ATE231149T1 - (1,8)-naphthyridinderivate derivate mit antiviraler wirkung - Google Patents

(1,8)-naphthyridinderivate derivate mit antiviraler wirkung

Info

Publication number
ATE231149T1
ATE231149T1 AT00906096T AT00906096T ATE231149T1 AT E231149 T1 ATE231149 T1 AT E231149T1 AT 00906096 T AT00906096 T AT 00906096T AT 00906096 T AT00906096 T AT 00906096T AT E231149 T1 ATE231149 T1 AT E231149T1
Authority
AT
Austria
Prior art keywords
derivatives
naphthyridine
antiviral effect
hepatitis
virus
Prior art date
Application number
AT00906096T
Other languages
English (en)
Inventor
Benoit Bachand
Nghe Nguyen-Ba
Arshad Siddiqui
Sophie Levesque
Original Assignee
Shire Biochem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Biochem Inc filed Critical Shire Biochem Inc
Application granted granted Critical
Publication of ATE231149T1 publication Critical patent/ATE231149T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT00906096T 1999-02-22 2000-02-22 (1,8)-naphthyridinderivate derivate mit antiviraler wirkung ATE231149T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12108099P 1999-02-22 1999-02-22
PCT/CA2000/000181 WO2000050424A1 (en) 1999-02-22 2000-02-22 [1,8] naphthyridine derivatives having antiviral activity

Publications (1)

Publication Number Publication Date
ATE231149T1 true ATE231149T1 (de) 2003-02-15

Family

ID=22394395

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00906096T ATE231149T1 (de) 1999-02-22 2000-02-22 (1,8)-naphthyridinderivate derivate mit antiviraler wirkung

Country Status (8)

Country Link
US (2) US6340690B1 (de)
EP (1) EP1155017B1 (de)
JP (1) JP2002537396A (de)
AT (1) ATE231149T1 (de)
AU (1) AU777040B2 (de)
CA (1) CA2364652A1 (de)
DE (1) DE60001218D1 (de)
WO (1) WO2000050424A1 (de)

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JP3705975B2 (ja) 1999-11-26 2005-10-12 独立行政法人科学技術振興機構 ミスマッチ認識分子
ES2319732T3 (es) * 2000-04-13 2009-05-12 Pharmasset, Inc. Derivados de nucleosido 3'- o 2'-hidroximetilo sustituido para el tratamiento de infecciones virales.
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
JP5230052B2 (ja) * 2000-05-26 2013-07-10 イデニクス（ケイマン）リミテツド フラビウイルスおよびペスチウイルス治療のための方法および組成物
EP1321463B1 (de) * 2001-12-21 2007-08-08 Virochem Pharma Inc. Thiazolderivate und ihre Verwendung zur Behandlung oder Vorbeugung von Infektionen durch Flaviviren
AU2003215826A1 (en) * 2002-04-01 2003-10-13 Pfizer Inc. Pyranon and pyrandion inhibitors of hepatitis c virus rna-dependent rna polymerase
AP2005003213A0 (en) * 2002-06-28 2005-03-31 Univ Cagliari 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections.
NZ537662A (en) * 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
BR0313743A (pt) * 2002-08-23 2005-07-05 Chiron Corp Benzimidazol quinolinonas e usos destas
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
MXPA05006230A (es) * 2002-12-12 2005-09-20 Idenix Cayman Ltd Proceso para la produccion de nucleosidos ramificados-2'.
DE10311563A1 (de) * 2003-03-17 2004-09-30 Bayer Healthcare Ag Replikationsassay zur Auffindung antiviraler Substanzen mit HTS Verfahren
CN1852915A (zh) * 2003-07-25 2006-10-25 艾登尼科斯（开曼）有限公司 治疗包括丙型肝炎的黄病毒科病毒所致疾病的嘌呤核苷类似物
US7932272B2 (en) * 2003-09-30 2011-04-26 Eisai R&D Management Co., Ltd. Antifungal agent containing heterocyclic compound
JP2007509057A (ja) * 2003-10-15 2007-04-12 カイロン コーポレイション ウイルス阻害のための組成物および方法
EP2666481B9 (de) * 2003-12-26 2019-05-22 HAGIWARA, Masatoshi Verfahren zur Regulierung der Phosphorylierung von SR-Proteinen und Antiviruswirkstoffen mit einem SR-Proteinaktivitätsregler als Wirkstoff
AU2005256963A1 (en) * 2004-06-23 2006-01-05 Centre National De La Recherche Scientifique 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
TWI385169B (zh) * 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
ES2422290T3 (es) * 2005-12-23 2013-09-10 Idenix Pharmaceuticals Inc Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados
WO2008035726A1 (en) * 2006-09-21 2008-03-27 Eisai R & D Management Co., Ltd. Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
US8513420B2 (en) 2007-03-19 2013-08-20 Monika Mazik Amino-naphthyridine derivatives
EP1972627A1 (de) * 2007-03-19 2008-09-24 Technische Universität Carolo-Wilhelmina zu Braunschweig Aminonaphthyridin-Derivate
TW200841879A (en) * 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
EP2143723A4 (de) * 2007-04-27 2011-05-18 Eisai R&D Man Co Ltd Salz eines heterocyclus-substituierten pyridinderivats oder kristall davon
US8513287B2 (en) * 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
US8188119B2 (en) 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
JP2012176900A (ja) * 2009-06-24 2012-09-13 Eisai R & D Management Co Ltd （（ホスホノオキシ）メチル）ピリジニウム環を有するピリジン誘導体およびそれらを含有する抗真菌剤
KR101317656B1 (ko) * 2011-06-30 2013-10-15 연세대학교 산학협력단 복제효소 인산화를 조절하는 신규 ｃ형 간염 예방 또는 치료용 조성물
US9487476B2 (en) 2011-10-12 2016-11-08 Yale University Catechol diethers as potent anti-HIV agents
MX2020005927A (es) 2017-12-07 2020-10-07 Amplyx Pharmaceuticals Inc Agentes antifunales derivados de piridina heterociclica sustituida.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2263752A1 (en) 1974-03-14 1975-10-10 Rhone Poulenc Ind 1,8-Naphthyridine derivs - tranquillizers and anti-convulsants
FR2567887B1 (fr) 1984-07-19 1986-12-19 Rhone Poulenc Sante Nouveaux amides substitues, leur preparation et les medicaments qui les contiennent
EP0208621B1 (de) 1985-07-11 1989-04-12 Rhone-Poulenc Sante Substituierte Amide, ihre Herstellung und diese enthaltende Zubereitungen
FR2592882B2 (fr) 1986-01-16 1988-03-11 Rhone Poulenc Sante Nouveaux amides substitues, leur preparation et les medicaments qui les contiennent
US4753941A (en) 1986-01-16 1988-06-28 Rhone-Poulenc Sante Amides based on certain 1,8-naphtyridine-2-amines useful as anxiolytics
DE3907938A1 (de) 1989-03-11 1990-09-13 Basf Ag 2,3-substituierte 1,8-naphthyridine, verfahren zu ihrer herstellung und ihre verwendung als antidots
FR2676056B1 (fr) 1991-05-03 1993-07-16 Adir Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
CA2123728A1 (en) * 1993-05-21 1994-11-22 Noriyoshi Sueda Urea derivatives and their use as acat inhibitors
GB9605437D0 (en) 1996-03-15 1996-05-15 Iaf Biochem Int Cytomegalovirus inhibiting compounds
AU2218997A (en) * 1996-03-22 1997-10-10 Neurogen Corporation Certain fused pyrrolecarboxamides as gaba brain receptor ligands

Also Published As

Publication number Publication date
EP1155017B1 (de) 2003-01-15
AU777040B2 (en) 2004-09-30
DE60001218D1 (de) 2003-02-20
EP1155017A1 (de) 2001-11-21
CA2364652A1 (en) 2000-08-31
US6340690B1 (en) 2002-01-22
AU2788300A (en) 2000-09-14
JP2002537396A (ja) 2002-11-05
WO2000050424A1 (en) 2000-08-31
US20020099072A1 (en) 2002-07-25
US6605614B2 (en) 2003-08-12

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