ATE224184T1 - Verfahren zur mikroverkapselung von antigenen und verwendung der zusammensetzungen als impfstoffe - Google Patents
Verfahren zur mikroverkapselung von antigenen und verwendung der zusammensetzungen als impfstoffeInfo
- Publication number
- ATE224184T1 ATE224184T1 AT94930794T AT94930794T ATE224184T1 AT E224184 T1 ATE224184 T1 AT E224184T1 AT 94930794 T AT94930794 T AT 94930794T AT 94930794 T AT94930794 T AT 94930794T AT E224184 T1 ATE224184 T1 AT E224184T1
- Authority
- AT
- Austria
- Prior art keywords
- vaccines
- compositions
- antigens
- microspheres
- microencapsulating antigens
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 4
- 102000036639 antigens Human genes 0.000 title abstract 4
- 108091007433 antigens Proteins 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 239000004005 microsphere Substances 0.000 abstract 3
- 239000002671 adjuvant Substances 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14179693A | 1993-10-22 | 1993-10-22 | |
| US14355593A | 1993-10-25 | 1993-10-25 | |
| PCT/US1994/011753 WO1995011010A1 (en) | 1993-10-22 | 1994-10-13 | Methods and compositions for microencapsulation of antigens for use as vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE224184T1 true ATE224184T1 (de) | 2002-10-15 |
Family
ID=26839455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94930794T ATE224184T1 (de) | 1993-10-22 | 1994-10-13 | Verfahren zur mikroverkapselung von antigenen und verwendung der zusammensetzungen als impfstoffe |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0724432B1 (de) |
| JP (1) | JPH09504027A (de) |
| AT (1) | ATE224184T1 (de) |
| AU (1) | AU7980794A (de) |
| CA (1) | CA2172509C (de) |
| DE (1) | DE69431404T2 (de) |
| DK (1) | DK0724432T3 (de) |
| ES (1) | ES2184769T3 (de) |
| WO (1) | WO1995011010A1 (de) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE40786E1 (en) * | 1984-03-16 | 2009-06-23 | The United States Of America As Represented By The Secretary Of The Army | Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres |
| US5912015A (en) | 1992-03-12 | 1999-06-15 | Alkermes Controlled Therapeutics, Inc. | Modulated release from biocompatible polymers |
| US6514533B1 (en) | 1992-06-11 | 2003-02-04 | Alkermas Controlled Therapeutics, Inc. | Device for the sustained release of aggregation-stabilized, biologically active agent |
| DK0686045T3 (da) * | 1993-02-23 | 2001-03-05 | Genentech Inc | Stabilisering af med organisk opløsningsmiddel behandlede polypeptider med et hjælpestof |
| DE69415684T2 (de) * | 1993-10-22 | 1999-06-10 | Genentech Inc., San Francisco, Calif. | Verfahren zur herstellung von mikrospharen mit einer wirbelschichtstufe |
| GB9514285D0 (en) * | 1995-07-13 | 1995-09-13 | Univ Nottingham | Polymeric lamellar substrate particles for drug delivery |
| GB2317340B (en) * | 1995-07-13 | 1998-12-23 | Danbiosyst Uk | Polymeric lamellar substrate particles for drug delivery |
| US6265389B1 (en) | 1995-08-31 | 2001-07-24 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of oligonucleotides |
| AU710347B2 (en) * | 1995-08-31 | 1999-09-16 | Alkermes Controlled Therapeutics, Inc. | Composition for sustained release of an agent |
| GB9709900D0 (en) * | 1997-05-15 | 1997-07-09 | Microbiological Res Authority | Microencapsulated DNA for vaccination and gene therapy |
| EP1579851A3 (de) * | 1997-08-29 | 2009-09-02 | Corixa Corporation | Schnellfreisetzende enkapsulierte bioaktive Wirkstoffe zur Induzierung oder Erhöhung einer immunantwort und Verwendung derselben |
| ES2248914T3 (es) * | 1997-08-29 | 2006-03-16 | Corixa Corporation | Agentes bioactivos encapsulados de liberacion rapida que permiten inducir o potenciar una respuesta inmunitaria y metodos para utilizar los mismos. |
| CA2314934C (en) * | 1997-12-16 | 2006-08-29 | Chiron Corporation | Use of microparticles combined with submicron oil-in-water emulsions |
| US7393630B2 (en) | 1997-12-16 | 2008-07-01 | Novartis Vaccines And Diagnostics, Inc. | Use of microparticles combined with submicron oil-in-water emulsions |
| SE9801288D0 (sv) * | 1998-04-14 | 1998-04-14 | Astra Ab | Vaccine delivery system and metod of production |
| US7087236B1 (en) | 1998-09-01 | 2006-08-08 | Merrion Research I Limited | Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof |
| CN1242750C (zh) * | 2000-02-08 | 2006-02-22 | 分子农业生物学院 | 可生物降解的且生物相容的封装有肠炎沙门氏菌的聚合物微球体 |
| ES2160089B1 (es) * | 2000-03-15 | 2002-05-16 | Inst Cientifico Tecnol Navarra | Procedimiento y aparato para la produccion de microparticulas para la liberacion controlada de farmacos hidrosolubles y vectores virales. aplicacion a la adiministracion de adn plasmidico y de adenovirus recombinantes defectivos. |
| US6565888B1 (en) | 2000-08-23 | 2003-05-20 | Alkermes Controlled Therapeutics, Inc. | Methods and compositions for the targeted delivery of biologically active agents |
| EP1417236A4 (de) * | 2001-07-10 | 2010-03-17 | Corixa Corp | Zusammensetzungen und verfahren zur abgabe von proteinen und adjuvantien in einer mikrokügelchen-kapsel |
| CN100339070C (zh) | 2002-10-24 | 2007-09-26 | 莫茨药物股份两合公司 | 包含1－氨基环己烷衍生物类和乙酰胆碱酯酶抑制剂类的药物组合物 |
| WO2005000216A2 (en) | 2003-05-27 | 2005-01-06 | Forest Laboratories, Inc. | Combination of an nmda receptor antagonist and a selective serotonin reuptake inhibitor for the treatment of depression and other mood disorders |
| US20050260217A1 (en) * | 2004-03-04 | 2005-11-24 | Corixa Corporation | Co-encapsulated WT1 polypeptide and immunostimulant microsphere formulations and methods thereof |
| CN100342916C (zh) * | 2004-12-08 | 2007-10-17 | 上海第二医科大学附属第九人民医院 | 一种可生物降解医用材料标记物及其制备 |
| CN101437539B (zh) | 2005-07-05 | 2013-10-02 | 康奈尔研究基金会（有限公司） | 通过干扰cd99l2阻断白细胞迁出和炎症 |
| CN101247826A (zh) | 2005-08-25 | 2008-08-20 | 大鹏药品工业株式会社 | 固定或内包t细胞识别抗原表位肽的生物降解性纳米粒子 |
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| MX2010002733A (es) | 2007-09-12 | 2010-04-09 | Merz Pharma Gmbh & Co Kgaa | Terapia de intervalo para el tratamiento de tinnitus. |
| ES2358703B1 (es) * | 2007-11-14 | 2012-03-21 | Universidad Del Pais Vasco | Empleo de micropart�?culas para su uso como vacunas y la liberación de moléculas biológicamente activas. |
| ES2327375B1 (es) | 2007-11-14 | 2010-08-05 | Universidad Del Pais Vasco | Empleo de microparticulas para su uso como vacunas y la liberacion de moleculas biologicamente activas. |
| EP2085120A1 (de) | 2008-02-01 | 2009-08-05 | Merz Pharma GmbH & Co. KGaA | Verwendung von Substanzen zur Behandlung zentraler und peripherer Insulinrezeptorbeeinträchtigung oder Insulinresistenz |
| EP2318832B1 (de) | 2008-07-15 | 2013-10-09 | Academia Sinica | Glycan-arrays auf objektträgern mit ptfe-aluminiumbeschichtung und entsprechende verfahren |
| TWI432188B (zh) | 2008-12-19 | 2014-04-01 | Merz Pharma Gmbh & Co Kgaa | 供治療發炎性皮膚疾病之１－胺基－烷基環己烷衍生物類 |
| MX2011006353A (es) | 2008-12-19 | 2011-07-13 | Merz Pharma Gmbh & Co Kgaa | Derivados de 1-amino-alquilciclohexano para el tratamiento de enfermedades mediadas por mastocitos. |
| EP2448579A1 (de) | 2009-06-30 | 2012-05-09 | Merz Pharma GmbH & Co. KGaA | Eltoprazin zur behandlung von gewichtsstörungen |
| EP2448580A1 (de) | 2009-06-30 | 2012-05-09 | Merz Pharma GmbH & Co. KGaA | Eltoprazin zur behandlung von angstzuständen |
| WO2011000564A1 (en) | 2009-06-30 | 2011-01-06 | Merz Pharma Gmbh & Co. Kgaa | Eltoprazine for the treatment of drug addiction |
| WO2011000562A1 (en) | 2009-06-30 | 2011-01-06 | Merz Pharma Gmbh & Co. Kgaa | Eltoprazine for the treatment of certain movement disorders |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10338069B2 (en) | 2010-04-12 | 2019-07-02 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| US20110294890A1 (en) | 2010-05-28 | 2011-12-01 | Merz Pharma Gmbh & Co. Kgaa | Neramexane for the treatment or prevention of inner ear disorders |
| US9109007B2 (en) | 2010-08-18 | 2015-08-18 | Purdue Pharma L.P. | MHC-I restricted epitopes containing non-natural amino acid residues |
| EP2665474A1 (de) | 2011-01-20 | 2013-11-27 | Merz Pharma GmbH & Co. KGaA | Neramexan zur behandlung oder vorbeugung von stressbedingtem tinnitus oder akutem hörverlust |
| WO2012171653A1 (en) | 2011-06-15 | 2012-12-20 | Merz Pharma Gmbh & Co. Kgaa | Sarizotan for use in the treatment of attention deficit hyperactivity disorder (adhd) |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| TW201412325A (zh) | 2012-06-20 | 2014-04-01 | 梅茲製藥有限兩合公司 | 用於治療患有青光眼及其他退化性眼疾之人類視力喪失的間隔醫療 |
| JP6302909B2 (ja) | 2012-08-18 | 2018-03-28 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | シアリダーゼの同定および画像化のための細胞透過性プローブ |
| WO2014074114A1 (en) * | 2012-11-09 | 2014-05-15 | Evonik Corporation | Drying methods for tuning microparticle properties |
| US10086054B2 (en) | 2013-06-26 | 2018-10-02 | Academia Sinica | RM2 antigens and use thereof |
| WO2014210564A1 (en) | 2013-06-27 | 2014-12-31 | Academia Sinica | Glycan conjugates and use thereof |
| CA2923579C (en) | 2013-09-06 | 2023-09-05 | Academia Sinica | Human inkt cell activation using glycolipids with altered glycosyl groups |
| SG11201510740YA (en) | 2013-09-17 | 2016-01-28 | Obi Pharma Inc | Compositions of a carbohydrate vaccine for inducing immune responses and uses thereof in cancer treatment |
| JP2017507165A (ja) * | 2013-12-16 | 2017-03-16 | マサチューセッツ インスティテュート オブ テクノロジー | マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤 |
| SG11201604805XA (en) | 2013-12-16 | 2016-07-28 | Massachusetts Inst Technology | Fortified micronutrient salt formulations |
| US9982041B2 (en) | 2014-01-16 | 2018-05-29 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| CN106415244B (zh) | 2014-03-27 | 2020-04-24 | 中央研究院 | 反应性标记化合物及其用途 |
| US20150344585A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Anti-cd20 glycoantibodies and uses thereof |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| EP3904388A1 (de) | 2014-05-27 | 2021-11-03 | Academia Sinica | Fucosidase aus bacteroiden und verfahren damit |
| CN106661099A (zh) | 2014-05-27 | 2017-05-10 | 中央研究院 | 抗her2醣抗体及其用途 |
| EP3154582A4 (de) | 2014-05-28 | 2018-01-10 | Academia Sinica | Anti-tnf-alpha-glycoantikörper und verwendungen davon |
| US9439864B2 (en) * | 2014-07-07 | 2016-09-13 | Antriabio, Inc. | Solvent extraction from biodegradable microparticles |
| EP3191500A4 (de) | 2014-09-08 | 2018-04-11 | Academia Sinica | Aktivierung menschlicher inkt-zellen mithilfe von glykolipiden |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| CA2972072A1 (en) | 2015-01-24 | 2016-07-28 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
| JP2018532990A (ja) | 2015-09-04 | 2018-11-08 | オービーアイ ファーマ，インコーポレイテッド | グリカンアレイおよび使用の方法 |
| KR20180114210A (ko) | 2016-03-08 | 2018-10-17 | 아카데미아 시니카 | N-글리칸의 모듈 합성 방법 및 그의 어레이 |
| TWI780045B (zh) | 2016-03-29 | 2022-10-11 | 台灣浩鼎生技股份有限公司 | 抗體、醫藥組合物及方法 |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| AU2017252128B2 (en) | 2016-04-22 | 2024-06-06 | Obi Pharma, Inc. | Cancer immunotherapy by immune activation or immune modulation via Globo series antigens |
| JP2019522486A (ja) | 2016-07-13 | 2019-08-15 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 抗原提示細胞模倣足場およびそれを作製および使用するための方法 |
| KR20230117482A (ko) | 2016-07-27 | 2023-08-08 | 오비아이 파머 인코퍼레이티드 | 면역원성/치료 글리칸 조성물 및 그의 용도 |
| JP7121724B2 (ja) | 2016-07-29 | 2022-08-18 | オービーアイ ファーマ，インコーポレイテッド | ヒト抗体、医薬組成物及び方法 |
| US10538592B2 (en) | 2016-08-22 | 2020-01-21 | Cho Pharma, Inc. | Antibodies, binding fragments, and methods of use |
| WO2018094414A1 (en) | 2016-11-21 | 2018-05-24 | Obi Pharma, Inc. | Conjugated biological molecules, pharmaceutical compositions and methods |
| TWI853822B (zh) | 2018-06-27 | 2024-09-01 | 台灣浩鼎生技股份有限公司 | 用於糖蛋白工程的糖苷合成酶變體及其使用方法 |
| EP3791873A1 (de) | 2019-09-16 | 2021-03-17 | Universite De Bordeaux | Verfahren zur behandlung und/oder vorbeugung von erkrankungen und symptomen im zusammenhang mit bkca- und/oder sk-kanalophathien |
| CA3178260A1 (en) | 2020-05-13 | 2021-11-18 | Massachusetts Institute Of Technology | Compositions of polymeric microdevices and their use in cancer immunotherapy |
| US11992559B2 (en) | 2021-02-24 | 2024-05-28 | Oakwood Laboratories, Llc | Microsphere formulations comprising lurasidone and methods for making and using the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5075109A (en) * | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| ES2102347T3 (es) * | 1987-02-20 | 1997-08-01 | Genentech Inc | Metodos y composiciones para la utilizacion de polipeptidos env y anticuerpos anti-env de hiv. |
| US5008116A (en) * | 1988-11-14 | 1991-04-16 | Frederick Cahn | Immunostimulatory microsphere |
| JP2653255B2 (ja) * | 1990-02-13 | 1997-09-17 | 武田薬品工業株式会社 | 長期徐放型マイクロカプセル |
-
1994
- 1994-10-13 DK DK94930794T patent/DK0724432T3/da active
- 1994-10-13 JP JP7512118A patent/JPH09504027A/ja not_active Withdrawn
- 1994-10-13 DE DE69431404T patent/DE69431404T2/de not_active Expired - Lifetime
- 1994-10-13 AU AU79807/94A patent/AU7980794A/en not_active Abandoned
- 1994-10-13 CA CA2172509A patent/CA2172509C/en not_active Expired - Lifetime
- 1994-10-13 ES ES94930794T patent/ES2184769T3/es not_active Expired - Lifetime
- 1994-10-13 AT AT94930794T patent/ATE224184T1/de active
- 1994-10-13 EP EP94930794A patent/EP0724432B1/de not_active Expired - Lifetime
- 1994-10-13 WO PCT/US1994/011753 patent/WO1995011010A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE69431404T2 (de) | 2003-04-30 |
| ES2184769T3 (es) | 2003-04-16 |
| WO1995011010A1 (en) | 1995-04-27 |
| DE69431404D1 (de) | 2002-10-24 |
| CA2172509A1 (en) | 1995-04-27 |
| EP0724432A1 (de) | 1996-08-07 |
| DK0724432T3 (da) | 2003-01-27 |
| JPH09504027A (ja) | 1997-04-22 |
| AU7980794A (en) | 1995-05-08 |
| CA2172509C (en) | 2010-08-24 |
| EP0724432B1 (de) | 2002-09-18 |
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