ATE235560T1 - Diagnostisches verfahren basierend auf der quantifizierung extramitochondrialer dna - Google Patents

Diagnostisches verfahren basierend auf der quantifizierung extramitochondrialer dna

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Publication number
ATE235560T1
ATE235560T1 AT99931800T AT99931800T ATE235560T1 AT E235560 T1 ATE235560 T1 AT E235560T1 AT 99931800 T AT99931800 T AT 99931800T AT 99931800 T AT99931800 T AT 99931800T AT E235560 T1 ATE235560 T1 AT E235560T1
Authority
AT
Austria
Prior art keywords
quantification
method based
diagnostic method
sequences
dna
Prior art date
Application number
AT99931800T
Other languages
English (en)
Inventor
Corinna Herrnstadt
Soumitra S Ghosh
William Clevenger
Eoin D Fahy
Robert E Davis
Original Assignee
Mitokor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/098,079 external-priority patent/US6489095B2/en
Priority claimed from US09/097,889 external-priority patent/US6218117B1/en
Application filed by Mitokor filed Critical Mitokor
Application granted granted Critical
Publication of ATE235560T1 publication Critical patent/ATE235560T1/de

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/172Haplotypes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pathology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
AT99931800T 1998-06-15 1999-06-14 Diagnostisches verfahren basierend auf der quantifizierung extramitochondrialer dna ATE235560T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/098,079 US6489095B2 (en) 1998-06-15 1998-06-15 Diagnostic method based on quantification of extramitochondrial DNA
US09/097,889 US6218117B1 (en) 1998-06-15 1998-06-15 Compositions and methods for identifying agents that quantitatively alter detectable extramitochondrial DNA:mitochondrial DNA ratios
US09/302,681 US6441149B1 (en) 1998-06-15 1999-04-30 Diagnostic method based on quantification of extramitochondrial DNA
PCT/US1999/013426 WO1999066075A2 (en) 1998-06-15 1999-06-14 Diagnostic method based on quantification of extramitochondrial dna

Publications (1)

Publication Number Publication Date
ATE235560T1 true ATE235560T1 (de) 2003-04-15

Family

ID=27378465

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99931800T ATE235560T1 (de) 1998-06-15 1999-06-14 Diagnostisches verfahren basierend auf der quantifizierung extramitochondrialer dna

Country Status (8)

Country Link
US (1) US6441149B1 (de)
EP (1) EP1086249B1 (de)
JP (1) JP2002518023A (de)
AT (1) ATE235560T1 (de)
AU (1) AU4823099A (de)
CA (1) CA2330840A1 (de)
DE (1) DE69906284T2 (de)
WO (1) WO1999066075A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002033128A2 (en) 2000-10-18 2002-04-25 Pharmasset Limited Multiplex quantification of nucleic acids in diseased cells
EP1211323A1 (de) * 2000-12-04 2002-06-05 Amsterdam Support Diagnostics B.V. Auf endosymbiotischen Zellorganellnukleinsäuren basierende Tests
CN1322143C (zh) * 2000-12-04 2007-06-20 普里马根公司 检测线粒体核酸与核基因核酸比率确定药物活性和/或副作用的方法
NL1021160C2 (nl) * 2002-07-26 2004-01-27 Multigen Internat B V Werkwijze voor het bepalen van het kopieaantal van een nucleotidevolgorde.
EP1493823A1 (de) * 2003-07-02 2005-01-05 PrimaGen Holding B.V. Inhibitoren der HMG-CoA Reduktase beeinflussen den DNA-Gehalt der Mitochondrien von Zellen
CN100348732C (zh) * 2004-06-15 2007-11-14 中山大学中山眼科中心 Leber’s遗传性视神经病病人的线粒体DNA突变定量检测方法
EP1652935A1 (de) * 2004-10-29 2006-05-03 PrimaGen Holding B.V. Verfahren zur Bestimmung des Gesundheitsstatus eines Individuums durch die Verwendung von mitochondrialen Nukleinsäuren
WO2006062389A2 (en) 2004-10-29 2006-06-15 Primagen Holding B.V. Methods using mitochondrial nucleic acid for determining a health status of an individual
GB0912394D0 (en) * 2009-07-16 2009-08-26 Univ Birmingham Screening methods
CA2771621A1 (en) * 2011-12-15 2013-06-15 Sabine Mai Methods for diagnosing alzheimer's disease
ES2482866B1 (es) * 2012-11-22 2015-05-12 Consejo Superior De Investigaciones Científicas (Csic) Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas.
CA2856419C (en) 2013-09-20 2018-06-26 Telo Genomics Holdings Corp. Methods for evaluating alzheimer's disease and disease severity
EP3181701A1 (de) * 2015-12-17 2017-06-21 Consejo Superior De Investigaciones Cientificas Verfahren zur unterklassifizierung von patienten mit morbus parkinson

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GB9208000D0 (en) 1992-04-10 1992-05-27 Univ London Quantitative viral assay
US5464945A (en) 1992-08-28 1995-11-07 Hoffmann-La Roche Inc. Oligonucleotide probes specific for the human alpha satellite locus
WO1994009155A1 (en) 1992-10-13 1994-04-28 Duke University Methods of detecting alzheimer's disease
US5840493A (en) 1994-03-30 1998-11-24 Mitokor Mitochondrial DNA mutations that segregate with late onset diabetes mellitus
JPH09511398A (ja) 1994-03-30 1997-11-18 ミトコアー ミトコンドリアの欠陥に関連する病気の診断、治療、並びに細胞および動物モデル
US6022683A (en) 1996-12-16 2000-02-08 Nova Molecular Inc. Methods for assessing the prognosis of a patient with a neurodegenerative disease

Also Published As

Publication number Publication date
EP1086249A2 (de) 2001-03-28
AU4823099A (en) 2000-01-05
JP2002518023A (ja) 2002-06-25
US6441149B1 (en) 2002-08-27
CA2330840A1 (en) 1999-12-23
WO1999066075A3 (en) 2000-06-02
DE69906284T2 (de) 2004-01-29
EP1086249B1 (de) 2003-03-26
WO1999066075A2 (en) 1999-12-23
DE69906284D1 (de) 2003-04-30

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