ATE2318T1 - Peptide mit somatostatin-wirkung, sie enthaltende zusammensetzungen und verfahren zur herstellung der peptide. - Google Patents

Peptide mit somatostatin-wirkung, sie enthaltende zusammensetzungen und verfahren zur herstellung der peptide.

Info

Publication number: ATE2318T1
Authority: AT; Austria
Prior art keywords: peptides; image; tyr; somatostatin; inhibiting
Prior art date: 1979-03-13

Application number

AT80101112T

Other languages

English (en)

Inventor

Daniel F. Veber

Original Assignee

Merck & Co. Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-03-13

Filing date

1980-03-05

Publication date

1983-02-15

1980-03-05 Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.

1983-02-15 Application granted granted Critical

1983-02-15 Publication of ATE2318T1 publication Critical patent/ATE2318T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
102000005157 Somatostatin Human genes 0.000 title abstract 2
108010056088 Somatostatin Proteins 0.000 title abstract 2
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 2
229960000553 somatostatin Drugs 0.000 title abstract 2
239000000203 mixture Substances 0.000 title 1
230000002401 inhibitory effect Effects 0.000 abstract 3
OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical group OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
125000001711 D-phenylalanine group Chemical group [H]N([H])[C@@]([H])(C(=O)[*])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
AYFVYJQAPQTCCC-STHAYSLISA-N D-threonine Chemical compound C[C@H](O)[C@@H](N)C(O)=O AYFVYJQAPQTCCC-STHAYSLISA-N 0.000 abstract 1
KZSNJWFQEVHDMF-SCSAIBSYSA-N D-valine Chemical compound CC(C)[C@@H](N)C(O)=O KZSNJWFQEVHDMF-SCSAIBSYSA-N 0.000 abstract 1
102400000321 Glucagon Human genes 0.000 abstract 1
108060003199 Glucagon Proteins 0.000 abstract 1
102000018997 Growth Hormone Human genes 0.000 abstract 1
108010051696 Growth Hormone Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 1
229960004666 glucagon Drugs 0.000 abstract 1
239000000122 growth hormone Substances 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
238000010532 solid phase synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/16—Somatostatin; related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Zoology (AREA)
Toxicology (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT80101112T 1979-03-13 1980-03-05 Peptide mit somatostatin-wirkung, sie enthaltende zusammensetzungen und verfahren zur herstellung der peptide. ATE2318T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/020,148 US4190648A (en)	1979-03-13	1979-03-13	Peptides having somatostatin activity
EP80101112A EP0017746B1 (de)	1979-03-13	1980-03-05	Peptide mit Somatostatin-Wirkung, sie enthaltende Zusammensetzungen und Verfahren zur Herstellung der Peptide

Publications (1)

Publication Number	Publication Date
ATE2318T1 true ATE2318T1 (de)	1983-02-15

Family

ID=21797013

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT80101112T ATE2318T1 (de)	1979-03-13	1980-03-05	Peptide mit somatostatin-wirkung, sie enthaltende zusammensetzungen und verfahren zur herstellung der peptide.

Country Status (6)

Country	Link
US (1)	US4190648A (de)
EP (1)	EP0017746B1 (de)
JP (1)	JPS55124747A (de)
AT (1)	ATE2318T1 (de)
DE (1)	DE3061721D1 (de)
DK (1)	DK105680A (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4310518A (en) *	1979-10-31	1982-01-12	Merck & Co., Inc.	Cyclic hexapeptide somatostatin analogs
DE3062075D1 (en) *	1979-11-27	1983-03-24	Sandoz Ag	Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use
US4358439A (en) *	1979-12-21	1982-11-09	Ciba-Geigy Corporation	Cyclooctapeptides
US4360516A (en) *	1981-04-13	1982-11-23	Merck & Co., Inc.	Modified D-retro cyclic hexapeptide somatostatin analogs
EP0113029B1 (de) *	1982-12-06	1989-04-19	Merck & Co. Inc.	Dicyclische Hexapeptiden, deren Verfahren zur Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4871717A (en) *	1987-01-07	1989-10-03	Administrators Of The Tulane Educational Fund	Peptides
US4994554A (en) *	1988-05-11	1991-02-19	Immunobiology Research Institute, Inc.	Probursin
US5504069A (en) *	1993-02-11	1996-04-02	Biomeasure, Inc.	Inhibition of trauma-induced tumor growth
US5597894A (en) *	1995-06-05	1997-01-28	The Louisiana State University Medical Center Foundation	Multi-tyrosinated somatostatin analogs
WO1998051330A1 (en) *	1997-05-13	1998-11-19	Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.)	Method and compositions for treating hyperlipidemia and other conditions
AU7655098A (en) *	1997-05-13	1998-12-08	Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)	Somatostatin and somatostatin agonists for decreasing body weight
US6004928A (en) *	1997-05-13	1999-12-21	Biomeasure, Incorporated	Method of treating hyperlipidemia
ES2216290T3 (es) *	1997-05-13	2004-10-16	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Somatostatina y agonistas de la somatostatina para el tratamiento de insensibilidad a la insulina y de sindrome x.
US5968903A (en) *	1998-05-07	1999-10-19	Biomeasure, Incorporated	Inhibition of H. pylori proliferation
BR0210915A (pt)	2001-06-08	2004-06-08	Sod Conseils Rech Applic	Análogos quiméricos de somatostatina-dopamina
CN101791409A (zh)	2003-04-22	2010-08-04	研究及应用科学协会股份有限公司	肽载体
CA2727082C (en)	2008-06-12	2019-02-26	Syntaxin Limited	Fusion proteins for use in suppression of acromegaly
CN102083451A (zh)	2008-06-12	2011-06-01	赛恩泰新公司	癌症的抑制
GB0820970D0 (en)	2008-11-17	2008-12-24	Syntaxin Ltd	Suppression of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2860734D1 (en) *	1977-06-08	1981-09-03	Merck & Co Inc	Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them
US4140767A (en) *	1977-12-01	1979-02-20	Merck & Co., Inc.	Somatostatin analogs
US4139526A (en) *	1977-12-01	1979-02-13	Merck & Co., Inc.	Somatostatin analogs

1979
- 1979-03-13 US US06/020,148 patent/US4190648A/en not_active Expired - Lifetime
1980
- 1980-03-05 EP EP80101112A patent/EP0017746B1/de not_active Expired
- 1980-03-05 DE DE8080101112T patent/DE3061721D1/de not_active Expired
- 1980-03-05 AT AT80101112T patent/ATE2318T1/de not_active IP Right Cessation
- 1980-03-12 DK DK105680A patent/DK105680A/da unknown
- 1980-03-13 JP JP3214580A patent/JPS55124747A/ja active Pending

Also Published As

Publication number	Publication date
DE3061721D1 (en)	1983-03-03
US4190648A (en)	1980-02-26
JPS55124747A (en)	1980-09-26
DK105680A (da)	1980-09-14
EP0017746B1 (de)	1983-01-26
EP0017746A1 (de)	1980-10-29

Legal Events

Date	Code	Title	Description
1984-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE2318T1 (de)	1983-02-15	Peptide mit somatostatin-wirkung, sie enthaltende zusammensetzungen und verfahren zur herstellung der peptide.
IE781151L (en)	1978-12-08	Somatostatin analogs
US4563352A (en)	1986-01-07	Human pancreatic GRF
ES531585A0 (es)	1986-04-01	Un procedimiento para preparar peptidos analogos al factor de liberacion de corticotropina
YU46023B (sh)	1992-12-21	Postupak za dobijanje novih analoga insulina
DK165749B (da)	1993-01-11	Grf-analoge peptider og farmaceutisk acceptable salte heraf samt farmaceutisk middel indeholdende disse
IL102848A0 (en)	1993-01-31	Polypeptides having growth hormone releasing activity,their use and pharmaceutical compositions containing them
DK162103B (da)	1991-09-16	Syntetiske grf-analoge peptider og farmaceutisk acceptable salte heraf samt farmaceutisk middel indeholdende peptidet eller et ikke-toksisk salt deraf
JPH0133118B2 (de)	1989-07-11
KR900003205A (ko)	1990-03-26	제약 화합물
KR927002373A (ko)	1992-09-03	성장 호르몬 분비 활성을 갖는 폴리펩타이드 화합물
HUP0001431A2 (hu)	2001-02-28	Módosított tandem peptid, ezt tartalmazó immunogén gyógyászati készítmény és vakcina az LHRH hormon termelés ellen, és eljárás a sertéshús minőségének javítására
IE781724L (en)	1979-02-28	Peptides
IE802224L (en)	1981-04-30	Cyclic hexapeptide somatostatin
ATE2622T1 (de)	1983-03-15	2-niedrigalkyl-7-substituierte-2 oder 3-cephem-4- carbonsaeuren, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
US4428942A (en)	1984-01-31	Analogs of somatostatin
AU646451B2 (en)	1994-02-24	Hybrid calcitonin
KR0163033B1 (ko)	1998-11-16	Grf 유사체 viia
IE800168L (en)	1980-08-02	Cyclic hexapeptide and dipeptide composition
EP0107890B1 (de)	1986-01-29	PGRF von Säugetieren
GB1059854A (en)	1967-02-22	Improvements in or relating to a cyclic nonapeptide
KR890005149A (ko)	1989-05-13	합성 펩타이드 및 이를 포함한 제약학적 조성물
ATE4590T1 (de)	1983-09-15	Pentapeptide, verfahren zu ihrer herstellung, bei solchen verfahren verwendete zwischenverbindungen, verwendung in pharmazeutischen zusammensetzungen und diese enthaltende zusammensetzungen.
Reubi	1987	Somatostatin receptors as markers for endocrine tumors
KR880013970A (ko)	1988-12-22	신규한 알킬화 성장 호르몬-방출 펩티드와 그것으로 포유동물을 처리하는 방법