ATE231858T1 - Verfahren zur herstellung von 3-substituierten 4- phenyl-piperidin derivaten - Google Patents
Verfahren zur herstellung von 3-substituierten 4- phenyl-piperidin derivatenInfo
- Publication number
- ATE231858T1 ATE231858T1 AT00116505T AT00116505T ATE231858T1 AT E231858 T1 ATE231858 T1 AT E231858T1 AT 00116505 T AT00116505 T AT 00116505T AT 00116505 T AT00116505 T AT 00116505T AT E231858 T1 ATE231858 T1 AT E231858T1
- Authority
- AT
- Austria
- Prior art keywords
- phenyl
- substituted
- producing
- piperidine derivatives
- derivatives
- Prior art date
Links
- -1 3-SUBSTITUTED 4-PHENYL-PIPERIDINE Chemical class 0.000 title abstract 2
- 229940051803 opioid analgesics phenylpiperidine derivative Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 abstract 1
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229940117916 cinnamic aldehyde Drugs 0.000 abstract 1
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI001731A IT1313702B1 (it) | 1999-08-02 | 1999-08-02 | Processo per la preparazione di derivati 3-sostituiti di 4-fenil-piperidine. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE231858T1 true ATE231858T1 (de) | 2003-02-15 |
Family
ID=11383481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00116505T ATE231858T1 (de) | 1999-08-02 | 2000-07-31 | Verfahren zur herstellung von 3-substituierten 4- phenyl-piperidin derivaten |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6444822B1 (de) |
| EP (1) | EP1074550B1 (de) |
| JP (1) | JP2001081089A (de) |
| AT (1) | ATE231858T1 (de) |
| CA (1) | CA2314750A1 (de) |
| DE (1) | DE60001296T2 (de) |
| ES (1) | ES2191587T3 (de) |
| IT (1) | IT1313702B1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1394160A1 (de) | 1996-06-13 | 2004-03-03 | SUMIKA FINE CHEMICALS Co., Ltd. | Verfahren zur Herstellung von kristallinem Paroxetin-Hydrochlorid |
| GB9930577D0 (en) * | 1999-12-23 | 2000-02-16 | Smithkline Beecham Plc | Novel process |
| NZ532432A (en) | 2001-10-22 | 2005-02-25 | Synthon Bv | N-formyl paroxetine compounds and their use in a synthetic route for obtaining paroxetine |
| CN102008978B (zh) * | 2010-11-24 | 2012-10-03 | 郑州大学 | 手性催化剂及其制备方法和应用 |
| US20190315691A1 (en) * | 2015-09-03 | 2019-10-17 | Piramal Enterprises Limited | An improved process for the preparation of paroxetine and its intermediate |
| US20250042855A1 (en) * | 2021-12-02 | 2025-02-06 | The Johns Hopkins University | Peripherally and luminally-restricted inhibitors of the serotonin transporter as treatments for disorders of gastrointestinal motility and gut-brain axis |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1422263A (en) | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| EP0190496A3 (de) | 1984-12-13 | 1987-05-27 | Beecham Group Plc | Piperidinderivate mit gastro-intestinaler Wirkung |
| EP0223334B1 (de) | 1985-08-10 | 1991-07-10 | Beecham Group Plc | Verfahren zur Herstellung von Arylpiperidincarbinol |
| DK715988D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Etherifikation og dealkylering af piperidin-derivater samt intermediater |
| DK716088D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Reduktion af piperidin-dion-derivater samt intermediat |
| US5258517A (en) * | 1992-08-06 | 1993-11-02 | Sepracor, Inc. | Method of preparing optically pure precursors of paroxetine |
| CN1068597C (zh) | 1995-05-17 | 2001-07-18 | 诺沃挪第克公司 | 制备4－芳基－哌啶衍生物的方法 |
| TR199800409T1 (xx) * | 1995-09-07 | 1998-05-21 | F.Hoffmann-La Roche Ag | Kalp ve b�brek yetersizli�inin tedavii�in yeni 4-(oksialkoksifenil)-3-oksi-piperidinler |
| HU221921B1 (hu) * | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
| EP0986389B1 (de) * | 1997-05-29 | 2004-10-13 | Smithkline Beecham Corporation | Neues verfahren |
-
1999
- 1999-08-02 IT IT1999MI001731A patent/IT1313702B1/it active
-
2000
- 2000-07-28 US US09/627,689 patent/US6444822B1/en not_active Expired - Fee Related
- 2000-07-31 EP EP00116505A patent/EP1074550B1/de not_active Expired - Lifetime
- 2000-07-31 DE DE60001296T patent/DE60001296T2/de not_active Expired - Fee Related
- 2000-07-31 AT AT00116505T patent/ATE231858T1/de not_active IP Right Cessation
- 2000-07-31 ES ES00116505T patent/ES2191587T3/es not_active Expired - Lifetime
- 2000-08-01 CA CA002314750A patent/CA2314750A1/en not_active Abandoned
- 2000-08-02 JP JP2000234404A patent/JP2001081089A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE60001296D1 (de) | 2003-03-06 |
| ES2191587T3 (es) | 2003-09-16 |
| EP1074550B1 (de) | 2003-01-29 |
| DE60001296T2 (de) | 2003-12-11 |
| JP2001081089A (ja) | 2001-03-27 |
| EP1074550A1 (de) | 2001-02-07 |
| US6444822B1 (en) | 2002-09-03 |
| ITMI991731A1 (it) | 2001-02-02 |
| IT1313702B1 (it) | 2002-09-09 |
| CA2314750A1 (en) | 2001-02-02 |
| ITMI991731A0 (it) | 1999-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1074550 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |