ATE235560T1 - Diagnostisches verfahren basierend auf der quantifizierung extramitochondrialer dna - Google Patents

Diagnostisches verfahren basierend auf der quantifizierung extramitochondrialer dna

Info

Publication number
ATE235560T1
ATE235560T1 AT99931800T AT99931800T ATE235560T1 AT E235560 T1 ATE235560 T1 AT E235560T1 AT 99931800 T AT99931800 T AT 99931800T AT 99931800 T AT99931800 T AT 99931800T AT E235560 T1 ATE235560 T1 AT E235560T1
Authority
AT
Austria
Prior art keywords
quantification
method based
diagnostic method
sequences
dna
Prior art date
Application number
AT99931800T
Other languages
English (en)
Inventor
Corinna Herrnstadt
Soumitra S Ghosh
William Clevenger
Eoin D Fahy
Robert E Davis
Original Assignee
Mitokor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/097,889 external-priority patent/US6218117B1/en
Priority claimed from US09/098,079 external-priority patent/US6489095B2/en
Application filed by Mitokor filed Critical Mitokor
Application granted granted Critical
Publication of ATE235560T1 publication Critical patent/ATE235560T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pathology (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
AT99931800T 1998-06-15 1999-06-14 Diagnostisches verfahren basierend auf der quantifizierung extramitochondrialer dna ATE235560T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/097,889 US6218117B1 (en) 1998-06-15 1998-06-15 Compositions and methods for identifying agents that quantitatively alter detectable extramitochondrial DNA:mitochondrial DNA ratios
US09/098,079 US6489095B2 (en) 1998-06-15 1998-06-15 Diagnostic method based on quantification of extramitochondrial DNA
US09/302,681 US6441149B1 (en) 1998-06-15 1999-04-30 Diagnostic method based on quantification of extramitochondrial DNA
PCT/US1999/013426 WO1999066075A2 (en) 1998-06-15 1999-06-14 Diagnostic method based on quantification of extramitochondrial dna

Publications (1)

Publication Number Publication Date
ATE235560T1 true ATE235560T1 (de) 2003-04-15

Family

ID=27378465

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99931800T ATE235560T1 (de) 1998-06-15 1999-06-14 Diagnostisches verfahren basierend auf der quantifizierung extramitochondrialer dna

Country Status (8)

Country Link
US (1) US6441149B1 (de)
EP (1) EP1086249B1 (de)
JP (1) JP2002518023A (de)
AT (1) ATE235560T1 (de)
AU (1) AU4823099A (de)
CA (1) CA2330840A1 (de)
DE (1) DE69906284T2 (de)
WO (1) WO1999066075A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030124512A1 (en) 2000-10-18 2003-07-03 Lieven Stuyver Simultaneous quantification of nucleic acids in diseased cells
NZ543940A (en) 2000-12-04 2008-04-30 Primagen B V Determining the ratio of genomic DNA and mtDNA or their related gene products with regards to determining the stage of an asymptomatic disease
EP1211323A1 (de) * 2000-12-04 2002-06-05 Amsterdam Support Diagnostics B.V. Auf endosymbiotischen Zellorganellnukleinsäuren basierende Tests
NL1021160C2 (nl) 2002-07-26 2004-01-27 Multigen Internat B V Werkwijze voor het bepalen van het kopieaantal van een nucleotidevolgorde.
EP1493823A1 (de) * 2003-07-02 2005-01-05 PrimaGen Holding B.V. Inhibitoren der HMG-CoA Reduktase beeinflussen den DNA-Gehalt der Mitochondrien von Zellen
CN100348732C (zh) * 2004-06-15 2007-11-14 中山大学中山眼科中心 Leber’s遗传性视神经病病人的线粒体DNA突变定量检测方法
CA2585587C (en) 2004-10-29 2016-02-16 Maarten Tjerk Penning Methods using mitochondrial nucleic acid for determining a health status of an individual
EP1652935A1 (de) * 2004-10-29 2006-05-03 PrimaGen Holding B.V. Verfahren zur Bestimmung des Gesundheitsstatus eines Individuums durch die Verwendung von mitochondrialen Nukleinsäuren
GB0912394D0 (en) * 2009-07-16 2009-08-26 Univ Birmingham Screening methods
CA2771621A1 (en) * 2011-12-15 2013-06-15 Sabine Mai Methods for diagnosing alzheimer's disease
ES2482866B1 (es) * 2012-11-22 2015-05-12 Consejo Superior De Investigaciones Científicas (Csic) Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas.
CA2856419C (en) 2013-09-20 2018-06-26 Telo Genomics Holdings Corp. Methods for evaluating alzheimer's disease and disease severity
EP3181701A1 (de) * 2015-12-17 2017-06-21 Consejo Superior De Investigaciones Cientificas Verfahren zur unterklassifizierung von patienten mit morbus parkinson

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GB9208000D0 (en) 1992-04-10 1992-05-27 Univ London Quantitative viral assay
US5464945A (en) 1992-08-28 1995-11-07 Hoffmann-La Roche Inc. Oligonucleotide probes specific for the human alpha satellite locus
EP0625212B1 (de) 1992-10-13 2004-03-24 Duke University VERFAHREN ZUM nachweis der Alzheimer Krankheit
MX9604400A (es) 1994-03-30 1997-12-31 Mitokor Diagnostico, terapia y modelos celular y animal para enfermedades asociadas con defectos mitocondriales.
US5840493A (en) 1994-03-30 1998-11-24 Mitokor Mitochondrial DNA mutations that segregate with late onset diabetes mellitus
US6022683A (en) 1996-12-16 2000-02-08 Nova Molecular Inc. Methods for assessing the prognosis of a patient with a neurodegenerative disease

Also Published As

Publication number Publication date
DE69906284T2 (de) 2004-01-29
WO1999066075A2 (en) 1999-12-23
AU4823099A (en) 2000-01-05
CA2330840A1 (en) 1999-12-23
JP2002518023A (ja) 2002-06-25
WO1999066075A3 (en) 2000-06-02
EP1086249A2 (de) 2001-03-28
DE69906284D1 (de) 2003-04-30
EP1086249B1 (de) 2003-03-26
US6441149B1 (en) 2002-08-27

Similar Documents

Publication Publication Date Title
ATE235560T1 (de) Diagnostisches verfahren basierend auf der quantifizierung extramitochondrialer dna
ATE438737T1 (de) Verfahren für den nachweis von erkrankungen
DE69938662D1 (de) Spurendetektion von analyten mit hilfe artifizieller olfaktometrie
ATE310955T1 (de) Zusammensetzungen und verfahren zum nachweis und zur behandlung von mit chemokinrezeptoren verbundenen krankheiten
DE69729122D1 (de) KüNSTLICHE FEHLHYBRIDISIERUNG
ATE121416T1 (de) Oligonukleotid-analoge.
ATE420204T1 (de) Verfahren zur detektion von erkrankungen
ATE331811T1 (de) Verfahren zur detektion von nukleinsäuren, welche auf krebs hinweisen
DE69423346D1 (de) Schnelles verfahren fur die dns sequenzierung und diagnostische anwendungen
ATE194391T1 (de) Amplifikationsoligonukleotide und sonden für borrelia, die mit lyme kranheit assoziiert sind
EA200300027A1 (ru) Способ лечения сердечно-сосудистых заболеваний
DE69918442D1 (de) Vorrichtung zur durchführung von sich auf tiere beziehende handlungen
ATE81750T1 (de) Verfahren zum einlegen oder einpoekeln von fleisch.
BR0014150A (pt) Diagnósticos e terapêuticos para osteoporose
ATE317452T1 (de) Verfahren zur behandlung von neurologischen erkrankungen mit hilfe der bestimmung des bche genotyps
PT879296E (pt) Marcadores de adn para o tamanho da ninhada no suino
WO2000063441A3 (en) Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease
ATE456799T1 (de) Verfahren zum identifizieren von präneoplastischen und neoplastischen stadien in säugern
DE59404520D1 (de) Verfahren zur Hydroformylierung von Butadien-1.3
EP1092783A4 (de) Verfahren zur krebsdiagnose auf basis des nachweises von chromosomenabnormalitäten
DE59000468D1 (de) Verfahren zur schnellen pruefung der wirksamkeit von agenzien auf mikroorganismen.
ATE392619T1 (de) Verfahren zur diagnose von synovialen oder osteoartikulären erkrankungen
ATE275268T1 (de) Verfahren zur diagnose von sjögren-syndrom
ATE228173T1 (de) Verfahren und vorrichtung zum identifizieren einer markierung
DE69710469D1 (de) Diagnoseverfahren und vorrichtung zum nachweis der prädisposition zu bestimmten krankheitszuständen, insbesondere osteoporose, auf basis von il-6 genpolymorphismus

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties