de)	1999-06-15	2-(piperidin-4-yl, pyridin-4-yl und tetrahydropyridin-4-yl)-benzofuran-7-carbamat derivate, ihre herstellung und verwendung als acetylcholinesterase inhibitoren
DE69623580D1 (de)	2002-10-17	3-((5-Substituierte Benzyl)Amino)-2-Phenylpiperidine als Substance-P-Antagonisten
EP1034783A4 (de)	2001-03-28	Amidederivaten
DK0824100T3 (da)	2000-11-20	Tricykliske piperidinylaminoforbindelser som substans P-antagonister
DE69703725D1 (de)	2001-01-25	Tetrazolyl-substituierte Chinuclidine als Substanz P Antagonisten
AU640590B2 (en)	1993-08-26	3-(1h-indazol-3-yl)-4-pyridinamines
MX9700096A (es)	1997-12-31	3-[(bencil 5-substituido)amino] 2-fenilpiperidinas como antagonistas de la sustancia p.
NO20020475D0 (no)	2002-01-29	2-aminotetralinderivater for terapi av glaukom