ATE232873T1 - Phosphonsaürederivate als ptp-1b-inhibitoren - Google Patents

Phosphonsaürederivate als ptp-1b-inhibitoren

Info

Publication number: ATE232873T1
Authority: AT; Austria
Prior art keywords: ptp; inhibitors; acid derivatives; phosphonic acid; encompasses
Prior art date: 1998-09-21

Application number

AT99944200T

Other languages

English (en)

Inventor

Yves Leblanc

Claude Dufresne

Zhaoyin Wang

Chun Sing Li

Jacques Y Gauthier

Michel Therien

Cheuk K Lau

Patrick Roy

Original Assignee

Merck Frosst Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-21

Filing date

1999-09-21

Publication date

2003-03-15

1999-09-21 Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc

2003-03-15 Application granted granted Critical

2003-03-15 Publication of ATE232873T1 publication Critical patent/ATE232873T1/de

Links

229940042400 direct acting antivirals phosphonic acid derivative Drugs 0.000 title 1
150000003007 phosphonic acid derivatives Chemical class 0.000 title 1
239000003801 protein tyrosine phosphatase 1B inhibitor Substances 0.000 title 1
102100033001 Tyrosine-protein phosphatase non-receptor type 1 Human genes 0.000 abstract 2
101710128896 Tyrosine-protein phosphatase non-receptor type 1 Proteins 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04M—TELEPHONIC COMMUNICATION
- H04M3/00—Automatic or semi-automatic exchanges
- H04M3/42—Systems providing special services or facilities to subscribers
- H04M3/42314—Systems providing special services or facilities to subscribers in private branch exchanges
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3856—Polyphosphonic acids containing halogen or nitro(so) substituents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3865—Polyphosphonic acids containing sulfur substituents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3869—Polyphosphonic acids containing carboxylic acid or carboxylic acid derivative substituents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3882—Arylalkanephosphonic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6518—Five-membered rings
- C07F9/65188—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
- C07F9/65306—Five-membered rings containing two nitrogen atoms
- C07F9/65318—Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
- C07F9/65324—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/65392—Five-membered rings containing two nitrogen atoms
- C07F9/65395—Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
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- H04Q3/00—Selecting arrangements
- H04Q3/58—Arrangements providing connection between main exchange and sub-exchange or satellite
- H04Q3/62—Arrangements providing connection between main exchange and sub-exchange or satellite for connecting to private branch exchanges
- H04Q3/625—Arrangements in the private branch exchange
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- H04Q2213/13389—LAN, internet

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Computer Networks & Wireless Communication (AREA)
Astronomy & Astrophysics (AREA)
General Physics & Mathematics (AREA)
Signal Processing (AREA)
Obesity (AREA)
Physics & Mathematics (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Ink Jet (AREA)

AT99944200T 1998-09-21 1999-09-21 Phosphonsaürederivate als ptp-1b-inhibitoren ATE232873T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US10116498P	1998-09-21	1998-09-21
US12742099P	1999-04-01	1999-04-01
US09/398,356 US6174874B1 (en)	1998-09-21	1999-09-17	Phosphonic acids derivatives as inhibitors of protein tyrosine phosphate 1B (PTP-1B)
PCT/CA1999/000864 WO2000017211A1 (en)	1998-09-21	1999-09-21	Phosphonic acids derivatives as inhibitors of ptp-1b

Publications (1)

Publication Number	Publication Date
ATE232873T1 true ATE232873T1 (de)	2003-03-15

Family

ID=27379139

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99944200T ATE232873T1 (de)	1998-09-21	1999-09-21	Phosphonsaürederivate als ptp-1b-inhibitoren

Country Status (9)

Country	Link
US (1)	US6174874B1 (de)
EP (1)	EP1115729B1 (de)
JP (1)	JP2002526505A (de)
AT (1)	ATE232873T1 (de)
AU (1)	AU761596B2 (de)
CA (1)	CA2344927A1 (de)
DE (1)	DE69905476T2 (de)
ES (1)	ES2192396T3 (de)
WO (1)	WO2000017211A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU4738600A (en) *	1999-05-14	2000-12-05	Merck Frosst Canada & Co.	Phosphonic and carboxylic acid derivatives as inhibitors of protein tyrosine phosphatase-1b (ptp-1b)
JP2003518129A (ja) *	1999-12-22	2003-06-03	メルクフロストカナダアンドカンパニー	タンパク質チロシンホスファターゼ１ｂ（ｐｔｐ−１ｂ）のインヒビターとなるホスホン酸誘導体
WO2001046206A1 (en)	1999-12-22	2001-06-28	Merck Frosst Canada & Co.	Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1b (ptp-1b)
CA2394834A1 (en) *	1999-12-22	2001-06-28	Merck Frosst Canada Inc.	Phosphonic acid biaryl derivatives as inhibitors of protein tyrosine phosphatase 1b (ptp-1b)
JP2003518128A (ja) *	1999-12-22	2003-06-03	メルクフロストカナダアンドカンパニー	タンパク質チロシンホスファターゼ１ｂ（ｐｔｐ−１ｂ）のインヒビターとなる芳香族ホスホネート
US6777433B2 (en)	1999-12-22	2004-08-17	Merck Frosst Canada & Co.	Protein tyrosine phosphatase 1B (PTP-1B) inhibitors containing two ortho-substituted aromatic phosphonates
US6498151B2 (en)	2000-03-22	2002-12-24	Merck Frosst Canada & Co.	Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors
WO2002102813A1 (en) *	2001-06-20	2002-12-27	Merck Frosst Canada & Co.	Aryldifluoromethylphosphonic acids for treatment of diabetes
US20040191926A1 (en) *	2001-09-26	2004-09-30	Zhong-Yin Zhang	Ptp1b inhibitors and ligands
JP2005509616A (ja) *	2001-10-16	2005-04-14	センジェント・セラピューティクス・インク	チロシンホスファターゼに対する有機硫黄阻害剤
WO2003048140A1 (en)	2001-12-03	2003-06-12	Japan Tobacco Inc.	Azole compound and medicinal use thereof
BR0312133A (pt) *	2002-06-11	2005-04-05	Ciba Sc Holding Ag	Formas dìmeras e multìmeras de óxidos de monoacifosfinas e bis-acifosfinas, processo para a preparação das mesmas, bem como composição fotopolimerizável
US20040186151A1 (en) *	2003-02-12	2004-09-23	Mjalli Adnan M.M.	Substituted azole derivatives as therapeutic agents
AU2004210711B2 (en) *	2003-02-12	2010-07-08	Transtech Pharma, Inc.	Substituted azole derivatives as therapeutic agents
WO2005035551A2 (en)	2003-10-08	2005-04-21	Incyte Corporation	Inhibitors of proteins that bind phosphorylated molecules
WO2005080346A1 (en) *	2004-02-12	2005-09-01	Transtech Pharma, Inc.	Substituted azole derivatives, compositions, and methods of use
US7736911B2 (en) *	2004-04-15	2010-06-15	Albert Einstein College Of Medicine Of Yeshiva University	Activity-based probes for protein tyrosine phosphatases
US20060135773A1 (en) *	2004-06-17	2006-06-22	Semple Joseph E	Trisubstituted nitrogen modulators of tyrosine phosphatases
WO2006017124A2 (en) *	2004-07-09	2006-02-16	Cengent Therapeutics, Inc.	Oxygen/nitrogen heterocycle inhibitors of tyrosine phosphatases
WO2006028970A1 (en)	2004-09-02	2006-03-16	Cengent Therapeutics, Inc.	Derivatives of thiazole and thiadiazole inhibitors of tyrosine phosphatases
WO2006038719A1 (ja) *	2004-10-08	2006-04-13	Kotobuki Pharmaceutical Co., Ltd.	ホスホン酸誘導体及び血中の高リン酸が関与する疾患の治療剤
NZ554783A (en)	2004-11-15	2010-12-24	Ceptyr Inc	Protein tyrosine phosphatase inhibitors and methods of use thereof
EP1991544B1 (de) *	2006-01-30	2018-08-15	vTv Therapeutics LLC	Substituierte imidazol- derivate und ihre verwendung als ptpase inhibitoren
US8168815B2 (en) *	2007-01-26	2012-05-01	Kaneq Pharma Inc.	Fused aromatic PTP-1B inhibitors
JP5701063B2 (ja)	2008-01-02	2015-04-15	ツェオシスゲゼルシャフトミットベシュレンクテルハフツングＺｅｏＳｙｓＧｍｂＨ	ハロゲン化炭化水素の回収方法
DE102014006224B4 (de) *	2014-04-30	2020-10-22	Chiracon Gmbh	Verfahren zur Herstellung von 2-Aryl-2-Alkyl-malonsäuren
CN106631885B (zh) *	2016-09-28	2018-08-07	荆门医药工业技术研究院	一种制备4-甲醛肟基苯甲酸酯类衍生物的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2381397A (en)	1996-04-19	1997-11-12	Novo Nordisk A/S	Modulators of molecules with phosphotyrosine recognition units
EP0937157A1 (de)	1996-11-04	1999-08-25	Merck Frosst Canada & Co.	Hydrolase bindungstest

1999
- 1999-09-17 US US09/398,356 patent/US6174874B1/en not_active Expired - Fee Related
- 1999-09-21 DE DE69905476T patent/DE69905476T2/de not_active Expired - Fee Related
- 1999-09-21 EP EP99944200A patent/EP1115729B1/de not_active Expired - Lifetime
- 1999-09-21 ES ES99944200T patent/ES2192396T3/es not_active Expired - Lifetime
- 1999-09-21 WO PCT/CA1999/000864 patent/WO2000017211A1/en not_active Ceased
- 1999-09-21 AT AT99944200T patent/ATE232873T1/de not_active IP Right Cessation
- 1999-09-21 CA CA002344927A patent/CA2344927A1/en not_active Abandoned
- 1999-09-21 JP JP2000574120A patent/JP2002526505A/ja not_active Withdrawn
- 1999-09-21 AU AU57241/99A patent/AU761596B2/en not_active Ceased

Also Published As

Publication number	Publication date
EP1115729A1 (de)	2001-07-18
AU761596B2 (en)	2003-06-05
WO2000017211A1 (en)	2000-03-30
EP1115729B1 (de)	2003-02-19
JP2002526505A (ja)	2002-08-20
US6174874B1 (en)	2001-01-16
CA2344927A1 (en)	2000-03-30
DE69905476T2 (de)	2003-12-24
AU5724199A (en)	2000-04-10
DE69905476D1 (en)	2003-03-27
ES2192396T3 (es)	2003-10-01

Legal Events

Date	Code	Title	Description
2003-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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