ATE223906T1 - Metallchelate von makrocyclischen polyaminocarbocyclischen derivaten und deren verwendung zur diagnostik-bilderzeugung - Google Patents

Metallchelate von makrocyclischen polyaminocarbocyclischen derivaten und deren verwendung zur diagnostik-bilderzeugung

Info

Publication number
ATE223906T1
ATE223906T1 AT98403108T AT98403108T ATE223906T1 AT E223906 T1 ATE223906 T1 AT E223906T1 AT 98403108 T AT98403108 T AT 98403108T AT 98403108 T AT98403108 T AT 98403108T AT E223906 T1 ATE223906 T1 AT E223906T1
Authority
AT
Austria
Prior art keywords
alkyl
macrocyclic
derivatives
polyaminocarbocyclic
metal chelates
Prior art date
Application number
AT98403108T
Other languages
English (en)
Inventor
Dominique Meyer
Marc Port
Olivier Rousseaux
Christian Simonot
Original Assignee
Guerbet Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet Sa filed Critical Guerbet Sa
Application granted granted Critical
Publication of ATE223906T1 publication Critical patent/ATE223906T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
AT98403108T 1997-12-10 1998-12-09 Metallchelate von makrocyclischen polyaminocarbocyclischen derivaten und deren verwendung zur diagnostik-bilderzeugung ATE223906T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9715642A FR2772025B1 (fr) 1997-12-10 1997-12-10 Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique

Publications (1)

Publication Number Publication Date
ATE223906T1 true ATE223906T1 (de) 2002-09-15

Family

ID=9514428

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98403108T ATE223906T1 (de) 1997-12-10 1998-12-09 Metallchelate von makrocyclischen polyaminocarbocyclischen derivaten und deren verwendung zur diagnostik-bilderzeugung

Country Status (22)

Country Link
US (1) US6187285B1 (de)
EP (1) EP0922700B1 (de)
JP (1) JP3020938B2 (de)
KR (1) KR100473240B1 (de)
CN (1) CN1132822C (de)
AT (1) ATE223906T1 (de)
AU (1) AU743361B2 (de)
BR (1) BR9805801A (de)
CA (1) CA2254261A1 (de)
CZ (1) CZ293218B6 (de)
DE (1) DE69807830T2 (de)
DK (1) DK0922700T3 (de)
EA (1) EA001387B1 (de)
ES (1) ES2183303T3 (de)
FR (1) FR2772025B1 (de)
HU (1) HU221604B (de)
IL (1) IL127467A (de)
NO (1) NO318037B1 (de)
NZ (1) NZ333264A (de)
PL (1) PL330214A1 (de)
PT (1) PT922700E (de)
TR (1) TR199802559A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2793795B1 (fr) * 1999-05-21 2001-08-03 Guerbet Sa Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale
FR2829492B1 (fr) * 2001-09-11 2005-01-28 Guerbet Sa Procede de preparation de la disorbitylamine
FR2836916B1 (fr) * 2002-03-05 2004-06-11 Guerbet Sa Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese
MXPA05000778A (es) 2002-07-18 2005-08-29 Helix Biopharma Corp Uso de ureasa para inhibir el crecimiento de celulas cancerosas.
EP1608319A4 (de) * 2003-04-03 2007-02-28 Univ California Verbesserte hemmer für lösliche epoxidhydrolase
FR2856689A1 (fr) * 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite
FR2857967B1 (fr) * 2003-07-25 2015-04-24 Centre Nat Rech Scient Complexes de lanthanide, leur preparation et leurs utilisations
FR2867473B1 (fr) * 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
CN102532321B (zh) 2004-06-18 2018-10-12 Ambrx公司 新颖抗原结合多肽和其用途
FR2886294B1 (fr) 2005-05-26 2007-07-20 Rhodia Chimie Sa Procede de preparation de composes organosiliciques
FR2914303A1 (fr) 2007-03-28 2008-10-03 Guerbet Sa Composes pour le diagnostic de l'apoptose.
EP2192922A4 (de) 2007-09-17 2010-09-29 Univ California Auf prostatazellen in situ abzielende internalisierende humane monoklonale antikörper
JP5579862B2 (ja) * 2009-10-23 2014-08-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ミクロソームプロスタグランジンｅ２シンターゼ−１のインヒビター
CN105388287A (zh) 2011-03-11 2016-03-09 内布拉斯加大学董事委员会 冠状动脉疾病的生物标志物
US20160145304A1 (en) 2013-07-12 2016-05-26 Helmholtz-Zentrum für Infektionsforschung GmbH Cystobactamides
US10519099B2 (en) 2014-11-26 2019-12-31 Helmholtz-Zentrum für Infektionsforschung GmbH Cystobactamides
GB201421162D0 (en) * 2014-11-28 2015-01-14 Ge Healthcare As Lanthanide complex formulations
ES2975747T3 (es) 2015-11-30 2024-07-12 Univ California Administración de carga útil específica de tumor y activación inmunitaria utilizando un anticuerpo humano que se dirige a un antígeno de superficie celular de tumor altamente específico
WO2018089829A1 (en) 2016-11-10 2018-05-17 Fortis Therapeutics, Inc. Cd46-specific effector cells and uses thereof
FR3069245B1 (fr) * 2017-07-21 2019-07-26 Guerbet Ligands macrocycliques lipophiles, leurs complexes ainsi que leurs utilisations medicales
CN108610274B (zh) * 2018-02-12 2021-09-28 中国人民解放军第二军医大学 一组环γ-聚谷氨酸系列分子及其制备方法和应用
US20200298194A1 (en) * 2019-03-21 2020-09-24 Massachusetts Institute Of Technology Aramid amphiphile self-assembled nanostructures
AU2021320333A1 (en) 2020-08-07 2023-03-30 Fortis Therapeutics, Inc. Immunoconjugates targeting CD46 and methods of use thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648063A (en) * 1981-07-24 1997-07-15 Schering Aktiengesellschaft Sterile composition comprising a chelate complex for magnetic resonance imaging
US5422096A (en) * 1985-05-08 1995-06-06 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
MX174467B (es) * 1986-01-23 1994-05-17 Squibb & Sons Inc 1,4,7-triscarboximetil-1,4,7,10-tetraazaciclodo decano substituido en 1 y compuestos analogos
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
US5679810A (en) * 1990-01-19 1997-10-21 Salutar, Inc. Linear oligomeric polychelant compounds
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
CA2111354C (en) * 1991-06-21 2003-02-04 Nazeer A. Bhore Olefin oligomerization process
DE69426811T2 (de) * 1993-12-30 2001-09-13 Guerbet, Villepinte Polyaminierte Liganden, Metallkomplexe, Verfahren zur Herstellung und diagnostische und therapeutische Verwendungen
GB9407435D0 (en) * 1994-04-14 1994-06-08 Nycomed Salutar Inc Compounds
IT1274038B (it) * 1994-07-29 1997-07-14 Bracco Spa Chelanti macrociclici loro chelati e relativi usi in campo diagnostico
IT1272870B (it) * 1995-01-10 1997-07-01 Ing Ruggeri Guido Dr Apparecchiatura per il prelievo multiplo di campioni liquidi e procedimento per il suo impiego
JPH11508766A (ja) * 1995-06-20 1999-08-03 ザ・ジェネラル・ホスピタル・コーポレイション Ｂ型肝炎複製の抑制
FR2736051B3 (fr) * 1995-06-29 1997-09-26 Guerbet Sa Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique
US5900228A (en) * 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye

Also Published As

Publication number Publication date
HUP9802849A3 (en) 2001-09-28
PL330214A1 (en) 1999-06-21
ES2183303T3 (es) 2003-03-16
CA2254261A1 (fr) 1999-06-10
HK1021976A1 (en) 2000-07-21
PT922700E (pt) 2002-12-31
NO985762D0 (no) 1998-12-09
TR199802559A3 (tr) 1999-06-21
TR199802559A2 (xx) 1999-06-21
NO985762L (no) 1999-06-11
DE69807830T2 (de) 2003-08-07
KR100473240B1 (ko) 2005-05-16
KR19990063025A (ko) 1999-07-26
EA199800998A2 (ru) 1999-08-26
CZ293218B6 (cs) 2004-03-17
IL127467A (en) 2001-04-30
EP0922700B1 (de) 2002-09-11
AU9613398A (en) 1999-07-01
CZ405498A3 (cs) 1999-06-16
IL127467A0 (en) 1999-10-28
DE69807830D1 (de) 2002-10-17
US6187285B1 (en) 2001-02-13
HUP9802849A2 (hu) 1999-10-28
EA199800998A3 (ru) 1999-12-29
NO318037B1 (no) 2005-01-24
CN1225922A (zh) 1999-08-18
CN1132822C (zh) 2003-12-31
EP0922700A1 (de) 1999-06-16
DK0922700T3 (da) 2003-01-20
HU221604B (hu) 2002-11-28
HU9802849D0 (en) 1999-02-01
FR2772025A1 (fr) 1999-06-11
JP3020938B2 (ja) 2000-03-15
AU743361B2 (en) 2002-01-24
FR2772025B1 (fr) 2000-03-03
EA001387B1 (ru) 2001-02-26
NZ333264A (en) 2000-05-26
BR9805801A (pt) 2001-03-20
JPH11279163A (ja) 1999-10-12

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