ATE235813T1 - Verfahren zur vorbereitung von organen auf die kryokonservierung - Google Patents

Verfahren zur vorbereitung von organen auf die kryokonservierung

Info

Publication number: ATE235813T1
Authority: AT; Austria
Prior art keywords: cryopreservation; organ; growth factor; transforming growth; factor beta
Prior art date: 1994-08-18

Application number

AT95928376T

Other languages

English (en)

Inventor

Gregory M Fahy

Bijan Khirabadi

Yasumitsu Okouchi

Thomas Maciag

Original Assignee

American Nat Red Cross

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-18

Filing date

1995-08-11

Publication date

2003-04-15

1995-08-11 Application filed by American Nat Red Cross filed Critical American Nat Red Cross

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE235813T1 publication Critical patent/ATE235813T1/de

Links

210000000056 organ Anatomy 0.000 title abstract 6
238000005138 cryopreservation Methods 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
102000046299 Transforming Growth Factor beta1 Human genes 0.000 abstract 3
101800002279 Transforming growth factor beta-1 Proteins 0.000 abstract 3
229940099456 transforming growth factor beta 1 Drugs 0.000 abstract 3
239000003795 chemical substances by application Substances 0.000 abstract 2
239000002577 cryoprotective agent Substances 0.000 abstract 2
229960002240 iloprost Drugs 0.000 abstract 2
HIFJCPQKFCZDDL-ACWOEMLNSA-N iloprost Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)C(C)CC#CC)[C@H](O)C[C@@H]21 HIFJCPQKFCZDDL-ACWOEMLNSA-N 0.000 abstract 2
238000002054 transplantation Methods 0.000 abstract 2
229940124549 vasodilator Drugs 0.000 abstract 2
239000003071 vasodilator agent Substances 0.000 abstract 2
XHVAWZZCDCWGBK-WYRLRVFGSA-M Aurothioglucose Chemical compound OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O XHVAWZZCDCWGBK-WYRLRVFGSA-M 0.000 abstract 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
229920001612 Hydroxyethyl starch Polymers 0.000 abstract 1
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 1
229930195725 Mannitol Natural products 0.000 abstract 1
MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 abstract 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
229930006000 Sucrose Natural products 0.000 abstract 1
MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 abstract 1
229960004308 acetylcysteine Drugs 0.000 abstract 1
210000001367 artery Anatomy 0.000 abstract 1
229960001799 aurothioglucose Drugs 0.000 abstract 1
239000006172 buffering agent Substances 0.000 abstract 1
229940050526 hydroxyethylstarch Drugs 0.000 abstract 1
210000003734 kidney Anatomy 0.000 abstract 1
210000004185 liver Anatomy 0.000 abstract 1
239000000594 mannitol Substances 0.000 abstract 1
235000010355 mannitol Nutrition 0.000 abstract 1
230000003204 osmotic effect Effects 0.000 abstract 1
230000010412 perfusion Effects 0.000 abstract 1
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 abstract 1
239000005720 sucrose Substances 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
- A01N1/142—Apparatus
- A01N1/143—Apparatus for organ perfusion

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Dentistry (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT95928376T 1994-08-18 1995-08-11 Verfahren zur vorbereitung von organen auf die kryokonservierung ATE235813T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/292,001 US5723282A (en)	1991-07-08	1994-08-18	Method of preparing organs for vitrification
PCT/US1995/010223 WO1996005727A1 (en)	1994-08-18	1995-08-11	Methods of preparing organs for cryopreservation and subsequent transplantation

Publications (1)

Publication Number	Publication Date
ATE235813T1 true ATE235813T1 (de)	2003-04-15

Family

ID=23122767

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95928376T ATE235813T1 (de)	1994-08-18	1995-08-11	Verfahren zur vorbereitung von organen auf die kryokonservierung

Country Status (9)

Country	Link
US (4)	US5723282A (de)
EP (1)	EP0777413B1 (de)
JP (1)	JPH10504568A (de)
KR (1)	KR970705337A (de)
AT (1)	ATE235813T1 (de)
AU (1)	AU692292B2 (de)
CA (1)	CA2197773A1 (de)
DE (1)	DE69530212T2 (de)
WO (1)	WO1996005727A1 (de)

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1994
- 1994-08-18 US US08/292,001 patent/US5723282A/en not_active Expired - Lifetime
1995
- 1995-05-31 US US08/455,027 patent/US5821045A/en not_active Expired - Fee Related
- 1995-08-11 EP EP95928376A patent/EP0777413B1/de not_active Expired - Lifetime
- 1995-08-11 KR KR1019970701070A patent/KR970705337A/ko not_active Withdrawn
- 1995-08-11 AU AU32174/95A patent/AU692292B2/en not_active Ceased
- 1995-08-11 WO PCT/US1995/010223 patent/WO1996005727A1/en not_active Ceased
- 1995-08-11 CA CA002197773A patent/CA2197773A1/en not_active Abandoned
- 1995-08-11 JP JP8508140A patent/JPH10504568A/ja not_active Ceased
- 1995-08-11 DE DE69530212T patent/DE69530212T2/de not_active Expired - Fee Related
- 1995-08-11 AT AT95928376T patent/ATE235813T1/de not_active IP Right Cessation
1998
- 1998-02-27 US US09/031,893 patent/US5962214A/en not_active Expired - Fee Related
- 1998-04-28 US US09/066,809 patent/US6187529B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0777413B1 (de)	2003-04-02
US5962214A (en)	1999-10-05
US5723282A (en)	1998-03-03
US6187529B1 (en)	2001-02-13
DE69530212T2 (de)	2003-12-04
CA2197773A1 (en)	1996-02-29
US5821045A (en)	1998-10-13
KR970705337A (ko)	1997-10-09
DE69530212D1 (de)	2003-05-08
AU692292B2 (en)	1998-06-04
WO1996005727A1 (en)	1996-02-29
JPH10504568A (ja)	1998-05-06
AU3217495A (en)	1996-03-14
EP0777413A1 (de)	1997-06-11

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Publication	Publication Date	Title
DE69530212D1 (de)	2003-05-08	Verfahren zur vorbereitung von organen auf die kryokonservierung
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