ATE227287T1 - Derivate des benzopyrans und des benzothiopyrans, deren herstellung und deren verwendung als agonisten von dopamin rezeptoren - Google Patents

Derivate des benzopyrans und des benzothiopyrans, deren herstellung und deren verwendung als agonisten von dopamin rezeptoren

Info

Publication number: ATE227287T1
Authority: AT; Austria
Prior art keywords: benzothiopyrane; benzopyrane; agonists; derivatives; preparation
Prior art date: 1994-09-13

Application number

AT95931987T

Other languages

English (en)

Inventor

Mauro Napoletano

Paolo Cavalleri

Cristina Fraire

Gian Carlo Grancini

Stefania Montanari

Francesco Santangelo

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-13

Filing date

1995-09-05

Publication date

2002-11-15

1995-09-05 Application filed by Zambon Spa filed Critical Zambon Spa

2002-11-15 Application granted granted Critical

2002-11-15 Publication of ATE227287T1 publication Critical patent/ATE227287T1/de

Links

ONJRTQUWKRDCTA-UHFFFAOYSA-N 2h-thiochromene Chemical compound C1=CC=C2C=CCSC2=C1 ONJRTQUWKRDCTA-UHFFFAOYSA-N 0.000 title 1
102000015554 Dopamine receptor Human genes 0.000 title 1
108050004812 Dopamine receptor Proteins 0.000 title 1
239000000556 agonist Substances 0.000 title 1
150000001562 benzopyrans Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
200000000007 Arterial disease Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
208000001647 Renal Insufficiency Diseases 0.000 abstract 1
208000037849 arterial hypertension Diseases 0.000 abstract 1
208000026106 cerebrovascular disease Diseases 0.000 abstract 1
230000000302 ischemic effect Effects 0.000 abstract 1
201000006370 kidney failure Diseases 0.000 abstract 1
230000002093 peripheral effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT95931987T 1994-09-13 1995-09-05 Derivate des benzopyrans und des benzothiopyrans, deren herstellung und deren verwendung als agonisten von dopamin rezeptoren ATE227287T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI941870A IT1271009B (it)	1994-09-13	1994-09-13	Derivati del benzopirano e del benzotiopirano attivi sul sistema cardiovascolare
PCT/EP1995/003478 WO1996008489A1 (en)	1994-09-13	1995-09-05	Derivatives of benzopyran and of benzothiopyran, their preparation and their use as agonists of dopaminergic receptors

Publications (1)

Publication Number	Publication Date
ATE227287T1 true ATE227287T1 (de)	2002-11-15

Family

ID=11369550

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95931987T ATE227287T1 (de)	1994-09-13	1995-09-05	Derivate des benzopyrans und des benzothiopyrans, deren herstellung und deren verwendung als agonisten von dopamin rezeptoren

Country Status (8)

Country	Link
EP (1)	EP0781280B1 (de)
JP (1)	JPH10505095A (de)
AT (1)	ATE227287T1 (de)
AU (1)	AU3521695A (de)
DE (1)	DE69528770T2 (de)
ES (1)	ES2185716T3 (de)
IT (1)	IT1271009B (de)
WO (1)	WO1996008489A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7125904B2 (en)	2002-10-11	2006-10-24	Portela & C.A., S.A.	Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
GB0426061D0 (en) *	2004-11-26	2004-12-29	Pfizer Ltd	Chroman compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4801605A (en) *	1986-08-29	1989-01-31	Ciba-Geigy Corporation	3-amino-dihydro-[1]-benzopyrans and benzothiopyrans
IT1224405B (it) *	1987-12-23	1990-10-04	Simes	Composti attivi sul sistema cardiovascolare
CA2047236C (en) *	1989-04-27	1997-07-22	Bengt Ronny Andersson	Substituted 3-amino chromans
IT1254521B (it) *	1992-03-17	1995-09-25	Zambon Spa	Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare
IT1271411B (it) *	1993-09-14	1997-05-28	Zambon Spa	Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare

1994
- 1994-09-13 IT ITMI941870A patent/IT1271009B/it active IP Right Grant
1995
- 1995-09-05 WO PCT/EP1995/003478 patent/WO1996008489A1/en not_active Ceased
- 1995-09-05 AT AT95931987T patent/ATE227287T1/de not_active IP Right Cessation
- 1995-09-05 EP EP95931987A patent/EP0781280B1/de not_active Expired - Lifetime
- 1995-09-05 ES ES95931987T patent/ES2185716T3/es not_active Expired - Lifetime
- 1995-09-05 AU AU35216/95A patent/AU3521695A/en not_active Abandoned
- 1995-09-05 JP JP8509870A patent/JPH10505095A/ja not_active Ceased
- 1995-09-05 DE DE69528770T patent/DE69528770T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ITMI941870A1 (it)	1996-03-13
IT1271009B (it)	1997-05-26
EP0781280A1 (de)	1997-07-02
WO1996008489A1 (en)	1996-03-21
ES2185716T3 (es)	2003-05-01
DE69528770D1 (de)	2002-12-12
JPH10505095A (ja)	1998-05-19
DE69528770T2 (de)	2003-07-17
AU3521695A (en)	1996-03-29
ITMI941870A0 (it)	1994-09-13
EP0781280B1 (de)	2002-11-06

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Legal Events

Date	Code	Title	Description
2003-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties