ATE229018T1 - ANTITUMOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, METHOD FOR THE PRODUCTION THEREOF AND METHODS OF TREATMENT - Google Patents

ANTITUMOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, METHOD FOR THE PRODUCTION THEREOF AND METHODS OF TREATMENT

Info

Publication number
ATE229018T1
ATE229018T1 AT94912300T AT94912300T ATE229018T1 AT E229018 T1 ATE229018 T1 AT E229018T1 AT 94912300 T AT94912300 T AT 94912300T AT 94912300 T AT94912300 T AT 94912300T AT E229018 T1 ATE229018 T1 AT E229018T1
Authority
AT
Austria
Prior art keywords
treatment
pharmaceutical compositions
production
methods
antitumor compounds
Prior art date
Application number
AT94912300T
Other languages
German (de)
Inventor
Iwao Ojima
Ezio Bombardelli
Original Assignee
Univ New York State Res Found
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found, Indena Spa filed Critical Univ New York State Res Found
Application granted granted Critical
Publication of ATE229018T1 publication Critical patent/ATE229018T1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) <IMAGE>rmula (V). <IMAGE> (V) The invention also provides pharmaceutical compositions including the novel taxanes and method for treatment of certain cancers with these new compounds.
AT94912300T 1993-03-26 1994-03-24 ANTITUMOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, METHOD FOR THE PRODUCTION THEREOF AND METHODS OF TREATMENT ATE229018T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/040,189 US5475011A (en) 1993-03-26 1993-03-26 Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
PCT/US1994/003215 WO1994022856A1 (en) 1993-03-26 1994-03-24 Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment

Publications (1)

Publication Number Publication Date
ATE229018T1 true ATE229018T1 (en) 2002-12-15

Family

ID=21909617

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94912300T ATE229018T1 (en) 1993-03-26 1994-03-24 ANTITUMOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, METHOD FOR THE PRODUCTION THEREOF AND METHODS OF TREATMENT

Country Status (19)

Country Link
US (3) US5475011A (en)
EP (1) EP0690856B1 (en)
JP (2) JP3157165B2 (en)
KR (1) KR100223720B1 (en)
CN (1) CN1067682C (en)
AT (1) ATE229018T1 (en)
AU (1) AU676041B2 (en)
CA (1) CA2158147C (en)
CZ (1) CZ288924B6 (en)
DE (1) DE69431833T2 (en)
DK (1) DK0690856T3 (en)
ES (1) ES2190440T3 (en)
HU (1) HUT73848A (en)
NO (1) NO311722B1 (en)
PL (2) PL179587B1 (en)
PT (1) PT690856E (en)
RU (1) RU2137764C1 (en)
SK (1) SK282317B6 (en)
WO (1) WO1994022856A1 (en)

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Also Published As

Publication number Publication date
JP3145993B2 (en) 2001-03-12
EP0690856A1 (en) 1996-01-10
NO953796D0 (en) 1995-09-25
KR960701045A (en) 1996-02-24
US5599820A (en) 1997-02-04
JP3157165B2 (en) 2001-04-16
PL310827A1 (en) 1996-01-08
SK282317B6 (en) 2002-01-07
JPH11322737A (en) 1999-11-24
NO953796L (en) 1995-11-15
DE69431833D1 (en) 2003-01-16
AU676041B2 (en) 1997-02-27
RU2137764C1 (en) 1999-09-20
EP0690856B1 (en) 2002-12-04
PL179587B1 (en) 2000-09-29
CN1123547A (en) 1996-05-29
DK0690856T3 (en) 2003-03-31
NO311722B1 (en) 2002-01-14
KR100223720B1 (en) 1999-10-15
CA2158147C (en) 1999-10-05
WO1994022856A1 (en) 1994-10-13
HU9502642D0 (en) 1995-11-28
US5705508A (en) 1998-01-06
SK118395A3 (en) 1996-06-05
CA2158147A1 (en) 1994-10-13
AU6491694A (en) 1994-10-24
PL180708B1 (en) 2001-03-30
CZ288924B6 (en) 2001-09-12
HUT73848A (en) 1996-09-30
EP0690856A4 (en) 1996-02-07
CZ248095A3 (en) 1996-03-13
DE69431833T2 (en) 2003-11-06
PT690856E (en) 2003-04-30
ES2190440T3 (en) 2003-08-01
US5475011A (en) 1995-12-12
CN1067682C (en) 2001-06-27
JPH08508497A (en) 1996-09-10

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