ATE234926T1 - Prozess zur effizienten produktion von 7-adca via 3-(carboxyethylthio)propionyl-7-adca - Google Patents

Prozess zur effizienten produktion von 7-adca via 3-(carboxyethylthio)propionyl-7-adca

Info

Publication number
ATE234926T1
ATE234926T1 AT94926136T AT94926136T ATE234926T1 AT E234926 T1 ATE234926 T1 AT E234926T1 AT 94926136 T AT94926136 T AT 94926136T AT 94926136 T AT94926136 T AT 94926136T AT E234926 T1 ATE234926 T1 AT E234926T1
Authority
AT
Austria
Prior art keywords
adca
pct
carboxyethylthio
propionyl
date
Prior art date
Application number
AT94926136T
Other languages
English (en)
Inventor
Roelof Ary Lans Bovenberg
Bertus Pieter Koekman
Andreas Hoekema
Der Laan Jan Metske Van
Jan Verweij
Vroom Erik De
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Application granted granted Critical
Publication of ATE234926T1 publication Critical patent/ATE234926T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT94926136T 1993-07-30 1994-07-29 Prozess zur effizienten produktion von 7-adca via 3-(carboxyethylthio)propionyl-7-adca ATE234926T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP93202260 1993-07-30
EP93203695 1993-12-24
PCT/EP1994/002544 WO1995004149A1 (en) 1993-07-30 1994-07-29 Process for the efficient production of 7-adca via 3-(carboxyethylthio)propionyl-7-adca

Publications (1)

Publication Number Publication Date
ATE234926T1 true ATE234926T1 (de) 2003-04-15

Family

ID=26133941

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94926136T ATE234926T1 (de) 1993-07-30 1994-07-29 Prozess zur effizienten produktion von 7-adca via 3-(carboxyethylthio)propionyl-7-adca

Country Status (17)

Country Link
US (1) US5795733A (de)
EP (1) EP0711348B1 (de)
JP (1) JP3574453B2 (de)
KR (1) KR100327881B1 (de)
CN (1) CN1087780C (de)
AT (1) ATE234926T1 (de)
BR (1) BR9407104A (de)
CA (1) CA2168004A1 (de)
CZ (1) CZ285622B6 (de)
DE (1) DE69432303D1 (de)
ES (1) ES2194873T3 (de)
HU (1) HU219265B (de)
PL (1) PL180565B1 (de)
PT (1) PT711348E (de)
SI (1) SI0711348T1 (de)
SK (1) SK282617B6 (de)
WO (1) WO1995004149A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6709859B1 (en) 1986-01-31 2004-03-23 Beecham Group P.L.C. Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
DE3789880T2 (de) * 1986-01-31 1994-09-08 Beecham Group Plc Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen.
CN1084791C (zh) * 1995-06-02 2002-05-15 吉斯特·布罗卡迪斯股份有限公司 通过扩环酶活性作用于青霉素g生产7－adca的方法
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G
GB2323361A (en) * 1995-11-27 1998-09-23 Gist Brocades Bv Improved process for the production of semi-synthetic cephalosporins via expandase activity on penicillin G
KR20000022108A (ko) 1997-04-22 2000-04-25 한스 발터 라벤 탈아실화된 세팔로스포린의 발효제조방법
PL330760A1 (en) 1997-04-22 1999-05-24 Gist Brocades Bv Method of obatining decylated cephalosporins by fermentation process
CN100390285C (zh) * 1998-05-19 2008-05-28 Dsm公司 体内生产头孢菌素的改良
US6455603B1 (en) 1998-06-30 2002-09-24 Dow Global Technologies Inc. Polymer polyols and a process for the production thereof
CN1331751A (zh) * 1998-12-22 2002-01-16 Dsm公司 改进的头孢菌素的体内生产方法
EP1974029A2 (de) 2005-12-28 2008-10-01 DSMIP Assets B.V. Mutante acylasen
EP2123772A1 (de) 2008-04-29 2009-11-25 DSM IP Assets B.V. Beta-Lactamantibiotikum produzierende Stämme
CN102131917A (zh) * 2008-08-05 2011-07-20 帝斯曼知识产权资产管理有限公司 生产己二酰基-7-adca的菌株
EP2310487A2 (de) 2008-08-05 2011-04-20 DSM IP Assets B.V. Adipoyl-7-adca produzierende stämme
CN102369290A (zh) 2009-04-03 2012-03-07 帝斯曼知识产权资产管理有限公司 发酵工艺
WO2011161004A1 (en) 2010-06-22 2011-12-29 Dsm Ip Assets B.V. Air bubble fermentation process
EP2614066B1 (de) * 2010-09-07 2017-11-29 DSM Sinochem Pharmaceuticals Netherlands B.V. Verfahren zur herstellung von cephalosporinen
WO2012117038A1 (en) 2011-03-03 2012-09-07 Dsm Sinochem Pharmaceuticals Netherlands B.V. Degradation of penicillin compounds
HK1201877A1 (en) 2012-01-31 2015-09-11 灿盛制药有限公司荷兰公司 Mbth-like proteins in the production of semi synthetic antibiotics
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5070020A (en) * 1988-05-09 1991-12-03 Eli Lilly And Company Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase
US5082772A (en) * 1988-10-24 1992-01-21 Eli Lilly And Company Process for preparing deacetylcephalosporin c
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
KR100227711B1 (ko) * 1991-10-15 1999-12-01 한스 발터 라벤 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정

Also Published As

Publication number Publication date
KR100327881B1 (ko) 2002-07-02
CN1128545A (zh) 1996-08-07
US5795733A (en) 1998-08-18
BR9407104A (pt) 1996-08-27
WO1995004149A1 (en) 1995-02-09
EP0711348A1 (de) 1996-05-15
CZ15796A3 (en) 1996-07-17
HUT75367A (en) 1997-05-28
HU9600195D0 (en) 1996-03-28
DE69432303D1 (de) 2003-04-24
SK282617B6 (sk) 2002-10-08
HU219265B (en) 2001-03-28
PT711348E (pt) 2003-08-29
SI0711348T1 (en) 2003-08-31
EP0711348B1 (de) 2003-03-19
CZ285622B6 (cs) 1999-10-13
ES2194873T3 (es) 2003-12-01
CN1087780C (zh) 2002-07-17
JPH09503908A (ja) 1997-04-22
PL180565B1 (pl) 2001-02-28
KR960704048A (ko) 1996-08-31
CA2168004A1 (en) 1995-02-09
JP3574453B2 (ja) 2004-10-06
PL312747A1 (en) 1996-05-13
SK9896A3 (en) 1996-09-04

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