ATE231921T1 - Verfahren zur identifizierung von knochenwachstum modulatoren - Google Patents

Verfahren zur identifizierung von knochenwachstum modulatoren

Info

Publication number
ATE231921T1
ATE231921T1 AT96923207T AT96923207T ATE231921T1 AT E231921 T1 ATE231921 T1 AT E231921T1 AT 96923207 T AT96923207 T AT 96923207T AT 96923207 T AT96923207 T AT 96923207T AT E231921 T1 ATE231921 T1 AT E231921T1
Authority
AT
Austria
Prior art keywords
bone growth
growth modulators
identifying bone
identifying
modulators
Prior art date
Application number
AT96923207T
Other languages
English (en)
Inventor
Stephen E Harris
Gregory R Mundy
Nandini Ghosh-Choudhury
Jian Q Feng
Original Assignee
Osteoscreen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osteoscreen Inc filed Critical Osteoscreen Inc
Application granted granted Critical
Publication of ATE231921T1 publication Critical patent/ATE231921T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT96923207T 1995-06-02 1996-05-31 Verfahren zur identifizierung von knochenwachstum modulatoren ATE231921T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/458,434 US6083690A (en) 1995-06-02 1995-06-02 Methods and compositions for identifying osteogenic agents
PCT/US1996/008197 WO1996038590A1 (en) 1995-06-02 1996-05-31 Methods and compositions for identifying osteogenic agents

Publications (1)

Publication Number Publication Date
ATE231921T1 true ATE231921T1 (de) 2003-02-15

Family

ID=23820773

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96923207T ATE231921T1 (de) 1995-06-02 1996-05-31 Verfahren zur identifizierung von knochenwachstum modulatoren

Country Status (8)

Country Link
US (1) US6083690A (de)
EP (1) EP0832297B1 (de)
JP (1) JPH11506009A (de)
AT (1) ATE231921T1 (de)
AU (1) AU6377996A (de)
CA (1) CA2221621A1 (de)
DE (1) DE69626015D1 (de)
WO (1) WO1996038590A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5834188A (en) * 1995-07-26 1998-11-10 Creative Biomolecule, Inc. Methods and compositions for identifying morphogen analogs
US6103491A (en) * 1995-07-26 2000-08-15 Creative Biomolecules, Inc. Methods and compositions for identifying morphogen analogs
US7306903B1 (en) * 1995-07-26 2007-12-11 Curis, Inc. Methods and compositions for identifying morphogen analogs
US5932716A (en) * 1995-07-26 1999-08-03 Creative Biomolecules, Inc. Morphogen-responsive regulatory elements
US6090544A (en) * 1995-07-26 2000-07-18 Creative Biomolecules, Inc. Methods and compositions for identifying morphogen analogs
US6008208A (en) * 1995-10-23 1999-12-28 Osteoscreen, Inc. Compositions and methods for treating bone deficit conditions
US5928940A (en) * 1996-09-24 1999-07-27 Creative Biomolecules, Inc. Morphogen-responsive signal transducer and methods of use thereof
CA2272345A1 (en) * 1996-11-22 1998-06-04 Akzo Nobel Nv Bmp-4 promoter and use thereof in screening of therapeutic agents for the prevention and/or treatment of osteoporosis
US6376476B1 (en) * 1996-12-13 2002-04-23 Zymogenetics Corporation Isoprenoid pathway inhibitors for stimulating bone growth
ATE389727T1 (de) * 1997-05-29 2008-04-15 Curis Inc Modulatoren der expression von morphogenen und deren identifizierungsverfahren
EP0890639A3 (de) * 1997-07-09 2001-10-10 Gesellschaft für biotechnologische Forschung mbH (GBF) BPM2-induziertes cDNA und seine Verwendung
US6649631B1 (en) 1997-10-23 2003-11-18 The Board Of Regents Of The University Of Texas System Compositions and methods for treating bone deficit conditions
JPH11313673A (ja) * 1998-04-30 1999-11-16 Hoechst Marion Roussel Kk ヒトｂｍｐ−２プロモーターおよびこれを用いた骨関連物質の探索法
JPH11313675A (ja) 1998-04-30 1999-11-16 Hoechst Marion Roussel Kk ヒトｂｍｐ−７プロモーターおよびこれを用いた骨関連物質の探索法
JPH11313674A (ja) 1998-04-30 1999-11-16 Hoechst Marion Roussel Kk ヒトｂｍｐ−４プロモーターおよびこれを用いた骨関連物質の探索法
US6462019B1 (en) 1998-07-10 2002-10-08 Osteoscreen, Inc. Inhibitors of proteasomal activity and production for stimulating bone growth
US6838436B1 (en) 1998-07-10 2005-01-04 Osteoscreen Inc. Inhibitors of proteasomal activity for stimulating bone growth
US6902721B1 (en) 1998-07-10 2005-06-07 Osteoscreen, Inc. Inhibitors of proteasomal activity for stimulating bone growth
US7687462B2 (en) * 1999-10-05 2010-03-30 The Regents Of The University Of California Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
WO2004072100A2 (en) * 2003-02-07 2004-08-26 The Regents Of The University Of California Nell peptide expression systems and bone formation activity of nell peptide
US7052856B2 (en) * 1999-10-05 2006-05-30 The Regents Of The University Of California NELL-1 enhanced bone mineralization
US7884066B2 (en) * 1999-10-05 2011-02-08 The Regents Of The University Of California NELL-1 enhanced bone mineralization
US20090060988A1 (en) * 1999-10-05 2009-03-05 Kang Ting Nell-1 enhanced bone mineralization
WO2002037313A2 (en) * 2000-11-06 2002-05-10 Thrasos, Inc. Computer method and apparatus for classifying objects
CA2431552A1 (en) * 2000-11-06 2002-05-16 Thrasos, Inc. Screening methods for bone morphogenetic mimetics
US7251568B2 (en) * 2001-04-18 2007-07-31 Wyeth Methods and compositions for regulating bone and cartilage formation
WO2002085285A2 (en) * 2001-04-18 2002-10-31 Wyeth Methods and reagents for regulating bone and cartilage formation
US7041309B2 (en) * 2002-06-13 2006-05-09 Neuropro Technologies, Inc. Spinal fusion using an HMG-CoA reductase inhibitor
RU2005107330A (ru) * 2002-08-16 2005-10-10 Уайт (Us) Эстроген-чувствительный элемент вмр-2 и способы его применения
US7029006B2 (en) * 2002-08-29 2006-04-18 Canon Kabushiki Kaisha Sheet feeding apparatus and image forming apparatus
AU2003270736A1 (en) * 2002-09-13 2004-04-30 The Regents Of The University Of California Nell-1 enhanced bone mineralization
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
WO2004091626A1 (en) * 2003-04-07 2004-10-28 Osteoscreen, Inc. Bone growth stimulation with no/statin and other no modulating combinations
US7427677B2 (en) * 2003-07-01 2008-09-23 Academia Sinica Expression of zebrafish bone morphogenetic protein 4
US7691607B2 (en) * 2004-02-09 2010-04-06 The Regents Of The University Of California Expression system of NELL peptide
WO2006014899A2 (en) 2004-07-26 2006-02-09 Dow Global Technologies Inc. Process for improved protein expression by strain engineering
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
EP1851237A4 (de) * 2005-02-16 2009-01-07 Univ California Pharmazeutische zusammensetzungen zur behandlung oder prävention von knochenerkrankungen
US7910552B2 (en) 2005-05-27 2011-03-22 Bbs-Bioactive Bone Substitutes Oy Bone morphogenetic proteins containing a heparin binding site and osteogenic devices and pharmaceutical products containing thereof
US7807627B2 (en) 2005-05-27 2010-10-05 Bbs-Bioactive Bone Substitutes Oy Bone morphogenetic protein 4 and osteogenic devices and pharmaceutical products containing thereof
EP3138403A1 (de) 2005-08-09 2017-03-08 Revivicor, Inc. Ctla4-ig exprimierende transgene huftiere und verwendungen davon
US20080262633A1 (en) * 2006-05-08 2008-10-23 Williams Michelle Leroux Cancellous bone treated with collagenase and essentially free of blood cells
CN101453961B (zh) 2006-05-08 2011-08-10 纽瓦西弗公司 胶原酶处理的并且基本上不含血细胞的松质骨
KR101530395B1 (ko) 2007-04-27 2015-06-19 피페넥스 인크. 향상된 수율 및(또는) 품질로 이종 단백질을 발현하는 특정 균주를 동정하기 위해 미생물 숙주를 신속히 스크리닝하는 방법
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9216181B2 (en) 2011-06-08 2015-12-22 Southwest Research Institute BMP-2 upregulating compounds for healing bone tissue and screening methods for selecting such compounds
US10780197B1 (en) 2012-10-29 2020-09-22 Nuvasive, Inc. Malleable, cryopreserved osteogenic compositions with viable cells

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
WO1992013091A1 (en) * 1991-01-18 1992-08-06 Oncogene Science, Inc. Methods of transcriptionally modulating expression of oncogenes and tumor suppressor genes
IL109990A (en) * 1993-06-21 1999-06-20 Lilly Co Eli Materials and methods for screening anti-osteoporosis agents
US5491084A (en) * 1993-09-10 1996-02-13 The Trustees Of Columbia University In The City Of New York Uses of green-fluorescent protein

Also Published As

Publication number Publication date
EP0832297A4 (de) 1999-10-20
AU6377996A (en) 1996-12-18
CA2221621A1 (en) 1996-12-05
EP0832297A1 (de) 1998-04-01
US6083690A (en) 2000-07-04
EP0832297B1 (de) 2003-01-29
WO1996038590A1 (en) 1996-12-05
DE69626015D1 (de) 2003-03-06
JPH11506009A (ja) 1999-06-02

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