ATE227125T1 - Behandlung und prophylaxe von unerwünschten effekten reaktiver sauerstoffverbindungen - Google Patents

Behandlung und prophylaxe von unerwünschten effekten reaktiver sauerstoffverbindungen

Info

Publication number: ATE227125T1
Authority: AT; Austria
Prior art keywords: reactive oxygen; prophylaxis; treatment; adverse effects; oxygen species
Prior art date: 1996-02-09

Application number

AT97905855T

Other languages

English (en)

Inventor

Lawrence D Horwitz

Original Assignee

Univ Colorado

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-09

Filing date

1997-02-07

Publication date

2002-11-15

1997-02-07 Application filed by Univ Colorado filed Critical Univ Colorado

2002-11-15 Application granted granted Critical

2002-11-15 Publication of ATE227125T1 publication Critical patent/ATE227125T1/de

Links

230000002411 adverse Effects 0.000 title 1
230000000694 effects Effects 0.000 title 1
150000002927 oxygen compounds Chemical class 0.000 title 1
238000011321 prophylaxis Methods 0.000 title 1
238000011282 treatment Methods 0.000 title 1
VUAFHZCUKUDDBC-SCSAIBSYSA-N (2s)-2-[(2-methyl-2-sulfanylpropanoyl)amino]-3-sulfanylpropanoic acid Chemical compound CC(C)(S)C(=O)N[C@H](CS)C(O)=O VUAFHZCUKUDDBC-SCSAIBSYSA-N 0.000 abstract 2
239000004201 L-cysteine Substances 0.000 abstract 2
230000017531 blood circulation Effects 0.000 abstract 2
229960004272 bucillamine Drugs 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000006378 damage Effects 0.000 abstract 2
239000003642 reactive oxygen metabolite Substances 0.000 abstract 2
206010021143 Hypoxia Diseases 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000005779 cell damage Effects 0.000 abstract 1
208000037887 cell injury Diseases 0.000 abstract 1
230000001146 hypoxic effect Effects 0.000 abstract 1
208000028867 ischemia Diseases 0.000 abstract 1
210000004165 myocardium Anatomy 0.000 abstract 1
210000000056 organ Anatomy 0.000 abstract 1
230000006950 reactive oxygen species formation Effects 0.000 abstract 1
230000010410 reperfusion Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polyurethanes Or Polyureas (AREA)

AT97905855T 1996-02-09 1997-02-07 Behandlung und prophylaxe von unerwünschten effekten reaktiver sauerstoffverbindungen ATE227125T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/598,926 US5670545A (en)	1996-02-09	1996-02-09	Method for the treatment of ischemic disease and reperfusion injury and the prevention of the adverse effects of reactive oxygen species
PCT/US1997/002024 WO1997028792A1 (en)	1996-02-09	1997-02-07	Traitement and prevention of adverse effects of reactive oxygen species

Publications (1)

Publication Number	Publication Date
ATE227125T1 true ATE227125T1 (de)	2002-11-15

Family

ID=24397503

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97905855T ATE227125T1 (de)	1996-02-09	1997-02-07	Behandlung und prophylaxe von unerwünschten effekten reaktiver sauerstoffverbindungen

Country Status (13)

Country	Link
US (2)	US5670545A (de)
EP (1)	EP0910355B1 (de)
JP (1)	JP2001500104A (de)
CN (1)	CN1097457C (de)
AT (1)	ATE227125T1 (de)
AU (1)	AU713754B2 (de)
CA (1)	CA2246236C (de)
CZ (1)	CZ291763B6 (de)
DE (1)	DE69716914T2 (de)
EA (2)	EA001800B1 (de)
ES (1)	ES2185909T3 (de)
HU (1)	HUP9901969A3 (de)
WO (1)	WO1997028792A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6391899B1 (en) *	1998-07-17	2002-05-21	North Shore—Long Island Jewish Research Institute	Compounds and compositions for treating tissue ischemia
EP1475434A1 (de) *	2003-05-09	2004-11-10	Oncoscience AG	Verfahren zur Lagerung von Tumorzellen
US8735154B2 (en)	2006-10-30	2014-05-27	The University Of Kansas	Templated islet cells and small islet cell clusters for diabetes treatment
US20090263780A1 (en) *	2008-04-17	2009-10-22	Yanming Wang	Organ preservation fluid
WO2010014953A1 (en) *	2008-08-01	2010-02-04	The Regents Of The University Of Colorado, A Body Corporate	Prolonged administration of a dithiol anti-oxidant protects against ventricular remodeling
EP2736536A4 (de)	2011-07-27	2015-03-11	Univ Kansas	Template-inselzellen und kleine inselzellcluster zur behandlung von diabetes
WO2023184031A1 (en) *	2022-03-30	2023-10-05	Revive Therapeutics Ltd	Method and use of bucillamine in the prevention and treatment of stroke

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS51148090A (en) *	1975-06-12	1976-12-18	Santen Pharmaceut Co Ltd	Process for stabilizing an aqueous lysozyme solution
JPS535112A (en) *	1976-03-08	1978-01-18	Santen Pharmaceutical Co Ltd	New cysteine derivatives
US4053651A (en) *	1976-05-10	1977-10-11	E. R. Squibb & Sons, Inc.	Compounds and method for alleviating angiotensin related hypertension
JPS545916A (en) *	1977-06-17	1979-01-17	Santen Pharmaceutical Co Ltd	Novel cystein derivative
JPS5912119B2 (ja) *	1977-10-29	1984-03-21	参天製薬株式会社	アミノ酸誘導体の製造方法
JPS5551021A (en) *	1978-10-11	1980-04-14	Santen Pharmaceut Co Ltd	Remedy for hepatic disorder
JPS6011888B2 (ja) *	1978-10-11	1985-03-28	参天製薬株式会社	リウマチ疾患治療薬
JPS6058908B2 (ja) *	1978-10-11	1985-12-23	参天製薬株式会社	システイン誘導体
JPS5756454A (en) *	1980-09-20	1982-04-05	Santen Pharmaceut Co Ltd	Disulfide type cysteine derivative
US5292926A (en) *	1988-01-25	1994-03-08	Santen Pharmaceutical Co., Ltd.	Cysteine derivatives
JPH04154714A (ja) *	1990-10-17	1992-05-27	Shiseido Co Ltd	毛髪還元剤及び毛髪化粧料
JP2816500B2 (ja) *	1990-10-17	1998-10-27	参天製薬株式会社	抗骨粗鬆剤
JP3066608B2 (ja) *	1991-01-16	2000-07-17	参天製薬株式会社	腎疾患治療剤
JP2814033B2 (ja) *	1992-01-10	1998-10-22	参天製薬株式会社	シスチン尿症治療剤
JP2843955B2 (ja) *	1992-08-01	1999-01-06	参天製薬株式会社	抗白内障剤
JP2899740B2 (ja) *	1994-02-08	1999-06-02	参天製薬株式会社	炎症性腸疾患治療剤

1996
- 1996-02-09 US US08/598,926 patent/US5670545A/en not_active Expired - Lifetime
1997
- 1997-02-07 CZ CZ19982469A patent/CZ291763B6/cs not_active IP Right Cessation
- 1997-02-07 HU HU9901969A patent/HUP9901969A3/hu unknown
- 1997-02-07 AU AU22644/97A patent/AU713754B2/en not_active Ceased
- 1997-02-07 ES ES97905855T patent/ES2185909T3/es not_active Expired - Lifetime
- 1997-02-07 EA EA199800665A patent/EA001800B1/ru not_active IP Right Cessation
- 1997-02-07 WO PCT/US1997/002024 patent/WO1997028792A1/en not_active Ceased
- 1997-02-07 DE DE69716914T patent/DE69716914T2/de not_active Expired - Lifetime
- 1997-02-07 CN CN97192118A patent/CN1097457C/zh not_active Expired - Fee Related
- 1997-02-07 AT AT97905855T patent/ATE227125T1/de not_active IP Right Cessation
- 1997-02-07 EP EP97905855A patent/EP0910355B1/de not_active Expired - Lifetime
- 1997-02-07 JP JP09528699A patent/JP2001500104A/ja active Pending
- 1997-02-07 CA CA002246236A patent/CA2246236C/en not_active Expired - Fee Related
- 1997-02-07 EA EA200000762A patent/EA200000762A1/ru unknown
- 1997-05-23 US US08/862,534 patent/US5756547A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0910355A1 (de)	1999-04-28
CZ291763B6 (cs)	2003-05-14
HUP9901969A2 (hu)	1999-11-29
US5756547A (en)	1998-05-26
AU713754B2 (en)	1999-12-09
DE69716914D1 (de)	2002-12-12
EP0910355B1 (de)	2002-11-06
CZ246998A3 (cs)	1998-11-11
EA001800B1 (ru)	2001-08-27
CA2246236C (en)	2006-12-19
EP0910355A4 (de)	1999-04-28
ES2185909T3 (es)	2003-05-01
CN1097457C (zh)	2003-01-01
HUP9901969A3 (en)	2001-08-28
DE69716914T2 (de)	2003-07-03
JP2001500104A (ja)	2001-01-09
US5670545A (en)	1997-09-23
EA199800665A1 (ru)	1999-08-26
CA2246236A1 (en)	1997-08-14
CN1210461A (zh)	1999-03-10
EA200000762A1 (ru)	2001-04-23
AU2264497A (en)	1997-08-28
WO1997028792A1 (en)	1997-08-14

Legal Events

Date	Code	Title	Description
2003-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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