ATE231845T1 - 1,2,4-triazinderivate zur inhibierung der proteinglycosylierung - Google Patents

1,2,4-triazinderivate zur inhibierung der proteinglycosylierung

Info

Publication number
ATE231845T1
ATE231845T1 AT97919945T AT97919945T ATE231845T1 AT E231845 T1 ATE231845 T1 AT E231845T1 AT 97919945 T AT97919945 T AT 97919945T AT 97919945 T AT97919945 T AT 97919945T AT E231845 T1 ATE231845 T1 AT E231845T1
Authority
AT
Austria
Prior art keywords
triazine derivatives
inhibiting
inhibiting protein
protein glycosylation
composition
Prior art date
Application number
AT97919945T
Other languages
English (en)
Inventor
Dilip R Wagle
Michael E Lankin
San-Bao Hwang
Original Assignee
Alteon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/825,114 external-priority patent/US5932578A/en
Application filed by Alteon Inc filed Critical Alteon Inc
Application granted granted Critical
Publication of ATE231845T1 publication Critical patent/ATE231845T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT97919945T 1996-03-28 1997-03-28 1,2,4-triazinderivate zur inhibierung der proteinglycosylierung ATE231845T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62304596A 1996-03-28 1996-03-28
US64324296A 1996-05-03 1996-05-03
US08/825,114 US5932578A (en) 1996-03-28 1997-03-27 Triazine compounds and methods of use therefor
PCT/US1997/005110 WO1997035849A1 (en) 1996-03-28 1997-03-28 1,2,4-triazine derivatives for the inhibition of protein glycosylation

Publications (1)

Publication Number Publication Date
ATE231845T1 true ATE231845T1 (de) 2003-02-15

Family

ID=27417336

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97919945T ATE231845T1 (de) 1996-03-28 1997-03-28 1,2,4-triazinderivate zur inhibierung der proteinglycosylierung

Country Status (8)

Country Link
EP (1) EP0889884B1 (de)
JP (1) JP2002515870A (de)
AT (1) ATE231845T1 (de)
AU (1) AU727846B2 (de)
CA (1) CA2249999A1 (de)
DE (1) DE69718775T2 (de)
ES (1) ES2191837T3 (de)
WO (1) WO1997035849A1 (de)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4036632A (en) * 1966-04-16 1977-07-19 Bayer Aktiengesellschaft Herbicidal agents
US5399560A (en) * 1984-03-19 1995-03-21 The Rockefeller University 1,2,4-triazine products resulting from the inhibition of advanced glycosylation
US5114943A (en) * 1984-03-19 1992-05-19 The Rockefeller University Amino-substituted pyrimidines, derivatives and methods of use therefor

Also Published As

Publication number Publication date
WO1997035849A1 (en) 1997-10-02
ES2191837T3 (es) 2003-09-16
AU727846B2 (en) 2001-01-04
CA2249999A1 (en) 1997-10-02
EP0889884A1 (de) 1999-01-13
DE69718775D1 (de) 2003-03-06
DE69718775T2 (de) 2003-10-16
JP2002515870A (ja) 2002-05-28
AU2425497A (en) 1997-10-17
EP0889884B1 (de) 2003-01-29

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties