ATE234362T1 - Konditionell-replizierende virale vektoren und ihre verwendung. - Google Patents

Konditionell-replizierende virale vektoren und ihre verwendung.

Info

Publication number
ATE234362T1
ATE234362T1 AT96942083T AT96942083T ATE234362T1 AT E234362 T1 ATE234362 T1 AT E234362T1 AT 96942083 T AT96942083 T AT 96942083T AT 96942083 T AT96942083 T AT 96942083T AT E234362 T1 ATE234362 T1 AT E234362T1
Authority
AT
Austria
Prior art keywords
image
viral
vector
replicating viral
viral vectors
Prior art date
Application number
AT96942083T
Other languages
English (en)
Inventor
Boro Dropulic
Paula M Pitha
Original Assignee
Univ Johns Hopkins Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins Med filed Critical Univ Johns Hopkins Med
Application granted granted Critical
Publication of ATE234362T1 publication Critical patent/ATE234362T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT96942083T 1995-11-28 1996-11-27 Konditionell-replizierende virale vektoren und ihre verwendung. ATE234362T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56345995A 1995-11-28 1995-11-28
PCT/US1996/018997 WO1997020060A1 (en) 1995-11-28 1996-11-27 Conditionally replicating viral vectors and their use

Publications (1)

Publication Number Publication Date
ATE234362T1 true ATE234362T1 (de) 2003-03-15

Family

ID=24250568

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02027910T ATE455858T1 (de) 1995-11-28 1996-11-27 Konditionell replizierende virale vektoren und ihre verwendung
AT96942083T ATE234362T1 (de) 1995-11-28 1996-11-27 Konditionell-replizierende virale vektoren und ihre verwendung.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT02027910T ATE455858T1 (de) 1995-11-28 1996-11-27 Konditionell replizierende virale vektoren und ihre verwendung

Country Status (18)

Country Link
EP (2) EP0871757B1 (de)
JP (2) JP2000503527A (de)
KR (1) KR100537458B1 (de)
CN (3) CN1940076A (de)
AT (2) ATE455858T1 (de)
AU (3) AU1124997A (de)
BR (1) BR9612574A (de)
CA (1) CA2236868C (de)
CZ (1) CZ294170B6 (de)
DE (2) DE69638120D1 (de)
DK (1) DK0871757T3 (de)
ES (1) ES2188802T3 (de)
IL (2) IL124636A0 (de)
NO (1) NO329619B1 (de)
NZ (1) NZ324157A (de)
PT (1) PT871757E (de)
RU (1) RU2270250C2 (de)
WO (1) WO1997020060A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1037669A4 (de) * 1997-12-12 2003-04-02 Cell Genesys Inc Therapeutische nutzung von lentiviralen vektoren
GB9803351D0 (en) * 1998-02-17 1998-04-15 Oxford Biomedica Ltd Anti-viral vectors
GB9906177D0 (en) * 1999-03-17 1999-05-12 Oxford Biomedica Ltd Anti-viral vectors
CZ2003784A3 (cs) * 2000-09-22 2003-11-12 Virxsys Corporation Zlepšené podmíněně se replikující vektory, způsoby jejich produkce a jejich použití
US20030026791A1 (en) * 2001-03-27 2003-02-06 Laurent Humeau Conditionally replicating vectors for inhibiting viral infections
TR201802323T4 (tr) 2007-12-11 2018-03-21 Univ North Carolina Chapel Hill Polipürin yolu modifiye edilmiş retroviral vektörler.
EP3520813B1 (de) * 2010-10-11 2023-04-19 GlaxoSmithKline Biologicals S.A. Antigenfreisetzungsplattformen
CA2977687C (en) * 2015-02-24 2024-02-13 Hwai Wen Chang Conditionally active proteins
CN104711294A (zh) * 2015-04-02 2015-06-17 扬州大学 一种基于禽网状内皮组织增生症病毒ltr的真核表达线性化载体的构建方法及应用
GB2543730A (en) * 2015-05-26 2017-05-03 Andrzejewski Slawomir Use of replication competent vector to eradicate viral latency presented on human immunodeficiency virus

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225337A (en) * 1989-09-25 1993-07-06 Innovir Laboratories, Inc. Ribozyme compositions and methods for use
IL108719A0 (en) * 1993-02-25 1994-08-26 Ortho Pharma Corp Expression constructs containing hiv inhibitory antisense and other nucleotide sequences, retroviralvectors and recombinant retroviruses containing them
EP0702716A4 (de) * 1993-05-17 1999-05-26 Univ California Gentherapy bei hiv-infektion und aids mit hilfe von ribozymen
AU698730B2 (en) * 1994-01-05 1998-11-05 Gene Shears Pty. Limited Ribozymes targeting the retroviral packaging sequence expression construct s and recombinant retroviruses containing such constructs
AU2419595A (en) * 1994-05-10 1995-11-29 Hisamitsu Pharmaceutical Co., Inc. Recombinant human immunodeficiency virus vector and process for producing the same
TW438601B (en) * 1994-05-18 2001-06-07 Janssen Pharmaceutica Nv New mucoadhesive emulsion compositions and a process for the preparation thereof

Also Published As

Publication number Publication date
ATE455858T1 (de) 2010-02-15
DE69626681D1 (de) 2003-04-17
CZ294170B6 (cs) 2004-10-13
EP0871757A1 (de) 1998-10-21
NO982418L (no) 1998-07-27
PT871757E (pt) 2003-08-29
JP2007014341A (ja) 2007-01-25
AU2004200663B2 (en) 2007-07-05
CA2236868C (en) 2014-01-21
JP4384146B2 (ja) 2009-12-16
IL124636A (en) 2009-12-24
CN1940076A (zh) 2007-04-04
CN100390291C (zh) 2008-05-28
CN1207775A (zh) 1999-02-10
AU767620B2 (en) 2003-11-20
CN1651577A (zh) 2005-08-10
EP1380650B1 (de) 2010-01-20
CA2236868A1 (en) 1997-06-05
EP0871757B1 (de) 2003-03-12
NO982418D0 (no) 1998-05-27
HK1060152A1 (en) 2004-07-30
IL124636A0 (en) 1998-12-06
CZ162498A3 (cs) 1998-12-16
DK0871757T3 (da) 2003-07-14
ES2188802T3 (es) 2003-07-01
BR9612574A (pt) 2000-04-25
AU2004200663A1 (en) 2004-04-08
EP1380650A1 (de) 2004-01-14
AU1000001A (en) 2001-05-17
NZ324157A (en) 2000-10-27
WO1997020060A1 (en) 1997-06-05
JP2000503527A (ja) 2000-03-28
KR100537458B1 (ko) 2008-09-08
KR19990071728A (ko) 1999-09-27
RU2270250C2 (ru) 2006-02-20
AU1124997A (en) 1998-06-19
DE69626681T2 (de) 2004-02-12
NO329619B1 (no) 2010-11-22
DE69638120D1 (de) 2010-03-11

Similar Documents

Publication Publication Date Title
HUP9702377A2 (hu) Önfelerősítő, gyógyszeres úton szabályozható expressziós rendszerek
PT836648E (pt) Virus mva recombinante e sua utilizacao
HUP0203409A2 (hu) Gamma-interferon-konjugátumok
CZ63995A3 (en) Virus vectors and their use in gene therapy
IL207348A0 (en) Circular dna molecules, processes for their preparation, pharmaceutical compositions comprising them, and use thereof in the manufacture of medicinal products for producing recombinant proteins in vivo
ATE335831T1 (de) Nukleinsäurevektor, einen solchen vektor enthaltene verbindung und impfstoff zur immunisierung gegen hepatitis
DE69626681D1 (de) Konditionell-replizierende virale vektoren und ihre verwendung.
DK0839194T3 (da) Varianter af P53-proteinet og terapeutiske anvendelser
NO973663D0 (no) Fremgangsmåte for fremstilling av genomet av rekombinante adenoviruser
NO953329L (no) Rekombinante viruser og deres anvendelse i genterapien for behandling av öyesykdommer
ATE189481T1 (de) Leberspezifischer adenovirus-expressionsvektor
EP1190040A4 (de) Herpes-simplex virus, das fremde gene exprimiert, und ein verfahren, um damit krebs zu behandeln
WO2002078631A3 (en) Improved conditionally replicating vectors for inhibiting viral infections
DK0843731T3 (da) Adenovirusvektorer til genterapi
DK0781344T3 (da) Hidtil ukendt implantat og hidtil ukendt vektor til behandling af erhvervede sygdomme
DK0817859T3 (da) Rekombinante DNA vektorer til Genterapi
ATE269064T1 (de) Impfstoffe gegen den hepatitis b und c virus

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0871757

Country of ref document: EP