ATE225788T1 - Verfahren zur herstellung einer sehr sauberen phenotiazin verbindung - Google Patents
Verfahren zur herstellung einer sehr sauberen phenotiazin verbindungInfo
- Publication number
- ATE225788T1 ATE225788T1 AT00115899T AT00115899T ATE225788T1 AT E225788 T1 ATE225788 T1 AT E225788T1 AT 00115899 T AT00115899 T AT 00115899T AT 00115899 T AT00115899 T AT 00115899T AT E225788 T1 ATE225788 T1 AT E225788T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- following
- production
- give
- alkali metal
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 10
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
- -1 trimethyloxosulfonium halide Chemical class 0.000 abstract 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- ZKMZPXWMMSBLNO-UHFFFAOYSA-N 1-azabicyclo[2.2.2]octan-3-one Chemical compound C1CC2C(=O)CN1CC2 ZKMZPXWMMSBLNO-UHFFFAOYSA-N 0.000 abstract 1
- WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 abstract 1
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001339 alkali metal compounds Chemical class 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 239000007789 gas Substances 0.000 abstract 1
- 229910000039 hydrogen halide Inorganic materials 0.000 abstract 1
- 239000012433 hydrogen halide Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229950000688 phenothiazine Drugs 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21131099 | 1999-07-26 | ||
| JP32178699 | 1999-11-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE225788T1 true ATE225788T1 (de) | 2002-10-15 |
Family
ID=26518559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00115899T ATE225788T1 (de) | 1999-07-26 | 2000-07-25 | Verfahren zur herstellung einer sehr sauberen phenotiazin verbindung |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6433168B1 (de) |
| EP (1) | EP1074552B1 (de) |
| AT (1) | ATE225788T1 (de) |
| DE (1) | DE60000560T2 (de) |
| DK (1) | DK1074552T3 (de) |
| ES (1) | ES2180490T3 (de) |
| PT (1) | PT1074552E (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2911606B1 (fr) * | 2007-01-18 | 2009-04-17 | Pierre Fabre Medicament Sa | Nouveau derive de la quinuclidine utile dans la preparation de la mequitazine |
| CN105085513B (zh) * | 2014-05-20 | 2017-10-31 | 中山奕安泰医药科技有限公司 | 一种制备(r)‑3‑奎宁环醇的方法 |
| CN110204540B (zh) * | 2019-05-29 | 2022-06-24 | 宁波斯迈克制药有限公司 | 一种工业化生产美喹他嗪的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3725410A (en) | 1970-07-15 | 1973-04-03 | American Home Prod | 3-aminomethyl-3-quinuclidinols |
| US3792053A (en) | 1970-07-15 | 1974-02-12 | American Home Prod | 3-(1,2,3,4-tetrahydroisoquinolinomethyl)-3-quinuclidinol |
| US4855290A (en) | 1985-05-10 | 1989-08-08 | State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research | Derivatives of quinuclidine |
| US4876260A (en) | 1987-10-28 | 1989-10-24 | State Of Israel, Israel Institute Of Biological Research | Oxathiolanes |
| JP2835413B2 (ja) | 1990-10-30 | 1998-12-14 | 住化ファインケム株式会社 | フェノチアジン誘導体およびその製造方法 |
| JP2979358B2 (ja) | 1991-11-22 | 1999-11-15 | 住化ファインケム株式会社 | フェノチアジン誘導体 |
| GB9216721D0 (en) | 1992-08-06 | 1992-09-23 | Ici Plc | Therapeutic heterocyclic derivatives |
| FR2772029B1 (fr) | 1997-12-08 | 2000-02-25 | Pf Medicament | Procede de preparation de la mequitazine et nouvel intermediaire de synthese |
-
2000
- 2000-07-21 US US09/621,782 patent/US6433168B1/en not_active Expired - Fee Related
- 2000-07-25 DK DK00115899T patent/DK1074552T3/da active
- 2000-07-25 EP EP00115899A patent/EP1074552B1/de not_active Expired - Lifetime
- 2000-07-25 ES ES00115899T patent/ES2180490T3/es not_active Expired - Lifetime
- 2000-07-25 PT PT00115899T patent/PT1074552E/pt unknown
- 2000-07-25 AT AT00115899T patent/ATE225788T1/de active
- 2000-07-25 DE DE60000560T patent/DE60000560T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6433168B1 (en) | 2002-08-13 |
| DE60000560D1 (de) | 2002-11-14 |
| ES2180490T3 (es) | 2003-02-16 |
| EP1074552A3 (de) | 2001-03-07 |
| EP1074552A2 (de) | 2001-02-07 |
| PT1074552E (pt) | 2003-02-28 |
| EP1074552B1 (de) | 2002-10-09 |
| DE60000560T2 (de) | 2003-06-05 |
| DK1074552T3 (da) | 2003-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1074552 Country of ref document: EP |
|
| EEIH | Change in the person of patent owner |