ATE236878T1 - Neue produktionsmethode - Google Patents

Neue produktionsmethode

Info

Publication number
ATE236878T1
ATE236878T1 AT99963732T AT99963732T ATE236878T1 AT E236878 T1 ATE236878 T1 AT E236878T1 AT 99963732 T AT99963732 T AT 99963732T AT 99963732 T AT99963732 T AT 99963732T AT E236878 T1 ATE236878 T1 AT E236878T1
Authority
AT
Austria
Prior art keywords
production method
new production
new
production
Prior art date
Application number
AT99963732T
Other languages
English (en)
Inventor
Anders Mattson
Carina Svensson
Karin Thoernblom
Christina Oedman
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE236878T1 publication Critical patent/ATE236878T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
AT99963732T 1998-11-23 1999-11-22 Neue produktionsmethode ATE236878T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9804002A SE9804002D0 (sv) 1998-11-23 1998-11-23 New manufacturing process
PCT/SE1999/002155 WO2000031035A1 (en) 1998-11-23 1999-11-22 New manufacturing process

Publications (1)

Publication Number Publication Date
ATE236878T1 true ATE236878T1 (de) 2003-04-15

Family

ID=20413379

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99963732T ATE236878T1 (de) 1998-11-23 1999-11-22 Neue produktionsmethode

Country Status (12)

Country Link
US (1) US6350877B1 (de)
EP (1) EP1133473B1 (de)
JP (1) JP4553490B2 (de)
AR (1) AR021369A1 (de)
AT (1) ATE236878T1 (de)
AU (1) AU759211B2 (de)
CA (1) CA2349195C (de)
DE (1) DE69906787T2 (de)
NZ (1) NZ511503A (de)
SE (1) SE9804002D0 (de)
WO (1) WO2000031035A1 (de)
ZA (1) ZA200103434B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011001241A (es) 2008-08-01 2011-08-03 Medicines Co Composiciones farmaceuticas y metodos para estabilizar las mismas.
EP2320740B1 (de) * 2008-08-01 2014-03-26 The Medicines Company Pharmazeutische zusammensetzungen von clividipine und verfahren zur herstellung von konzentrationen daraus mit geringem verunreinigungsgrad
CA2701087A1 (en) * 2010-04-12 2011-10-12 Alphora Research Inc. Preparation of clevidipine butyrate ring the same
CA2701272A1 (en) * 2010-04-21 2011-10-21 Alphora Research Inc. Preparation of intermediates for the synthesis of dihydropyridine calcium channel blockers
US8455655B2 (en) 2010-05-07 2013-06-04 Laboratorios Lesvi, S.L. Preparation of dihydropyridines
EP2386544B1 (de) 2010-05-07 2016-02-10 Laboratorios Lesvi, S.L. Herstellung von Dihydropyridinen
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
BR112013008601B1 (pt) 2010-10-12 2020-03-31 Chiesi Farmaceutici S.P.A. Formulações de emulsão de clevidipina contendo agentes antimicrobianos
CN102001992B (zh) * 2010-10-14 2012-05-23 清远嘉博制药有限公司 一种丁酸氯维地平的制备方法
CN102531998A (zh) * 2010-12-09 2012-07-04 天津药物研究院 α型多晶型丁酸氯维地平结晶、其制备方法、用途和药物组合物
BR112013025368A8 (pt) 2011-04-01 2018-06-12 The Medicines Co Medicamento, método para preparar um medicamento útil para reduzir danos por derrame em um sujeito com derrame, método para preparar um medicamento útil para reduzir a pressão sanguínea e reduzir danos por derrame em um sujeito com derrame
CN102827068A (zh) * 2011-06-17 2012-12-19 张锐豪 一种4-(2, 3-二氯苯基)-2, 6-二甲基-1, 4-二氢-5-甲氧基羰基-3-吡啶羧酸的制备方法
CN103420899B (zh) * 2012-05-25 2016-01-27 四川科伦药物研究有限公司 一种丁酸氯维地平的纯化方法
CN110840890A (zh) 2012-10-26 2020-02-28 凯西制药公司 用于在心力衰竭中控制血压和减轻呼吸困难的方法
CN103086956B (zh) * 2013-01-17 2015-11-04 北京嘉林药业股份有限公司 一种丁酸氯维地平中间体的纯化方法
MX385243B (es) 2014-05-19 2025-03-14 The Medicines Co Nanoparticulas de clevidipina y composiciones farmaceuticas que las contienen.
CN105198797B (zh) * 2015-11-12 2017-12-08 华仁药业股份有限公司 丁酸氯维地平的纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1093549A (en) 1976-02-16 1981-01-13 Michael Gregson Cephalosporin antibiotics
SE9303657D0 (sv) * 1993-11-05 1993-11-05 Astra Ab Short-acting dihydropyridines
SE9303744D0 (sv) * 1993-11-12 1993-11-12 Astra Ab Pharmaceutical emulsion

Also Published As

Publication number Publication date
AR021369A1 (es) 2002-07-17
SE9804002D0 (sv) 1998-11-23
DE69906787T2 (de) 2004-02-05
EP1133473A1 (de) 2001-09-19
EP1133473B1 (de) 2003-04-09
NZ511503A (en) 2002-11-26
WO2000031035A1 (en) 2000-06-02
US6350877B1 (en) 2002-02-26
AU759211B2 (en) 2003-04-10
DE69906787D1 (de) 2003-05-15
JP2002530376A (ja) 2002-09-17
CA2349195A1 (en) 2000-06-02
AU2010500A (en) 2000-06-13
ZA200103434B (en) 2002-07-26
CA2349195C (en) 2008-12-30
JP4553490B2 (ja) 2010-09-29

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties