ATE233095T1 - Kombinationspraeparat, welches cyclosporin a oder fk-506 oder rapamycin und ein xanthinderivat enthaelt - Google Patents

Kombinationspraeparat, welches cyclosporin a oder fk-506 oder rapamycin und ein xanthinderivat enthaelt

Info

Publication number: ATE233095T1
Authority: AT; Austria
Prior art keywords: rapamycin; preparation containing; combination preparation; xanthine derivative; containing cyclosporin
Prior art date: 1994-08-25

Application number

AT95929805T

Other languages

English (en)

Inventor

Martin Schoenharting

Ulrich Gebert

Mark Waer

Original Assignee

Hoechst Ag

Univ Leuven Kath

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-25

Filing date

1995-08-07

Publication date

2003-03-15

1995-08-07 Application filed by Hoechst Ag, Univ Leuven Kath filed Critical Hoechst Ag

2003-03-15 Application granted granted Critical

2003-03-15 Publication of ATE233095T1 publication Critical patent/ATE233095T1/de

Links

LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 title abstract 2
229930105110 Cyclosporin A Natural products 0.000 title 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
108010036949 Cyclosporine Proteins 0.000 title 1
229960001265 ciclosporin Drugs 0.000 title 1
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title 1
229960002930 sirolimus Drugs 0.000 title 1
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
230000001506 immunosuppresive effect Effects 0.000 abstract 2
101000729818 Bacillus licheniformis Glutamate racemase Proteins 0.000 abstract 1
241000845077 Iare Species 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Transplantation (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT95929805T 1994-08-25 1995-08-07 Kombinationspraeparat, welches cyclosporin a oder fk-506 oder rapamycin und ein xanthinderivat enthaelt ATE233095T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4430127A DE4430127A1 (de)	1994-08-25	1994-08-25	Kombinationspräparat, enthaltend Cyclosporin A oder FK506 und ein Xanthinderivat
PCT/EP1995/003126 WO1996005854A2 (en)	1994-08-25	1995-08-07	Combination preparation, containing cyclosporin a or fk506 or rapamycin and a xanthine derivative

Publications (1)

Publication Number	Publication Date
ATE233095T1 true ATE233095T1 (de)	2003-03-15

Family

ID=6526514

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95929805T ATE233095T1 (de)	1994-08-25	1995-08-07	Kombinationspraeparat, welches cyclosporin a oder fk-506 oder rapamycin und ein xanthinderivat enthaelt

Country Status (9)

Country	Link
US (2)	US6046328A (de)
EP (1)	EP0797448B1 (de)
CN (1)	CN1096859C (de)
AT (1)	ATE233095T1 (de)
AU (1)	AU714129B2 (de)
CA (1)	CA2199949A1 (de)
DE (2)	DE4430127A1 (de)
MX (1)	MX9702181A (de)
WO (1)	WO1996005854A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100840816B1 (ko)	2000-05-12	2008-06-23	젠자임 코포레이션	ＴＮＦ-α시그널링의 조절물질
US6641611B2 (en)	2001-11-26	2003-11-04	Swaminathan Jayaraman	Therapeutic coating for an intravascular implant
US20040137066A1 (en) *	2001-11-26	2004-07-15	Swaminathan Jayaraman	Rationally designed therapeutic intravascular implant coating
PT1562571E (pt) *	2002-11-21	2011-11-25	Genzyme Corp	Combinação de derivados de diamina e agentes imunossupressores para a indução da tolerância imunológica
DE60335652D1 (de) *	2002-11-21	2011-02-17	Genzyme Corp	Verwendung eines diamidderivats zur verhinderung der chronischen transplantatabstossung
WO2007041506A1 (en) *	2005-10-03	2007-04-12	Melior Discovery, Inc.	Purine formulations and methods for managing disorders
EP1787645A1 (de) *	2005-11-18	2007-05-23	Institut Curie	Neue Krebsbehandlung durch Modulierung des Calcineurin- und/oder Calcineurin/NFAT-Weg
CA2921063C (en)	2006-09-15	2020-01-28	Ottawa Hospital Research Institute	Oncolytic rhabdovirus
WO2008122965A2 (en) *	2007-04-04	2008-10-16	Sigmoid Pharma Limited	Pharmaceutical cyclosporin compositions
AU2009217680B2 (en)	2008-02-29	2013-09-05	Concert Pharmaceuticals, Inc	Substituted xanthine derivatives
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
US8263601B2 (en)	2009-02-27	2012-09-11	Concert Pharmaceuticals, Inc.	Deuterium substituted xanthine derivatives
CN101897964B (zh) *	2009-04-27	2013-04-10	中国农业大学	一种预防自身免疫疾病的药物
WO2011028820A1 (en)	2009-09-02	2011-03-10	Concert Pharmaceuticals, Inc.	Substituted derivatives of bicyclic [4.3.0] heteroaryl compounds
WO2012031073A1 (en)	2010-09-01	2012-03-08	Concert Pharmaceuticals, Inc.	Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
WO2012031072A1 (en)	2010-09-01	2012-03-08	Concert Pharmaceuticals, Inc.	Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
EP2836492B1 (de)	2012-04-13	2018-03-14	Concert Pharmaceuticals Inc.	Substituierte xanthinderivate
EP2705856A1 (de)	2012-09-07	2014-03-12	Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.	Verbindungen zur Behandlung von neurodegenerativen Erkrankungen
US9814703B2 (en)	2013-11-14	2017-11-14	The Board Of Trustees Of The Leland Stanford Junior University	Methods for treating cancer by activation of BMP signaling
WO2022042390A1 (zh) *	2020-08-25	2022-03-03	广东众生睿创生物科技有限公司	羟基嘌呤类化合物用于治疗皮肤疾病的用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU9084991A (en) *	1990-11-01	1992-05-26	Board Of Regents, The University Of Texas System	Antifungal activity of and prevention of drug induced nephrotoxicity by methylxanthine analogues
EP0490181A1 (de) *	1990-11-30	1992-06-17	Hoechst-Roussel Pharmaceuticals Incorporated	Verwendung von Xanthinen zur Herstellung eines Medikaments mit immunsuppressiver Wirkung
EP0493682A3 (en) *	1990-11-30	1992-11-19	Hoechst-Roussel Pharmaceuticals Incorporated	Use of xanthines for the preparation of a medicament effective for inhibiting the effects of allograft reaction in humans
IL99368A (en) *	1991-09-02	1996-01-19	Teva Pharma	Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine
DK0584347T3 (da) *	1992-03-04	2003-02-24	Cell Therapeutics Inc	Enantiomere hydroxylerede xanthinforbindelser

1994
- 1994-08-25 DE DE4430127A patent/DE4430127A1/de not_active Withdrawn
1995
- 1995-08-07 EP EP95929805A patent/EP0797448B1/de not_active Expired - Lifetime
- 1995-08-07 CN CN95195562A patent/CN1096859C/zh not_active Expired - Fee Related
- 1995-08-07 WO PCT/EP1995/003126 patent/WO1996005854A2/en not_active Ceased
- 1995-08-07 DE DE69529769T patent/DE69529769D1/de not_active Expired - Lifetime
- 1995-08-07 US US08/817,218 patent/US6046328A/en not_active Expired - Fee Related
- 1995-08-07 AT AT95929805T patent/ATE233095T1/de not_active IP Right Cessation
- 1995-08-07 CA CA002199949A patent/CA2199949A1/en not_active Abandoned
- 1995-08-07 AU AU33428/95A patent/AU714129B2/en not_active Ceased
- 1995-08-07 MX MX9702181A patent/MX9702181A/es unknown
1999
- 1999-11-10 US US09/437,829 patent/US6432968B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0797448A2 (de)	1997-10-01
DE69529769D1 (de)	2003-04-03
US6432968B1 (en)	2002-08-13
MX9702181A (es)	1997-06-28
CA2199949A1 (en)	1996-02-29
AU3342895A (en)	1996-03-14
EP0797448B1 (de)	2003-02-26
CN1096859C (zh)	2002-12-25
WO1996005854A3 (en)	1996-04-11
DE4430127A1 (de)	1996-03-14
WO1996005854A2 (en)	1996-02-29
CN1162919A (zh)	1997-10-22
US6046328A (en)	2000-04-04
AU714129B2 (en)	1999-12-16

Legal Events

Date

Code

Title

Description

2003-08-15

UEP

Publication of translation of european patent specification

Ref document number: 0797448

Country of ref document: EP

2005-05-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE233095T1 (de)	2003-03-15	Kombinationspraeparat, welches cyclosporin a oder fk-506 oder rapamycin und ein xanthinderivat enthaelt
EP1149581A3 (de)	2003-12-03	Verwendung von Rapamycinderivaten zur Behandlung von Gefässerkrankungen und Xenotransplantationen
EP0659715A3 (de)	1995-09-27	Gaserzeugende Zusammenasetzungen.
FI935298A0 (fi)	1993-11-29	Anvaendning av rapamycin prolaekemedel som immunosuppressiva medel
DK0839126T3 (da)	2001-08-06	Fremgangsmåde til fremstilling af organiske nitrogenforbindelser, specielle organiske nitrogenforbindelser og blandinger af sådanne forbindelser samt deres anvendelse som brændstof- og smøremiddeladditiver
HU910659D0 (en)	1991-09-30	Ignition unit for kitchen functioning with liquified gas
PH31253A (en)	1998-06-18	Carbamates of rapamycin.
ZA977475B (en)	1998-02-19	N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action.
DE59702823D1 (de)	2001-02-01	Sitz,lehnen oder liegenpolsterung
EP0662935A4 (de)	1996-04-10	Gasgenerator.
DE69016218D1 (de)	1995-03-09	Hydraulisch blockierbare Gasfeder.
EP0634608A3 (de)	1995-06-21	Doppelring-Gasbrenner.
FR2665726B1 (fr)	1993-07-02	Soufflante de turbomachine a amortisseur dynamique a cames.
EP0369685A3 (de)	1991-03-27	Fluoxetin-Analogon
ES2196824T3 (es)	2003-12-16	Derivado de triazolo-piridazina sustituido y composiciones farmaceuticas fabricadas con el mismo.
DK0610744T3 (da)	1999-07-19	Sulfonamidaminomethylenderivater som immunosuppressive stoffer
BG99638A (en)	1996-04-30	Derivatives of xanthine as diuretic form
EP0631092A3 (de)	1996-03-20	Gasfeuerzeug.
DE69417584D1 (de)	1999-05-06	7-[carboxyalkyl oder alkenyl]-6-[alkyl oder alkenyl] 3-oxo-2,4-dioxobicyclo-[3.2.1]octan und dessen derivate
IL111522A0 (en)	1995-01-24	Percussion primer compound, and methods for the preparation of same
EP0660045A3 (de)	1996-04-03	Taschenfeuerzeug.
GB2315216B (en)	1998-10-14	Microemulsion preconcentrates comprising FK506 or 33-epi-chloro-33-desoxy-ascomycin
AU6580500A (en)	2001-03-19	Igniters for gas generators
EP0656510A3 (de)	1996-03-20	Taschenfeuerzeug.
KR940020019U (ko)	1994-09-15	행사용포켓화기