ATE226206T1 - Benzoxazine zur erhöhung der synaptischen reaktionen - Google Patents
Benzoxazine zur erhöhung der synaptischen reaktionenInfo
- Publication number
- ATE226206T1 ATE226206T1 AT97919965T AT97919965T ATE226206T1 AT E226206 T1 ATE226206 T1 AT E226206T1 AT 97919965 T AT97919965 T AT 97919965T AT 97919965 T AT97919965 T AT 97919965T AT E226206 T1 ATE226206 T1 AT E226206T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- subjects
- ampa receptors
- benzoxazine
- reactions
- Prior art date
Links
- CMLFRMDBDNHMRA-UHFFFAOYSA-N 2h-1,2-benzoxazine Chemical compound C1=CC=C2C=CNOC2=C1 CMLFRMDBDNHMRA-UHFFFAOYSA-N 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 title 1
- 230000000946 synaptic effect Effects 0.000 title 1
- 102000003678 AMPA Receptors Human genes 0.000 abstract 3
- 108090000078 AMPA Receptors Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000007812 deficiency Effects 0.000 abstract 2
- 230000002708 enhancing effect Effects 0.000 abstract 2
- 230000001771 impaired effect Effects 0.000 abstract 2
- 210000004556 brain Anatomy 0.000 abstract 1
- 230000036992 cognitive tasks Effects 0.000 abstract 1
- 230000002964 excitative effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 210000000225 synapse Anatomy 0.000 abstract 1
- 230000009782 synaptic response Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/624,335 US5736543A (en) | 1996-04-03 | 1996-04-03 | Benzoxazines for enhancing synaptic response |
| PCT/US1997/005184 WO1997036907A1 (en) | 1996-04-03 | 1997-03-28 | Benzoxazines for enhancing synaptic response |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE226206T1 true ATE226206T1 (de) | 2002-11-15 |
Family
ID=24501596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97919965T ATE226206T1 (de) | 1996-04-03 | 1997-03-28 | Benzoxazine zur erhöhung der synaptischen reaktionen |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5736543A (de) |
| EP (1) | EP0891365B1 (de) |
| JP (1) | JP3170294B2 (de) |
| AT (1) | ATE226206T1 (de) |
| AU (1) | AU708212B2 (de) |
| DE (1) | DE69716414T2 (de) |
| DK (1) | DK0891365T3 (de) |
| ES (1) | ES2185932T3 (de) |
| NZ (1) | NZ331992A (de) |
| WO (1) | WO1997036907A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU721936B2 (en) * | 1996-04-03 | 2000-07-20 | Regents Of The University Of California, The | Benzoxazines for enhancing synaptic response |
| US6110935A (en) * | 1997-02-13 | 2000-08-29 | The Regents Of The University Of California | Benzofurazan compounds for enhancing glutamatergic synaptic responses |
| BR9814106A (pt) * | 1997-10-27 | 2000-10-03 | Cortex Pharma Inc | Processo para tratar da esquizofrenia em um indivìduo, e, conjunto |
| US5985871A (en) * | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
| US6943159B1 (en) | 1998-02-18 | 2005-09-13 | Neurosearch A/S | Compounds and their use as positive AMPA receptor modulators |
| US6124278A (en) * | 1998-04-03 | 2000-09-26 | The Regents Of The University Of California | Acylbenzoxazines for enhancing synaptic response |
| US6011991A (en) * | 1998-12-07 | 2000-01-04 | Technology Patents, Llc | Communication system and method including brain wave analysis and/or use of brain activity |
| US7455836B2 (en) * | 2000-05-08 | 2008-11-25 | The University Of Melbourne | Method of treatment and agents useful for same |
| TWI232863B (en) | 2001-06-11 | 2005-05-21 | Akzo Nobel Nv | Benzoxazepine derivatives |
| AU2002320841B2 (en) | 2001-06-14 | 2008-02-28 | Merck Sharp & Dohme B.V. | (Pyrido/thieno)-[f]-oxazepin-5-one derivatives as positive modulators of the AMPA receptor |
| CZ2004632A3 (cs) * | 2001-11-26 | 2004-08-18 | Cortexápharmaceuticalsźáinc | Karbonylbenzoxazinové sloučeniny pro zvýšení glutamátergních synaptických odpovědí |
| MXPA05002620A (es) * | 2002-09-09 | 2005-05-05 | Nektar Therapeutics Al Corp | Alcanales polimericos solubles en agua. |
| EA200501117A1 (ru) | 2003-01-13 | 2006-02-24 | Кортекс Фармасеутикалс, Инк. | Способ лечения снижения когнитивной способности вследствие лишения сна и стресса |
| US20060063707A1 (en) * | 2004-09-17 | 2006-03-23 | Lifelike Biomatic, Inc. | Compositions for enhancing memory and methods therefor |
| TW200800959A (en) | 2005-06-10 | 2008-01-01 | Wyeth Corp | Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor |
| EP2255848A3 (de) | 2006-09-04 | 2011-04-06 | NeuroSearch AS | Pharmazeutische Kombinationen von Nicotin Rezeptor Modulatoren und Agenzien zur Verbesserung der kognitiven Fähigkeiten |
| WO2008085506A1 (en) * | 2007-01-03 | 2008-07-17 | Cortex Pharmaceuticals, Inc. | 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses |
| NZ578290A (en) * | 2007-01-03 | 2012-03-30 | Cortex Pharma Inc | 3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses |
| CL2008000119A1 (es) | 2007-01-16 | 2008-05-16 | Wyeth Corp | Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia. |
| CA2680920A1 (en) * | 2007-03-23 | 2008-10-02 | The Regents Of The University Of California | Treatment of female sexual dysfunction by compounds that positively modulate ampa-type glutamate receptors |
| WO2008143963A1 (en) * | 2007-05-17 | 2008-11-27 | Cortex Pharmaceuticals, Inc. | Di-substituted amides for enhancing glutamatergic synaptic responses |
| BRPI0823262A2 (pt) * | 2007-08-10 | 2013-09-24 | Cortex Pharma Inc | mÉtodo de tratamento de depressço respiratària e uso de um composto na fabricaÇço de um medicamento para o tratamento de depressço respiratària |
| US8119632B2 (en) | 2007-08-10 | 2012-02-21 | Cortex Pharmaceuticals, Inc. | Bicyclic amide derivatives for enhancing glutamatergic synaptic responses |
| US8071914B2 (en) | 2007-12-26 | 2011-12-06 | Noboru Oshima | Heating apparatus |
| US20110218190A1 (en) * | 2008-11-10 | 2011-09-08 | The Regents Of The University Of California | Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction |
| WO2011109398A2 (en) | 2010-03-02 | 2011-09-09 | President And Fellows Of Harvard College | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
| CA2829006A1 (en) | 2011-03-04 | 2012-09-13 | The Regents Of The University Of California | Locally released growth factors to mediate motor recovery after stroke |
| EP2948135B1 (de) | 2013-01-25 | 2019-01-02 | Case Western Reserve University | Zusammensetzungen und verfahren zur behandlung von erkrankungen mit pervasiver entwicklung |
| WO2014201411A1 (en) | 2013-06-13 | 2014-12-18 | Veroscience Llc | Compositions and methods for treating metabolic disorders |
| WO2018009256A1 (en) | 2016-03-29 | 2018-01-11 | Respirerx Pharmaceuticals, Inc. | Compositions and methods for treating attention deficit disorders |
| CN107286114B (zh) | 2016-04-13 | 2020-08-18 | 中国人民解放军军事医学科学院毒物药物研究所 | Ampa受体增效剂的脑靶向前药及其医药用途 |
| WO2019060298A1 (en) | 2017-09-19 | 2019-03-28 | Neuroenhancement Lab, LLC | METHOD AND APPARATUS FOR NEURO-ACTIVATION |
| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
| US11273283B2 (en) | 2017-12-31 | 2022-03-15 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| EP3849410A4 (de) | 2018-09-14 | 2022-11-02 | Neuroenhancement Lab, LLC | System und verfahren zur verbesserung des schlafs |
| US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3257396A (en) * | 1962-06-11 | 1966-06-21 | Geigy Chem Corp | Certain 1, 3-benzoxazinone derivatives |
| ES2174851T3 (es) * | 1992-07-24 | 2002-11-16 | Univ California | Farmacos que aumentan las respuestas sinapticas mediadas por receptores ampa. |
| US5650409A (en) * | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
-
1996
- 1996-04-03 US US08/624,335 patent/US5736543A/en not_active Expired - Lifetime
-
1997
- 1997-03-28 DE DE69716414T patent/DE69716414T2/de not_active Expired - Lifetime
- 1997-03-28 EP EP97919965A patent/EP0891365B1/de not_active Expired - Lifetime
- 1997-03-28 ES ES97919965T patent/ES2185932T3/es not_active Expired - Lifetime
- 1997-03-28 AT AT97919965T patent/ATE226206T1/de not_active IP Right Cessation
- 1997-03-28 NZ NZ331992A patent/NZ331992A/xx unknown
- 1997-03-28 JP JP53548897A patent/JP3170294B2/ja not_active Expired - Fee Related
- 1997-03-28 WO PCT/US1997/005184 patent/WO1997036907A1/en not_active Ceased
- 1997-03-28 DK DK97919965T patent/DK0891365T3/da active
- 1997-03-28 AU AU24274/97A patent/AU708212B2/en not_active Ceased
-
1998
- 1998-02-06 US US09/019,883 patent/US5962447A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP3170294B2 (ja) | 2001-05-28 |
| WO1997036907A1 (en) | 1997-10-09 |
| ES2185932T3 (es) | 2003-05-01 |
| EP0891365B1 (de) | 2002-10-16 |
| DK0891365T3 (da) | 2003-02-10 |
| NZ331992A (en) | 1999-02-25 |
| US5962447A (en) | 1999-10-05 |
| DE69716414T2 (de) | 2003-06-12 |
| EP0891365A1 (de) | 1999-01-20 |
| AU2427497A (en) | 1997-10-22 |
| US5736543A (en) | 1998-04-07 |
| AU708212B2 (en) | 1999-07-29 |
| DE69716414D1 (de) | 2002-11-21 |
| JP2000503664A (ja) | 2000-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |