ATE228502T1 - Substituierte analoge von indol-3-carbinol und von diindolmethan als antiestrogene - Google Patents

Substituierte analoge von indol-3-carbinol und von diindolmethan als antiestrogene

Info

Publication number: ATE228502T1
Authority: AT; Austria
Prior art keywords: indole; diindolmethane; antestrogens; carbinol; substituted analogues
Prior art date: 1997-03-07

Application number

AT98943171T

Other languages

English (en)

Inventor

Stephen F Safe

Original Assignee

Texas A & M Univ Sys

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-07

Filing date

1998-03-06

Publication date

2002-12-15

1998-03-06 Application filed by Texas A & M Univ Sys filed Critical Texas A & M Univ Sys

2002-12-15 Application granted granted Critical

2002-12-15 Publication of ATE228502T1 publication Critical patent/ATE228502T1/de

Links

RUMVKBSXRDGBGO-UHFFFAOYSA-N indole-3-carbinol Chemical class C1=CC=C[C]2C(CO)=CN=C21 RUMVKBSXRDGBGO-UHFFFAOYSA-N 0.000 title 1
VFTRKSBEFQDZKX-UHFFFAOYSA-N 3,3'-diindolylmethane Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4NC=3)=CNC2=C1 VFTRKSBEFQDZKX-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
TWJAXIHBWPVMIR-UHFFFAOYSA-N diindolylmethane Natural products C1=CC=C2NC(CC=3NC4=CC=CC=C4C=3)=CC2=C1 TWJAXIHBWPVMIR-UHFFFAOYSA-N 0.000 abstract 1
229940011871 estrogen Drugs 0.000 abstract 1
239000000262 estrogen Substances 0.000 abstract 1
235000002279 indole-3-carbinol Nutrition 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Cosmetics (AREA)

AT98943171T 1997-03-07 1998-03-06 Substituierte analoge von indol-3-carbinol und von diindolmethan als antiestrogene ATE228502T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/813,365 US5948808A (en)	1997-03-07	1997-03-07	Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens
PCT/US1998/004669 WO1998050357A2 (en)	1997-03-07	1998-03-06	Substituted analogs of indole-3-carbinol and of diindolymethane as antiestrogens

Publications (1)

Publication Number	Publication Date
ATE228502T1 true ATE228502T1 (de)	2002-12-15

Family

ID=25212179

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98943171T ATE228502T1 (de)	1997-03-07	1998-03-06	Substituierte analoge von indol-3-carbinol und von diindolmethan als antiestrogene

Country Status (7)

Country	Link
US (1)	US5948808A (de)
EP (1)	EP0971890B1 (de)
AT (1)	ATE228502T1 (de)
AU (1)	AU9102198A (de)
CA (1)	CA2283520C (de)
DE (1)	DE69809726T2 (de)
WO (1)	WO1998050357A2 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6150395A (en) *	1997-05-30	2000-11-21	The Regents Of The University Of California	Indole-3-carbinol (I3C) derivatives and methods
EP1214298B1 (de) *	1999-09-17	2012-05-30	Baylor University	Indol-enthaltende und combrestatin-anverwandte anti-mitotische und die tubulin-polymerisation hemmende wirkstoffe
US6689387B1 (en) *	1999-09-23	2004-02-10	Bioresponse Llc	Phytochemicals for treatment of mastalgia and endometriosis
US7384971B2 (en) *	1999-09-23	2008-06-10	Bioresponse L.L.C.	Phytochemicals for the treatment of cervical dysplasia
US6399645B1 (en) *	2000-03-20	2002-06-04	Maria Bell	Chemoprevention and treatment of cervical or vaginal neoplasia
US7709520B2 (en)	2000-10-06	2010-05-04	The Texas A&M University System	Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers
GB2368843A (en) *	2000-11-08	2002-05-15	Leuven K U Res & Dev	Non-porphyrin multipurpose contrast agents
CN100352805C (zh)	2000-11-08	2007-12-05	鲁汶天主教大学研究开发部	用作造影剂的取代的联吲哚衍生物、包含它们的药物组合物以及制造它们的中间体
US6605605B2 (en) *	2000-11-13	2003-08-12	Milton Hammerly	Estrogenic substances combined with cruciferous indole compounds
US7348352B2 (en) *	2001-10-23	2008-03-25	Bioresponse L.L.C.	Diindolylmethane for the treatment of HPV infection
US6544564B1 (en) *	2001-11-27	2003-04-08	Michael Donald Farley	Cytotoxic pharmaceutical composition
AU2003248091A1 (en) *	2002-07-19	2004-02-09	Meiji Dairies Corporation	Indole derivatives and drugs containing the same
DE60333112D1 (de) *	2002-08-02	2010-08-05	Univ Ohio State Res Found	2-heterosubstituierte 3-aryl-4-h-1-benzopyran-4-one als neue therapeutika bei brustkrebs
US6800655B2 (en) *	2002-08-20	2004-10-05	Sri International	Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
WO2005007223A2 (en) *	2003-07-16	2005-01-27	Sasha John	Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
US20050058600A1 (en) *	2003-09-16	2005-03-17	Bjeldanes Leonard F.	3,3'-Diindolylmethane antiandrogenic compositions
BRPI0510717B8 (pt) *	2004-05-06	2021-05-25	Bioresponse Llc	uso de 3,3' diindolilmetano (dim) ou 2-(indol-3-ilmetil)-3,3´-diindolilmetano (ltr)
WO2006023891A2 (en) *	2004-08-23	2006-03-02	The Texas A & M University System	Ligand-dependant activation of nur77 and uses thereof
US20060100264A1 (en) *	2004-11-06	2006-05-11	Bjeldanes Leonard F	3,3'-Diindolylmethane immune activating compositions
ATE497762T1 (de) *	2004-12-30	2011-02-15	Bioresponse Llc	Verwendung von diindolylmethan-verwandten indolen zur behandlung und prävention von erkrankungen im zusammenhang mit dem respiratory syncytial virus
US20060229355A1 (en) *	2005-04-08	2006-10-12	The Regents Of The University Of California	3.3'-Diindolylmethane compositions inhibit angiogenesis
CA2609980C (en)	2005-05-27	2015-10-13	Queen's University At Kingston	Treatment of protein folding disorders
RU2317980C1 (ru) *	2006-09-13	2008-02-27	Андрей Александрович Иващенко	Способ получения индол-3-карбинола гидрата (варианты)
US8586621B2 (en) *	2006-10-27	2013-11-19	Michael A. Zeligs	Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
WO2008144263A1 (en) *	2007-05-18	2008-11-27	The Ohio State University Research Foundation	Potent indole-3-carbinol-derived antitumor agents
WO2010042657A1 (en) *	2008-10-07	2010-04-15	Colorado State University Research Foundation	Use of diindolylmethane (dim) compounds and derivatives as neuroprotective agents
US8153680B2 (en)	2009-08-25	2012-04-10	The Ohio State University Research Foundation	Alkyl indole-3-carbinol-derived antitumor agents
CN101940568B (zh) *	2010-08-17	2012-11-14	合肥博太医药生物技术发展有限公司	吲哚-3-甲醇、二吲哚甲烷及其衍生物在制备治疗蒽环抗癌药引起的心脏衰竭药物中的应用
US8916604B2 (en) *	2011-05-31	2014-12-23	Rutgers, The State University Of New Jersey	Compositions and methods for epigenetic modification of nucleic acid sequences
US8968801B1 (en) *	2011-09-14	2015-03-03	Cellhealth Technologies Ltd.	Supplement composition for supporting DNA repair and method of use
CN102389419A (zh) *	2011-10-08	2012-03-28	合肥博太医药生物技术发展有限公司	吲哚-3-甲醇、二吲哚甲烷及其衍生物在制备防治动脉粥样硬化药物中的应用
CN103214408B (zh) *	2013-05-07	2015-09-30	南京理工大学	一种合成双吲哚甲烷衍生物的方法
CN107835685A (zh)	2015-07-07	2018-03-23	生命物质有限公司	用于抑制生物膜的群体感应抑制剂
US20210299094A1 (en) *	2018-07-24	2021-09-30	Cornell University	Methods of upregulating tiparp as anticancer strategies

1997
- 1997-03-07 US US08/813,365 patent/US5948808A/en not_active Expired - Lifetime
1998
- 1998-03-06 EP EP98943171A patent/EP0971890B1/de not_active Expired - Lifetime
- 1998-03-06 CA CA002283520A patent/CA2283520C/en not_active Expired - Fee Related
- 1998-03-06 AT AT98943171T patent/ATE228502T1/de not_active IP Right Cessation
- 1998-03-06 DE DE69809726T patent/DE69809726T2/de not_active Expired - Lifetime
- 1998-03-06 AU AU91021/98A patent/AU9102198A/en not_active Abandoned
- 1998-03-06 WO PCT/US1998/004669 patent/WO1998050357A2/en not_active Ceased

Also Published As

Publication number	Publication date
EP0971890A2 (de)	2000-01-19
DE69809726T2 (de)	2003-08-21
AU9102198A (en)	1998-11-27
US5948808A (en)	1999-09-07
WO1998050357A2 (en)	1998-11-12
CA2283520C (en)	2009-11-17
EP0971890B1 (de)	2002-11-27
CA2283520A1 (en)	1998-11-12
DE69809726D1 (de)	2003-01-09
WO1998050357A3 (en)	1999-03-11

Similar Documents

Publication	Publication Date	Title
ATE228502T1 (de)	2002-12-15	Substituierte analoge von indol-3-carbinol und von diindolmethan als antiestrogene
ATE271058T1 (de)	2004-07-15	Mycophenol bisphosponatverbindungen
EA199801031A1 (ru)	1999-06-24	Ингибиторы протеинфарнезилтрансферазы
ATE238307T1 (de)	2003-05-15	Substituierte porphyrinen
EA200001193A1 (ru)	2001-12-24	2-фенил-1-[4-(2-аминоэтокси)бензил]индол в комбинации с эстрогенами
EA199900324A1 (ru)	1999-08-26	Комбинированная терапия для лечения психозов
ATE247470T1 (de)	2003-09-15	Neue substituierte imidazolverbindungen
ES2193508T3 (es)	2003-11-01	Ftalizinonas.
DK0889886T3 (da)	2003-01-20	Hidtil ukendte, i 6-stilling substituerede phenanthridiner
TR199801255T2 (xx)	1998-10-21	Vitronektin resept�r antagonistleri.
PT935465E (pt)	2004-08-31	Compostos novos de imidazole substituido
EA199800667A1 (ru)	1999-02-25	Новые фенантридины
DE69729786D1 (de)	2004-08-12	Hochkonzentrierte, lyophilisierte und flüssige faktor-ix formulierungen
DE69708100D1 (de)	2001-12-13	Konjugate von cis-docosahexaensäure und paclitaxel
DK0918774T3 (da)	2002-05-21	Androgenreceptormodulatorforbindelser og fremgangsmåder
PT1083903E (pt)	2004-11-30	Indenopirrolocarbazoles em ponte
BG99177A (bg)	1995-07-28	Нови 7 бета-заместени-4-аза-5 алфа-холестанони като инхибитори на 5 алфа-редуктаза
UA50808C2 (uk)	2002-11-15	Композиція для лікування респіраторного дистрес-синдрому дорослих або респіраторного дистрес-синдрому новонароджених
DE69828964D1 (de)	2005-03-17	Aromatische maleimide und ihre verwendung als photoinitiatoren
EA200000519A1 (ru)	2000-10-30	2-АРИЛБЕНЗО[b]ТИОФЕНЫ, ПОЛЕЗНЫЕ ДЛЯ ЛЕЧЕНИЯ СИНДРОМА ЭСТРОГЕННОЙ НЕДОСТАТОЧНОСТИ
IL152097A0 (en)	2003-05-29	Use of pyrazole derivatives for treating infertility
EA199800867A1 (ru)	1999-02-25	Соединения тетрагидробетакарболина
EA200000520A1 (ru)	2000-10-30	2-АРИЛ-3-АРОИЛБЕНЗО[b]ТИОФЕНЫ, ПОЛЕЗНЫЕ ДЛЯ ЛЕЧЕНИЯ СИНДРОМА ЭСТРОГЕННОЙ НЕДОСТАТОЧНОСТИ
EA200000522A1 (ru)	2000-10-30	5-htагонисты
DE60026350D1 (de)	2006-04-27	Diaryl piperidyl-pyrrol-derivate als antiprotozoenmittel

Legal Events

Date	Code	Title	Description
2003-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties