ATE232544T1 - Selektive inhibitoren des mmp-12 - Google Patents

Selektive inhibitoren des mmp-12

Info

Publication number: ATE232544T1
Authority: AT; Austria
Prior art keywords: mmp; selective inhibitors; inhibitors; selective
Prior art date: 1998-12-31

Application number

AT99960295T

Other languages

English (en)

Inventor

Alan M Warshawsky

Michael J Janusz

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-31

Filing date

1999-11-12

Publication date

2003-02-15

1999-11-12 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2003-02-15 Application granted granted Critical

2003-02-15 Publication of ATE232544T1 publication Critical patent/ATE232544T1/de

Links

102100027998 Macrophage metalloelastase Human genes 0.000 title 1
101710187853 Macrophage metalloelastase Proteins 0.000 title 1
229940124639 Selective inhibitor Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT99960295T 1998-12-31 1999-11-12 Selektive inhibitoren des mmp-12 ATE232544T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US22455098A	1998-12-31	1998-12-31
PCT/US1999/026749 WO2000040600A1 (en)	1998-12-31	1999-11-12	Selective inhibitors of mmp-12

Publications (1)

Publication Number	Publication Date
ATE232544T1 true ATE232544T1 (de)	2003-02-15

Family

ID=22841172

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99960295T ATE232544T1 (de)	1998-12-31	1999-11-12	Selektive inhibitoren des mmp-12

Country Status (10)

Country	Link
EP (1)	EP1140984B1 (de)
JP (1)	JP2002534435A (de)
AR (1)	AR022170A1 (de)
AT (1)	ATE232544T1 (de)
AU (1)	AU1719700A (de)
CA (1)	CA2356919A1 (de)
DE (1)	DE69905397T2 (de)
DK (1)	DK1140984T3 (de)
ES (1)	ES2188277T3 (de)
WO (1)	WO2000040600A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6777443B2 (en)	2001-05-15	2004-08-17	Novartis Ag	Dipeptide derivatives
EP1394159A1 (de) *	2002-08-13	2004-03-03	Warner-Lambert Company LLC	Neue Thiophen-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
EP2907512A1 (de)	2014-02-14	2015-08-19	Commissariat A L'energie Atomique Et Aux Energies Alternatives	Hemmer von MMP-12 als antivirale Wirkstoffe

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL69795A (en) *	1983-09-23	1987-01-30	Univ Ramot	Ophthalmic preparations containing as active ingredient 2-mercaptoalkanoyl peptides
GB9607120D0 (en) *	1996-04-04	1996-06-12	Chiroscience Ltd	Compounds
GB9615976D0 (en) *	1996-07-30	1996-09-11	Center For Clinical & Basic Re	The use of proteinase inhibitors for the prevention or reduction of bone resorption
CA2317604C (en) *	1998-01-09	2004-12-21	Pfizer Inc.	Matrix metalloprotease inhibitors

1999
- 1999-11-12 EP EP99960295A patent/EP1140984B1/de not_active Expired - Lifetime
- 1999-11-12 WO PCT/US1999/026749 patent/WO2000040600A1/en not_active Ceased
- 1999-11-12 DK DK99960295T patent/DK1140984T3/da active
- 1999-11-12 JP JP2000592308A patent/JP2002534435A/ja active Pending
- 1999-11-12 AU AU17197/00A patent/AU1719700A/en not_active Abandoned
- 1999-11-12 CA CA002356919A patent/CA2356919A1/en not_active Abandoned
- 1999-11-12 AT AT99960295T patent/ATE232544T1/de not_active IP Right Cessation
- 1999-11-12 DE DE69905397T patent/DE69905397T2/de not_active Expired - Fee Related
- 1999-11-12 ES ES99960295T patent/ES2188277T3/es not_active Expired - Lifetime
- 1999-12-30 AR ARP990106864A patent/AR022170A1/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU1719700A (en)	2000-07-24
WO2000040600A1 (en)	2000-07-13
DK1140984T3 (da)	2003-05-26
AR022170A1 (es)	2002-09-04
EP1140984A1 (de)	2001-10-10
DE69905397T2 (de)	2003-12-18
EP1140984B1 (de)	2003-02-12
JP2002534435A (ja)	2002-10-15
DE69905397D1 (de)	2003-03-20
ES2188277T3 (es)	2003-06-16
CA2356919A1 (en)	2000-07-13

Legal Events

Date

Code

Title

Description

2003-09-15

UEP

Publication of translation of european patent specification

Ref document number: 1140984

Country of ref document: EP

2005-02-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69939689D1 (de)	2008-11-20	Caspase inhibitoren
PT1114051E (pt)	2003-07-31	Inibidores de p38
IS5711A (is)	2000-11-10	Heteróhringatálmar við P38
NO20004550D0 (no)	2000-09-12	Enzyminhibitorer
ATE295848T1 (de)	2005-06-15	C-aryl-glucosid-sglt2-inhibitoren
NO20012980L (no)	2001-08-01	Proteaseinhibitorer
PT1181017E (pt)	2003-06-30	Inibidores de metaloproteases
AR028253A1 (es)	2003-04-30	Inhibidores de la glucogeno fosforilasa
DE69716615D1 (de)	2002-11-28	Heterozyklische metalloproteaseinhibitoren
DK0958287T3 (da)	2003-01-20	Sulfamidmetalloprotease-inhibitorer
PT1194404E (pt)	2006-08-31	Inibidores de aspartil-protease
DE59806475D1 (de)	2003-01-09	Urokinase-inhibitoren
NO20003814L (no)	2000-07-25	Trombininhibitorer
ATE252547T1 (de)	2003-11-15	Matrixmetalloproteinaseinhibitoren
NO20010660D0 (no)	2001-02-07	Isolator
ID28032A (id)	2001-05-03	TRISIKLIK PIPERIDIN-Δ3-SEBAGAI ANTAGONIS-α2
NO20010085D0 (no)	2001-01-05	Angiogeneseinhibitorer
DK1098894T3 (da)	2002-10-28	FKBP-inhibitorer
DE69903507D1 (de)	2002-11-21	Beizvorrichtung
MA24877A1 (fr)	1999-12-31	INHIBITEURS DE PROTéASES
DE69901764D1 (de)	2002-07-18	Beizvorrichtung
EE200100017A (et)	2002-06-17	N-tert-butüülhüdroksüülamiini uued soolad
DE69905397D1 (de)	2003-03-20	Selektive inhibitoren des mmp-12
NO993161D0 (no)	1999-06-25	Cyklooksygenaseinhibitor
EP1025851A4 (de)	2001-07-04	alpha-GLUCOSIDASE HEMMER