ATE233795T1 - Xanthenfarbstoffe und ihre anwendung als lumineszenzlöschende verbindungen - Google Patents

Xanthenfarbstoffe und ihre anwendung als lumineszenzlöschende verbindungen

Info

Publication number
ATE233795T1
ATE233795T1 AT00926217T AT00926217T ATE233795T1 AT E233795 T1 ATE233795 T1 AT E233795T1 AT 00926217 T AT00926217 T AT 00926217T AT 00926217 T AT00926217 T AT 00926217T AT E233795 T1 ATE233795 T1 AT E233795T1
Authority
AT
Austria
Prior art keywords
compounds
quenching
canceling
luminescence
application
Prior art date
Application number
AT00926217T
Other languages
English (en)
Inventor
Richard P Haugland
Victoria L Singer
Stephen T Yue
Original Assignee
Molecular Probes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Probes Inc filed Critical Molecular Probes Inc
Application granted granted Critical
Publication of ATE233795T1 publication Critical patent/ATE233795T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/10—Amino derivatives of triarylmethanes
    • C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Luminescent Compositions (AREA)
AT00926217T 1999-04-23 2000-04-21 Xanthenfarbstoffe und ihre anwendung als lumineszenzlöschende verbindungen ATE233795T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13080899P 1999-04-23 1999-04-23
PCT/US2000/010740 WO2000064988A1 (en) 1999-04-23 2000-04-21 Xanthene dyes and their application as luminescence quenching compounds

Publications (1)

Publication Number Publication Date
ATE233795T1 true ATE233795T1 (de) 2003-03-15

Family

ID=22446438

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00926217T ATE233795T1 (de) 1999-04-23 2000-04-21 Xanthenfarbstoffe und ihre anwendung als lumineszenzlöschende verbindungen

Country Status (7)

Country Link
US (1) US6399392B1 (de)
EP (1) EP1090073B1 (de)
AT (1) ATE233795T1 (de)
AU (1) AU751168B2 (de)
CA (1) CA2335359C (de)
DE (1) DE60001531T2 (de)
WO (1) WO2000064988A1 (de)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6583168B1 (en) 1997-11-25 2003-06-24 Applera Corporation Sulfonated diarylrhodamine dyes
US5936087A (en) 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes
US8114850B2 (en) * 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
JP2002541264A (ja) 1999-04-08 2002-12-03 ユーエイビー・リサーチ・ファウンデーション 冨ｇオリゴヌクレオチドの抗増殖活性およびヌクレオリンに結合するためのその使用方法
US20080318889A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20080318890A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US7960540B2 (en) * 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
CA2395353A1 (en) * 1999-11-29 2001-05-31 Glaxo Group Limited Continuous time-resolved resonance energy-transfer assay for polynucleic acid polymerases
US6727356B1 (en) * 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
US20040081959A9 (en) * 1999-12-08 2004-04-29 Epoch Biosciences, Inc. Fluorescent quenching detection reagents and methods
US7169922B2 (en) * 2000-08-04 2007-01-30 Invitrogen Corporation Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
AU2002227156A1 (en) * 2000-12-01 2002-06-11 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US6979530B2 (en) 2001-05-21 2005-12-27 Applera Corporation Peptide conjugates and fluorescence detection methods for intracellular caspase assay
US20030059811A1 (en) * 2001-06-14 2003-03-27 Hakim Djaballah Methods of screening for ligands of target molecules
US20030099949A1 (en) * 2001-10-05 2003-05-29 Surmodics, Inc. Arrays having clustered arrangements and methods of making and using
US8323903B2 (en) * 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
US20050069962A1 (en) 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
GB0126976D0 (en) * 2001-11-09 2002-01-02 Microsens Biophage Ltd Multiple virus reaction assay
US20040054195A1 (en) * 2002-01-10 2004-03-18 Jianxin Gao Xanthene derivatives
CN1665790A (zh) 2002-05-03 2005-09-07 莫莱丘莱尔探针公司 用于检测和分离磷酸化分子的组合物及方法
US7445894B2 (en) 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US20040171034A1 (en) * 2002-05-03 2004-09-02 Brian Agnew Compositions and methods for detection and isolation of phosphorylated molecules
WO2003099780A2 (en) * 2002-05-24 2003-12-04 Molecular Devices Corporation Luminogenic protease substrates
WO2004003510A2 (en) * 2002-07-01 2004-01-08 Guava Technologies, Inc. Fluorescent dyes, energy transfer couples and methods
US20050233307A1 (en) 2002-09-12 2005-10-20 Kyle Gee Site-specific labeling of affinity tags in fusion proteins
CA2498320A1 (en) * 2002-09-20 2004-04-01 Integrated Dna Technologies, Inc. Anthraquinone quencher dyes, their methods of preparation and use
US7459285B2 (en) * 2002-12-10 2008-12-02 Echelon Biosciences Incorporated Compounds and methods of use thereof for assaying lysophospholipase D activity
US7785782B2 (en) * 2002-12-12 2010-08-31 Novartis Vaccines And Diagnostics, Inc. Device and method for in-line blood testing using biochips
DE10259374A1 (de) * 2002-12-18 2004-07-08 Atto-Tec Gmbh Carboxamid-substituierte Farbstoffe für analytische Anwendungen
EP1611254B1 (de) 2003-03-31 2014-09-10 Roche Diagnostics GmbH Zusammensetzungen und verfahren zum nachweis bestimmter flaviviren, einschliesslich mitgliedern der japanese-encephalitis-virus-serogruppe
US20050250214A1 (en) * 2004-05-05 2005-11-10 Gee Kyle R Zinc binding compounds and their method of use
WO2004101709A1 (en) 2003-05-09 2004-11-25 Applera Corporation Phenyl xanthene dyes
US7432298B2 (en) 2003-05-09 2008-10-07 Applied Biosystems Inc. Fluorescent polymeric materials containing lipid soluble rhodamine dyes
WO2005005977A2 (en) * 2003-06-30 2005-01-20 Applera Corporation Fluorescent phospholipase assays and compositions
US7727752B2 (en) 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
US7619059B2 (en) 2003-07-29 2009-11-17 Life Technologies Corporation Bimolecular optical probes
CA2445420A1 (en) 2003-07-29 2005-01-29 Invitrogen Corporation Kinase and phosphatase assays
US7271265B2 (en) * 2003-08-11 2007-09-18 Invitrogen Corporation Cyanine compounds and their application as quenching compounds
US20050064485A1 (en) * 2003-09-12 2005-03-24 Kurt Vogel Multiplex binding and activity assays
US7282339B2 (en) * 2003-09-17 2007-10-16 Invitrogen Corporation Competitive immunoassay
US20050118619A1 (en) * 2003-09-22 2005-06-02 Wensheng Xia Dark quenchers for fluorescence resonance energy transfer (FRET) in bioassays
WO2005049849A2 (en) 2003-11-14 2005-06-02 Integrated Dna Technologies, Inc. Fluorescence quenching azo dyes, their methods of preparation and use
US7776529B2 (en) 2003-12-05 2010-08-17 Life Technologies Corporation Methine-substituted cyanine dye compounds
EP2607431B1 (de) * 2003-12-05 2016-08-24 Life Technologies Corporation Cyanin Farbstoffverbindungen
JP2007515639A (ja) * 2003-12-22 2007-06-14 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ エネルギー移動に基づく光ナノワイヤバイオセンサ
WO2005065241A2 (en) * 2003-12-24 2005-07-21 Argose, Inc. Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors
WO2005071096A2 (en) 2004-01-21 2005-08-04 Molecular Probes, Inc. Derivatives of cephalosporin and clavulanic acid for detecting beta-lacamase in a sample
US7344701B2 (en) * 2004-02-03 2008-03-18 Biosearch Technologies, Inc. Xanthene dyes
WO2005077125A2 (en) * 2004-02-11 2005-08-25 Applera Corporation Methods and compositions for detecting nucleic acids
ES2602732T3 (es) * 2004-04-13 2017-02-22 Biosearch Technologies, Inc. Colorantes de xanteno
US7939251B2 (en) 2004-05-06 2011-05-10 Roche Molecular Systems, Inc. SENP1 as a marker for cancer
GB0419325D0 (en) * 2004-09-01 2004-09-29 Perkinelmer Ltd A method of analysing a sample including fluorescent labels and apparatus therefor
EP1789794A1 (de) 2004-09-14 2007-05-30 Applera Corporation, Applied Biosystems Group Multichromophore quencher-konstrukte zur verwendung bei hochsensitiven energieübertragungssonden
TWI278615B (en) * 2004-12-29 2007-04-11 Ind Tech Res Inst Nano-micelle carrier using in near infrared image detection and detection method therewith
CA2599709A1 (en) 2005-03-09 2006-09-21 Cepheid Polar dyes
JP2008533167A (ja) 2005-03-15 2008-08-21 アプレラ コーポレイション 分析物の検出のための、抗体の代替抗原系の使用
JP2008535518A (ja) 2005-04-14 2008-09-04 アプレラ コーポレイション プソイドイソシトシン核酸塩基誘導体を含む３’改変オリゴヌクレオチド、およびプライマーまたはプローブとしてのその適用
JP5306811B2 (ja) * 2005-05-11 2013-10-02 ライフ テクノロジーズ コーポレーション ２本鎖ｄｎａへの高い選択性を有する蛍光化学物質及びそれらの使用
JP2008545659A (ja) 2005-05-20 2008-12-18 インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド オリゴヌクレオチドを標識する化合物及び方法
US8227621B2 (en) 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
US7494821B2 (en) * 2005-08-01 2009-02-24 Massachusetts Institute Of Technology Fluorescein based sensors for tracking nitric oxide in live cells
US8968700B2 (en) * 2005-08-11 2015-03-03 The Board Of Trustees Of The Leland Stanford Junior University Imaging of protease activity in live cells using activity based probes
CA2621137C (en) 2005-09-02 2014-07-29 Visen Medical, Inc. Biocompatible n,n-disubstituted sulfonamide-containing fluorescent dye labels
WO2007033514A1 (fr) * 2005-09-19 2007-03-29 Xiamen University Combinaison de protéines caractérisée dans le transfert d'énergie entre molécules fluorescentes et utilisation de cette combinaison de protéines
US8129365B2 (en) * 2005-10-11 2012-03-06 The Regents Of The University Of California Water-soluble, fluorescent compounds for detection of potassium ions
US7772009B2 (en) * 2005-11-22 2010-08-10 SCR Research, LLC Room temperature phosphorescence apparatus and methods
US20070218490A1 (en) * 2006-03-15 2007-09-20 Integrated Dna Technologies, Inc. Nucleic acid monomers with 2'-chemical moieties
USRE49362E1 (en) 2006-05-18 2023-01-10 Illumina Cambridge Limited Dye compounds and the use of their labelled conjugates
US20090247984A1 (en) * 2007-10-24 2009-10-01 Masimo Laboratories, Inc. Use of microneedles for small molecule metabolite reporter delivery
US20090131351A1 (en) * 2007-11-16 2009-05-21 Antisoma Research Limited Methods, compositions, and kits for modulating tumor cell proliferation
WO2009078970A1 (en) * 2007-12-14 2009-06-25 Biotium, Inc. Fluorescent compounds
WO2009094536A1 (en) * 2008-01-24 2009-07-30 Life Technologies Corporation Fluorogenic hydrazine-substituted compounds
US8114904B2 (en) 2008-04-05 2012-02-14 Versitech Limited & Morningside Ventures Limited Luminescence quenchers and fluorogenic probes for detection of reactive species
US8332007B2 (en) * 2009-01-12 2012-12-11 The Board Of Trustees Of The University Of Illinois Quantitative three-dimensional mapping of oxygen tension
JP2011014187A (ja) * 2009-06-30 2011-01-20 Fujifilm Corp 同時２光子吸収記録再生方法およびそれに用いる同時２光子吸収記録材料
GB0915664D0 (en) 2009-09-08 2009-10-07 Enigma Diagnostics Ltd Reaction method
US8658434B2 (en) * 2009-10-28 2014-02-25 Biotium, Inc. Fluorescent pyrene compounds
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
EP2553123B1 (de) 2010-03-26 2016-08-24 Integrated DNA Technologies, Inc. Verfahren zur verstärkung einer nukleinsäurehybridisierung
AU2011299233B2 (en) 2010-09-07 2016-09-15 Integrated Dna Technologies, Inc. Modifications for antisense compounds
US9181375B2 (en) 2011-02-14 2015-11-10 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Fluorescent potassium ion sensors
WO2012118715A2 (en) 2011-02-28 2012-09-07 The Board Of Trustees Of Leland Stanford Junior University Non-peptidic quenched fluorescent imaging probes
JP2013036006A (ja) * 2011-08-11 2013-02-21 Sumitomo Chemical Co Ltd 化合物
JP5948826B2 (ja) * 2011-12-02 2016-07-06 住友化学株式会社 化合物
JP5948827B2 (ja) * 2011-12-02 2016-07-06 住友化学株式会社 化合物
CN104220438B (zh) 2012-01-30 2017-03-08 香港大学 用于检测过氧亚硝酸盐的二芳基胺‑基荧光探针
EP2821444A4 (de) * 2012-02-29 2015-03-11 Fujifilm Corp Farbige zusammensetzung, tintenstrahlaufzeichnungstinte und tintenstrahlaufzeichnungsverfahren
US8754244B1 (en) * 2013-03-08 2014-06-17 Illumina Cambridge Limited Rhodamine compounds and their use as fluorescent labels
EP4218829A3 (de) 2013-03-15 2023-08-16 The Board of Trustees of the Leland Stanford Junior University Aktivitätsbasierte sondenverbindungen, zusammensetzungen und verfahren zur verwendung
CA2901379C (en) 2013-03-15 2023-05-16 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection
US10004815B2 (en) 2013-12-04 2018-06-26 The University Of Tokyo Near-infrared quenching group
DE102014203266B4 (de) 2014-02-24 2018-07-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Zusammensetzung mit FRET-Paar in definierter Geometrie
CN104152141B (zh) * 2014-08-27 2016-06-01 中国科学院理化技术研究所 胰蛋白酶荧光化学传感器的制备方法
JP6424068B2 (ja) * 2014-11-06 2018-11-14 東友ファインケム株式会社Ｄｏｎｇｗｏｏ Ｆｉｎｅ−Ｃｈｅｍ Ｃｏ．， Ｌｔｄ． 化合物
CN107001807B (zh) * 2014-12-18 2020-04-03 富士胶片和光纯药株式会社 化合物以及聚合物
CN107743487B (zh) * 2015-06-17 2021-08-20 株式会社Lg化学 呫吨系化合物以及包含其的感光性树脂组合物
WO2017123647A1 (en) 2016-01-15 2017-07-20 Quantapore, Inc. Optically-based nanopore analysis with reduced background
KR102067855B1 (ko) * 2016-03-31 2020-01-17 주식회사 엘지화학 3차 아민을 포함하는 잔텐계 화합물 제조방법
AU2017250778B2 (en) 2016-04-15 2021-09-23 Beckman Coulter, Inc. Photoactive macromolecules and uses thereof
CA3031812A1 (en) 2016-08-19 2018-02-22 Quantapore, Inc. Optically-based nanopore sequencing using quenching agents
ES2992410T3 (es) 2016-09-16 2024-12-12 Lighthouse Pharmaceuticals Inc Inhibidores cetónicos de la lisina gingipaína
JP6937109B2 (ja) * 2016-11-07 2021-09-22 東友ファインケム株式会社Ｄｏｎｇｗｏｏ Ｆｉｎｅ−Ｃｈｅｍ Ｃｏ．， Ｌｔｄ． 着色樹脂組成物
JP6984909B2 (ja) 2016-12-23 2021-12-22 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 活性ベースのプローブ化合物、組成物、および使用方法
EP3592757A2 (de) 2017-03-09 2020-01-15 ELITechGroup, Inc. Nitrodiarylethene als fluoreszenz-quencher für nukleinsäuresonden
EP3441766B1 (de) 2017-08-11 2020-03-11 Life Science Inkubator Sachsen GmbH & Co. KG Neuartige antikörperkonjugate zur verwendung in diskreten fluoreszenzlöschenden verdrängungsimmunoassays
EP3668884B1 (de) 2017-08-17 2022-03-09 ELITechGroup Inc. Duplex stabilisierende fluorescenz quencher für nuklein säure sonden.
EP4491743A3 (de) * 2018-03-02 2025-03-19 Life Technologies Corporation Neuartiger quencher und reporterfarbstoffkombinationen
US12247126B2 (en) 2018-05-09 2025-03-11 Board Of Trustees Of Michigan State University Near-infrared harvesting transparent luminescent solar concentrators with engineered stokes shift
US11584825B2 (en) 2018-12-14 2023-02-21 Beckman Coulter, Inc. Polymer dye modification and applications
KR20210038343A (ko) * 2019-09-30 2021-04-07 호도가야 가가쿠 고교 가부시키가이샤 크산텐계 색소, 염료 조성물, 양극 산화알루미늄용 착색제 및 착색 방법, 그리고 그 색소의 제조 방법
AU2022216619A1 (en) 2021-02-05 2023-09-07 Beckman Coulter, Inc. Compositions and methods for preventing non-specific interactions between polymer dyes-antibody conjugates
US20250092261A1 (en) 2021-07-21 2025-03-20 Life Technologies Corporation Dibenzoxanthene Quenchers, Uses, and Methods of Preparation
CN113582940B (zh) * 2021-09-07 2022-05-20 四川大学华西医院 一类脂滴特异性荧光探针及其合成方法
US20240400893A1 (en) 2021-09-30 2024-12-05 Beckman Coulter, Inc. Water-soluble tetrahydropyrene based fluorescent polymers
CA3237877A1 (en) 2021-11-12 2023-05-19 Aditya JARARE Novel formulation for drying of polymer dye conjugated antibodies
US20250383357A1 (en) 2022-07-01 2025-12-18 Beckman Coulter, Inc. Novel fluorescent dyes and polymers from dihydrophenanthrene derivatives
WO2024044327A1 (en) 2022-08-26 2024-02-29 Beckman Coulter, Inc. Dhnt monomers and polymer dyes with modified photophysical properties
CN120435524A (zh) 2022-12-21 2025-08-05 巴斯夫欧洲公司 波长在650至1200nm范围内的呫吨化合物
CN116003817B (zh) * 2022-12-31 2023-12-12 长江师范学院 一种基于苝四羧酸酐的聚集体材料及其制备方法和应用
EP4680677A1 (de) 2023-03-17 2026-01-21 Beckman Coulter, Inc. Benzothienpyrrolcyaninfarbstoffe
CN121866309A (zh) 2023-09-21 2026-04-14 贝克曼库尔特有限公司 用于流式细胞术的二氢菲（dhp）桥接染料

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2337488C2 (de) 1973-07-24 1975-09-11 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von reaktiven Xanthenfarbstoffen
DE2460491A1 (de) 1974-12-20 1976-07-01 Hoechst Ag Verfahren zur herstellung von xanthenfarbstoffen
DE2535077A1 (de) 1975-08-06 1977-02-17 Bayer Ag Reaktivfarbstoffe
DE2657217A1 (de) 1976-12-17 1978-06-22 Hoechst Ag Verfahren zur herstellung von unsymmetrischen xantheniumverbindungen
US4405788A (en) 1979-12-26 1983-09-20 Polaroid Corporation Bicyclo nitrogenheterocyclic substituted sulfofluoresceins, fluoresceins and xanthenes
US4258118A (en) 1979-12-26 1981-03-24 Polaroid Corporation Novel xanthene compounds and photographic products and processes employing the same
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
JPS5897044A (ja) 1981-12-04 1983-06-09 Konishiroku Photo Ind Co Ltd カラ−画像形成方法
US4439359A (en) 1982-07-02 1984-03-27 Merck & Co., Inc. Cyclic octapeptide analogs of neurotensin
DE3347246A1 (de) 1983-12-28 1985-07-11 Bayer Ag, 5090 Leverkusen Reaktivfarbstoffe der diarylaminoxanthen-reihe, ihre herstellung und verwendung
US4720449A (en) 1985-06-03 1988-01-19 Polaroid Corporation Thermal imaging method
US4812409A (en) 1986-01-31 1989-03-14 Eastman Kodak Company Hydrolyzable fluorescent substrates and analytical determinations using same
US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US5047519A (en) 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US4810636A (en) 1986-12-09 1989-03-07 Miles Inc. Chromogenic acridinone enzyme substrates
US4774339A (en) 1987-08-10 1988-09-27 Molecular Probes, Inc. Chemically reactive dipyrrometheneboron difluoride dyes
JP2566623B2 (ja) 1988-07-15 1996-12-25 保土谷化学工業株式会社 フルオラン化合物およびそれを用いた記録材料
US5134432A (en) 1990-02-14 1992-07-28 Asahi Kogaku Kogyo Kabushiki Kaisha Camera with mid-exposure zooming function
US5274113A (en) 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
US5227487A (en) 1990-04-16 1993-07-13 Molecular Probes, Inc. Certain tricyclic and pentacyclic-hetero nitrogen rhodol dyes
US5433896A (en) 1994-05-20 1995-07-18 Molecular Probes, Inc. Dibenzopyrrometheneboron difluoride dyes
US5714327A (en) 1990-07-19 1998-02-03 Kreatech Diagnostics Platinum-containing compounds, methods for their preparation and applications thereof
US5248782A (en) 1990-12-18 1993-09-28 Molecular Probes, Inc. Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes
US5187288A (en) 1991-05-22 1993-02-16 Molecular Probes, Inc. Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis
GB9220964D0 (en) 1991-11-15 1992-11-18 Ici Plc Anionic compounds
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
JPH09255882A (ja) 1996-03-22 1997-09-30 Konica Corp キサンテン系色素及びそれを含有するインクジェット記録液
US6162931A (en) 1996-04-12 2000-12-19 Molecular Probes, Inc. Fluorinated xanthene derivatives
US5800996A (en) 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence
US5691145A (en) 1996-08-27 1997-11-25 Becton, Dickinson And Company Detection of nucleic acids using G-quartets
US5830912A (en) 1996-11-15 1998-11-03 Molecular Probes, Inc. Derivatives of 6,8-difluoro-7-hydroxycoumarin
US5696157A (en) 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
GB2311075A (en) 1997-04-26 1997-09-17 Zeneca Ltd Ester or amide containing xanthene dyes for use in ink jet or hot melt inks
US5846726A (en) 1997-05-13 1998-12-08 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
US6130101A (en) 1997-09-23 2000-10-10 Molecular Probes, Inc. Sulfonated xanthene derivatives
US6008379A (en) * 1997-10-01 1999-12-28 The Perkin-Elmer Corporation Aromatic-substituted xanthene dyes
US5936087A (en) 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes

Also Published As

Publication number Publication date
EP1090073A1 (de) 2001-04-11
CA2335359A1 (en) 2000-11-02
DE60001531D1 (de) 2003-04-10
WO2000064988A1 (en) 2000-11-02
AU751168B2 (en) 2002-08-08
CA2335359C (en) 2007-07-17
EP1090073B1 (de) 2003-03-05
US6399392B1 (en) 2002-06-04
AU4478100A (en) 2000-11-10
DE60001531T2 (de) 2003-10-02

Similar Documents

Publication Publication Date Title
ATE233795T1 (de) Xanthenfarbstoffe und ihre anwendung als lumineszenzlöschende verbindungen
Yuan et al. Dynamic anti-counterfeiting security features using multicolor dianthryl sulfoxides
Wegner Azobenzenes in a new light—switching in vivo
WO2005009943A3 (en) Substituted tetracycline compounds
DE69805060D1 (de) Fluoreszente zusammensetzungen und ihre anwendung
DE60237986D1 (de) Polymer auf basis von konjugierten dienen, herstellungsverfahren dafür und dieses enthaltende kautschukzusammensetzungen
EP1709699B8 (de) Konjugierte polymere, deren darstellung und verwendung
MEP51508A (en) Ruthenium complexes as (pre)catalysts for metathesis reactions
BRPI0416557A (pt) composições de pigmento de pigmento disazo amarelo e pigmento orgánico
CA2440383A1 (en) 7,9-substituted tetracycline compounds
DE60027576D1 (de) Verkapselung von fluoreszierenden partikeln
DE60114156D1 (de) Pigment mit vom betrachungswinkel abhängiger farbigkeit, dessen herstellung und verwendung, sowie zusammensetzung diese enthaltend
GB0108318D0 (en) Organic compounds
TR200003389T2 (tr) 2-(2-klorofenil)-3,4-dihidro-2H-pirol türevleri.
AU2002358707A1 (en) Rare earth metal compounds and mixtures of these
Zhao et al. Dual-Fluorescent Donor− Acceptor Dyad with Tercarbazole Donor and Switchable Imide Acceptor: Promising Structure for an Integrated Logic Gate
ATE361920T1 (de) Funktionalisierte thiophenoligomere und ihre verwendung als fluoreszenzmarker
Zhang et al. Giant multi‐photon absorption by heptazine organometalation
Meier et al. Star‐shaped push‐pull compounds having 1, 3, 5‐triazine cores
Umar et al. Donor‐Acceptor Fluorescent Molecular Rotors Appended with Benzocrown Ethers as Doubly Twisted Intramolecular Charge Transfer Based Ratiometric Acidic pH Sensors
Zhu et al. Synthesis of a fluorescent polymer bearing covalently linked thienylene moieties and rhodamine for efficient sensing
ATE280169T1 (de) Serotonerge benzothiophene
Tasior et al. V‐shaped, Strongly‐emitting, π‐Expanded Hydrophilic Azacyanines: Synthesis, Linear and Nonlinear Optical Properties
Dang et al. Aqueous Light‐Harvesting Systems Constructed from Pillar [n] Arene‐Based Supra‐Amphiphiles
EA200400670A1 (ru) Фармацевтические композиции, содержащие 3,4-пропинопергидропурины, и их применение для блокирования нейронной передачи

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties