ATE233096T1 - Zusammensetzungen und methoden zur steigerung der darmfunktion - Google Patents

Zusammensetzungen und methoden zur steigerung der darmfunktion

Info

Publication number: ATE233096T1
Authority: AT; Austria
Prior art keywords: methods; compositions; glp; intestinal function; increase intestinal
Prior art date: 1996-12-10

Application number

AT97946986T

Other languages

English (en)

Inventor

Daniel J Drucker

Original Assignee

Ontario Inc 1149336

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-10

Filing date

1997-12-10

Publication date

2003-03-15

1997-12-10 Application filed by Ontario Inc 1149336 filed Critical Ontario Inc 1149336

2003-03-15 Application granted granted Critical

2003-03-15 Publication of ATE233096T1 publication Critical patent/ATE233096T1/de

Links

230000003871 intestinal function Effects 0.000 title 1
239000000203 mixture Substances 0.000 title 1
102400000326 Glucagon-like peptide 2 Human genes 0.000 abstract 3
101800000221 Glucagon-like peptide 2 Proteins 0.000 abstract 3
TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 abstract 3
239000000813 peptide hormone Substances 0.000 abstract 3
210000002429 large intestine Anatomy 0.000 abstract 2
210000000813 small intestine Anatomy 0.000 abstract 2
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
235000016709 nutrition Nutrition 0.000 abstract 1
208000030212 nutrition disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
210000002966 serum Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Obesity (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT97946986T 1996-12-10 1997-12-10 Zusammensetzungen und methoden zur steigerung der darmfunktion ATE233096T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/763,177 US5952301A (en)	1996-12-10	1996-12-10	Compositions and methods for enhancing intestinal function
PCT/CA1997/000945 WO1998025644A1 (en)	1996-12-10	1997-12-10	Compositions and methods for enhancing intestinal function

Publications (1)

Publication Number	Publication Date
ATE233096T1 true ATE233096T1 (de)	2003-03-15

Family

ID=25067085

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97946986T ATE233096T1 (de)	1996-12-10	1997-12-10	Zusammensetzungen und methoden zur steigerung der darmfunktion

Country Status (10)

Country	Link
US (1)	US5952301A (de)
EP (1)	EP0944396B1 (de)
AT (1)	ATE233096T1 (de)
AU (1)	AU5220098A (de)
CA (1)	CA2274596C (de)
DE (1)	DE69719360T2 (de)
DK (1)	DK0944396T3 (de)
ES (1)	ES2193406T3 (de)
PT (1)	PT944396E (de)
WO (1)	WO1998025644A1 (de)

Families Citing this family (41)

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Publication number	Priority date	Publication date	Assignee	Title
US20020025933A1 (en) *	1996-08-30	2002-02-28	Knudsen Liselotte Bjerre	GLP-2 derivatives
CA2236519C (en) *	1997-05-02	2011-09-13	1149336 Ontario Inc.	Methods of enhancing functioning of the large intestine
CN1264307B (zh) *	1997-05-16	2013-10-30	1149336安大略公司	改善上胃肠道功能的方法
EP2823812A1 (de) *	1998-02-02	2015-01-14	Trustees Of Tufts College	Dipeptidylpeptidase-IV-Hemmer zur Behandlung von Typ-II Diabetes
WO1999058144A1 (en) *	1998-05-11	1999-11-18	1149336 Ontario Inc.	Methods of enhancing functioning of the large intestine
AU5480199A (en) *	1998-08-21	2000-03-14	Point Therapeutics, Inc.	Regulation of substrate activity
US6979697B1 (en)	1998-08-21	2005-12-27	Point Therapeutics, Inc.	Regulation of substrate activity
GB9906714D0 (en)	1999-03-23	1999-05-19	Ferring Bv	Compositions for improving fertility
GB9906715D0 (en)	1999-03-23	1999-05-19	Ferring Bv	Compositions for promoting growth
EP1187619A1 (de) *	1999-05-25	2002-03-20	Point Therapeutics, Inc.	Anti-tumor präparate enthaltend boroprolin verbindungen
EP1806138A1 (de) *	1999-05-25	2007-07-11	Point Therapeutics, Inc.	Anti-tumor präparate enthaltend boroprolin verbindungen
US6890904B1 (en)	1999-05-25	2005-05-10	Point Therapeutics, Inc.	Anti-tumor agents
EP1229927B1 (de) *	1999-11-03	2007-12-19	Novo Nordisk A/S	Verwendung eines wachstumshormons oder eines wachstumshormon-sekretion fördernden mittels zur appetit-unterdrückung bzw. sättigungsinduktion
US6599882B1 (en)	1999-11-05	2003-07-29	Joseph A. Rogoff	Secretin and secretin pharmaceuticals for treating lactose intolerance
GB9930882D0 (en) *	1999-12-30	2000-02-23	Nps Allelix Corp	GLP-2 formulations
US20080249016A1 (en) *	2000-09-18	2008-10-09	Sanos Bioscience A/S	Use of GLP-2 in a combination treatment for bone-related disorders
DE60134251D1 (de)	2000-09-18	2008-07-10	Sanos Bioscience As	Verwendung von glp-2-peptiden
US7371721B2 (en) *	2000-09-18	2008-05-13	Sanos Bioscience A/S	Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes
US20070135345A1 (en) *	2000-09-18	2007-06-14	Henriksen Dennis B	Use of GLP-2 for the treatment or prevention, of bone-related disorders
EP1980572A1 (de) *	2001-02-16	2008-10-15	ConjuChem Biotechnologies Inc.	Glucagonartiges Peptid 2 (GLP-2) mit Langzeitwirkung für die Behandlung von Magendarmerkrankungen und -störungen
EP1469873A4 (de) *	2001-11-26	2007-10-03	Tufts College	Peptidomimetische inhibitoren von hinter prolin spaltenden enzymen
CA2466870A1 (en) *	2001-11-26	2003-06-05	Trustees Of Tufts College	Methods for treating autoimmune disorders, and reagents related thereto
US20040038864A1 (en) *	2002-06-27	2004-02-26	Per Balschmidt	Use of dimethyl sulfone as isotonicity agent
WO2004035624A2 (en) *	2002-10-14	2004-04-29	Novo Nordisk A/S	Glucagon - like peptide - 2 variants
US20050026859A1 (en) *	2002-11-12	2005-02-03	John Hilfinger	Methods and compositions of gene delivery agents for systemic and local therapy
US20080026077A1 (en) *	2002-11-12	2008-01-31	John Hilfinger	Methods and compositions of gene delivery agents for systemic and local therapy
US7317109B2 (en) *	2003-11-12	2008-01-08	Phenomix Corporation	Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
NZ547752A (en) *	2003-11-12	2009-12-24	Phenomix Corp	Heterocyclic boronic acid compounds for inhibiting dipeptidyl peptidase-IV
US7767828B2 (en) *	2003-11-12	2010-08-03	Phenomix Corporation	Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US7576121B2 (en) *	2003-11-12	2009-08-18	Phenomix Corporation	Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
AU2005261778A1 (en) *	2004-07-14	2006-01-19	Novartis Ag	Combination of DPP-IV inhibitors and compounds modulating 5-HT3 and/or 5-HT4 receptors
CA2607150C (en) *	2005-05-04	2014-08-05	Bjarne Due Larsen	Glucagon-like-peptide-2 (glp-2) analogues
US7825139B2 (en) *	2005-05-25	2010-11-02	Forest Laboratories Holdings Limited (BM)	Compounds and methods for selective inhibition of dipeptidyl peptidase-IV
CA2669806C (en)	2006-11-08	2018-10-02	Zealand Pharma A/S	Selective glucagon-like-peptide-2 (glp-2) analogues
US20110295151A1 (en) *	2010-05-26	2011-12-01	Bakos Gregory J	Enteroendocrine Manipulation for Metabolic Effect
EA028929B1 (ru)	2012-05-03	2018-01-31	Зилэнд Фарма А/С	Аналоги глюкагоноподобного пептида-2 (glp-2)
WO2015006228A1 (en)	2013-07-08	2015-01-15	The University Of Utah Research Foundation	Methods for treatment of and prophylaxis against inflammatory disorders
CN106167789B (zh) *	2015-05-21	2020-08-04	中国科学院上海营养与健康研究所	低氧处理的间充质干细胞及其应用
CN106589110B (zh) *	2015-10-15	2020-01-17	上海迈迹生物医药科技有限公司	包含聚合物和glp-2衍生物的缀合物
BR112019010624A2 (pt)	2016-12-09	2019-10-22	Zealand Pharma As	agonistas duplos de glp-1/glp-2 acilados e composição
KR102504200B1 (ko)	2017-06-16	2023-02-28	질랜드 파마 에이/에스	글루카곤-유사-펩티드-2 (glp-2) 유사체의 투여를 위한 용량요법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU661242B2 (en) *	1991-10-07	1995-07-13	Brigham And Women's Hospital	Method for enhancing gut absorption
NZ260309A (en) *	1992-06-08	1997-07-27	Pharmacia Ab Substituted For K	Use of 1gf-2 for prevention or treatment of nutritional or gastrointestinal disorders and promoting neonatal growth
US5990077A (en) *	1995-04-14	1999-11-23	1149336 Ontario Inc.	Glucagon-like peptide-2 and its therapeutic use
ES2351661T3 (es) *	1996-04-12	2011-02-09	1149336 Ontario Inc.	Péptido-2 análogo al glucagón.

1996
- 1996-12-10 US US08/763,177 patent/US5952301A/en not_active Expired - Lifetime
1997
- 1997-12-10 ES ES97946986T patent/ES2193406T3/es not_active Expired - Lifetime
- 1997-12-10 PT PT97946986T patent/PT944396E/pt unknown
- 1997-12-10 CA CA002274596A patent/CA2274596C/en not_active Expired - Fee Related
- 1997-12-10 WO PCT/CA1997/000945 patent/WO1998025644A1/en not_active Ceased
- 1997-12-10 DK DK97946986T patent/DK0944396T3/da active
- 1997-12-10 DE DE69719360T patent/DE69719360T2/de not_active Expired - Lifetime
- 1997-12-10 AU AU52200/98A patent/AU5220098A/en not_active Abandoned
- 1997-12-10 AT AT97946986T patent/ATE233096T1/de active
- 1997-12-10 EP EP97946986A patent/EP0944396B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK0944396T3 (da)	2003-06-23
DE69719360T2 (de)	2003-12-04
CA2274596C (en)	2004-11-09
WO1998025644A1 (en)	1998-06-18
DE69719360D1 (de)	2003-04-03
CA2274596A1 (en)	1998-06-18
ES2193406T3 (es)	2003-11-01
AU5220098A (en)	1998-07-03
EP0944396A1 (de)	1999-09-29
PT944396E (pt)	2003-07-31
US5952301A (en)	1999-09-14
EP0944396B1 (de)	2003-02-26

Legal Events

Date

Code

Title

Description

2003-10-15

UEP

Publication of translation of european patent specification

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Country of ref document: EP

Publication	Publication Date	Title
ATE233096T1 (de)	2003-03-15	Zusammensetzungen und methoden zur steigerung der darmfunktion
DK0981362T3 (da)	2004-03-15	Anvendelse af GLP-2-agonister, der forbedrer funktionen af den øvre mavetarmkanal
DE69736634D1 (de)	2006-10-19	Antagonisten des intestinotrophen glp-2 peptides
EP1231218A3 (de)	2002-10-30	Peptid zur Appetitzügelung, dessen Zusammensetzungen und Verwendung
EA200000445A1 (ru)	2000-10-30	Способы лечения состояния гиперкоагуляции или приобретенной недостаточности белка c
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