ATE234627T1 - Verfahren und zusammensetzung für die modulation der wirtsimmunantwort auf allergene - Google Patents

Verfahren und zusammensetzung für die modulation der wirtsimmunantwort auf allergene

Info

Publication number
ATE234627T1
ATE234627T1 AT94928143T AT94928143T ATE234627T1 AT E234627 T1 ATE234627 T1 AT E234627T1 AT 94928143 T AT94928143 T AT 94928143T AT 94928143 T AT94928143 T AT 94928143T AT E234627 T1 ATE234627 T1 AT E234627T1
Authority
AT
Austria
Prior art keywords
antibody
tcr
derived
molecules
allergens
Prior art date
Application number
AT94928143T
Other languages
English (en)
Inventor
Vera S Byers
Roger W Baldwin
Original Assignee
Allergene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergene Inc filed Critical Allergene Inc
Application granted granted Critical
Publication of ATE234627T1 publication Critical patent/ATE234627T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/166—Animal cells resulting from interspecies fusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT94928143T 1993-09-16 1994-09-16 Verfahren und zusammensetzung für die modulation der wirtsimmunantwort auf allergene ATE234627T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/123,746 US5512283A (en) 1990-07-06 1993-09-16 Methods for the selective suppression of an immune response to dust mite der Pi
PCT/US1994/010466 WO1995007933A1 (en) 1993-09-16 1994-09-16 Methods and composition for the modulation of host immune response to allergens

Publications (1)

Publication Number Publication Date
ATE234627T1 true ATE234627T1 (de) 2003-04-15

Family

ID=22410634

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94928143T ATE234627T1 (de) 1993-09-16 1994-09-16 Verfahren und zusammensetzung für die modulation der wirtsimmunantwort auf allergene

Country Status (7)

Country Link
US (1) US5512283A (de)
EP (1) EP0722463B1 (de)
JP (1) JPH09502969A (de)
AT (1) ATE234627T1 (de)
AU (1) AU7729594A (de)
DE (1) DE69432307D1 (de)
WO (1) WO1995007933A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2651997A (en) * 1996-05-10 1997-12-05 Kirin Beer Kabushiki Kaisha T-cell receptor alpha-chain constant-region peptides, processes for producing the peptides, and use thereof
WO1997042973A1 (en) * 1996-05-15 1997-11-20 Altarex, Corp. Method and composition for reconforming multi-epitopic antigens to initiate an immune response
US7318921B2 (en) * 1996-05-15 2008-01-15 Altarex Medical Corp. Therapeutic compositions that alter the immune response
US7361346B1 (en) * 1996-05-15 2008-04-22 Altarex Corp. Therapeutic compositions that produce an immune response
US20060159688A1 (en) * 1996-05-15 2006-07-20 Ragupathy Madiyalakan Method for diagnosing efficacy of xenotypic antibody therapy
US8038994B2 (en) * 1996-05-15 2011-10-18 Quest Pharmatech Inc. Combination therapy for treating disease
CA2319437C (en) 1998-01-31 2009-06-16 University Of Arkansas Methods and reagents for decreasing allergic reactions
EP1086135B1 (de) * 1998-05-28 2004-02-25 Bayer HealthCare AG Monoklonaler antikörper und assay zur bestimmung von n-terminalem prokollagen-propeptid typ iii (piiinp)
JP2004538237A (ja) * 1998-12-18 2004-12-24 シーア ファーマスーティカルズ エルエルシー 表面アレルゲンに対するアレルギー反応を減少させるための方法および組成物
WO2000052154A2 (en) * 1999-03-02 2000-09-08 The Board Of Trustees Of The University Of Arkansas Methods and reagents for decreasing clinical reaction to allergy
GB9908533D0 (en) 1999-04-14 1999-06-09 Novartis Ag Organic compounds
US20030149113A1 (en) 2001-10-12 2003-08-07 Caplan Michael J. Conductance of improperly folded proteins through the secretory pathway and related methods for treating disease
US7189405B1 (en) 1999-10-29 2007-03-13 Rice Peter A Peptide mimics of conserved gonococcal epitopes and methods and compositions using them
CN1437482A (zh) * 2000-05-26 2003-08-20 西福根有限公司 用于治疗变态反应的重组的或纯化的多克隆抗体
WO2001094419A2 (en) * 2000-06-07 2001-12-13 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Method to induce the th1 immune response
EP1195606A1 (de) * 2000-10-03 2002-04-10 VBC-Genomics Forschungsges.m.b.H. Allergen-Assay auf Basis von Mikroanordnungen
WO2002066979A1 (en) * 2001-02-22 2002-08-29 Takara Bio Inc. Method of detecting antigen causative of bronchial asthma
US7265208B2 (en) * 2001-05-01 2007-09-04 The Regents Of The University Of California Fusion molecules and treatment of IgE-mediated allergic diseases
US6869519B2 (en) * 2001-09-27 2005-03-22 National Institute Of Advanced Industrial Science And Technology Electrolytic process for the production of metallic copper and apparatus therefor
HRP20041037A2 (en) * 2002-04-11 2005-06-30 Altarex Medical Corporation Binding agents and their use in targeting tumor cells
US7585518B2 (en) 2002-11-19 2009-09-08 Kimberly-Clark Worldwide, Inc. Products and methods for maintaining or increasing ceramide levels in skin
US7037535B2 (en) * 2002-11-19 2006-05-02 Kimberly-Clark Worldwide, Inc. Method and composition for neutralizing house dust mite feces
US20050019379A1 (en) 2003-07-22 2005-01-27 Kimberly-Clark Worldwide, Inc. Wipe and methods for improving skin health
CN101300033A (zh) * 2005-11-07 2008-11-05 泰坦医药品公司 用镓对不良肝脏病症的治疗和预防
CN100374152C (zh) 2005-12-23 2008-03-12 中国农业大学 一种过敏性反应抑制剂
WO2010107400A1 (en) * 2009-03-20 2010-09-23 Agency For Science, Technology And Research Genetically modified animal and method of obtaining the same
CN105903012B (zh) 2010-06-03 2022-02-01 爱尔开-阿贝优公司 包含螨过敏原提取物的药品及其制备方法
BR112012030705B1 (pt) * 2010-06-03 2021-08-03 Alk-Abelló A/S Produto farmacêutico comprimido sublingual de rápida dissolução compreendendo extrato(s) de alérgeno de ácaro de pó doméstico e seu uso
JO3820B1 (ar) 2012-05-03 2021-01-31 Regeneron Pharma أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها
EP3036543B1 (de) * 2013-08-23 2019-06-19 Regeneron Pharmaceuticals, Inc. Diagnostische tests und verfahren zur beurteilung der sicherheit, der wirksamkeit oder des ergebnisses einer allergenspezifischen immuntherapie
JP2015145381A (ja) * 2015-03-09 2015-08-13 チャイナ アグリカルチュラル ユニバーシティ アレルギー抑制剤の組成物及びキットならびにその使用方法
PL3558347T3 (pl) 2016-12-22 2026-04-20 Regeneron Pharmaceuticals, Inc. Sposób leczenia alergii swoistymi dla alergenu przeciwciałami monoklonalnymi

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984002848A1 (en) * 1983-01-28 1984-08-02 Centocor Inc Anti-idiotypic antibodies to t cell antigen receptors
US5026545A (en) * 1984-09-17 1991-06-25 Baxter International, Inc. Treatment of allergy and composition therefor
US4740371A (en) * 1984-09-17 1988-04-26 International Institute Of Cellular And Molecular Pathology Treatment of allergy
CA1336818C (en) * 1987-04-16 1995-08-29 International Institute Of Cellular And Molecular Pathology Treatment of allergy and composition thereof
JP2516842B2 (ja) * 1991-02-06 1996-07-24 アサヒビール株式会社 ダニ抗原に対するモノクロ―ナル抗体とその利用

Also Published As

Publication number Publication date
AU7729594A (en) 1995-04-03
US5512283A (en) 1996-04-30
EP0722463A1 (de) 1996-07-24
WO1995007933A1 (en) 1995-03-23
EP0722463B1 (de) 2003-03-19
EP0722463A4 (de) 1999-04-14
JPH09502969A (ja) 1997-03-25
DE69432307D1 (de) 2003-04-24

Similar Documents

Publication Publication Date Title
DE69432307D1 (de) Verfahren und zusammensetzung für die modulation der wirtsimmunantwort auf allergene
Samelson et al. Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid.
Olsson et al. Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity.
Reth et al. Analysis of the repertoire of anti‐(4‐hydroxy‐3‐nitro‐phenyl) acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti‐idiotope antibodies
Binz et al. Antigen-binding, idiotypic receptors from T lymphocytes: an analysis of their biochemistry, genetics, and use as immunogens to produce specific immune tolerance
CA2066433A1 (en) Chicken-specific immunoglobulin g-producing hybridoma
DE69434465D1 (de) Verfahren zur Regulierung der Immunantwort durch den Gebrauch von CTLA4-Bindungsmoleküle und IL4-Bindungsmoleküle
CN115785270B (zh) 一种针对人cd20蛋白的单克隆抗体、制备方法及其应用
Jones et al. Restriction of Gene Expression in B Lymphocytes and Their Progeny: III. Endogenous IgA and IgM on the Membranes of Different Plasma Cell Precursors
Groves et al. Veterinary sources of nonrodent monoclonal antibodies: interspecific and intraspecific hybridomas
Bluestone et al. Anti-idiotypes to monoclonal anti-H-2 antibodies. II. Expression of anti-H-2Kk idiotypes on antibodies induced by anti-idiotype or H-2Kk antigen.
DE59209079D1 (de) Monoklonale Antikörper gegen humane Pankreas-Inselzellen
Ferguson et al. Isolation and characterization of an antigen-specific suppressor inducer molecule from serum of hyperimmune mice by using a monoclonal antibody.
Sarnesto et al. Relative immunogenicity in mice of different regions of the human IgG
Thammana et al. Immunoglobulin heavy chain class switch from IgM to IgG in a hybridoma
Hammond et al. Characterization of a monoclonal antibody to human sex hormone binding globulin
Emmrich et al. A cross‐reacting human idiotype (B17) associated with antibodies to N‐acetyl‐d‐glucosamine Specificity, immunoglobulin class association, and distribution in the population
Shin et al. Monoclonal antibodies with various reactivity to p58 killer inhibitory receptors
CN112501273B (zh) 用于扩增马抗体的巢式pcr引物、试剂盒及其应用
Fudenberg et al. Genetics of immunoglobulins
CN110894237B (zh) 抗cd127的抗体、分泌该抗体的细胞株及其制备方法和应用
Perosa et al. Syngeneic anti-idiotypic antisera to murine monoclonal antibodies to monomorphic and polymorphic determinants of HLA class I antigens.
CN118027191B (zh) 结合人染色体重塑分子的单克隆抗体及应用
Quaranta et al. A recurrent idiotype on monoclonal anti-human Ia antibodies.
JPS59132888A (ja) 直接凝集テストで反応し、ヒト血液型抗原ｄに対して特異的なモノクロ−ナル抗体並びにこれを産生するハイブリド−マ細胞ライン

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties