ATE236993T1 - Antithrombose mittel und gegen den von willebrand-faktor gerichtete monoklonale antikörper - Google Patents

Antithrombose mittel und gegen den von willebrand-faktor gerichtete monoklonale antikörper

Info

Publication number
ATE236993T1
ATE236993T1 AT95938608T AT95938608T ATE236993T1 AT E236993 T1 ATE236993 T1 AT E236993T1 AT 95938608 T AT95938608 T AT 95938608T AT 95938608 T AT95938608 T AT 95938608T AT E236993 T1 ATE236993 T1 AT E236993T1
Authority
AT
Austria
Prior art keywords
von willebrand
willebrand factor
monoclonal antibodies
directed against
antibodies directed
Prior art date
Application number
AT95938608T
Other languages
English (en)
Inventor
Mitsuyo Nagano
Hiroshi Yamamoto
Morikazu Kito
Ryota Yoshimoto
Tsuyoshi Kobayashi
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of ATE236993T1 publication Critical patent/ATE236993T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT95938608T 1994-11-30 1995-11-29 Antithrombose mittel und gegen den von willebrand-faktor gerichtete monoklonale antikörper ATE236993T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP29707094 1994-11-30
PCT/JP1995/002435 WO1996017078A1 (en) 1994-11-30 1995-11-29 Antithrombotic agent and anti-von willebrand factor monoclonal antibodies

Publications (1)

Publication Number Publication Date
ATE236993T1 true ATE236993T1 (de) 2003-04-15

Family

ID=17841828

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95938608T ATE236993T1 (de) 1994-11-30 1995-11-29 Antithrombose mittel und gegen den von willebrand-faktor gerichtete monoklonale antikörper

Country Status (13)

Country Link
US (3) US5916805A (de)
EP (1) EP0795608B1 (de)
JP (1) JP3331377B2 (de)
KR (1) KR100406072B1 (de)
CN (1) CN1254275C (de)
AT (1) ATE236993T1 (de)
DE (1) DE69530316T2 (de)
DK (1) DK0795608T3 (de)
ES (1) ES2197210T3 (de)
FI (1) FI119734B (de)
NO (1) NO319738B1 (de)
PT (1) PT795608E (de)
WO (1) WO1996017078A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0795608T3 (da) * 1994-11-30 2003-07-21 Ajinomoto Kk Antitrombotisk middel og monoklonale anti-von Willebrandfaktor antistoffer
EP0852951A1 (de) 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
US6228360B1 (en) * 1998-08-19 2001-05-08 Ajinomoto Co., Inc. Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody
CA2344606A1 (en) * 1998-10-23 2000-05-04 Huabing Yuan Conformation-specific anti-von willebrand factor antibodies
CN1198198C (zh) * 2001-02-27 2005-04-20 索尼公司 字符输入方法及字符输入装置
JP2005298336A (ja) * 2002-01-29 2005-10-27 Ajinomoto Co Inc 炎症性疾患治療用薬剤
US20050136056A1 (en) * 2002-07-29 2005-06-23 Shunsuke Kageyama Pharmaceutical composition for the treatment of thrombocytopenia
AU2003252701A1 (en) * 2002-07-29 2004-02-16 Ajinomoto Co., Inc. Medicinal composition for treating thrombopenia
AU2003251238A1 (en) * 2002-08-07 2004-02-25 Umc Utrecht Holding B.V. Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha
US20070178082A1 (en) * 2002-11-08 2007-08-02 Ablynx N.V. Stabilized single domain antibodies
EP1558647B1 (de) * 2002-11-08 2015-06-10 Ablynx N.V. Einzeldomaene antikörpern gegen tnf-alpha und ihre verwendungen
US9320792B2 (en) 2002-11-08 2016-04-26 Ablynx N.V. Pulmonary administration of immunoglobulin single variable domains and constructs thereof
WO2004041862A2 (en) * 2002-11-08 2004-05-21 Ablynx N.V. Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
US20100003253A1 (en) * 2002-11-08 2010-01-07 Ablynx N.V. Single domain antibodies directed against epidermal growth factor receptor and uses therefor
US20060034845A1 (en) * 2002-11-08 2006-02-16 Karen Silence Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
NZ576284A (en) * 2003-01-10 2010-07-30 Ablynx Nv Therapeutic polypeptides, homologues thereof, fragments thereof and for use in modulating platelet-mediated aggregation
RU2357974C2 (ru) 2003-01-10 2009-06-10 Аблинкс Н.В. Терапевтические полипептиды, их гомологи, их фрагменты и их применение для модуляции агрегации, опосредованной тромбоцитами
CN1323713C (zh) * 2003-07-07 2007-07-04 张新侯 可溶性p－选择素及炭疽致死毒素的新用途
CA2578046A1 (en) * 2004-09-07 2006-03-16 Archemix Corp. Aptamer medicinal chemistry
US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
KR20070101227A (ko) 2004-09-07 2007-10-16 아케믹스 코포레이션 폰 빌레브란트 인자에 대한 앱타머 및 이의 혈전증치료제로서의 용도
PL1836500T3 (pl) * 2005-01-14 2010-12-31 Ablynx Nv Sposoby i testy do rozróżniania między różnymi postaciami chorób i zaburzeń cechujących się małopłytkowością i/lub samoistną interakcją między czynnikiem von Willebranda (vWF) a płytkami krwi
DK2444424T3 (en) 2005-05-20 2018-12-03 Ablynx Nv IMPROVED NANOL BODIES (TM) FOR TREATING AGGREGATED MEDICINAL DISORDERS
EP1918302A3 (de) * 2006-05-18 2009-11-18 AvantGen, Inc. Verfahren zur Identifikation und Isolation von epitopspezifischen Antikörpern
US8669045B2 (en) 2007-02-13 2014-03-11 Ajinomoto Co., Inc. Method for inactivating viruses with slightly acidic arginine
US20090203766A1 (en) * 2007-06-01 2009-08-13 Archemix Corp. vWF aptamer formulations and methods for use
AR070141A1 (es) * 2008-01-23 2010-03-17 Glenmark Pharmaceuticals Sa Anticuerpos humanizados especificos para el factor von willebrand
EP2252303A2 (de) * 2008-03-21 2010-11-24 Ablynx NV Von-willebrand-faktor-spezifische bindemittel und verfahren zu ihrer verwendung
EP2281827B1 (de) 2008-05-08 2013-08-21 Ajinomoto Co., Inc. Verfahren zur rückfaltung einer proteinstruktur
CN102532316B (zh) * 2010-12-24 2014-06-18 神州细胞工程有限公司 一种抗vWF单克隆抗体及其应用
CN103608463A (zh) 2011-06-23 2014-02-26 味之素株式会社 由使具有免疫球蛋白折叠结构的蛋白和能够形成亚单元结构的蛋白融合而得到的单体蛋白组成的多聚体蛋白的制备方法
US20160320416A1 (en) * 2013-12-18 2016-11-03 Siemens Healthcare Diagnostics Inc. Detection of endothelial disease
ES2924393T3 (es) * 2014-04-16 2022-10-06 Inst Nat Sante Rech Med Anticuerpos para la prevención o el tratamiento de episodios hemorrágicos
JP7775080B2 (ja) 2019-07-01 2025-11-25 トニックス ファーマ リミテッド 抗ｃｄ１５４抗体およびその使用
WO2021118845A1 (en) * 2019-12-12 2021-06-17 Corning Incorporated Light-diffusing element configured to affect thrombi formation on intravenous catheter
US20240059781A1 (en) 2021-01-06 2024-02-22 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies
WO2025248134A1 (en) 2024-05-31 2025-12-04 Tonix Pharma Limited Treatment methods comprising administration of modified cd154 antibodies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202264A (en) * 1989-10-27 1993-04-13 Health Research, Incorporated ELISA using multi-species antibodies for detection of von Willebrand factor in multiple species
US5342830A (en) * 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents
DK0795608T3 (da) * 1994-11-30 2003-07-21 Ajinomoto Kk Antitrombotisk middel og monoklonale anti-von Willebrandfaktor antistoffer
AU724579B2 (en) 1996-04-01 2000-09-28 Sankyo Company Limited Anti-Fas recombinant antibodies and DNA therefor

Also Published As

Publication number Publication date
CN1254275C (zh) 2006-05-03
US6280731B1 (en) 2001-08-28
FI972279A0 (fi) 1997-05-29
NO972253L (no) 1997-07-29
DE69530316D1 (de) 2003-05-15
ES2197210T3 (es) 2004-01-01
EP0795608B1 (de) 2003-04-09
WO1996017078A1 (en) 1996-06-06
US5916805A (en) 1999-06-29
EP0795608A1 (de) 1997-09-17
DK0795608T3 (da) 2003-07-21
CN1174575A (zh) 1998-02-25
NO319738B1 (no) 2005-09-12
KR100406072B1 (ko) 2004-03-30
FI972279L (fi) 1997-07-29
EP0795608A4 (de) 2001-11-28
US20020028204A1 (en) 2002-03-07
FI119734B (fi) 2009-02-27
US6793920B2 (en) 2004-09-21
PT795608E (pt) 2003-08-29
JP3331377B2 (ja) 2002-10-07
DE69530316T2 (de) 2004-02-12
NO972253D0 (no) 1997-05-16

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