ATE236128T1 - N-alkylacridancarboxylderivate, geeignet für die detektion von chemilumineszenz - Google Patents
N-alkylacridancarboxylderivate, geeignet für die detektion von chemilumineszenzInfo
- Publication number
- ATE236128T1 ATE236128T1 AT94107632T AT94107632T ATE236128T1 AT E236128 T1 ATE236128 T1 AT E236128T1 AT 94107632 T AT94107632 T AT 94107632T AT 94107632 T AT94107632 T AT 94107632T AT E236128 T1 ATE236128 T1 AT E236128T1
- Authority
- AT
- Austria
- Prior art keywords
- chemiluminescence
- alkylacridanecarboxyl
- derivatives
- detection
- compounds
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title 1
- 102000003992 Peroxidases Human genes 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- -1 carboxylic acid derivative compounds Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/061,810 US5491072A (en) | 1993-05-17 | 1993-05-17 | N-alkylacridan carboxyl derivatives useful for chemiluminescent detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE236128T1 true ATE236128T1 (de) | 2003-04-15 |
Family
ID=22038290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94107632T ATE236128T1 (de) | 1993-05-17 | 1994-05-17 | N-alkylacridancarboxylderivate, geeignet für die detektion von chemilumineszenz |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5491072A (de) |
| EP (1) | EP0625510B1 (de) |
| JP (1) | JP3231777B2 (de) |
| AT (1) | ATE236128T1 (de) |
| AU (1) | AU666814B2 (de) |
| CA (1) | CA2123235C (de) |
| DE (1) | DE69432382T2 (de) |
| WO (1) | WO1994026927A1 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6414152B1 (en) * | 1981-12-11 | 2002-07-02 | University Of Wales College Of Medicine Of Heath Park | Luminescent labelling material and procedures |
| US7122671B1 (en) * | 1979-07-19 | 2006-10-17 | University College Cardiff Consultants Limited | Luminescent labelling materials and procedures |
| US5686258A (en) * | 1993-05-17 | 1997-11-11 | Lumigen, Inc. | Chemiluminescent detection of hydrolytic enzymes using an acridan |
| US5723295A (en) * | 1993-05-17 | 1998-03-03 | Lumigen, Inc. | Methods, acridan compounds and kits for producing light |
| US5593845A (en) * | 1993-05-17 | 1997-01-14 | Lumigen, Inc. | Aryl N-alkylacridancarboxylate derivatives useful for chemiluminescent detection |
| WO1996007912A1 (en) * | 1994-09-02 | 1996-03-14 | Lumigen, Inc. | Novel method and kits for producing light from an acridan compound |
| US5843666A (en) * | 1994-09-02 | 1998-12-01 | Lumigen, Inc. | Chemiluminescent detection methods using dual enzyer-labeled binding partners |
| US5731148A (en) * | 1995-06-07 | 1998-03-24 | Gen-Probe Incorporated | Adduct protection assay |
| AU6683896A (en) * | 1995-07-31 | 1997-02-26 | Charm Sciences, Inc. | Chemiluminescent method of monitoring products after heat treatment |
| CN1173954C (zh) * | 1996-01-16 | 2004-11-03 | 鲁米根公司 | 与磷酸酶反应产生化学发光的化合物、组合物和方法 |
| PT915851E (pt) * | 1996-07-16 | 2002-09-30 | Staat Nl Verteg Door Min Welzi | Esteres dibenzodihidropiridinecarboxilicos e seu uso no ensaio dos metodos quimiluminiscente |
| US5922558A (en) * | 1997-09-12 | 1999-07-13 | Lumigen, Inc. | Methods and compositions for generating chemiluminescence with a peroxidase |
| AU9102398A (en) * | 1997-09-12 | 1999-04-05 | Lumigen, Inc. | Novel compounds for generating chemiluminescence with a peroxidase |
| AU2001234612A1 (en) * | 2000-01-28 | 2001-08-07 | Brij Pal Giri | Novel stabilized formulations for chemiluminescent assays |
| US7186568B1 (en) | 2000-06-26 | 2007-03-06 | Lumigen Inc. | Electrochemiluminescence from acridan compounds |
| WO2003053934A1 (en) | 2001-12-20 | 2003-07-03 | Lumigen, Inc. | Improved compounds for generating chemiluminescence with a peroxidase |
| US6872828B2 (en) | 2001-12-20 | 2005-03-29 | Lumigen, Inc. | Compounds for generating chemiluminescence with a peroxidase |
| JP2004535423A (ja) | 2001-06-01 | 2004-11-25 | エフ．ホフマン−ラ ロシュ アーゲー | 化学発光手順のための新規化合物 |
| US6723851B2 (en) * | 2001-10-31 | 2004-04-20 | Quest Diagnostics Investment Incorporated | Chemiluminescent compounds and use thereof |
| US6897036B2 (en) * | 2002-06-06 | 2005-05-24 | Lumigen, Inc. | Fluorescent detection of peroxidase enzymes |
| US7390670B2 (en) | 2003-02-20 | 2008-06-24 | Lumigen, Inc. | Signalling compounds and methods for detecting hydrogen peroxide |
| EP1735621A4 (de) * | 2004-04-14 | 2012-12-12 | Brij P Giri | Neue ultraempfindliche chemielumineszenzsubstrate für enzyme und deren konjugate |
| US7732153B2 (en) | 2006-05-09 | 2010-06-08 | Beckman Coulter, Inc. | Nonseparation assay methods |
| US7799534B2 (en) | 2006-05-09 | 2010-09-21 | Beckman Coulter, Inc. | Nonseparation assay methods |
| US7906293B2 (en) * | 2007-04-09 | 2011-03-15 | Abbott Laboratories | Acridinium phenyl esters useful in the analysis of biological |
| US20100240070A1 (en) * | 2007-11-07 | 2010-09-23 | Beckman Coulter, Inc. | Nonseparation Assay Methods Using Peroxide Generating Enzymes |
| CN102333885A (zh) | 2009-02-27 | 2012-01-25 | 贝克曼考尔特公司 | 使用选择性信号抑制剂的非分离式测定 |
| PL2401392T3 (pl) | 2009-02-27 | 2017-08-31 | Beckman Coulter, Inc. | Homogeniczne oznaczenia fazy roztworu |
| JP5311662B2 (ja) * | 2009-08-24 | 2013-10-09 | キッコーマン株式会社 | ペルオキシダーゼ化学発光反応の発光増強方法及びペルオキシダーゼ化学発光反応用発光増強剤 |
| US20110097723A1 (en) * | 2009-09-19 | 2011-04-28 | Qun Liu | Methods and reagents for analyte detection |
| CN112400113B (zh) | 2018-07-13 | 2022-04-15 | 3M创新有限公司 | 特异性结合化学发光测定法 |
| WO2020012391A1 (en) | 2018-07-13 | 2020-01-16 | 3M Innovative Properties Company | Assay |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2510431A (en) * | 1946-11-02 | 1950-06-06 | Goodrich Co B F | Insecticidal composition comprising a dodecahydro acridane |
| US2645594A (en) * | 1948-10-19 | 1953-07-14 | Abbott Lab | Antiseptic acridane compounds |
| CH451144A (de) * | 1961-12-18 | 1968-05-15 | Siegfried Ag | Verfahren zur Herstellung von Salzen von 10-Aminoalkyl-5,5-dialkylacridanen |
| US3917603A (en) * | 1970-05-13 | 1975-11-04 | Ciba Geigy Corp | Methyl(9-methyl-acaidan-9-yl)-ketones |
| US3830919A (en) * | 1971-06-17 | 1974-08-20 | Colgate Palmolive Co | Antimicrobial haidressing |
| US3962252A (en) * | 1973-02-28 | 1976-06-08 | Mead Johnson & Company | 10-imidoylacridans |
| US4094981A (en) * | 1976-03-26 | 1978-06-13 | Mead Johnson & Company | Smooth muscle relaxant employing 10-imidoylacridans |
| GB1461877A (en) * | 1974-02-12 | 1977-01-19 | Wellcome Found | Assay method utilizing chemiluminescence |
| US4263398A (en) * | 1978-10-23 | 1981-04-21 | Morton-Norwich Products, Inc. | 9-(P-diethylaminophenyl)-9-chloro-10-phenylacridan agar medium |
| DE3279029D1 (en) * | 1981-12-11 | 1988-10-20 | Welsh Nat School Med | Luminescent labelling materials and procedures |
| US4687747A (en) * | 1984-07-02 | 1987-08-18 | Mallinckrodt, Inc. | Phenanthridinium ester as a labelling compound in luminometric immunoassay |
| DE3628573C2 (de) * | 1986-08-22 | 1994-10-13 | Hoechst Ag | Chemilumineszierende Acridinderivate, Verfahren zu deren Herstellung und ihre Verwendung in Lumineszenzimmunoassays |
| US4918192A (en) * | 1986-10-06 | 1990-04-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
| US5110932A (en) * | 1986-10-06 | 1992-05-05 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
| US4745181A (en) * | 1986-10-06 | 1988-05-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
| US5290936A (en) * | 1987-12-31 | 1994-03-01 | London Diagnostics, Inc. | Nitro substituted chemiluminescent labels and their conjugates, and assays therefrom |
| NZ227506A (en) * | 1987-12-31 | 1992-06-25 | London Diagnostics Inc | Specific binding assays using chemiluminescent compounds |
| AU634716B2 (en) * | 1988-08-01 | 1993-03-04 | Ciba Corning Diagnostics Corp. | Method for detection of an analyte using acridinium esters and liposomes |
| US5132204A (en) * | 1989-05-31 | 1992-07-21 | Chiron Corporation | Chemiluminescent double-triggered 1, 2-dioxetanes |
| JPH0767394B2 (ja) * | 1991-03-20 | 1995-07-26 | 三洋化成工業株式会社 | 化学発光増強剤、化学発光利用検出・定量法及びキット |
-
1993
- 1993-05-17 US US08/061,810 patent/US5491072A/en not_active Expired - Lifetime
-
1994
- 1994-05-10 CA CA002123235A patent/CA2123235C/en not_active Expired - Fee Related
- 1994-05-12 AU AU63025/94A patent/AU666814B2/en not_active Ceased
- 1994-05-16 JP JP52576694A patent/JP3231777B2/ja not_active Expired - Fee Related
- 1994-05-16 WO PCT/US1994/005437 patent/WO1994026927A1/en not_active Ceased
- 1994-05-17 EP EP94107632A patent/EP0625510B1/de not_active Expired - Lifetime
- 1994-05-17 AT AT94107632T patent/ATE236128T1/de not_active IP Right Cessation
- 1994-05-17 DE DE69432382T patent/DE69432382T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2123235A1 (en) | 1994-11-18 |
| JPH08500125A (ja) | 1996-01-09 |
| AU6302594A (en) | 1994-12-01 |
| DE69432382T2 (de) | 2004-02-12 |
| EP0625510A2 (de) | 1994-11-23 |
| AU666814B2 (en) | 1996-02-22 |
| US5491072A (en) | 1996-02-13 |
| DE69432382D1 (de) | 2003-05-08 |
| CA2123235C (en) | 1999-09-21 |
| JP3231777B2 (ja) | 2001-11-26 |
| EP0625510B1 (de) | 2003-04-02 |
| EP0625510A3 (de) | 1997-03-05 |
| WO1994026927A1 (en) | 1994-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |