ATE231130T1 - Funktionalisierte hydrophile akridinium ester - Google Patents
Funktionalisierte hydrophile akridinium esterInfo
- Publication number
- ATE231130T1 ATE231130T1 AT95913298T AT95913298T ATE231130T1 AT E231130 T1 ATE231130 T1 AT E231130T1 AT 95913298 T AT95913298 T AT 95913298T AT 95913298 T AT95913298 T AT 95913298T AT E231130 T1 ATE231130 T1 AT E231130T1
- Authority
- AT
- Austria
- Prior art keywords
- assays
- acridinium ester
- functionalized hydrophilic
- hydrophilic acridinium
- disclosed
- Prior art date
Links
- RXNXLAHQOVLMIE-UHFFFAOYSA-N phenyl 10-methylacridin-10-ium-9-carboxylate Chemical compound C12=CC=CC=C2[N+](C)=C2C=CC=CC2=C1C(=O)OC1=CC=CC=C1 RXNXLAHQOVLMIE-UHFFFAOYSA-N 0.000 title 1
- 238000003556 assay Methods 0.000 abstract 3
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 abstract 2
- 241000710799 Rubella virus Species 0.000 abstract 1
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical class C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 abstract 1
- 239000012491 analyte Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000005081 chemiluminescent agent Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 238000000159 protein binding assay Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229960003604 testosterone Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/64—Acridine or hydrogenated acridine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/586—Liposomes, microcapsules or cells
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Pyridine Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/225,165 US5656426A (en) | 1988-08-01 | 1994-04-08 | Functionaized hydrophilic acridinium esters |
| PCT/IB1995/000244 WO1995027702A1 (en) | 1994-04-08 | 1995-04-06 | Novel functionalized hydrophilic acridinium esters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE231130T1 true ATE231130T1 (de) | 2003-02-15 |
Family
ID=22843803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95913298T ATE231130T1 (de) | 1994-04-08 | 1995-04-06 | Funktionalisierte hydrophile akridinium ester |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5656426A (de) |
| EP (2) | EP0982298A1 (de) |
| JP (1) | JP3844358B2 (de) |
| AT (1) | ATE231130T1 (de) |
| AU (1) | AU703436B2 (de) |
| BR (1) | BR9507307A (de) |
| CA (1) | CA2186463A1 (de) |
| DE (1) | DE69529409T2 (de) |
| ES (1) | ES2188654T3 (de) |
| PL (1) | PL316794A1 (de) |
| WO (1) | WO1995027702A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514987B1 (en) * | 1997-01-06 | 2003-02-04 | Cerus Corporation | Frangible compounds for pathogen inactivation |
| AU9498098A (en) | 1997-09-22 | 1999-04-12 | Chiron Corporation | Buffers for stabilizing antigens |
| DE69837155T2 (de) | 1997-09-22 | 2007-06-21 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Verfahren zum nachweiss von antikörpern in einer probe |
| JP4672144B2 (ja) | 1998-08-11 | 2011-04-20 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド | 近赤外化学発光性アクリジニウム化合物およびその使用。 |
| JP2002530678A (ja) * | 1998-11-25 | 2002-09-17 | バイエル コーポレイション | 化学発光性アクリジニウム化合物を使用するヒドリドの測定 |
| US6673560B1 (en) | 1998-11-25 | 2004-01-06 | Bayer Corporation | Measurement of hydride using chemiluminescent acridinium compounds and applications thereof |
| JP3819294B2 (ja) * | 1999-07-30 | 2006-09-06 | バイエル コーポレイション | 燐酸酵素のような加水分解性酵素の化学発光基質 |
| US6783948B1 (en) * | 1999-07-30 | 2004-08-31 | Bayer Corporation | Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes |
| US6348317B1 (en) * | 1999-11-18 | 2002-02-19 | The Arizona Board Of Regents | Fluorescent and DNA cleavage properties of peptide/dye conjugates |
| WO2001083821A2 (en) * | 2000-05-01 | 2001-11-08 | Gen-Probe Incorporated | Polynucleotide probes for detection and quantitation of candida species |
| US6664043B2 (en) * | 2001-07-03 | 2003-12-16 | Bayer Corporation | Acridinium ester labels having hydrophilic modifiers |
| US6723851B2 (en) | 2001-10-31 | 2004-04-20 | Quest Diagnostics Investment Incorporated | Chemiluminescent compounds and use thereof |
| US20030232386A1 (en) * | 2002-06-17 | 2003-12-18 | Shah Dinesh O. | Assay conjugate and uses thereof |
| ATE553089T1 (de) * | 2002-08-20 | 2012-04-15 | Quest Diagnostics Invest Inc | Hydrophile, chemilumineszente acridiniummarkierungsreagenzien |
| US6924154B2 (en) * | 2002-08-20 | 2005-08-02 | Quest Diagnostics Investments Incorporated | Hydrophilic chemilumescent acridinium labeling reagents |
| US7319041B2 (en) * | 2002-09-27 | 2008-01-15 | Siemens Medical Solutions Diagnostic | Applications of acridinium compounds and derivatives in homogeneous assays |
| US7309615B2 (en) * | 2002-09-27 | 2007-12-18 | Siemens Medical Solutions Diagnostic | High quantum yield acridinium compounds and their uses in improving assay sensitivity |
| US20090068635A1 (en) * | 2007-09-06 | 2009-03-12 | Muerhoff Anthony S | Indirectly labelled assay conjugates and methods of preparing and using same |
| US8293908B2 (en) * | 2007-11-20 | 2012-10-23 | Siemens Healthcare Diagnostics Inc. | Facile N-alkylation of acridine compounds in ionic liquids |
| US20120015390A1 (en) | 2009-03-27 | 2012-01-19 | Protea Biopharma N.V. | Methods for the Detection and Treatment of Aberrant Prion Disease |
| US8778624B2 (en) | 2009-11-16 | 2014-07-15 | Siemens Healthcare Diagnostics Inc. | Zwitterion-containing acridinium compounds |
| CN102905690B (zh) | 2010-05-21 | 2016-03-30 | 西门子医疗保健诊断公司 | 两性离子试剂 |
| ES2618042T3 (es) | 2012-07-10 | 2017-06-20 | Siemens Healthcare Diagnostics Inc. | Síntesis de compuestos de acridinio mediante n-alquilación de acridanos |
| ES2769887T3 (es) | 2013-05-14 | 2020-06-29 | Siemens Healthcare Diagnostics Inc | Tensioactivos catiónicos degradables y su uso para la mejora de la quimioluminiscencia |
| CN105378029B (zh) | 2013-07-08 | 2020-12-18 | 西门子医疗保健诊断公司 | 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯 |
| CN104262250A (zh) * | 2014-09-01 | 2015-01-07 | 深圳市美凯特科技有限公司 | 三碘代甲状腺素半抗原发光标记物及合成方法 |
| CN106749185A (zh) * | 2016-11-29 | 2017-05-31 | 湖南师范大学 | 吖啶酯类化学发光底物dmae·nhs的合成 |
| JP7003144B2 (ja) * | 2017-02-23 | 2022-02-10 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | 化学発光アンドロステンジオンコンジュゲート |
| WO2019116234A1 (en) | 2017-12-12 | 2019-06-20 | Nestec S.A. | Methods for determining microbiome ribosomal rna composition changes |
| CN112368265A (zh) | 2018-06-25 | 2021-02-12 | 美国西门子医学诊断股份有限公司 | 9,10-二氢吖啶的n-烷基化 |
| US11237170B2 (en) | 2018-12-04 | 2022-02-01 | Aat Bioquest, Inc. | Styryl phenols, derivatives and their use in methods of analyte detection |
| WO2021178988A1 (en) * | 2020-03-04 | 2021-09-10 | Siemens Healthcare Diagnostics Inc. | Methods for amplifying immunoassay signals |
| US20230112563A1 (en) * | 2020-03-04 | 2023-04-13 | Siemens Healthcare Diagnostics Inc. | Compositions and methods of using modified liposomes |
| CN112684163B (zh) * | 2021-01-29 | 2022-08-09 | 安邦（厦门）生物科技有限公司 | 一种吖啶类化合物标记原料工作液及制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4031117A (en) * | 1975-09-22 | 1977-06-21 | Becton, Dickinson And Company | Testosterone derivatives |
| US4197286A (en) * | 1977-09-27 | 1980-04-08 | Southwest Research Institute | Testosterone derivatives and assay method |
| DE3279029D1 (en) * | 1981-12-11 | 1988-10-20 | Welsh Nat School Med | Luminescent labelling materials and procedures |
| US4745181A (en) * | 1986-10-06 | 1988-05-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
| DE3750503T2 (de) * | 1986-10-22 | 1995-02-09 | Abbott Lab | Chemilumineszierende Acridinium- und Phenantridiniumsalze. |
| US5290936A (en) * | 1987-12-31 | 1994-03-01 | London Diagnostics, Inc. | Nitro substituted chemiluminescent labels and their conjugates, and assays therefrom |
| NZ227506A (en) * | 1987-12-31 | 1992-06-25 | London Diagnostics Inc | Specific binding assays using chemiluminescent compounds |
| US5321136A (en) * | 1987-12-31 | 1994-06-14 | London Diagnostics, Inc. | Peri substituted fused ring chemiluminescent labels and their conjugates, and assays therefrom |
| AU634716B2 (en) * | 1988-08-01 | 1993-03-04 | Ciba Corning Diagnostics Corp. | Method for detection of an analyte using acridinium esters and liposomes |
| CA1339491C (en) * | 1988-09-26 | 1997-10-07 | Say-Jong Law | Nucleophilic polysubstituted aryl acridinium ester and uses thereof |
| US5241070A (en) * | 1988-09-26 | 1993-08-31 | Ciba Corning Diagnostics Corp. | Nucleophilic polysubstituted aryl acridinium esters and uses thereof |
| JP3584379B2 (ja) * | 1993-02-04 | 2004-11-04 | 持田製薬株式会社 | アクリジニウム化合物およびアクリジニウム化合物複合体 |
-
1994
- 1994-04-08 US US08/225,165 patent/US5656426A/en not_active Expired - Lifetime
-
1995
- 1995-04-06 ES ES95913298T patent/ES2188654T3/es not_active Expired - Lifetime
- 1995-04-06 EP EP99203889A patent/EP0982298A1/de not_active Withdrawn
- 1995-04-06 EP EP95913298A patent/EP0754178B1/de not_active Expired - Lifetime
- 1995-04-06 CA CA002186463A patent/CA2186463A1/en not_active Abandoned
- 1995-04-06 AT AT95913298T patent/ATE231130T1/de not_active IP Right Cessation
- 1995-04-06 JP JP52621695A patent/JP3844358B2/ja not_active Expired - Lifetime
- 1995-04-06 BR BR9507307A patent/BR9507307A/pt not_active Application Discontinuation
- 1995-04-06 WO PCT/IB1995/000244 patent/WO1995027702A1/en not_active Ceased
- 1995-04-06 PL PL95316794A patent/PL316794A1/xx unknown
- 1995-04-06 DE DE69529409T patent/DE69529409T2/de not_active Expired - Lifetime
- 1995-04-06 AU AU20816/95A patent/AU703436B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU703436B2 (en) | 1999-03-25 |
| EP0754178A1 (de) | 1997-01-22 |
| WO1995027702A1 (en) | 1995-10-19 |
| CA2186463A1 (en) | 1995-10-19 |
| JP3844358B2 (ja) | 2006-11-08 |
| BR9507307A (pt) | 1997-09-02 |
| US5656426A (en) | 1997-08-12 |
| JPH10503169A (ja) | 1998-03-24 |
| EP0754178B1 (de) | 2003-01-15 |
| ES2188654T3 (es) | 2003-07-01 |
| AU2081695A (en) | 1995-10-30 |
| DE69529409D1 (de) | 2003-02-20 |
| PL316794A1 (en) | 1997-02-17 |
| DE69529409T2 (de) | 2003-08-14 |
| EP0982298A1 (de) | 2000-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |