ATE236247T1 - Methoden zum aufspüren von anti- östrogenverbindungen - Google Patents

Methoden zum aufspüren von anti- östrogenverbindungen

Info

Publication number
ATE236247T1
ATE236247T1 AT94927989T AT94927989T ATE236247T1 AT E236247 T1 ATE236247 T1 AT E236247T1 AT 94927989 T AT94927989 T AT 94927989T AT 94927989 T AT94927989 T AT 94927989T AT E236247 T1 ATE236247 T1 AT E236247T1
Authority
AT
Austria
Prior art keywords
compounds
methods
detecting anti
reporter gene
estrogen compounds
Prior art date
Application number
AT94927989T
Other languages
English (en)
Inventor
Peter Kushner
Paul Webb
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE236247T1 publication Critical patent/ATE236247T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743Steroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/723Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
AT94927989T 1993-09-01 1994-09-01 Methoden zum aufspüren von anti- östrogenverbindungen ATE236247T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11516193A 1993-09-01 1993-09-01
PCT/US1994/009898 WO1995006754A1 (en) 1993-09-01 1994-09-01 Methods for screening antiestrogen compounds

Publications (1)

Publication Number Publication Date
ATE236247T1 true ATE236247T1 (de) 2003-04-15

Family

ID=22359653

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94927989T ATE236247T1 (de) 1993-09-01 1994-09-01 Methoden zum aufspüren von anti- östrogenverbindungen

Country Status (9)

Country Link
EP (1) EP0724648B1 (de)
JP (1) JP3503945B2 (de)
KR (1) KR100355647B1 (de)
AT (1) ATE236247T1 (de)
AU (1) AU682398B2 (de)
CA (1) CA2169466A1 (de)
DE (1) DE69432422T2 (de)
NO (1) NO960715D0 (de)
WO (1) WO1995006754A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723291A (en) * 1993-09-01 1998-03-03 The Regents Of The University Of California Methods for screening compounds for estrogenic activity
US6156723A (en) * 1993-09-01 2000-12-05 The Regents Of The University Of California Compositions comprising inhibitors of estrogen response
GB9424497D0 (en) * 1994-12-05 1995-01-25 Karobio Ab Reporter cell line
WO1997034144A1 (de) * 1996-03-14 1997-09-18 Schering Aktiengesellschaft Verfahren zum nachweis der wirkung von testsubstanzen unter verwendung von hühner-urokinase
WO1997041242A1 (en) * 1996-04-18 1997-11-06 Geron Corporation Senescence responsive transcriptional element
US5783435A (en) * 1996-08-06 1998-07-21 Lamparski; Henry G. Prostate cancer drug screenings
US6051417A (en) * 1996-08-06 2000-04-18 Calydon, Inc. Prostate cancer drug screening using hKLK2 enhancer
EP1045035B1 (de) 1999-04-14 2006-09-20 Sumitomo Chemical Company, Limited Zelle zur Bestimmung der Fähigkeit die Aktivität eines Liganden-abhängigen Transkriptionskontrollfaktors zu kontrollieren
WO2010040446A1 (en) * 2008-10-09 2010-04-15 Merck Patent Gmbh Estrogen and anti-estrogen marker genes

Also Published As

Publication number Publication date
DE69432422D1 (de) 2003-05-08
EP0724648A4 (de) 1996-10-09
EP0724648A1 (de) 1996-08-07
EP0724648B1 (de) 2003-04-02
DE69432422T2 (de) 2004-03-04
NO960715L (no) 1996-02-22
AU682398B2 (en) 1997-10-02
CA2169466A1 (en) 1995-03-09
AU7719094A (en) 1995-03-22
KR100355647B1 (ko) 2002-12-28
JPH09502345A (ja) 1997-03-11
WO1995006754A1 (en) 1995-03-09
JP3503945B2 (ja) 2004-03-08
NO960715D0 (no) 1996-02-22

Similar Documents

Publication Publication Date Title
CA2215922A1 (en) Methods for screening compounds for estrogenic activity
TR200002224T2 (tr) Matris-bozucu metalloproteinasları inhibe eden sülfonilamino türevleri.
TR199900781T2 (xx) H�cre yap��ma inhibit�rleri
ATE43640T1 (de) Zusammensetzung und testvorrichtung zum nachweis von leukozyten, esterase und protease in einer testprobe.
EA199700087A1 (ru) Способ ингибирования катепсина к
DE60141950D1 (de) Vernetzte, nicht von pilzen kommende lipase enthaltende zusammensetzung und methoden zu deren verwendung
ATE271130T1 (de) Veränderte proteinkinasen, die modifizierte nukleotidtriphosphat substrate verwenden können
ATE239912T1 (de) Verfahren und vorrichtung zur referenzierung von fluoreszenzintensitätssignalen
ATE262178T1 (de) Identifizierung und charakterisierung von interagierenden molekülen
DE69717856D1 (de) Methoden und zusammensetzungen zur empfindlichen und schnellen funktionellen identifizierung genomischer polynukleotide und ihre anwendung in zelltests zum auffinden von medikamenten
ATE386814T1 (de) Gemischte g-proteinzusammensetzung und ihre verwendung
EP0804548A4 (de) Ptc gene und ihre verwendung
ATE287402T1 (de) Nanomolare, non-peptidische inhibitoren von cathepsin d
DK0474744T3 (da) PDGF-alfa-receptor
ATE147793T1 (de) Überprüfungsteste
DE69432422D1 (de) Methoden zum aufspüren von anti-östrogenverbindungen
IT1261847B (it) Metodo per marcare cellule eucariote.
BR0311318A (pt) Inibidores de peptìdeo desformilase
DE60103428D1 (de) Identifizierung von zellen während kinetischer versuchsreihen
DE59712319D1 (de) Genfallen-konstrukt zur identifizierung und isolierung von genen
DE69928250D1 (de) Analytisches verfahren unter verwendung von multipelviren-markierung
DE69905273D1 (de) Verfahren und zusammensetzung zur inhibierung der polymerisierung von ethylenisch ungesättigten kohlenwasserstoffen
ATE333510T1 (de) Enzymatische messung von mycophenolsäure
BR0209929A (pt) Biomarcador, métodos para identificar microorganismos, e toxinas maromoleculares, e, aparelho para a realização automática do método
ATE284955T1 (de) Map-kinase: polypeptide, polynukleotide und ihre verwendung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties