ATE228123T1 - Thiophennitronderivate - Google Patents

Thiophennitronderivate

Info

Publication number
ATE228123T1
ATE228123T1 AT99902243T AT99902243T ATE228123T1 AT E228123 T1 ATE228123 T1 AT E228123T1 AT 99902243 T AT99902243 T AT 99902243T AT 99902243 T AT99902243 T AT 99902243T AT E228123 T1 ATE228123 T1 AT E228123T1
Authority
AT
Austria
Prior art keywords
thiophennitron
derivatives
disclosed
compounds
therapeutics
Prior art date
Application number
AT99902243T
Other languages
English (en)
Inventor
Judith A Kelleher
Kirk R Maples
Yong-Kang Zhang
Original Assignee
Centaur Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centaur Pharmaceuticals Inc filed Critical Centaur Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE228123T1 publication Critical patent/ATE228123T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Automatic Cycles, And Cycles In General (AREA)
  • Semiconductor Lasers (AREA)
AT99902243T 1998-01-16 1999-01-14 Thiophennitronderivate ATE228123T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7279098P 1998-01-16 1998-01-16
PCT/US1999/000786 WO1999036420A1 (en) 1998-01-16 1999-01-14 Thiophene nitrone compounds

Publications (1)

Publication Number Publication Date
ATE228123T1 true ATE228123T1 (de) 2002-12-15

Family

ID=22109769

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99902243T ATE228123T1 (de) 1998-01-16 1999-01-14 Thiophennitronderivate

Country Status (10)

Country Link
US (1) US6015831A (de)
EP (1) EP1047688B1 (de)
JP (1) JP2002509147A (de)
CN (1) CN1136212C (de)
AT (1) ATE228123T1 (de)
AU (1) AU2226999A (de)
CA (1) CA2318555A1 (de)
DE (1) DE69904018D1 (de)
WO (1) WO1999036420A1 (de)
ZA (1) ZA99255B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002520386A (ja) 1998-07-17 2002-07-09 セントアー ファーマシューティカルズ インコーポレイテッド 炎症を処置するためのα−（２−ヒドロキシフェニル）ニトロン化合物、α−（２−ヒドロキシフェニル）ニトロン化合物を含む薬学的組成物およびそれらの使用
US6730700B2 (en) * 1998-12-02 2004-05-04 Renovis, Inc. 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
UA66401C2 (en) 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
DE10043282A1 (de) * 2000-09-02 2002-03-28 Kurt Heininger Verwendung von Inhibitoren der Amyloid-beta-Protein-Bildung
US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
CN101468970B (zh) * 2008-04-25 2011-05-11 暨南大学 一种硝酮类化合物及其制备方法和在制药中的应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3666754A (en) * 1965-11-06 1972-05-30 Dainippon Pharmaceutical Co 2-(5-nitrofuryl) nitrone derivatives
US3988159A (en) * 1967-07-28 1976-10-26 American Can Company Light-sensitive material containing nitrone for forming heat-fixed images
US3849934A (en) * 1971-05-03 1974-11-26 Scm Corp Alpha-aryl-n-lower alkyl nitrone-containing compositions useful as anti-fungal agents
US3834073A (en) * 1971-05-03 1974-09-10 Scm Corp Phenyl nitrone derivatives useful as seed protectants
US3950327A (en) * 1972-09-19 1976-04-13 Ciba-Geigy Corporation New nitrones, their manufacture and their use for the manufacture of n-substituted araliphatic aldehyde-nitrones
US3903049A (en) * 1974-01-30 1975-09-02 Goodyear Tire & Rubber Oxidation resistant sulfur curable rubbery polymers
US3917700A (en) * 1974-01-30 1975-11-04 Goodyear Tire & Rubber Nitrone compounds
GB1588417A (en) * 1977-03-15 1981-04-23 Agfa Gevaert Photoresist materials
US4153722A (en) * 1977-10-06 1979-05-08 William H. Rorer, Inc. Method of treatment
GB2137619A (en) * 1983-03-30 1984-10-10 Gerald Scott Nitrone compounds and stabilised rubber compositions containing them
US5723502A (en) * 1985-07-18 1998-03-03 Proctor; Peter H. Topical spin trap composition and method
US5352442A (en) * 1985-07-18 1994-10-04 Proctor Peter H Topical tempo
EP0245835B1 (de) * 1986-05-13 1993-05-05 Seitetsu Kagaku Co., Ltd. Thiophenderivate und Verfahren zu ihrer Herstellung
US4803282A (en) * 1986-08-27 1989-02-07 Pennwalt Corporation Alpha-substituted ketonitrone derivatives
US4871862A (en) * 1986-08-27 1989-10-03 Fisons Corporation α-Substituted ketonitrone derivatives
EP0327263B1 (de) * 1988-01-29 1994-09-07 PROCTOR, Peter H. Haarwachstumanregung mit Nitroxyd und anderen Radikalen
WO1991005552A1 (en) * 1989-10-17 1991-05-02 Oklahoma Medical Research Foundation Method and compositions for inhibition of disorders associated with oxidative damage
CA2111836C (en) * 1991-06-18 2006-08-29 John M. Carney Spin-trapping pharmaceutical compositions and methods for use thereof
US5292746A (en) * 1991-09-12 1994-03-08 Merrell Dow Pharmaceuticals Inc. Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock
GB9300894D0 (en) * 1992-02-07 1993-03-10 Zeneca Ltd Oxime derivatives
US5455272A (en) * 1993-10-22 1995-10-03 Oklahoma Medical Research Foundation Spin trap nitronyl hindered phenols
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
JPH11512427A (ja) * 1995-09-11 1999-10-26 ヘキスト・マリオン・ルセル・インコーポレイテツド 環状ニトロンおよびこれらを含有する医薬組成物
DE69636795D1 (de) * 1995-11-17 2007-02-08 Florida Internat University Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung
KR20000067915A (ko) * 1996-07-19 2000-11-25 센토르 파마슈티칼스, 인크. 푸란 니트론 화합물
TW429241B (en) * 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives

Also Published As

Publication number Publication date
CA2318555A1 (en) 1999-07-22
US6015831A (en) 2000-01-18
CN1136212C (zh) 2004-01-28
JP2002509147A (ja) 2002-03-26
EP1047688A1 (de) 2000-11-02
AU2226999A (en) 1999-08-02
DE69904018D1 (en) 2003-01-02
EP1047688B1 (de) 2002-11-20
WO1999036420A1 (en) 1999-07-22
ZA99255B (en) 1999-07-14
CN1291981A (zh) 2001-04-18

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties