ATE231181T1 - Bioreaktor - Google Patents

Bioreaktor

Info

Publication number
ATE231181T1
ATE231181T1 AT98922389T AT98922389T ATE231181T1 AT E231181 T1 ATE231181 T1 AT E231181T1 AT 98922389 T AT98922389 T AT 98922389T AT 98922389 T AT98922389 T AT 98922389T AT E231181 T1 ATE231181 T1 AT E231181T1
Authority
AT
Austria
Prior art keywords
bioreactor
cell loading
making
methods
providing
Prior art date
Application number
AT98922389T
Other languages
English (en)
Inventor
Bruce P Amiot
Original Assignee
Excorp Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Excorp Medical Inc filed Critical Excorp Medical Inc
Application granted granted Critical
Publication of ATE231181T1 publication Critical patent/ATE231181T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10—Hollow fibers or tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT98922389T 1997-05-22 1998-05-13 Bioreaktor ATE231181T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/861,503 US5955353A (en) 1997-05-22 1997-05-22 Hollow fiber bioreactor with an extrafilament flow plug
PCT/US1998/010111 WO1998053046A1 (en) 1997-05-22 1998-05-13 Bioreactor

Publications (1)

Publication Number Publication Date
ATE231181T1 true ATE231181T1 (de) 2003-02-15

Family

ID=25335987

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98922389T ATE231181T1 (de) 1997-05-22 1998-05-13 Bioreaktor

Country Status (9)

Country Link
US (1) US5955353A (de)
EP (1) EP0915965B1 (de)
JP (1) JP2000515391A (de)
AT (1) ATE231181T1 (de)
AU (1) AU738641B2 (de)
CA (1) CA2262812C (de)
DE (1) DE69810740T2 (de)
NZ (1) NZ333786A (de)
WO (1) WO1998053046A1 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033581A1 (de) * 1997-02-04 1998-08-06 Akzo Nobel N.V. Membranmodul enthaltend mindestens zwei gruppen von hohlfasermembranen und verfahren zu seiner herstellung
JP3553858B2 (ja) * 1999-08-25 2004-08-11 東洋紡績株式会社 血管網類似構造体を有する細胞培養用モジュール
US6752926B2 (en) 2000-10-20 2004-06-22 Trustees Of Stevens Institute Of Technology Method and apparatus for treatment of wastewater
US6582955B2 (en) * 2001-05-11 2003-06-24 Spectrum Laboratories, Inc. Bioreactor with application as blood therapy device
US6607501B2 (en) 2001-05-14 2003-08-19 Reynolds G. Gorsuch Process and apparatus for utilization of in vivo extracted plasma with tissue engineering devices, bioreactors, artificial organs, and cell therapy applications
US6566126B2 (en) 2001-06-22 2003-05-20 Fibercell Systems, Inc. Apparatus and method for growing cells
US6702561B2 (en) * 2001-07-12 2004-03-09 Nxstage Medical, Inc. Devices for potting a filter for blood processing
WO2003015616A2 (en) * 2001-08-17 2003-02-27 Spencer Dudley W C Hemodialysis assembly and method
US6852231B2 (en) * 2002-02-15 2005-02-08 Denco, Inc. Spin-hemodialysis assembly and method
AU2003211066A1 (en) * 2002-02-19 2003-09-09 Bioarttis, Inc. Artificial vessel scaffold and artificial organs therefrom
JP3933058B2 (ja) 2002-02-25 2007-06-20 日立化成工業株式会社 マイクロ流体システム用支持ユニット及びその製造方法
US7531351B2 (en) * 2004-06-14 2009-05-12 Probiogen Ag Liquid-gas-phase exposure reactor for cell culturing
US8480970B2 (en) 2004-11-30 2013-07-09 Hitachi Chemical Co., Ltd. Analytical pretreatment device
WO2006069737A1 (de) * 2004-12-27 2006-07-06 Fresenius Medical Care Deutschland Gmbh Reaktor und reaktoreinheit mit hohlfasern
DE102004062828B4 (de) * 2004-12-27 2007-01-11 Fresenius Medical Care Deutschland Gmbh Reaktor mit einer rotierbar angeordneten Reaktoreinheit
DE102005021305A1 (de) * 2005-05-09 2006-11-16 Fresenius Medical Care Deutschland Gmbh Reaktoreinheit und Reaktor mit einer derartigen Reaktoreinheit
US7989157B2 (en) * 2005-01-11 2011-08-02 Medtronic, Inc. Solution for storing bioprosthetic tissue used in a biological prosthesis
DE102006011828A1 (de) * 2006-03-13 2007-09-20 Gesellschaft für Schwerionenforschung mbH Bestrahlungsverifikationsvorrichtung für Strahlentherapieanlagen und Verfahren zur Handhabung derselben
ES2739457T3 (es) * 2006-04-12 2020-01-31 Quorus Biotech Pty Limited Biorreactor
US9057044B2 (en) 2006-08-30 2015-06-16 Meir Israelowitz Laminar flow reactor
US20080220522A1 (en) * 2007-03-05 2008-09-11 Gambro Bct, Inc. Methods to Control Cell Movement in Hollow Fiber Bioreactors
EP2129764B1 (de) 2007-03-05 2018-10-10 Terumo BCT, Inc. Zellexpansionssystem und anwendungsverfahren
DE102007011975A1 (de) 2007-03-09 2008-09-11 Hohner Maschinenbau Gmbh Vorrichtung zum Zusammentragen flacher Druckprodukte, insbesondere von gefalzten bzw. ungefalzten Bogen, Karten oder dergleichen
DE102009003972B4 (de) * 2009-01-07 2011-04-28 Sartorius Stedim Biotech Gmbh Abgassystem für Bioreaktoren
US20100247693A1 (en) * 2009-03-24 2010-09-30 Marini Jan L Cosmetic formulation to treat rosacea telangiectasia
US8778669B2 (en) * 2009-07-22 2014-07-15 Corning Incorporated Multilayer tissue culture vessel
AU2010314994B2 (en) 2009-11-09 2016-10-06 Spotlight Technology Partners Llc Fragmented hydrogels
JP5864429B2 (ja) 2009-11-09 2016-02-17 スポットライト テクノロジー パートナーズ エルエルシーＳｐｏｔｌｉｇｈｔ Ｔｅｃｈｎｏｌｏｇｙ Ｐａｒｔｎｅｒｓ Ｌｌｃ 架橋ヒドロゲル組成物、ヒドロゲル組成物の形成方法、及びキット
WO2011090605A2 (en) 2009-12-29 2011-07-28 Caridianbct, Inc. Method of loading and distributing cells in a bioreactor of a cell expansion system
CN101886032B (zh) * 2010-02-24 2013-01-23 中国科学院过程工程研究所 一种利用微管系统强化传质传热的生物反应器
CN101787348B (zh) * 2010-02-24 2013-01-23 中国科学院过程工程研究所 一种强化传质传热的仿生生物反应器
US9725689B2 (en) 2010-10-08 2017-08-08 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
CN102258817A (zh) * 2011-05-13 2011-11-30 浙江大学 螺旋形中空纤维管人工肝生物反应器
CN102225222A (zh) * 2011-05-13 2011-10-26 浙江大学 U形中空纤维管人工肝生物反应器
US9175259B2 (en) 2012-08-20 2015-11-03 Terumo Bct, Inc. Method of loading and distributing cells in a bioreactor of a cell expansion system
US9005550B2 (en) 2012-10-29 2015-04-14 Corning Incorporated Multi-layered cell culture vessel with manifold grips
EP3068867B1 (de) 2013-11-16 2018-04-18 Terumo BCT, Inc. Zellenexpansion in einem bioreaktor
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
US10077421B2 (en) 2014-04-24 2018-09-18 Terumo Bct, Inc. Measuring flow rate
EP3198006B1 (de) 2014-09-26 2021-03-24 Terumo BCT, Inc. Geplante fütterung
US10179896B2 (en) 2015-05-12 2019-01-15 Baker Group, LLP Method and system for a bioartificial organ
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017205667A1 (en) 2016-05-25 2017-11-30 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) * 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
JP7393945B2 (ja) 2017-03-31 2023-12-07 テルモ ビーシーティー、インコーポレーテッド 細胞増殖
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
CN108211032B (zh) * 2018-02-01 2023-11-17 南方医科大学珠江医院 组合型生物人工肝支持系统
EP4314244B1 (de) 2021-03-23 2025-07-23 Terumo BCT, Inc. Zellerfassung und -erweiterung
CN115537336A (zh) * 2021-06-29 2022-12-30 天信和(苏州)生物科技有限公司 一种载体和生物反应器
US12152699B2 (en) 2022-02-28 2024-11-26 Terumo Bct, Inc. Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device
EP4570362A1 (de) * 2023-12-14 2025-06-18 Gambro Lundia AB Vergussverteiler

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3734851A (en) * 1969-12-29 1973-05-22 K Matsumura Method and device for purifying blood
US3883393A (en) * 1972-05-18 1975-05-13 Us Health Education & Welfare Cell culture on semi-permeable tubular membranes
US4488911A (en) * 1975-10-22 1984-12-18 Luck Edward E Non-antigenic collagen and articles of manufacture
US4220725A (en) * 1978-04-03 1980-09-02 United States Of America Capillary cell culture device
US4241187A (en) * 1979-03-27 1980-12-23 United States Of America Method and apparatus for cell and tissue culture
US4293413A (en) * 1979-12-28 1981-10-06 Baxter Travenol Laboratories, Inc. Dialyzer blood circuit and bubble traps
US5106743A (en) * 1981-01-26 1992-04-21 Trustees Of Boston University Hydrogels capable of supporting cell growth
DE3107527A1 (de) * 1981-02-27 1982-09-16 Klaus Prof. Dr. 8400 Regensburg Heckmann Hyperfiltrationsmembranen mit trennschichten aus monomolekularen filmen von tensiden
JPS5928472A (ja) * 1982-08-09 1984-02-15 Koken:Kk 細胞培養用基質およびこの基質を用いた細胞培養・分離法
US4537860A (en) * 1982-12-08 1985-08-27 Monsanto Company Static cell culture maintenance system
US4514499A (en) * 1983-02-04 1985-04-30 Corning Glass Works Cell culture using a monolithic support
US4692411A (en) * 1983-09-06 1987-09-08 Ghose Rabindra N Separation of specific biological cells by a biochemical filter
DE3409501A1 (de) * 1984-03-15 1985-10-24 Sandoz-Patent-GmbH, 7850 Lörrach Verfahren zur kultivierung von zellen
US4804628A (en) * 1984-10-09 1989-02-14 Endotronics, Inc. Hollow fiber cell culture device and method of operation
US4647539A (en) * 1985-05-24 1987-03-03 Endotronics, Inc. Method and apparatus for growing cells in vitro
IL75554A (en) * 1985-06-18 1993-01-14 Yeda Res & Dev Matrix for cell cultivation in vitro
US4720462A (en) * 1985-11-05 1988-01-19 Robert Rosenson Culture system for the culture of solid tissue masses and method of using the same
US4675002A (en) * 1985-12-02 1987-06-23 Viles Joseph M Liver assist device employing transformed cell lines
US5510254A (en) * 1986-04-18 1996-04-23 Advanced Tissue Sciences, Inc. Three dimensional cell and tissue culture system
US5108923A (en) * 1986-04-25 1992-04-28 Collaborative Research, Inc. Bioadhesives for cell and tissue adhesion
US5254471A (en) * 1986-10-06 1993-10-19 Toray Industries, Inc. Carrier for cell culture
US5114627A (en) * 1986-10-16 1992-05-19 Cbs Lens Method for producing a collagen hydrogel
US4833083A (en) * 1987-05-26 1989-05-23 Sepragen Corporation Packed bed bioreactor
DE3720665A1 (de) * 1987-06-23 1989-01-05 Schael Wilfried Vorrichtung zur haemodialyse und haemofiltration
WO1989000188A1 (en) * 1987-06-30 1989-01-12 Brunswick Corporation Cell growth reactor with three compartments formed by hydrophobic and hydrophilic membranes
US5108926A (en) * 1987-09-08 1992-04-28 Board Of Regents, The University Of Texas System Apparatus for the precise positioning of cells
US5043260A (en) * 1987-11-02 1991-08-27 Rhode Island Hospital Perfusion device with hepatocytes
IT1215765B (it) * 1988-01-22 1990-02-22 Grace W R & Co Dispositivo di emodiafiltrazione erelativo procedimento di emodiafiltrazione.
US5015585A (en) * 1988-02-23 1991-05-14 Robinson James R Method and apparatus for culturing and diffusively oxygenating cells on isotropic membranes
US4999298A (en) * 1988-04-27 1991-03-12 W. R. Grace & Co.-Conn. Hollow fiber bioreactor culture system and method
US5605835A (en) * 1988-05-23 1997-02-25 Regents Of The University Of Minnesota Bioreactor device with application as a bioartificial liver
EP0380610B1 (de) * 1988-05-23 1995-03-29 Regents Of The University Of Minnesota Bioreaktor
US5595909A (en) * 1988-05-23 1997-01-21 Regents Of The University Of Minnesota Filter device
US4837379A (en) * 1988-06-02 1989-06-06 Organogenesis Inc. Fibrin-collagen tissue equivalents and methods for preparation thereof
FR2640638B1 (fr) * 1988-12-20 1991-02-15 Commissariat Energie Atomique Bioreacteur et dispositif pour la culture de cellules animales
US4959148A (en) * 1989-01-23 1990-09-25 Clark Iii William T Method and apparatus for specific affinity enhanced transport bioreactor
US5254249A (en) * 1989-04-25 1993-10-19 Toray Industries, Inc. Anti-thrombogenic blood treating system
US5116493A (en) * 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with reseedable matrix
IL95429A (en) * 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
US5510257A (en) * 1989-10-04 1996-04-23 Sirkar; Kamalesh K. Hollow fiber immobilization with chopped microporous hollow fibers
US5013437A (en) * 1989-10-30 1991-05-07 The Dow Chemical Company Hollow fiber membrane fluid separation device adapted for boreside feed which contains multiple concentric stages
JP3117994B2 (ja) * 1990-05-16 2000-12-18 ベイラー・カレツジ・オブ・メデイシン 永久的ヒト肝細胞の細胞系および肝臓補助装置（ｌａｄ）におけるその使用
JPH0728722B2 (ja) * 1990-06-29 1995-04-05 富士写真フイルム株式会社 バイオリアクター装置
US5198110A (en) * 1990-07-02 1993-03-30 Asahi Medical Co., Ltd. Bundle of permselective hollow fibers and a fluid separator containing the same
AU9031591A (en) * 1990-10-29 1992-05-26 Regents Of The University Of Minnesota A bioartificial liver
US5270192A (en) * 1991-02-07 1993-12-14 Monsanto Company Biological artificial liver
JP3026516B2 (ja) * 1991-05-15 2000-03-27 株式会社クラレ 細胞培養器
US5211849B1 (en) * 1991-10-11 1997-05-27 Childrens Hosp Medical Center Hemofiltration system and method
US5240614A (en) * 1992-01-10 1993-08-31 Baxter International Inc. Process for removing unwanted materials from fluids and for producing biological products
US5480552A (en) * 1992-01-10 1996-01-02 Baxter International Inc. Method for concentrating a solute with an oscillating filtration device
US5527467A (en) * 1992-01-10 1996-06-18 Baxter International Inc. Rectifying dialyzer, bioreactor and membrane
DE4206585C2 (de) * 1992-03-03 1994-11-24 Augustinus Dr Med Bader Vorrichtung zur Massenkultur von Zellen
US5512474A (en) * 1992-05-29 1996-04-30 Bsi Corporation Cell culture support containing a cell adhesion factor and a positively-charged molecule
DE4230194C2 (de) * 1992-09-09 1995-07-27 Joerg Dr Med Gerlach Reaktor zur Züchtung und zur Nutzung von Stoffwechselleistungen und/oder zum Erhalt von Mikroorganismen
US5368555A (en) * 1992-12-29 1994-11-29 Hepatix, Inc. Organ support system
SE502222C2 (sv) * 1994-01-17 1995-09-18 Althin Medical Ab Sätt vid dialys
US5411662A (en) * 1994-02-25 1995-05-02 Praxair Technology, Inc. Fluid separation assembly having an purge control valve
ES2142981T3 (es) * 1994-09-02 2000-05-01 Terumo Corp Dializador.
US5643794A (en) * 1995-06-07 1997-07-01 W.R. Grace & Co.-Conn. Apparatus for bioprocessing a circulating fluid
WO1997016527A1 (en) * 1995-10-30 1997-05-09 Cellex Biosciences, Inc. Cultureware for bioartificial liver

Also Published As

Publication number Publication date
DE69810740T2 (de) 2003-10-16
JP2000515391A (ja) 2000-11-21
AU7494798A (en) 1998-12-11
US5955353A (en) 1999-09-21
NZ333786A (en) 2000-07-28
EP0915965B1 (de) 2003-01-15
WO1998053046A1 (en) 1998-11-26
CA2262812A1 (en) 1998-11-26
CA2262812C (en) 2011-02-08
DE69810740D1 (de) 2003-02-20
AU738641B2 (en) 2001-09-20
EP0915965A1 (de) 1999-05-19

Similar Documents

Publication Publication Date Title
DE69810740D1 (de) Bioreaktor
FI970217A0 (fi) Keinotekoisiin biologisiin välineisiin kapseloitujen solujen kasvun säätely
DE69737684D1 (de) Präzise wirksamkeitsbestimmungsmethode für wirkstoffe einschliesslich chemotherapeutika
FR2543158B1 (fr) Milieu de culture de cellules animales sans serum, sans hormones et sans facteurs de croissance et procedes de culture primaire et d'obtention de lignees cellulaires utilisant ce milieu
IT8467249A0 (it) Protesi valvolare cardiaca provvista di lembi valvolari di tessuto biologico
FR2559780B1 (fr) Systemes biocompatibles implantables a base de collagene permettant la conservation et/ou la culture cellulaires et/ou la liberation controlee de principes actifs
DK463586A (da) Fsh
DK0621766T3 (da) Hornhindeækvivalent-in-vitro-model
ATE442851T1 (de) 1-deoxy-galactonojirimycin-derivate zur vewendung bei der behandlung von lysosomalen speicherkrankheiten mittels steigerung der lysosomalen alpha galactosidase a
ES2195664T3 (es) Uso de fumaratos de dialquilo.
EP0599651A3 (de) Bioreaktor für die Perfusionskultur von Zellen.
ES2165368T3 (es) Cultivo de celulas animales.
JPS57150954A (en) Artery implant prosthesis
NO20006096D0 (no) Medium for dyrking av dyreceller og fremgangsmåte for fremstilling av protein ved anvendelse av det samme
KR920701463A (ko) 세포를 성장시키기 위한 방법 조성물 및 장치
DE69630955D1 (de) Immortalisierung bzw. desimmortalisierung von zellen
BR9305783A (pt) Processo para preparar grânulos dispersiveis em água e grânulos dispersíveis em água
ATE329603T1 (de) Implantat mit immunisolierten stromazellen und deren verwendung
ATE310082T1 (de) Pflanzenpromoter und dessen verwendung zur genexpression
ATE15693T1 (de) Zellkultur-verfahren.
DE69930660D1 (de) Zellen, kulturverfahren, und ihre verwendung in autologer transplantationstherapie
FI963373L (fi) Ruumiin ulkopuolinen soluviljelmä ja transplantaatiopakkauksia
DK1185621T3 (da) Overflade til cellekultur
DE3663030D1 (en) Monoclonal antibodies to tissue plasminogen activator derived from human normal cells
ES2132027A1 (es) Desarrollo de una piel artificial mediante cultivo de queratinocitos sobre una base de fibrina y fibroblastos humanos y metodo de preparacion de esta piel para trasplante.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties