ATE233104T1 - Kondensierte imidazolderivate zur erhöhung der oralen bioverfügbarkeit von pharmazeutika - Google Patents

Kondensierte imidazolderivate zur erhöhung der oralen bioverfügbarkeit von pharmazeutika

Info

Publication number
ATE233104T1
ATE233104T1 AT98954268T AT98954268T ATE233104T1 AT E233104 T1 ATE233104 T1 AT E233104T1 AT 98954268 T AT98954268 T AT 98954268T AT 98954268 T AT98954268 T AT 98954268T AT E233104 T1 ATE233104 T1 AT E233104T1
Authority
AT
Austria
Prior art keywords
4alkyl
hydrogen
4alkyloxy
halo
optionally substituted
Prior art date
Application number
AT98954268T
Other languages
English (en)
Inventor
Henricus Johannes Mathe Snoeck
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE233104T1 publication Critical patent/ATE233104T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98954268T 1997-09-18 1998-09-10 Kondensierte imidazolderivate zur erhöhung der oralen bioverfügbarkeit von pharmazeutika ATE233104T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97202862 1997-09-18
PCT/EP1998/005751 WO1999013871A2 (en) 1997-09-18 1998-09-10 Fused imidazole derivatives for improving oral bioavailability of pharmaceutical agents

Publications (1)

Publication Number Publication Date
ATE233104T1 true ATE233104T1 (de) 2003-03-15

Family

ID=8228735

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98954268T ATE233104T1 (de) 1997-09-18 1998-09-10 Kondensierte imidazolderivate zur erhöhung der oralen bioverfügbarkeit von pharmazeutika

Country Status (8)

Country Link
US (1) US6544979B1 (de)
EP (1) EP1011726B1 (de)
JP (1) JP3775780B2 (de)
AT (1) ATE233104T1 (de)
AU (1) AU1146099A (de)
DE (1) DE69811689T2 (de)
WO (1) WO1999013871A2 (de)
ZA (1) ZA988527B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586475B1 (en) 1998-11-20 2003-07-01 Takeda Chemical Industries, Ltd. β-amyloid protein production/secretion inhibitors
DE19932555A1 (de) * 1999-07-13 2001-01-18 Solvay Pharm Gmbh Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
CN100491378C (zh) 2001-06-12 2009-05-27 詹森药业有限公司 新的取代四环咪唑衍生物,其制备方法,包含它们的药物组合物及它们作为药物的用途
HRP20040427B1 (hr) * 2001-11-23 2012-09-30 Janssen Pharmaceutica N.V. Uporaba antihistaminika za akutno smanjenje povi‹enog intrakranijalnog tlaka
EP1495017A2 (de) * 2002-04-10 2005-01-12 Ortho-McNeil Pharmaceutical, Inc. Heteroaryl alkylamidderivate und deren verwendung als bradykinin rezeptor modulatoren
WO2014087208A2 (en) * 2012-12-06 2014-06-12 Enaltec Labs Pvt. Ltd. A process of preparing alcaftadine
CN113784713A (zh) * 2019-01-11 2021-12-10 纳吉斯制药股份有限公司 白三烯合成抑制剂
MX2023001448A (es) * 2020-08-04 2023-06-22 Prec Bio Therapeutics S R L Compuestos de quinolina como moduladores selectivos y/o duales de los receptores del acido biliar y los receptores del cisteinil-leucotrieno.
CN117362237A (zh) * 2023-10-10 2024-01-09 化学与精细化工广东省实验室 一种依托咪酯的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101851A (en) 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv 10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor
IL101850A (en) 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv 11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them
WO1994013680A1 (en) * 1992-12-04 1994-06-23 Janssen Pharmaceutica N.V. ANTIALLERGIC IMIDAZO[1,2-a](PYRROLO, THIENO OR FURANO)[2,3-d]AZEPINE DERIVATIVES
TW382017B (en) * 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
TW527186B (en) * 1996-03-19 2003-04-11 Janssen Pharmaceutica Nv Fused imidazole derivatives as multidrug resistance modulators

Also Published As

Publication number Publication date
JP3775780B2 (ja) 2006-05-17
EP1011726A2 (de) 2000-06-28
ZA988527B (en) 2000-03-22
AU1146099A (en) 1999-04-05
WO1999013871A2 (en) 1999-03-25
EP1011726B1 (de) 2003-02-26
US6544979B1 (en) 2003-04-08
JP2001516716A (ja) 2001-10-02
WO1999013871A3 (en) 1999-06-03
DE69811689T2 (de) 2003-12-18
DE69811689D1 (de) 2003-04-03

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Legal Events

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