ATE224458T1 - Techniken zu detektion von fehlpaarungen - Google Patents

Techniken zu detektion von fehlpaarungen

Info

Publication number
ATE224458T1
ATE224458T1 AT99904427T AT99904427T ATE224458T1 AT E224458 T1 ATE224458 T1 AT E224458T1 AT 99904427 T AT99904427 T AT 99904427T AT 99904427 T AT99904427 T AT 99904427T AT E224458 T1 ATE224458 T1 AT E224458T1
Authority
AT
Austria
Prior art keywords
nucleic acid
duplex nucleic
mismatch
detection techniques
agent
Prior art date
Application number
AT99904427T
Other languages
English (en)
Inventor
Borries Kemper
Karin Var Birkenkamp-Demtroder
Stefan Golz
Original Assignee
Variagenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Variagenics Inc filed Critical Variagenics Inc
Application granted granted Critical
Publication of ATE224458T1 publication Critical patent/ATE224458T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
  • Air Bags (AREA)
  • Geophysics And Detection Of Objects (AREA)
AT99904427T 1998-02-04 1999-01-29 Techniken zu detektion von fehlpaarungen ATE224458T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7371698P 1998-02-04 1998-02-04
PCT/US1999/001936 WO1999040222A1 (en) 1998-02-04 1999-01-29 Mismatch detection techniques

Publications (1)

Publication Number Publication Date
ATE224458T1 true ATE224458T1 (de) 2002-10-15

Family

ID=22115362

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99904427T ATE224458T1 (de) 1998-02-04 1999-01-29 Techniken zu detektion von fehlpaarungen

Country Status (8)

Country Link
US (1) US6110684A (de)
EP (1) EP1053352B1 (de)
JP (1) JP2002502614A (de)
AT (1) ATE224458T1 (de)
AU (1) AU753273B2 (de)
CA (1) CA2319712A1 (de)
DE (1) DE69902996T2 (de)
WO (1) WO1999040222A1 (de)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7195871B2 (en) * 1996-01-24 2007-03-27 Third Wave Technologies, Inc Methods and compositions for detecting target sequences
US6214552B1 (en) * 1998-09-17 2001-04-10 Igen International, Inc. Assays for measuring nucleic acid damaging activities
US6403309B1 (en) * 1999-03-19 2002-06-11 Valigen (Us), Inc. Methods for detection of nucleic acid polymorphisms using peptide-labeled oligonucleotides and antibody arrays
CA2397341A1 (en) * 2000-01-13 2001-07-19 Dhanesh Gohel Ferrofluid based arrays
GB0001005D0 (en) * 2000-01-18 2000-03-08 Zeneca Ltd Methods
GB0000995D0 (en) * 2000-01-18 2000-03-08 Zeneca Ltd Methods
GB0000992D0 (en) * 2000-01-18 2000-03-08 Astrazeneca Uk Ltd Methods
US6340566B1 (en) * 2000-03-28 2002-01-22 The Regents Of The University Of California Detection and quantitation of single nucleotide polymorphisms, DNA sequence variations, DNA mutations, DNA damage and DNA mismatches
US6365355B1 (en) * 2000-03-28 2002-04-02 The Regents Of The University Of California Chimeric proteins for detection and quantitation of DNA mutations, DNA sequence variations, DNA damage and DNA mismatches
GB0021286D0 (en) * 2000-08-30 2000-10-18 Gemini Genomics Ab Identification of drug metabolic capacity
US6539102B1 (en) * 2000-09-01 2003-03-25 Large Scale Proteomics Reference database
AU2002230526A1 (en) 2000-12-01 2002-06-11 Cornell Research Foundation, Inc. Detection of nucleic acid differences using combined endonuclease cleavage and ligation reactions
IL156752A0 (en) * 2001-01-06 2004-02-08 Gen Hospital Corp Gene for identifying individuals with familial dysautonomia
US20030092157A1 (en) * 2001-03-16 2003-05-15 Hayden Michael R. Compositions, screening systems and methods for modulating HDL cholesterol and triglyceride levels
AU2002305019A1 (en) * 2001-05-25 2002-12-09 University Of British Columbia Diagnostic methods for cardiovascular disease, low hdl-cholesterol levels, and high triglyceride levels
US20030220844A1 (en) * 2002-05-24 2003-11-27 Marnellos Georgios E. Method and system for purchasing genetic data
WO2004013606A2 (en) * 2002-08-02 2004-02-12 Stratatech Corporation Species specific dna detection
US20050101640A1 (en) * 2002-10-16 2005-05-12 Recordati Ireland Limited Lisinopril/lercanidipine combination therapy
US20040147566A1 (en) * 2002-10-16 2004-07-29 Amedeo Leonardi Lisinopril/lercanidipine combination therapy
EP2112229A3 (de) 2002-11-25 2009-12-02 Sequenom, Inc. Verfahren zum Identifizieren des Brustkrebsrisikos und zugehörige Behandlungen
JP4230457B2 (ja) 2002-12-18 2009-02-25 サード・ウェーブ・テクノロジーズ・インク 低分子核酸の検出方法
US8206904B2 (en) 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
US7297780B2 (en) 2003-01-06 2007-11-20 Third Wave Technologies, Inc. Reactive functional groups for preparation of modified nucleic acid
US7189512B2 (en) * 2003-02-20 2007-03-13 Noga Porat Methods for variation detection
WO2005017186A2 (en) * 2003-08-08 2005-02-24 Thomas Jefferson University Method for rapid identification of alternative splicing
US7462451B2 (en) * 2004-04-26 2008-12-09 Third Wave Technologies, Inc. Compositions for modifying nucleic acids
US20080199480A1 (en) * 2004-07-22 2008-08-21 Sequenom, Inc. Methods for Identifying Risk of Type II Diabetes and Treatments Thereof
CA2588865A1 (en) * 2004-11-23 2006-06-01 Xiao Bing Wang Detection of nucleic acid variation by cleavage-amplification method
US20070207455A1 (en) * 2005-11-17 2007-09-06 Third Wave Technologies, Inc. Compositions and methods for detecting an HCV-1 subtype
EP3260556B1 (de) 2006-05-31 2019-07-31 Sequenom, Inc. Verfahren zur nukleinsäureextraktion aus einer probe
CN103146825B (zh) 2006-06-01 2017-08-25 第三次浪潮技术公司 核酸的检测
US8153369B2 (en) 2006-06-05 2012-04-10 Cancer Care Ontario Assessment of risk for colorectal cancer
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
WO2008084571A1 (ja) * 2007-01-12 2008-07-17 Japan Science And Technology Agency 核酸応答性ゲルおよびその製造方法ならびにその利用
EP2118298B1 (de) * 2007-02-08 2013-01-09 Sequenom, Inc. Tests auf nukleinsäurebasis für rhd-typisierung
AU2008222563A1 (en) 2007-03-05 2008-09-12 Cancer Care Ontario Assessment of risk for colorectal cancer
EP2140031A4 (de) 2007-03-26 2011-04-20 Sequenom Inc Restriktionsendonukleaseverstärkte polymorphe sequenzerfassung
WO2008139902A1 (ja) * 2007-05-07 2008-11-20 Japan Science And Technology Agency 分子応答性ゲル微粒子およびその製造方法ならびにその利用
US7947446B2 (en) * 2007-05-29 2011-05-24 Ming-Sheng Lee High throughput mutation screening methods and kits using a universalized approach—differential sequence fill-in (DSF)-enabled sequential adapter ligation and amplification
GB0713183D0 (en) * 2007-07-06 2007-08-15 King S College London Method
WO2009032781A2 (en) 2007-08-29 2009-03-12 Sequenom, Inc. Methods and compositions for universal size-specific polymerase chain reaction
JP2010538612A (ja) * 2007-09-07 2010-12-16 サード ウェーブ テクノロジーズ,インコーポレーテッド 標的の定量化のための方法およびアプリケーション
WO2009114543A2 (en) 2008-03-11 2009-09-17 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
WO2009120808A2 (en) 2008-03-26 2009-10-01 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
IL313131A (en) 2009-02-11 2024-07-01 Caris Mpi Inc Molecular characterization of tumors
CN102428191A (zh) * 2009-03-18 2012-04-25 塞昆纳姆股份有限公司 热稳定性内切核酸酶在产生报道分子中的应用
US8771948B2 (en) 2009-04-03 2014-07-08 Sequenom, Inc. Nucleic acid preparation compositions and methods
US20110091931A1 (en) * 2009-04-24 2011-04-21 Colby Pharmaceutical Company Methods and Kits for Determining Oxygen Free Radical (OFR) Levels in Animal and Human Tissues as a Prognostic Marker for Cancer and Other Pathophysiologies
CA2779223A1 (en) 2009-10-27 2011-05-12 Caris Mpi, Inc. Molecular profiling for personalized medicine
US8394589B2 (en) 2009-12-21 2013-03-12 Northwestern University Methods for diagnosing scapuloperoneal spinal muscular atrophy or Charcot-Marie-Tooth disease type 2C by detecting mutations in TRPV4
DK2516680T3 (en) 2009-12-22 2016-05-02 Sequenom Inc Method and kits to identify aneuploidy
US10233501B2 (en) 2010-10-19 2019-03-19 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US20150218639A1 (en) 2014-01-17 2015-08-06 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US20150225792A1 (en) 2014-01-17 2015-08-13 Northwestern University Compositions and methods for identifying depressive disorders
US10093981B2 (en) 2010-10-19 2018-10-09 Northwestern University Compositions and methods for identifying depressive disorders
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
EP3441479B1 (de) 2011-02-02 2020-09-02 Exact Sciences Development Company, LLC Digitale sequenzanalyse einer dna-methylierung
WO2012117588A1 (ja) 2011-02-28 2012-09-07 独立行政法人科学技術振興機構 複数物質応答性ゲルおよびその製造方法並びにその利用
WO2012149339A2 (en) 2011-04-29 2012-11-01 Sequenom, Inc. Quantification of a minority nucleic acid species
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
CN103649298A (zh) 2011-05-12 2014-03-19 精密科学公司 核酸的分离
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
EP2723904A4 (de) * 2011-06-27 2015-03-04 Flir Systems Verfahren und zusammensetzungen zum trennen einer zielnukleinsäure von gemischten nukleinsäureproben
EP3269820A1 (de) 2011-12-22 2018-01-17 Ibis Biosciences, Inc. Kit für die amplifizierung einer sequenz aus einer ribonukleinsäure
EP4155401A1 (de) 2012-03-02 2023-03-29 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
US20140093873A1 (en) 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US9212392B2 (en) 2012-09-25 2015-12-15 Exact Sciences Corporation Normalization of polymerase activity
US9896728B2 (en) 2013-01-29 2018-02-20 Arcticrx Ltd. Method for determining a therapeutic approach for the treatment of age-related macular degeneration (AMD)
EP3597774A1 (de) 2013-03-13 2020-01-22 Sequenom, Inc. Primer zur analyse der dna-methylierung
EP2971179B1 (de) 2013-03-14 2019-01-09 Mayo Foundation for Medical Education and Research Neoplasma-erkennung
CA2924669C (en) 2013-09-20 2023-03-21 The Regents Of The University Of Michigan Compositions and methods for the analysis of radiosensitivity
US10253358B2 (en) 2013-11-04 2019-04-09 Exact Sciences Development Company, Llc Multiple-control calibrators for DNA quantitation
US9909181B2 (en) 2013-12-13 2018-03-06 Northwestern University Biomarkers for post-traumatic stress states
WO2015095689A1 (en) 2013-12-19 2015-06-25 Exact Sciences Corporation Synthetic nucleic acid control molecules
WO2015138774A1 (en) 2014-03-13 2015-09-17 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
WO2016094813A1 (en) 2014-12-12 2016-06-16 Exact Sciences Corporation Compositions and methods for performing methylation detection assays
CN113897432A (zh) 2014-12-12 2022-01-07 精密科学公司 用于进行甲基化检测测定的组合物和方法
WO2016160454A1 (en) 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders
JP6871926B2 (ja) 2015-08-31 2021-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチMayo Foundation for Medical Education and Research 胃の新生物を検出すること
CA3002196C (en) 2015-10-30 2024-05-14 Exact Sciences Development Company, Llc Multiplex amplification detection assay and isolation and detection of dna from plasma
AU2017260630B2 (en) 2016-05-05 2023-07-13 Exact Sciences Corporation Detection of lung neoplasia by analysis of methylated DNA
US20170321286A1 (en) 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by amplification of rna sequences
US11345949B2 (en) 2016-07-19 2022-05-31 Exact Sciences Corporation Methylated control DNA
WO2018017710A1 (en) 2016-07-19 2018-01-25 Exact Sciences Development Company, Llc Nucleic acid control molecules from non-human organisms
US20180066320A1 (en) 2016-09-02 2018-03-08 Mayo Foundation For Medical Education And Research Detecting hepatocellular carcinoma
EP3736324A1 (de) 2016-09-30 2020-11-11 The Governing Council Of The University Of Toronto System zur identifizierung und zum targeting einzelner zellen in einer heterogenen population zur selektiven extraktion von zellgehalt
AU2018211956B2 (en) 2017-01-27 2024-06-20 Exact Sciences Corporation Detection of colon neoplasia by analysis of methylated DNA
US10934592B2 (en) 2017-02-28 2021-03-02 Mayo Foundation For Medical Education And Research Detecting prostate cancer
AU2018374176B2 (en) 2017-11-30 2024-12-12 Exact Sciences Corporation Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
EP3775272B1 (de) 2018-04-02 2025-07-30 Enumera Molecular, Inc. Verfahren, systeme und zusammensetzungen zum zählen von nukleinsäuremolekülen
US11408030B2 (en) 2018-09-10 2022-08-09 Andy Madrid Test for detecting Alzheimer's disease
KR20210111254A (ko) 2018-11-30 2021-09-10 캐리스 엠피아이, 아이엔씨. 차세대 분자 프로파일링
CA3127329A1 (en) 2019-01-24 2020-07-30 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
WO2020206170A1 (en) 2019-04-02 2020-10-08 Progenity, Inc. Methods, systems, and compositions for counting nucleic acid molecules
AU2020254760B2 (en) 2019-04-03 2025-10-23 Exact Sciences Corporation Detecting pancreatic ductal adenocarcinoma in plasma
EP4031683A4 (de) 2019-09-16 2024-01-17 Exact Sciences Corporation Struktur- und temperaturabhängige flap-endonukleasesubstrate
JP7799607B2 (ja) 2019-10-31 2026-01-15 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 卵巣癌の検出
IL293489A (en) 2019-12-02 2022-08-01 Caris Mpi Inc predictor of pan-cancer platinum response
AU2021257479A1 (en) 2020-04-17 2022-11-10 Exact Sciences Corporation Ingestible sampling device
WO2022040306A1 (en) 2020-08-19 2022-02-24 Mayo Foundation For Medical Education And Research Detecting non-hodgkin lymphoma
WO2022061305A1 (en) 2020-09-21 2022-03-24 Progenity, Inc. Compositions and methods for isolation of cell-free dna
EP4314286A1 (de) 2021-08-06 2024-02-07 Sansure Biotech Inc. Zusammensetzungen zur verflüssigung einer viskosen biologischen probe, kombinationsprodukte, verflüssigungsmittel und kits dafür sowie verfahren und anwendung davon
WO2026055641A1 (en) 2024-09-06 2026-03-12 Exact Sciences Corporation Methods and compositions for preparing biomolecule analytes from complex samples

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217863A (en) * 1988-02-04 1993-06-08 Medical Research Council Detection of mutations in nucleic acids
AU3539089A (en) * 1988-04-08 1989-11-03 Salk Institute For Biological Studies, The Ligase-based amplification method
US5459039A (en) * 1989-05-12 1995-10-17 Duke University Methods for mapping genetic mutations
JPH07500493A (ja) * 1991-07-19 1995-01-19 バリジーン・コーポレーション 突然変異の検出法
AU3919293A (en) * 1992-03-27 1993-11-08 University Of Maryland At Baltimore Detection of gene mutations with mismatch repair enzymes
CA2188660C (en) * 1994-04-25 2005-01-18 Richard G. H. Cotton Detection of mutation by resolvase cleavage
US5851770A (en) * 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
EP0843736B1 (de) * 1995-05-11 1999-12-22 Ulf Landegren Nachweis von fehlpaarungen durch spaltung mit resolvase auf einem festträger
US5824471A (en) * 1995-06-05 1998-10-20 Brigham And Women's Hospital Detection of mismatches by cleavage of nucleic acid heteroduplexes
US5571676A (en) * 1995-06-07 1996-11-05 Ig Laboratories, Inc. Method for mismatch-directed in vitro DNA sequencing
WO1997009434A1 (en) * 1995-09-08 1997-03-13 University Of Dundee Dna structure-specific nucleases
US6027898A (en) * 1997-08-18 2000-02-22 Transgenomic, Inc. Chromatographic method for mutation detection using mutation site specifically acting enzymes and chemicals
DE19757144A1 (de) * 1997-12-20 1999-06-24 Boerries Prof Dr Rer Na Kemper Dualer enzymatischer Test zum Nachweis von Mutationen in DNA beliebiger Herkunft durch Endonuklease VII

Also Published As

Publication number Publication date
EP1053352B1 (de) 2002-09-18
WO1999040222A1 (en) 1999-08-12
DE69902996T2 (de) 2003-04-30
AU753273B2 (en) 2002-10-10
DE69902996D1 (de) 2002-10-24
US6110684A (en) 2000-08-29
EP1053352A1 (de) 2000-11-22
AU2482899A (en) 1999-08-23
CA2319712A1 (en) 1999-08-12
EP1053352A4 (de) 2001-03-21
JP2002502614A (ja) 2002-01-29

Similar Documents

Publication Publication Date Title
DE69902996D1 (de) Techniken zu detektion von fehlpaarungen
ATE220724T1 (de) Nachweis von nukleinsäure-amplifikation
DE69631483D1 (de) Detektion von fehlerhaften basenpaarungen durch spaltung mittels "resolvase" wobei magnetische kügelchen verwendet werden
EP0382433A3 (de) Nachweis von Nukleinsäuresequenzen unter Verwendung von Floureszenz-Polarisation
AU3806701A (en) Nucleic acid detection methods using universal priming
WO2001009381A3 (en) Methods of nucleic acid analysis by detecting molecular binding events
PT1409984E (pt) Processos e reagentes para a detecção de endotoxinas
ATE36413T1 (de) Testverfahren unter verwendung von enzymen als markierungssubstanzen.
DK0407789T3 (da) Fremgangsmåde til detektering af nukleinsyrer
DE69936532D1 (de) Verfahren zum quantitativen nachweis von nukleinsäuren
EP0964249A3 (de) Messverfahren für LDL-Cholesterol
WO2003010326A3 (en) Parallel, antiparallel, homologous or complementary binding of nucleic acids
EP0128018A3 (en) Molecular genetic probe, and method of forming same, assay technique and kit using said molecular genetic probe
WO1999024611A3 (en) Analyte detection process using dual labeled probes
DE69604051D1 (de) Verfahren zum sensitiven nachweis von reverser transcriptase
AUPR221400A0 (en) Diagnostic assay
WO1998053104A3 (en) Detection of retroviral subtypes based upon envelope specific sequences
WO1998026097A3 (en) NUCLEIC ACID PRIMERS AND PROBES FOR DETECTING $i(LEGIONELLA PNEUMOPHILA)
AU2813200A (en) Assay for measuring different enzyme activities simultaneously
AU4726896A (en) Detection of antibody production
ATE453859T1 (de) Verfahren zum nachweis einer reaktion zur molekularen erkennung
DE59907982D1 (de) Verfahren zum Nachweis einer bei Apoptose aktivierten Protease
WO1998035058A3 (en) Improved process for detection and quantification of nucleic acid molecules
AU2628697A (en) Method for detecting and/or quantifying a hapten in a homogeneous phase and device for implementation thereof
EP0352547A3 (de) Nachweis von LDH1

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties