ATE234837T1 - 3-bicycloindole als liganden des 5-ht 1d rezeptors - Google Patents

3-bicycloindole als liganden des 5-ht 1d rezeptors

Info

Publication number
ATE234837T1
ATE234837T1 AT99942679T AT99942679T ATE234837T1 AT E234837 T1 ATE234837 T1 AT E234837T1 AT 99942679 T AT99942679 T AT 99942679T AT 99942679 T AT99942679 T AT 99942679T AT E234837 T1 ATE234837 T1 AT E234837T1
Authority
AT
Austria
Prior art keywords
receptor
bicycloindole
ligands
general formula
ht1d receptor
Prior art date
Application number
AT99942679T
Other languages
English (en)
Inventor
Louise Edwards
Abdelmalik Slassi
Ashok Tehim
Tao Xin
Original Assignee
Nps Allelix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nps Allelix Corp filed Critical Nps Allelix Corp
Application granted granted Critical
Publication of ATE234837T1 publication Critical patent/ATE234837T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Conductive Materials (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)
AT99942679T 1998-09-18 1999-09-13 3-bicycloindole als liganden des 5-ht 1d rezeptors ATE234837T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/156,496 US6562809B1 (en) 1998-09-18 1998-09-18 3-bicycloindole compounds
PCT/CA1999/000833 WO2000017198A1 (en) 1998-09-18 1999-09-13 3-bicycloindole compounds as 5-ht1d ligands

Publications (1)

Publication Number Publication Date
ATE234837T1 true ATE234837T1 (de) 2003-04-15

Family

ID=22559821

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99942679T ATE234837T1 (de) 1998-09-18 1999-09-13 3-bicycloindole als liganden des 5-ht 1d rezeptors

Country Status (8)

Country Link
US (1) US6562809B1 (de)
EP (1) EP1114049B1 (de)
JP (1) JP2002526497A (de)
AT (1) ATE234837T1 (de)
AU (1) AU772960C (de)
CA (1) CA2343391A1 (de)
DE (1) DE69906101D1 (de)
WO (1) WO2000017198A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU779832B2 (en) * 1999-08-12 2005-02-10 Nps Pharmaceuticals, Inc. Azaindoles having serotonin receptor affinity
US6686374B1 (en) 1999-08-12 2004-02-03 Nps Allelix Corp. Azaindoles having serotonin receptor affinity
GB9926303D0 (en) * 1999-11-05 2000-01-12 Smithkline Beecham Plc Novel compounds
ATE489138T1 (de) 2005-04-13 2010-12-15 Neuraxon Inc Substituierte indolverbindungen mit nos-hemmender aktivität
EP1984351A1 (de) 2006-02-17 2008-10-29 Memory Pharmaceuticals Corporation Verbindungen mit 5-ht6-rezeptor-affinität
ZA200809659B (en) 2006-04-13 2010-03-31 Neuraxon Inc 1,5 and 3,6-substituted indole compounds having NOS inhibitory activity
EA201000808A1 (ru) 2007-11-16 2011-04-29 Ньюраксон, Инк. Индольные соединения и способы лечения висцеральной боли

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9519558D0 (en) * 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
GB9601786D0 (en) * 1996-01-30 1996-04-03 Merck Sharp & Dohme Therapeutic agents
WO1997043281A1 (en) * 1996-05-16 1997-11-20 Allelix Biopharmaceuticals Inc. Thiophene- and furan-tryptamine derivatives
CN1289479C (zh) * 1996-11-26 2006-12-13 Nps艾里利克斯有限公司 作为5－ht1d受体配位体的5－环吲哚化合物
EP0875513A1 (de) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituierte heteroaromatische 5-HT1F Agoniste
US6251893B1 (en) * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity

Also Published As

Publication number Publication date
AU5613599A (en) 2000-04-10
US6562809B1 (en) 2003-05-13
WO2000017198A1 (en) 2000-03-30
AU772960B2 (en) 2004-05-13
EP1114049A1 (de) 2001-07-11
CA2343391A1 (en) 2000-03-30
EP1114049B1 (de) 2003-03-19
AU772960C (en) 2005-04-07
DE69906101D1 (de) 2003-04-24
JP2002526497A (ja) 2002-08-20

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Legal Events

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