ATE229036T1 - Il-8 inhibitoren - Google Patents

Il-8 inhibitoren

Info

Publication number: ATE229036T1
Authority: AT; Austria
Prior art keywords: inhibitors; receptor; binding; compete; receptors
Prior art date: 1993-09-14

Application number

AT94929201T

Other languages

English (en)

Inventor

Patricia A Tekamp-Olson

Guy Mullenbach

Mary Ellen Wernette-Hammond

Original Assignee

Chiron Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-14

Filing date

1994-09-13

Publication date

2002-12-15

1994-09-13 Application filed by Chiron Corp filed Critical Chiron Corp

2002-12-15 Application granted granted Critical

2002-12-15 Publication of ATE229036T1 publication Critical patent/ATE229036T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Tropical Medicine & Parasitology (AREA)
Genetics & Genomics (AREA)
Rheumatology (AREA)
Biophysics (AREA)
Physical Education & Sports Medicine (AREA)
Transplantation (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
AIDS & HIV (AREA)
Pulmonology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT94929201T 1993-09-14 1994-09-13 Il-8 inhibitoren ATE229036T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/121,105 US6448379B1 (en)	1993-09-14	1993-09-14	IL8 inhibitors
PCT/US1994/010356 WO1995007934A2 (en)	1993-09-14	1994-09-13	Il8 inhibitors

Publications (1)

Publication Number	Publication Date
ATE229036T1 true ATE229036T1 (de)	2002-12-15

Family

ID=22394586

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT94929201T ATE229036T1 (de)	1993-09-14	1994-09-13	Il-8 inhibitoren
AT02017044T ATE388168T1 (de)	1993-09-14	1994-09-13	Antikörper gegen den il-8 rezeptor und deren therapeutische verwendungen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT02017044T ATE388168T1 (de)	1993-09-14	1994-09-13	Antikörper gegen den il-8 rezeptor und deren therapeutische verwendungen

Country Status (11)

Country	Link
US (2)	US6448379B1 (de)
EP (3)	EP1283217B1 (de)
JP (3)	JPH09502725A (de)
AT (2)	ATE229036T1 (de)
AU (1)	AU697190B2 (de)
CA (1)	CA2171289C (de)
DE (2)	DE69435083T2 (de)
DK (1)	DK1283217T3 (de)
ES (1)	ES2302774T3 (de)
PT (1)	PT1283217E (de)
WO (1)	WO1995007934A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997000893A1 (en) *	1995-06-20	1997-01-09	Chiron Corporation	Interleukin-8 receptor binding compounds
US7083983B2 (en)	1996-07-05	2006-08-01	Cancer Research Campaign Technology Limited	Inhibitors of the interaction between P53 and MDM2
AU777766B2 (en) *	1996-07-05	2004-10-28	Cancer Research Technology Limited	Inhibitors of the interaction between p53 and MDM2
WO1998006398A1 (en) *	1996-08-15	1998-02-19	Smithkline Beecham Corporation	Il-8 receptor antagonists
WO1998046597A1 (en) *	1997-04-14	1998-10-22	Emory University	Serine protease inhibitors
ES2156534B1 (es) *	1999-02-03	2002-02-01	Smithkline Beecham Sa	Nuevos inhibidores de la interaccion entre la interleuquina-8 y sus receptores
AU2001250412A1 (en) *	2000-03-31	2001-10-08	Ipf Pharmaceuticals Gmbh	Diagnostic and medicament for analysing the cell surface proteome of tumour and inflammatory cells and for treating tumorous and inflammatory diseases, preferably using specific chemokine receptor analysis and the chemokine receptor-ligand interaction
NZ541050A (en)	2002-12-16	2010-06-25	Genmab As	Human monoclonal antibodies against interleukin 8 (IL-8)
CL2008001071A1 (es) *	2007-04-17	2009-05-22	Smithkline Beecham Corp	Metodo para obtener anticuerpo penta-especifico contra il-8/cxcl8, gro-alfa/cxcl1, gro-beta/cxcl2), gro-gama/cxcl3 y ena-78/cxcl5 humanas; anticuerpo penta-especifico; proceso de produccion del mismo; vector, hbridoma o celela que lo comprende; composicion farmceutica; uso para tratar copd, otras enfermedades.
AU2011328246B2 (en)	2010-11-08	2016-06-30	Ablynx N.V.	CXCR2 binding polypeptides
US9328174B2 (en)	2012-05-09	2016-05-03	Novartis Ag	Chemokine receptor binding polypeptides
US20150224190A1 (en)	2012-07-06	2015-08-13	Mohamed Bentires-Alj	Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the IL-8/CXCR interaction
US11291641B2 (en) *	2016-10-03	2022-04-05	The Children's Medical Center Corporation	Prevention and treatment of diabetic nephropathy
CA3084370A1 (en)	2018-01-12	2019-07-18	Bristol-Myers Squibb Company	Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ207394A (en) *	1983-03-08	1987-03-06	Commw Serum Lab Commission	Detecting or determining sequence of amino acids
IE913192A1 (en)	1990-09-12	1992-02-25	Scripps Research Inst	Active site of interleukin-8: polypeptide analogs and¹antibodies
JP2866182B2 (ja)	1990-10-08	1999-03-08	日本ケミファ株式会社	エンドセリン受容体
US5440021A (en) *	1991-03-29	1995-08-08	Chuntharapai; Anan	Antibodies to human IL-8 type B receptor
US5571702A (en) *	1991-03-29	1996-11-05	Genentech, Inc.	Amplification method for detection of human PF4A receptors
JPH06506596A (ja) *	1991-04-10	1994-07-28	ザ　トラスティーズ　オブ　ボストン　ユニバーシティー	インターロイキン−８受容体及び関連分子及び方法
US5374506A (en) *	1991-09-13	1994-12-20	The United States Of America As Represented By The Department Of Health And Human Services	Amino acid sequence for a functional human interleukin-8 receptor

1993
- 1993-09-14 US US08/121,105 patent/US6448379B1/en not_active Expired - Lifetime
1994
- 1994-09-13 EP EP02017044A patent/EP1283217B1/de not_active Expired - Lifetime
- 1994-09-13 JP JP7509317A patent/JPH09502725A/ja not_active Withdrawn
- 1994-09-13 ES ES02017044T patent/ES2302774T3/es not_active Expired - Lifetime
- 1994-09-13 DE DE69435083T patent/DE69435083T2/de not_active Expired - Lifetime
- 1994-09-13 PT PT02017044T patent/PT1283217E/pt unknown
- 1994-09-13 WO PCT/US1994/010356 patent/WO1995007934A2/en not_active Ceased
- 1994-09-13 AU AU78348/94A patent/AU697190B2/en not_active Ceased
- 1994-09-13 EP EP94929201A patent/EP0719285B1/de not_active Expired - Lifetime
- 1994-09-13 DK DK02017044T patent/DK1283217T3/da active
- 1994-09-13 EP EP08000646A patent/EP1932856A3/de not_active Withdrawn
- 1994-09-13 AT AT94929201T patent/ATE229036T1/de not_active IP Right Cessation
- 1994-09-13 DE DE69431843T patent/DE69431843T2/de not_active Expired - Lifetime
- 1994-09-13 CA CA002171289A patent/CA2171289C/en not_active Expired - Fee Related
- 1994-09-13 AT AT02017044T patent/ATE388168T1/de not_active IP Right Cessation
1995
- 1995-06-07 US US08/487,795 patent/US6436390B1/en not_active Expired - Lifetime
2004
- 2004-09-08 JP JP2004261714A patent/JP4122321B2/ja not_active Expired - Fee Related
2008
- 2008-03-14 JP JP2008066818A patent/JP2008169227A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
WO1995007934A2 (en)	1995-03-23
EP1283217A2 (de)	2003-02-12
JP2008169227A (ja)	2008-07-24
AU7834894A (en)	1995-04-03
JP4122321B2 (ja)	2008-07-23
EP0719285A1 (de)	1996-07-03
EP1932856A2 (de)	2008-06-18
EP0719285B1 (de)	2002-12-04
PT1283217E (pt)	2008-06-11
WO1995007934A3 (en)	1995-04-13
EP1283217A3 (de)	2003-09-17
EP1932856A3 (de)	2009-09-30
DE69431843T2 (de)	2003-07-10
DK1283217T3 (da)	2008-07-07
CA2171289C (en)	2007-04-10
JP2005023085A (ja)	2005-01-27
ES2302774T3 (es)	2008-08-01
DE69435083T2 (de)	2009-03-12
ATE388168T1 (de)	2008-03-15
JPH09502725A (ja)	1997-03-18
US6448379B1 (en)	2002-09-10
DE69435083D1 (de)	2008-04-17
AU697190B2 (en)	1998-10-01
CA2171289A1 (en)	1995-03-23
EP1283217B1 (de)	2008-03-05
US6436390B1 (en)	2002-08-20
DE69431843D1 (de)	2003-01-23

Legal Events

Date	Code	Title	Description
2003-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69431843D1 (de)	2003-01-23	Il-8 inhibitoren
ES2304795T3 (es)	2008-10-16	Anticuerpos agonistas para el receptor de trombopoyetina y sus usos terapeuticos.
EP0741748A4 (de)	2000-07-05	Monoklonale antikörper spezifisch gegen vegf-rezeptoren und ihre verwendung
BR0315123A (pt)	2005-08-16	Composições farmacêuticas direcionadas a receptores erb-b1
HU9402823D0 (en)	1995-01-30	Monoclonal antibodies against the interferon receptor, with neutralizing activity against type i interferon
DE69709561D1 (de)	2002-02-21	Östrogen-Rezeptor
ATE247667T1 (de)	2003-09-15	Gdnf-rezeptor und dessen verwendung
DK0851920T3 (da)	2008-09-22	Varianter af vaskulær endotelcellevækstfaktor, anvendelser af disse samt fremgangsmåder til fremstilling deraf
DK0502812T3 (da)	1996-09-02	Rekombinante antistoffer, som er specifikke for en vækstfaktorreceptor
CY1107133T1 (el)	2012-10-24	Κυκλικοι ανταγωνιστες των υποδοχεων c5a και συζευγμενοι με πρωτεϊνη g υποδοχεις
FI964845A7 (fi)	1996-12-04	CD44v6:n vastaiset monoklonaaliset vasta-aineet
DK407987A (da)	1988-02-07	Apolipoprotein b-specifikke monoklonale antistoffer og hybridomer, som producerer disse antistoffer
DK0457804T3 (da)	1996-09-23	M-CSF-monoklonale antistoffer, som genkender en neutraliserende, konformational epitop
DE69832797D1 (de)	2006-01-19	Neurturin-rezeptor
DE69633131D1 (de)	2004-09-16	Rezeptor des y-y5 neuropeptids
MXPA02008462A (es)	2004-05-14	Modulacion de la actividad de receptor de superficie celular endotelial en la regulacion de angiogenesis.
CY1109583T1 (el)	2014-08-13	Κυτοκινες θηλαστικων, αντιστοιχα αντιδραστηρια
IT1277827B1 (it)	1997-11-12	Anticorpo monoclonale chimerico murino/umano o un suo frammento specifico per il recettore egf (egf-r)
DE59611293D1 (de)	2005-12-15	Protein mit dnase-aktivität
FI956041A7 (fi)	1996-02-06	Kompositiot ja diagnostiset menetelmät, joissa käytetään monoklonaalis ia vasta-aineita CD44V6 vastaan