ATE236651T1 - Materialen und verfahren im zusammenhang mit der inhibierung der wechselwirkung der p53 und mdm2 - Google Patents

Materialen und verfahren im zusammenhang mit der inhibierung der wechselwirkung der p53 und mdm2

Info

Publication number
ATE236651T1
ATE236651T1 AT98917411T AT98917411T ATE236651T1 AT E236651 T1 ATE236651 T1 AT E236651T1 AT 98917411 T AT98917411 T AT 98917411T AT 98917411 T AT98917411 T AT 98917411T AT E236651 T1 ATE236651 T1 AT E236651T1
Authority
AT
Austria
Prior art keywords
mdm2
cells
inhibiting
interaction
materials
Prior art date
Application number
AT98917411T
Other languages
English (en)
Inventor
David Philip Lane
Original Assignee
Univ Dundee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Dundee filed Critical Univ Dundee
Application granted granted Critical
Publication of ATE236651T1 publication Critical patent/ATE236651T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Optical Record Carriers And Manufacture Thereof (AREA)
  • Cosmetics (AREA)
  • Paper (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98917411T 1997-04-22 1998-04-20 Materialen und verfahren im zusammenhang mit der inhibierung der wechselwirkung der p53 und mdm2 ATE236651T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9708092.3A GB9708092D0 (en) 1997-04-22 1997-04-22 Materials and methods relating to inhibiting the interaction of p53 and mdm2
PCT/GB1998/001144 WO1998047525A1 (en) 1997-04-22 1998-04-20 MATERIALS AND METHODS RELATING TO INHIBITING THE INTERACTION OF p53 AND mdm2

Publications (1)

Publication Number Publication Date
ATE236651T1 true ATE236651T1 (de) 2003-04-15

Family

ID=10811137

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98917411T ATE236651T1 (de) 1997-04-22 1998-04-20 Materialen und verfahren im zusammenhang mit der inhibierung der wechselwirkung der p53 und mdm2

Country Status (7)

Country Link
EP (1) EP0977580B1 (de)
AT (1) ATE236651T1 (de)
AU (1) AU731431B2 (de)
CA (1) CA2287344A1 (de)
DE (1) DE69813204T2 (de)
GB (1) GB9708092D0 (de)
WO (1) WO1998047525A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
EP2508531B1 (de) 2007-03-28 2016-10-19 President and Fellows of Harvard College Geheftete Polypeptide
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
JP6162135B2 (ja) * 2011-11-09 2017-07-12 メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー 短縮された生物活性を示す神経毒
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
BR112017005598A2 (pt) * 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
JP2018503595A (ja) 2014-09-24 2018-02-08 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその製剤
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
US11091522B2 (en) 2018-07-23 2021-08-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411860A (en) * 1992-04-07 1995-05-02 The Johns Hopkins University Amplification of human MDM2 gene in human tumors
US5770377A (en) * 1994-07-20 1998-06-23 University Of Dundee Interruption of binding of MDM2 and P53 protein and therapeutic application thereof
EP0958305B1 (de) * 1996-07-05 2008-06-04 Cancer Research Technology Limited Hemmer der interaktion zwischen p53 und mdm2

Also Published As

Publication number Publication date
DE69813204T2 (de) 2004-02-05
WO1998047525A1 (en) 1998-10-29
EP0977580B1 (de) 2003-04-09
DE69813204D1 (de) 2003-05-15
CA2287344A1 (en) 1998-10-29
GB9708092D0 (en) 1997-06-11
EP0977580A1 (de) 2000-02-09
AU731431B2 (en) 2001-03-29
AU7064498A (en) 1998-11-13

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