ATE236192T1 - 3-aminoethyl-n-amidino-2,5-dihydropyrrol derivative mit arginine-mimetischen eigenschaften - Google Patents

3-aminoethyl-n-amidino-2,5-dihydropyrrol derivative mit arginine-mimetischen eigenschaften

Info

Publication number: ATE236192T1
Authority: AT; Austria
Prior art keywords: amidino; aminoethyl; arginine mimetic; mimetic properties; derivatives
Prior art date: 1995-12-09

Application number

AT96943062T

Other languages

English (en)

Inventor

Richard Engh

Silvia Konetschny-Rapp

Hans-Willi Krell

Ulrich Martin

Christos Tsaklakidis

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-09

Filing date

1996-12-09

Publication date

2003-04-15

1996-12-09 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE236192T1 publication Critical patent/ATE236192T1/de

Links

YDRVFCVPWICTOV-UHFFFAOYSA-N 3-(2-aminoethyl)-2,5-dihydropyrrole-1-carboximidamide Chemical class NCCC1=CCN(C(N)=N)C1 YDRVFCVPWICTOV-UHFFFAOYSA-N 0.000 title 1
239000004475 Arginine Substances 0.000 title 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 title 1
MJSQLVQCYKAPNT-UHFFFAOYSA-N 2,3-dihydropyrrole-1-carboximidamide Chemical class NC(=N)N1CCC=C1 MJSQLVQCYKAPNT-UHFFFAOYSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Rheumatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Gastroenterology & Hepatology (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyrrole Compounds (AREA)
Peptides Or Proteins (AREA)

AT96943062T 1995-12-09 1996-12-09 3-aminoethyl-n-amidino-2,5-dihydropyrrol derivative mit arginine-mimetischen eigenschaften ATE236192T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19546018		1995-12-09
DE19614179		1996-04-11
PCT/EP1996/005494 WO1997021725A1 (en)	1995-12-09	1996-12-09	3-aminoethyl-n-amidino-2,5-dihydropyrrole derivatives having arginine mimetic properties

Publications (1)

Publication Number	Publication Date
ATE236192T1 true ATE236192T1 (de)	2003-04-15

Family

ID=26021108

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96943062T ATE236192T1 (de)	1995-12-09	1996-12-09	3-aminoethyl-n-amidino-2,5-dihydropyrrol derivative mit arginine-mimetischen eigenschaften

Country Status (9)

Country	Link
US (1)	US20020026034A1 (de)
EP (1)	EP0865445B1 (de)
JP (1)	JP2000502078A (de)
AT (1)	ATE236192T1 (de)
AU (1)	AU1192097A (de)
CA (1)	CA2239908A1 (de)
DE (1)	DE69627184D1 (de)
TW (1)	TW455580B (de)
WO (1)	WO1997021725A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0902036A1 (de) *	1997-09-05	1999-03-17	Roche Diagnostics GmbH	Peptide mit einem Arginine-Substitut für die Behandlung von Osteoporosis, deren Herstellung und diese enthaltende Verbindungen
US6403818B1 (en)	2000-02-28	2002-06-11	Eisai Co., Ltd.	Process for producing α-hydroxy-carbonyl compound
CN117164932B (zh) *	2023-10-31	2024-01-26	汕头市虹桥包装实业有限公司	一种注塑发泡聚丙烯材料及其制备方法和在轻量化高性能瓶盖中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9301916D0 (sv) *	1993-06-03	1993-06-03	Ab Astra	New peptides derivatives
SE9301912D0 (sv) *	1993-06-03	1993-06-03	Ab Astra	Process for the production of aminoalkylguandines

1996
- 1996-12-09 AU AU11920/97A patent/AU1192097A/en not_active Abandoned
- 1996-12-09 US US09/077,879 patent/US20020026034A1/en not_active Abandoned
- 1996-12-09 EP EP96943062A patent/EP0865445B1/de not_active Expired - Lifetime
- 1996-12-09 DE DE69627184T patent/DE69627184D1/de not_active Expired - Lifetime
- 1996-12-09 AT AT96943062T patent/ATE236192T1/de not_active IP Right Cessation
- 1996-12-09 JP JP09521726A patent/JP2000502078A/ja active Pending
- 1996-12-09 WO PCT/EP1996/005494 patent/WO1997021725A1/en not_active Ceased
- 1996-12-09 CA CA002239908A patent/CA2239908A1/en not_active Abandoned
- 1996-12-09 TW TW085115198A patent/TW455580B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1997021725A1 (en)	1997-06-19
TW455580B (en)	2001-09-21
EP0865445B1 (de)	2003-04-02
EP0865445A1 (de)	1998-09-23
DE69627184D1 (de)	2003-05-08
JP2000502078A (ja)	2000-02-22
US20020026034A1 (en)	2002-02-28
CA2239908A1 (en)	1997-06-19
AU1192097A (en)	1997-07-03

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Legal Events

Date	Code	Title	Description
2003-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties