ATE231158T1 - Verfahren zur reinigung von daunomycin - Google Patents
Verfahren zur reinigung von daunomycinInfo
- Publication number
- ATE231158T1 ATE231158T1 AT98938979T AT98938979T ATE231158T1 AT E231158 T1 ATE231158 T1 AT E231158T1 AT 98938979 T AT98938979 T AT 98938979T AT 98938979 T AT98938979 T AT 98938979T AT E231158 T1 ATE231158 T1 AT E231158T1
- Authority
- AT
- Austria
- Prior art keywords
- daunomycin
- purifying
- purified
- daunorubicin
- eluted
- Prior art date
Links
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 title abstract 7
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 title abstract 7
- WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 title abstract 6
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229960000975 daunorubicin Drugs 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229920003002 synthetic resin Polymers 0.000 abstract 1
- 239000000057 synthetic resin Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24598097 | 1997-08-28 | ||
| PCT/JP1998/003767 WO1999011650A1 (fr) | 1997-08-28 | 1998-08-25 | Procede de purification de daunomycine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE231158T1 true ATE231158T1 (de) | 2003-02-15 |
Family
ID=17141696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98938979T ATE231158T1 (de) | 1997-08-28 | 1998-08-25 | Verfahren zur reinigung von daunomycin |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6388058B1 (de) |
| EP (1) | EP1020475B1 (de) |
| JP (1) | JP3900241B2 (de) |
| AT (1) | ATE231158T1 (de) |
| AU (1) | AU8750698A (de) |
| CA (1) | CA2301654C (de) |
| DE (1) | DE69810796T2 (de) |
| WO (1) | WO1999011650A1 (de) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58223062A (ja) * | 1982-06-21 | 1983-12-24 | Toyo Soda Mfg Co Ltd | 生理活性物質及び／又は薬物の分離分析方法 |
| IT1155446B (it) | 1982-12-23 | 1987-01-28 | Erba Farmitalia | Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine |
| US5183808A (en) * | 1988-11-10 | 1993-02-02 | Bristol-Myers Squibb Company | Method for treating fungal infections with serine analogs of BU-3608 antibiotics |
| EP0387830A3 (de) * | 1989-03-15 | 1991-09-18 | Yamanouchi Pharmaceutical Co. Ltd. | Anthracyclinstoffe, Mikroorganismen für die Herstellung davon und Verfahren zur Herstellung davon |
-
1998
- 1998-08-25 JP JP2000508688A patent/JP3900241B2/ja not_active Expired - Fee Related
- 1998-08-25 CA CA002301654A patent/CA2301654C/en not_active Expired - Fee Related
- 1998-08-25 AU AU87506/98A patent/AU8750698A/en not_active Abandoned
- 1998-08-25 AT AT98938979T patent/ATE231158T1/de not_active IP Right Cessation
- 1998-08-25 US US09/486,289 patent/US6388058B1/en not_active Expired - Lifetime
- 1998-08-25 EP EP98938979A patent/EP1020475B1/de not_active Expired - Lifetime
- 1998-08-25 WO PCT/JP1998/003767 patent/WO1999011650A1/ja not_active Ceased
- 1998-08-25 DE DE69810796T patent/DE69810796T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2301654C (en) | 2008-02-26 |
| US6388058B1 (en) | 2002-05-14 |
| DE69810796T2 (de) | 2003-05-22 |
| EP1020475A1 (de) | 2000-07-19 |
| WO1999011650A1 (fr) | 1999-03-11 |
| AU8750698A (en) | 1999-03-22 |
| JP3900241B2 (ja) | 2007-04-04 |
| EP1020475B1 (de) | 2003-01-15 |
| DE69810796D1 (de) | 2003-02-20 |
| EP1020475A4 (de) | 2002-01-02 |
| CA2301654A1 (en) | 1999-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |