ATE236187T1 - Verfahren zur herstellung von 2'-fluoro-5-methyl- beta-l-arabino-furanosyluridin - Google Patents

Verfahren zur herstellung von 2'-fluoro-5-methyl- beta-l-arabino-furanosyluridin

Info

Publication number: ATE236187T1
Authority: AT; Austria
Prior art keywords: furanosyluridine; arabino; fluoro; beta; methyl
Prior art date: 1997-07-23

Application number

AT98939087T

Other languages

English (en)

Inventor

Chung K Chu

Yong S Choi

Jinfa Du

Original Assignee

Univ Georgia Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-23

Filing date

1998-07-23

Publication date

2003-04-15

1998-07-23 Application filed by Univ Georgia Res Found filed Critical Univ Georgia Res Found

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE236187T1 publication Critical patent/ATE236187T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/02—Monosaccharides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT98939087T 1997-07-23 1998-07-23 Verfahren zur herstellung von 2'-fluoro-5-methyl- beta-l-arabino-furanosyluridin ATE236187T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5348897P	1997-07-23	1997-07-23
PCT/US1998/015375 WO1999005158A1 (en)	1997-07-23	1998-07-23	PROCESS FOR THE PREPARATION OF 2'-FLUORO-5-METHYL-β -L-ARABINOFURANOSYLURIDINE

Publications (1)

Publication Number	Publication Date
ATE236187T1 true ATE236187T1 (de)	2003-04-15

Family

ID=21984622

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT03075945T ATE304547T1 (de)	1997-07-23	1998-07-23	Verfahren zur herstellung von l-ribose
AT98939087T ATE236187T1 (de)	1997-07-23	1998-07-23	Verfahren zur herstellung von 2'-fluoro-5-methyl- beta-l-arabino-furanosyluridin

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT03075945T ATE304547T1 (de)	1997-07-23	1998-07-23	Verfahren zur herstellung von l-ribose

Country Status (21)

Country	Link
US (2)	US6512107B2 (de)
EP (2)	EP1327637B1 (de)
KR (1)	KR100247505B1 (de)
CN (1)	CN1113892C (de)
AR (1)	AR009092A1 (de)
AT (2)	ATE304547T1 (de)
AU (1)	AU8758298A (de)
BR (1)	BR9810804B1 (de)
DE (2)	DE69812959T2 (de)
DK (1)	DK1327637T3 (de)
ES (2)	ES2249678T3 (de)
ID (1)	ID20624A (de)
IL (1)	IL121730A (de)
IN (1)	IN186807B (de)
MY (1)	MY117314A (de)
PT (2)	PT998482E (de)
SA (1)	SA98180771B1 (de)
SI (1)	SI1327637T1 (de)
TR (1)	TR199701051A2 (de)
TW (1)	TW434252B (de)
WO (2)	WO1999005157A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW434252B (en)	1997-07-23	2001-05-16	Univ Georgia Res Found	Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine
KR100449618B1 (ko) *	1998-03-27	2004-11-16	부광약품 주식회사	2'-플루오로-5-메틸-β-L-아라비노푸라노실유리딘의 제조방법
US6462191B1 (en) *	2000-07-13	2002-10-08	Air Products And Chemicals, Inc.	Synthesis of 2-deoxy-2-fluoro-arabinose derivatives
IL158185A0 (en) *	2001-03-30	2004-03-28	Triangle Pharmaceuticals Inc	PROCESS FOR THE PREPARATION OF 2'-HALO-&beta -L-ARABINOFURANOSYL NUCLEOSIDES
KR100487992B1 (ko) *	2001-10-25	2005-05-09	부광약품 주식회사	2'-플루오로-5-메틸-β-엘-아라비노푸라노실유리딘의 황유도체
EP1569658A4 (de) *	2001-12-20	2007-05-30	Pharmassett Ltd	Behandlung einer ebv- und khsv-infektion sowie einer damit zusammenhängenden abnormalen zellproliferation
KR100976778B1 (ko)	2003-04-17	2010-08-18	부광약품 주식회사	1-（2'-플루오로-베타-엘-아라비노푸라노실）티민의 황 유도체를 유효 활성 성분으로 하는 b형 간염 바이러스 치료제
ES2725457T3 (es)	2004-09-14	2019-09-24	Gilead Pharmasset Llc	Preparación de ribofuranosil pirimidinas y purinas 2'fluoro-2'-alquil-sustituidas u otras opcionalmente sustituidas y sus derivados
BRPI0613796A2 (pt)	2005-06-07	2011-02-15	Univ Yale	composicões farmacêuticas e seus usos, e métodos de tratamento de cáncer e outras condições ou estados patológicos, por meio do uso de clevudina (lfmau) e telbivudina (ldt)
PT2514750E (pt)	2007-06-18	2014-01-23	Sunshine Lake Pharma Co Ltd	Tiazolil dihidropirimidinas substituídas com bromo-fenilo
GB0907551D0 (en)	2009-05-01	2009-06-10	Univ Dundee	Treatment or prophylaxis of proliferative conditions
KR20200118827A (ko)	2018-02-02	2020-10-16	마베릭스 온콜로지, 잉크.	젬시타빈 모노포스페이트의 소분자 약물 컨쥬게이트
CN109320564B (zh) *	2018-10-26	2022-05-31	浙江晟格生物科技有限公司	一种l-来苏糖的制备工艺
CN109467541A (zh) *	2018-11-17	2019-03-15	扬州工业职业技术学院	一种绿色合成克拉夫定药物中间体的方法
CN109467583A (zh) *	2018-11-17	2019-03-15	扬州工业职业技术学院	一种克拉夫定的绿色合成工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3714473A1 (de) *	1987-04-30	1988-11-10	Basf Ag	Kontinuierliches verfahren zur epimerisierung von zuckern, insbesondere von d-arabinose zu d-ribose
EP0400064B1 (de)	1988-02-09	1993-04-21	Uop	Festkatalysatoren für kontinuierliche epimerisierung von aldose und aldoseanalogen
DE4002727A1 (de) *	1990-01-31	1991-08-01	Bayer Ag	Mischungen aus waessrigen polymerdispersionen
US5587362A (en)	1994-01-28	1996-12-24	Univ. Of Ga Research Foundation	L-nucleosides
US5808040A (en)	1995-01-30	1998-09-15	Yale University	L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
TW434252B (en)	1997-07-23	2001-05-16	Univ Georgia Res Found	Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine

1997
- 1997-08-16 TW TW086111816A patent/TW434252B/zh not_active IP Right Cessation
- 1997-08-29 WO PCT/IB1997/001254 patent/WO1999005157A1/en not_active Ceased
- 1997-09-08 CN CN97116278A patent/CN1113892C/zh not_active Expired - Lifetime
- 1997-09-10 IL IL12173097A patent/IL121730A/xx not_active IP Right Cessation
- 1997-09-13 MY MYPI97004259A patent/MY117314A/en unknown
- 1997-09-15 IN IN2616DE1997 patent/IN186807B/en unknown
- 1997-09-16 ID IDP973206A patent/ID20624A/id unknown
- 1997-09-25 AR ARP970104409A patent/AR009092A1/es active IP Right Grant
- 1997-09-26 TR TR97/01051A patent/TR199701051A2/xx unknown
1998
- 1998-01-04 SA SA98180771A patent/SA98180771B1/ar unknown
- 1998-01-19 KR KR1019980001421A patent/KR100247505B1/ko not_active Expired - Fee Related
- 1998-07-23 BR BRPI9810804-2A patent/BR9810804B1/pt not_active IP Right Cessation
- 1998-07-23 AT AT03075945T patent/ATE304547T1/de active
- 1998-07-23 SI SI9830792T patent/SI1327637T1/sl unknown
- 1998-07-23 EP EP03075945A patent/EP1327637B1/de not_active Expired - Lifetime
- 1998-07-23 AU AU87582/98A patent/AU8758298A/en not_active Abandoned
- 1998-07-23 DE DE69812959T patent/DE69812959T2/de not_active Expired - Lifetime
- 1998-07-23 ES ES03075945T patent/ES2249678T3/es not_active Expired - Lifetime
- 1998-07-23 WO PCT/US1998/015375 patent/WO1999005158A1/en not_active Ceased
- 1998-07-23 PT PT98939087T patent/PT998482E/pt unknown
- 1998-07-23 AT AT98939087T patent/ATE236187T1/de active
- 1998-07-23 ES ES98939087T patent/ES2195370T3/es not_active Expired - Lifetime
- 1998-07-23 US US09/121,294 patent/US6512107B2/en not_active Expired - Lifetime
- 1998-07-23 DK DK03075945T patent/DK1327637T3/da active
- 1998-07-23 PT PT03075945T patent/PT1327637E/pt unknown
- 1998-07-23 EP EP98939087A patent/EP0998482B1/de not_active Expired - Lifetime
- 1998-07-23 DE DE69831619T patent/DE69831619T2/de not_active Expired - Lifetime
2003
- 2003-01-24 US US10/351,222 patent/US6894159B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
TR199701051A3 (tr)	1999-03-22
US6512107B2 (en)	2003-01-28
WO1999005158A1 (en)	1999-02-04
SA98180771B1 (ar)	2006-10-29
CN1113892C (zh)	2003-07-09
DE69812959D1 (de)	2003-05-08
DE69831619T2 (de)	2006-06-14
BR9810804B1 (pt)	2012-01-10
EP0998482B1 (de)	2003-04-02
KR100247505B1 (ko)	2000-03-15
DE69831619D1 (de)	2005-10-20
IL121730A0 (en)	1998-02-22
TR199701051A2 (xx)	1999-03-22
EP0998482A1 (de)	2000-05-10
KR19990013297A (ko)	1999-02-25
DE69812959T2 (de)	2004-03-04
ES2249678T3 (es)	2006-04-01
TW434252B (en)	2001-05-16
ID20624A (id)	1999-01-28
PT1327637E (pt)	2005-11-30
BR9810804A (pt)	2000-09-12
EP1327637B1 (de)	2005-09-14
DK1327637T3 (da)	2006-01-16
SI1327637T1 (sl)	2005-12-31
AR009092A1 (es)	2000-03-08
US20020062018A1 (en)	2002-05-23
US6894159B2 (en)	2005-05-17
PT998482E (pt)	2003-08-29
AU8758298A (en)	1999-02-16
CN1206012A (zh)	1999-01-27
ATE304547T1 (de)	2005-09-15
IL121730A (en)	2005-03-20
MY117314A (en)	2004-06-30
IN186807B (de)	2001-11-10
US20030139593A1 (en)	2003-07-24
ES2195370T3 (es)	2003-12-01
WO1999005157A1 (en)	1999-02-04
EP1327637A1 (de)	2003-07-16

Legal Events

Date

Code

Title

Description

2003-12-15

UEP

Publication of translation of european patent specification

Ref document number: 0998482

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