ATE232515T1 - 3-(bis-substituierte-phenylmethylen)oxindol- derivate - Google Patents
3-(bis-substituierte-phenylmethylen)oxindol- derivateInfo
- Publication number
- ATE232515T1 ATE232515T1 AT97900425T AT97900425T ATE232515T1 AT E232515 T1 ATE232515 T1 AT E232515T1 AT 97900425 T AT97900425 T AT 97900425T AT 97900425 T AT97900425 T AT 97900425T AT E232515 T1 ATE232515 T1 AT E232515T1
- Authority
- AT
- Austria
- Prior art keywords
- prevention
- treatment
- phenylmethylene
- bis
- substituted
- Prior art date
Links
- -1 3-(BIS-SUBSTITUTED-PHENYLMETHYLENE)OXINDOLE Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 201000005569 Gout Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- 238000005469 granulation Methods 0.000 abstract 1
- 231100000304 hepatotoxicity Toxicity 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000028774 intestinal disease Diseases 0.000 abstract 1
- 230000007056 liver toxicity Effects 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 201000008383 nephritis Diseases 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 125000004095 oxindolyl group Chemical class N1(C(CC2=CC=CC=C12)=O)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP569396 | 1996-01-17 | ||
| JP1763696 | 1996-02-02 | ||
| PCT/JP1997/000066 WO1997026242A1 (en) | 1996-01-17 | 1997-01-16 | 3-(bis-substituted-phenylmethylene)oxindole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE232515T1 true ATE232515T1 (de) | 2003-02-15 |
Family
ID=26339674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97900425T ATE232515T1 (de) | 1996-01-17 | 1997-01-16 | 3-(bis-substituierte-phenylmethylen)oxindol- derivate |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5965600A (de) |
| EP (1) | EP0816338B1 (de) |
| KR (1) | KR100281867B1 (de) |
| AT (1) | ATE232515T1 (de) |
| AU (1) | AU702045B2 (de) |
| CA (1) | CA2214744C (de) |
| DE (1) | DE69718968T2 (de) |
| WO (1) | WO1997026242A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2527760T3 (es) * | 1998-07-23 | 2015-01-29 | Yeda Research And Development Co., Ltd. | Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos |
| CA2337688C (en) | 1998-07-23 | 2016-04-05 | Yeda Research And Development Co., Ltd. | Treatment of autoimmune conditions with copolymer 1 and related copolymers |
| US6800287B2 (en) * | 1998-09-25 | 2004-10-05 | Yeda Research And Development Co., Ltd. | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
| CN1158283C (zh) | 1998-12-17 | 2004-07-21 | 霍夫曼-拉罗奇有限公司 | 作为蛋白激酶抑制剂的4-和5-吡嗪基羟吲哚 |
| ZA200206457B (en) * | 2000-02-18 | 2003-08-13 | Yeda Res & Dev | Oral, nasal and pulmonary dosage formulations of copolymer 1. |
| US20020077278A1 (en) | 2000-06-05 | 2002-06-20 | Yong V. Wee | Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders |
| WO2002076503A1 (en) * | 2000-06-20 | 2002-10-03 | Mayo Foundation For Medical Education And Research | Treatment of central nervous system diseases by antibodies against glatiramer acetate |
| NZ533327A (en) * | 2001-12-04 | 2006-11-30 | Teva Pharma | Processes for the measurement of the potency of glatiramer acetate |
| US7008979B2 (en) | 2002-04-30 | 2006-03-07 | Hydromer, Inc. | Coating composition for multiple hydrophilic applications |
| CN103274988B (zh) * | 2013-06-20 | 2016-04-13 | 河北大学 | 3-(氰基-p-硝基苯甲撑基)-2-吲哚酮衍生物及其合成方法和用途 |
| JP6898334B6 (ja) | 2016-01-20 | 2021-07-28 | ケモセントリックス，インコーポレイティド | ２−オキシインドール化合物 |
| CN108484474B (zh) * | 2018-04-04 | 2020-09-22 | 华南理工大学 | 具有聚集诱导发光性质的发光材料及其制备与应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3413299A (en) * | 1963-07-11 | 1968-11-26 | Upjohn Co | 3', 3'-di-substituted[spiro-indoline-3, 2'-oxiran]-2 ones and derivatives |
| GB1101794A (en) * | 1965-04-28 | 1968-01-31 | Upjohn Co | Improvements in or relating to new substituted oxindoles and the manufacture thereof |
| US3428649A (en) * | 1968-01-23 | 1969-02-18 | Mcneilab Inc | Oxindole derivatives |
| JPS60222415A (ja) * | 1984-04-20 | 1985-11-07 | Nippon Iyakuhin Kogyo Kk | 抗炎症剤 |
-
1997
- 1997-01-16 AU AU13987/97A patent/AU702045B2/en not_active Ceased
- 1997-01-16 KR KR1019970706430A patent/KR100281867B1/ko not_active Expired - Fee Related
- 1997-01-16 CA CA002214744A patent/CA2214744C/en not_active Expired - Fee Related
- 1997-01-16 WO PCT/JP1997/000066 patent/WO1997026242A1/ja not_active Ceased
- 1997-01-16 DE DE69718968T patent/DE69718968T2/de not_active Expired - Fee Related
- 1997-01-16 EP EP97900425A patent/EP0816338B1/de not_active Expired - Lifetime
- 1997-01-16 AT AT97900425T patent/ATE232515T1/de not_active IP Right Cessation
- 1997-01-16 US US08/913,239 patent/US5965600A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU702045B2 (en) | 1999-02-11 |
| KR100281867B1 (ko) | 2001-02-15 |
| EP0816338A4 (de) | 2001-04-11 |
| US5965600A (en) | 1999-10-12 |
| CA2214744A1 (en) | 1997-07-24 |
| AU1398797A (en) | 1997-08-11 |
| KR19980703022A (ko) | 1998-09-05 |
| EP0816338B1 (de) | 2003-02-12 |
| CA2214744C (en) | 2002-12-24 |
| WO1997026242A1 (en) | 1997-07-24 |
| EP0816338A1 (de) | 1998-01-07 |
| DE69718968T2 (de) | 2003-10-09 |
| DE69718968D1 (de) | 2003-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69529614D1 (de) | Heterobizyklische derivate | |
| ATE180468T1 (de) | Anthranilsäure derivate | |
| FI940414A0 (fi) | Kinoliini- tai kinatsoliinijohdannaiset, niiden valmistus ja käyttö | |
| ATE226574T1 (de) | 4,6-diarylpyrimidin-derivate und deren salze | |
| DE69528005D1 (de) | Prolineamid-Derivate | |
| DK0623607T3 (da) | Benzofuranyl- og -thiophenyl-alkancarboxylsyrederivater | |
| DE69718968D1 (de) | 3-(bis-substituierte-phenylmethylen)oxindol-derivate | |
| ATE145906T1 (de) | Benzamid-derivate | |
| DE3673688D1 (de) | Succinimide derivate, herstellung und anwendung. | |
| DE69708484D1 (de) | Pyridinderivate,als Arzneimittel zur Behandlung von Geschwüren und als antibakterielle Mittel | |
| ATE228134T1 (de) | Kondensierte pyrimidinderivate und diese enthaltende pharmazeutische zubereitungen | |
| ATE222583T1 (de) | Derivate substituierter amidinonaphthylester | |
| DE69827706D1 (de) | 5-(Heteroaryl)alkyl)-3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid (PBI) Derivate zur Behandlung von Störungen des zentralen Nervensystems | |
| AP9400608A0 (en) | "New nicotinic acid derivative". |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |