ATE237614T1 - Benzo(c)chinolizin derivate,deren herstellung und verwendung als 5-alfa-reduktase inhibitoren - Google Patents

Benzo(c)chinolizin derivate,deren herstellung und verwendung als 5-alfa-reduktase inhibitoren

Info

Publication number: ATE237614T1
Authority: AT; Austria
Prior art keywords: benzo; preparation; derivatives; quinolicine; alfa
Prior art date: 1996-02-09

Application number

AT97903230T

Other languages

English (en)

Inventor

Antonio Guarna

Mario Serio

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-09

Filing date

1997-02-07

Publication date

2003-05-15

1997-02-07 Application filed by Applied Research Systems filed Critical Applied Research Systems

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE237614T1 publication Critical patent/ATE237614T1/de

Links

239000003112 inhibitor Substances 0.000 title 1
UOGFZJRMCBHRQU-UHFFFAOYSA-N 10ah-benzo[c]quinolizine Chemical class N12C=CC=CC2=CC=C2C1C=CC=C2 UOGFZJRMCBHRQU-UHFFFAOYSA-N 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)

AT97903230T 1996-02-09 1997-02-07 Benzo(c)chinolizin derivate,deren herstellung und verwendung als 5-alfa-reduktase inhibitoren ATE237614T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT96FI000019A IT1286545B1 (it)	1996-02-09	1996-02-09	Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi
PCT/EP1997/000552 WO1997029107A1 (en)	1996-02-09	1997-02-07	BENZO[C]QUINOLIZINE DERIVATIVES, THEIR PREPARATION AND USE AS 5α-REDUCTASES INHIBITORS

Publications (1)

Publication Number	Publication Date
ATE237614T1 true ATE237614T1 (de)	2003-05-15

Family

ID=11351478

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97903230T ATE237614T1 (de)	1996-02-09	1997-02-07	Benzo(c)chinolizin derivate,deren herstellung und verwendung als 5-alfa-reduktase inhibitoren

Country Status (25)

Country	Link
US (3)	US6303622B1 (de)
EP (1)	EP0880520B1 (de)
JP (1)	JP2000504680A (de)
KR (1)	KR100480448B1 (de)
CN (1)	CN1116296C (de)
AT (1)	ATE237614T1 (de)
AU (1)	AU711886C (de)
BG (1)	BG64596B1 (de)
CZ (1)	CZ298061B6 (de)
DE (1)	DE69720966T2 (de)
DK (1)	DK0880520T3 (de)
EA (1)	EA000975B1 (de)
EE (1)	EE04058B1 (de)
ES (1)	ES2192263T3 (de)
HU (1)	HUP9900509A3 (de)
IL (2)	IL125628A0 (de)
IT (1)	IT1286545B1 (de)
MX (1)	MX9806229A (de)
NO (2)	NO320155B1 (de)
NZ (1)	NZ331256A (de)
PL (1)	PL187618B1 (de)
PT (1)	PT880520E (de)
SK (1)	SK283299B6 (de)
UA (1)	UA67724C2 (de)
WO (1)	WO1997029107A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITFI970193A1 (it) *	1997-08-01	1999-02-01	Applied Research Systems	Uso di derivati benzo(c) chinolizinici come regolatori della crescita delle piante e composizioni ad uso agricolo che contengono tali
EP0926148A1 (de) *	1997-12-23	1999-06-30	Applied Research Systems Ars Holding N.V.	Benzo (c)quinolizine-derivate,deren herstellung und verwendung als 5-alpha-reduktase-hemmer
US6723850B1 (en) *	1998-08-03	2004-04-20	Applied Research Systems Ars Holding N.V.	Process for the synthesis of (1-H)-benzo[c]quinolizin-3-ones derivatives
AP2007004244A0 (en)	2005-05-10	2007-12-31	Intermune Inc	Method of modulating stress-activated protein kinase system
JP5463034B2 (ja) *	2005-05-20	2014-04-09	アラントス・フアーマシユーテイカルズ・ホールデイング・インコーポレイテツド	ピリミジン若しくはトリアジン縮合二環式メタロプロテアーゼ阻害薬
US20070155738A1 (en)	2005-05-20	2007-07-05	Alantos Pharmaceuticals, Inc.	Heterobicyclic metalloprotease inhibitors
EP2296653B1 (de)	2008-06-03	2016-01-27	Intermune, Inc.	Verbindungen und verfahren zur behandlung von entzündungserkrankungen und fibrotischen erkrankungen
AR092742A1 (es)	2012-10-02	2015-04-29	Intermune Inc	Piridinonas antifibroticas
RU2692485C2 (ru)	2014-04-02	2019-06-25	Интермьюн, Инк.	Противофиброзные пиридиноны
CN105001216B (zh) *	2015-07-08	2017-03-01	中国科学院兰州化学物理研究所	一种喹嗪酮的制备方法
CN107089980B (zh) *	2017-05-11	2019-08-30	合肥工业大学	一种手性苯并[a]喹嗪-2-酮类化合物及其不对称催化合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3455929A (en) *	1966-08-15	1969-07-15	Bristol Myers Co	Esters of 1,4-dihydroquinoline-n-carboxylic acids and thione acids
FR1534278A (fr) *	1966-08-15	1968-07-26	Bristol Myers Co	Procédé de fabrication de 1, 4-dihydroquinoléine-n-carboxylates d'alcoyle
US3625877A (en) *	1968-01-08	1971-12-07	Eastman Kodak Co	High-modulus polycarbonate compositions
SU1027166A1 (ru)	1981-09-11	1983-07-07	Киевский Ордена Ленина Государственный Университет Им.Т.Г.Шевченко	Способ получени 1,2-полиметиленкетоцианоазагетероциклов
IE57014B1 (en)	1983-03-25	1992-03-11	Wyeth John & Brother Ltd	Benzoquinolizines

1996
- 1996-02-09 IT IT96FI000019A patent/IT1286545B1/it active IP Right Grant
1997
- 1997-02-07 EE EE9800233A patent/EE04058B1/xx not_active IP Right Cessation
- 1997-02-07 DE DE69720966T patent/DE69720966T2/de not_active Expired - Fee Related
- 1997-02-07 WO PCT/EP1997/000552 patent/WO1997029107A1/en not_active Ceased
- 1997-02-07 PL PL97328123A patent/PL187618B1/pl not_active IP Right Cessation
- 1997-02-07 SK SK1044-98A patent/SK283299B6/sk not_active IP Right Cessation
- 1997-02-07 NZ NZ331256A patent/NZ331256A/xx unknown
- 1997-02-07 EP EP97903230A patent/EP0880520B1/de not_active Expired - Lifetime
- 1997-02-07 EA EA199800701A patent/EA000975B1/ru unknown
- 1997-02-07 HU HU9900509A patent/HUP9900509A3/hu unknown
- 1997-02-07 KR KR10-1998-0705848A patent/KR100480448B1/ko not_active Expired - Fee Related
- 1997-02-07 CZ CZ0228998A patent/CZ298061B6/cs not_active IP Right Cessation
- 1997-02-07 US US09/117,583 patent/US6303622B1/en not_active Expired - Fee Related
- 1997-02-07 IL IL12562897A patent/IL125628A0/xx active IP Right Grant
- 1997-02-07 PT PT97903230T patent/PT880520E/pt unknown
- 1997-02-07 DK DK97903230T patent/DK0880520T3/da active
- 1997-02-07 AT AT97903230T patent/ATE237614T1/de not_active IP Right Cessation
- 1997-02-07 AU AU17672/97A patent/AU711886C/en not_active Ceased
- 1997-02-07 JP JP9528158A patent/JP2000504680A/ja not_active Ceased
- 1997-02-07 CN CN97192097A patent/CN1116296C/zh not_active Expired - Fee Related
- 1997-02-07 ES ES97903230T patent/ES2192263T3/es not_active Expired - Lifetime
- 1997-07-02 UA UA98094739A patent/UA67724C2/uk unknown
1998
- 1998-07-24 NO NO19983444A patent/NO320155B1/no not_active IP Right Cessation
- 1998-07-30 BG BG102661A patent/BG64596B1/bg unknown
- 1998-08-03 IL IL125628A patent/IL125628A/en not_active IP Right Cessation
- 1998-08-03 MX MX9806229A patent/MX9806229A/es unknown
2001
- 2001-06-25 US US09/891,088 patent/US6552034B2/en not_active Expired - Fee Related
- 2001-06-25 US US09/888,952 patent/US6555549B2/en not_active Expired - Fee Related
2004
- 2004-11-24 NO NO20045132A patent/NO20045132L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1116296C (zh)	2003-07-30
US6303622B1 (en)	2001-10-16
EE04058B1 (et)	2003-06-16
EP0880520A1 (de)	1998-12-02
AU711886C (en)	2002-10-17
CZ298061B6 (cs)	2007-06-06
US20010047098A1 (en)	2001-11-29
CZ228998A3 (cs)	1998-10-14
HUP9900509A2 (hu)	1999-06-28
PL187618B1 (pl)	2004-08-31
EE9800233A (et)	1998-12-15
ES2192263T3 (es)	2003-10-01
NO983444D0 (no)	1998-07-24
SK283299B6 (sk)	2003-05-02
EA000975B1 (ru)	2000-08-28
JP2000504680A (ja)	2000-04-18
ITFI960019A0 (de)	1996-02-09
ITFI960019A1 (it)	1997-08-09
KR19990082126A (ko)	1999-11-15
KR100480448B1 (ko)	2005-08-31
DE69720966T2 (de)	2004-05-19
IT1286545B1 (it)	1998-07-15
BG64596B1 (bg)	2005-08-31
EP0880520B1 (de)	2003-04-16
UA67724C2 (en)	2004-07-15
US6555549B2 (en)	2003-04-29
MX9806229A (es)	1998-11-30
EA199800701A1 (ru)	1999-02-25
BG102661A (en)	1999-04-30
US6552034B2 (en)	2003-04-22
NO320155B1 (no)	2005-11-07
WO1997029107A1 (en)	1997-08-14
NO20045132L (no)	1998-07-24
HK1018783A1 (en)	2000-01-07
US20010044542A1 (en)	2001-11-22
NO983444L (no)	1998-07-24
PT880520E (pt)	2003-07-31
DK0880520T3 (da)	2003-08-11
IL125628A0 (en)	1999-04-11
AU1767297A (en)	1997-08-28
HUP9900509A3 (en)	1999-11-29
PL328123A1 (en)	1999-01-18
SK104498A3 (en)	1998-12-02
DE69720966D1 (de)	2003-05-22
CN1210536A (zh)	1999-03-10
NZ331256A (en)	1999-06-29
AU711886B2 (en)	1999-10-21
IL125628A (en)	2006-10-31

Legal Events

Date

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Title

Description

2003-11-15

UEP

Publication of translation of european patent specification

Ref document number: 0880520

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2010-11-15

REN

Ceased due to non-payment of the annual fee

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