ATE235510T1 - Integrinbindendes peptid und dessen verwendung - Google Patents

Integrinbindendes peptid und dessen verwendung

Info

Publication number
ATE235510T1
ATE235510T1 AT98933671T AT98933671T ATE235510T1 AT E235510 T1 ATE235510 T1 AT E235510T1 AT 98933671 T AT98933671 T AT 98933671T AT 98933671 T AT98933671 T AT 98933671T AT E235510 T1 ATE235510 T1 AT E235510T1
Authority
AT
Austria
Prior art keywords
binding peptide
integrin binding
lysine
peptides
integrin
Prior art date
Application number
AT98933671T
Other languages
English (en)
Inventor
Jyrki Heino
Johanna Ivaska
Jarmo Kaepylae
Original Assignee
Biotie Therapies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotie Therapies Corp filed Critical Biotie Therapies Corp
Application granted granted Critical
Publication of ATE235510T1 publication Critical patent/ATE235510T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT98933671T 1997-07-11 1998-07-09 Integrinbindendes peptid und dessen verwendung ATE235510T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/893,526 US6096707A (en) 1997-07-11 1997-07-11 Integrin binding peptide and use thereof
PCT/FI1998/000579 WO1999002551A1 (en) 1997-07-11 1998-07-09 Integrin binding peptide and use thereof

Publications (1)

Publication Number Publication Date
ATE235510T1 true ATE235510T1 (de) 2003-04-15

Family

ID=25401719

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98933671T ATE235510T1 (de) 1997-07-11 1998-07-09 Integrinbindendes peptid und dessen verwendung

Country Status (17)

Country Link
US (1) US6096707A (de)
EP (1) EP0994898B1 (de)
JP (1) JP2001509515A (de)
KR (1) KR100571046B1 (de)
CN (1) CN1262688A (de)
AT (1) ATE235510T1 (de)
AU (1) AU748134B2 (de)
BR (1) BR9810586A (de)
CA (1) CA2295219C (de)
DE (1) DE69812630T2 (de)
ES (1) ES2195361T3 (de)
HU (1) HU225326B1 (de)
NO (1) NO20000126D0 (de)
NZ (1) NZ501767A (de)
PL (1) PL338001A1 (de)
RU (1) RU2203902C2 (de)
WO (1) WO1999002551A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7914814B2 (en) * 1997-09-17 2011-03-29 Strategic Science & Technologies, Llc Topical delivery of arginine of cause beneficial effects
US7387779B2 (en) 1998-06-17 2008-06-17 Beth Israel Deaconess Medical Center Anti-angiogenic proteins and fragments and methods of use thereof
US6962974B1 (en) 1998-06-17 2005-11-08 Beth Israel Deaconess Medical Center Anti-angiogenic proteins and fragments and methods of use thereof
US6759047B1 (en) 1998-06-17 2004-07-06 Beth Israel Deaconess Hospital Corp. Anti-angiogenic proteins and methods of use thereof
GB9817623D0 (en) * 1998-08-13 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
WO2002066073A1 (en) * 2001-02-21 2002-08-29 Eisai C0. Ltd. Method of examining effect of angionegesis inhibitor mediated by the inhibition of integrin expression
AU2002306651B2 (en) * 2001-03-02 2007-12-13 Medimmune, Llc Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphav Beta3 antagonists
CA2478239A1 (en) * 2002-03-04 2003-09-18 Medimmune, Inc. The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents
JP2005525368A (ja) * 2002-03-04 2005-08-25 メディミューン，インコーポレーテッド インテグリンαｖβ３アンタゴニストをＨＭＧ−ＣｏＡ還元酵素阻害剤またはビスフォスフォネートと併用投与する障害の予防または治療方法
JP2005535572A (ja) * 2002-04-12 2005-11-24 メディミューン，インコーポレーテッド 組換え抗インターロイキン−９抗体
WO2003092632A2 (en) * 2002-05-06 2003-11-13 The Scripps Research Institute Cyclic peptide anti-cancer agents and methods
WO2004066956A2 (en) * 2003-01-30 2004-08-12 Medimmune, Inc. Uses of integrin alphavbeta3 antagonists
KR20110094361A (ko) * 2003-04-11 2011-08-23 메디뮨 엘엘씨 재조합 ｉｌ­９ 항체 및 그의 용도
US7196061B2 (en) * 2003-09-10 2007-03-27 Wyeth Compounds that modulate neuronal growth and their uses
US7351739B2 (en) * 2004-04-30 2008-04-01 Wellgen, Inc. Bioactive compounds and methods of uses thereof
WO2006047639A2 (en) 2004-10-27 2006-05-04 Medimmune, Inc. Modulation of antibody specificity by tailoring the affinity to cognate antigens
WO2006133338A1 (en) * 2005-06-07 2006-12-14 The Trustees Of The University Of Pennesylvania INHIBITORS OF THE α2β1/GPIa-IIa INTEGRIN
US8987306B2 (en) * 2005-06-07 2015-03-24 The Trustees Of The University Of Pennsylvania Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold
WO2007020405A2 (en) * 2005-08-12 2007-02-22 Cartela R & D Ab Integrin i-domain binding peptides
JP4826721B2 (ja) * 2005-08-18 2011-11-30 三菱電機株式会社 マンコンベアの制御装置
WO2007027742A2 (en) * 2005-08-31 2007-03-08 The Trustees Of The University Of Pennsylvania SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS
CA2623565A1 (en) 2005-09-28 2007-04-05 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
EP1976863B1 (de) * 2005-12-22 2012-12-12 Novabiotics Limited Cyclische antimikrobielle peptide
CA2657581A1 (en) 2006-07-11 2008-01-17 Roy C. Levitt Rhinosinusitis prevention and therapy with proinflammatory cytokine inhibitors
US8940683B2 (en) 2006-08-10 2015-01-27 Roy C. Levitt Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors
GB0618512D0 (en) * 2006-09-20 2006-11-01 Lexcicon Ltd Peptides
FI20075258A0 (fi) * 2007-04-17 2007-04-17 Biotie Therapies Corp Menetelmä integriiniinhibiittorirespondereiden seulomiseksi
WO2009052449A1 (en) * 2007-10-17 2009-04-23 University Of Southern California Novel peptides and uses thereof
US8563690B2 (en) * 2008-11-03 2013-10-22 The Board Of Trustees Of The University Of Illinois Modulation of platelet aggregation
CA2793838C (en) 2010-03-19 2019-09-17 H. Lee Moffitt Cancer Center & Research Institute, Inc. Integrin interaction inhibitors for the treatment of cancer
WO2012113803A1 (en) 2011-02-22 2012-08-30 Leo Pharma A/S A cyclic peptide and conjugate thereof for binding to keratinocytes
WO2015048477A1 (en) 2013-09-27 2015-04-02 H. Lee Moffitt Cancer Center And Research Institute, Inc. Cyclic peptide conjugates and methods of use
KR102698051B1 (ko) * 2015-02-27 2024-08-26 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 폴리펩타이드 치료제 및 이의 용도
WO2020055812A1 (en) 2018-09-10 2020-03-19 Lung Therapeutics, Inc. Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179007A (en) * 1989-07-07 1993-01-12 The Texas A & M University System Method and vector for the purification of foreign proteins
US5710123A (en) * 1992-12-18 1998-01-20 Centocor, Inc. Peptide inhibitors of selectin binding
US5627263A (en) * 1993-11-24 1997-05-06 La Jolla Cancer Research Foundation Integrin-binding peptides
CA2193828A1 (en) * 1994-06-29 1996-01-11 Timothy P. Kogan Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin
WO1996040781A1 (en) * 1995-06-07 1996-12-19 Tanabe Seiyaku Co., Ltd. CYCLIC PEPTIDE INHIBITORS OF β1 AND β2 INTEGRIN-MEDIATED ADHESION

Also Published As

Publication number Publication date
KR100571046B1 (ko) 2006-04-13
NO20000126L (no) 2000-01-10
NO20000126D0 (no) 2000-01-10
CN1262688A (zh) 2000-08-09
PL338001A1 (en) 2000-09-25
WO1999002551A1 (en) 1999-01-21
KR20010015547A (ko) 2001-02-26
US6096707A (en) 2000-08-01
HUP0002789A2 (hu) 2000-12-28
CA2295219A1 (en) 1999-01-21
AU8341398A (en) 1999-02-08
HU225326B1 (en) 2006-09-28
JP2001509515A (ja) 2001-07-24
NZ501767A (en) 2002-08-28
BR9810586A (pt) 2000-09-05
CA2295219C (en) 2007-01-02
EP0994898A1 (de) 2000-04-26
RU2203902C2 (ru) 2003-05-10
ES2195361T3 (es) 2003-12-01
EP0994898B1 (de) 2003-03-26
DE69812630T2 (de) 2004-02-05
AU748134B2 (en) 2002-05-30
DE69812630D1 (de) 2003-04-30
HUP0002789A3 (en) 2003-08-28

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