ATE229962T1 - Verfahren zur herstellung von zwischenprodukten in herstellung von carbapenem-seitenketten - Google Patents
Verfahren zur herstellung von zwischenprodukten in herstellung von carbapenem-seitenkettenInfo
- Publication number
- ATE229962T1 ATE229962T1 AT97944621T AT97944621T ATE229962T1 AT E229962 T1 ATE229962 T1 AT E229962T1 AT 97944621 T AT97944621 T AT 97944621T AT 97944621 T AT97944621 T AT 97944621T AT E229962 T1 ATE229962 T1 AT E229962T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- side chains
- intermediate products
- producing intermediate
- phenyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 2
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical group C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 abstract 1
- 239000005708 Sodium hypochlorite Substances 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 di-(substituted) phosphite Chemical class 0.000 abstract 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- PMMYEEVYMWASQN-IMJSIDKUSA-N trans-4-Hydroxy-L-proline Natural products O[C@@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-IMJSIDKUSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2896696P | 1996-10-10 | 1996-10-10 | |
| GBGB9700696.9A GB9700696D0 (en) | 1997-01-15 | 1997-01-15 | Process for synthesizing carbapenem side chain intermediates |
| PCT/US1997/017955 WO1998015561A1 (en) | 1996-10-10 | 1997-10-06 | Process for synthesizing carbapenem side chain intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE229962T1 true ATE229962T1 (de) | 2003-01-15 |
Family
ID=26310799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97944621T ATE229962T1 (de) | 1996-10-10 | 1997-10-06 | Verfahren zur herstellung von zwischenprodukten in herstellung von carbapenem-seitenketten |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0934324B1 (de) |
| JP (1) | JP2001501948A (de) |
| AT (1) | ATE229962T1 (de) |
| AU (1) | AU714155B2 (de) |
| CA (1) | CA2266701C (de) |
| DE (1) | DE69718039T2 (de) |
| ES (1) | ES2187825T3 (de) |
| WO (1) | WO1998015561A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109096333A (zh) * | 2018-08-29 | 2018-12-28 | 山东金城柯瑞化学有限公司 | N-(o,o-二异丙基磷酰基)-反-4-羟基-l-脯氨酸的制备方法 |
| CN112341371B (zh) * | 2020-11-18 | 2022-07-12 | 安徽古尔特科技有限公司 | 一种厄他培南侧链合成中间体的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4558034A (en) * | 1984-01-31 | 1985-12-10 | The Board Of Trustees Of The University Of Kentucky | Inhibitors of bacterial collagenase |
| US5041497A (en) * | 1989-04-10 | 1991-08-20 | Allied-Signal Inc. | Process for preparing co-poly(amides/peptides) |
| GB9202298D0 (en) * | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
-
1997
- 1997-10-06 CA CA002266701A patent/CA2266701C/en not_active Expired - Fee Related
- 1997-10-06 JP JP10517641A patent/JP2001501948A/ja not_active Ceased
- 1997-10-06 DE DE69718039T patent/DE69718039T2/de not_active Expired - Fee Related
- 1997-10-06 AT AT97944621T patent/ATE229962T1/de not_active IP Right Cessation
- 1997-10-06 EP EP97944621A patent/EP0934324B1/de not_active Expired - Lifetime
- 1997-10-06 ES ES97944621T patent/ES2187825T3/es not_active Expired - Lifetime
- 1997-10-06 WO PCT/US1997/017955 patent/WO1998015561A1/en not_active Ceased
- 1997-10-06 AU AU46076/97A patent/AU714155B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0934324A1 (de) | 1999-08-11 |
| EP0934324A4 (de) | 2000-07-26 |
| DE69718039T2 (de) | 2003-07-31 |
| CA2266701C (en) | 2002-12-24 |
| AU4607697A (en) | 1998-05-05 |
| WO1998015561A1 (en) | 1998-04-16 |
| JP2001501948A (ja) | 2001-02-13 |
| CA2266701A1 (en) | 1998-04-16 |
| DE69718039D1 (de) | 2003-01-30 |
| ES2187825T3 (es) | 2003-06-16 |
| AU714155B2 (en) | 1999-12-23 |
| EP0934324B1 (de) | 2002-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |