ATE237682T1 - Universale spenderzellen - Google Patents

Universale spenderzellen

Info

Publication number
ATE237682T1
ATE237682T1 AT92915715T AT92915715T ATE237682T1 AT E237682 T1 ATE237682 T1 AT E237682T1 AT 92915715 T AT92915715 T AT 92915715T AT 92915715 T AT92915715 T AT 92915715T AT E237682 T1 ATE237682 T1 AT E237682T1
Authority
AT
Austria
Prior art keywords
cells
cell
class
universal donor
donor cells
Prior art date
Application number
AT92915715T
Other languages
English (en)
Inventor
Peter J Simms
Alfred L M Bothwell
Eileen A Elliot
Richard A Flavell
Joseph Madri
Scott Rollins
Leonard Bell
Stephen Squinto
Original Assignee
Oklahoma Med Res Found
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Med Res Found, Univ Yale filed Critical Oklahoma Med Res Found
Application granted granted Critical
Publication of ATE237682T1 publication Critical patent/ATE237682T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
AT92915715T 1991-07-15 1992-07-14 Universale spenderzellen ATE237682T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72992691A 1991-07-15 1991-07-15
US90639492A 1992-06-29 1992-06-29
PCT/US1992/005920 WO1993002188A1 (en) 1991-07-15 1992-07-14 Universal donor cells

Publications (1)

Publication Number Publication Date
ATE237682T1 true ATE237682T1 (de) 2003-05-15

Family

ID=27111956

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92915715T ATE237682T1 (de) 1991-07-15 1992-07-14 Universale spenderzellen

Country Status (6)

Country Link
EP (2) EP0591462B1 (de)
JP (2) JPH06506604A (de)
AT (1) ATE237682T1 (de)
CA (1) CA2113089C (de)
DE (1) DE69233010T2 (de)
WO (1) WO1993002188A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9100481D0 (en) * 1991-01-10 1991-02-20 Inst Nat Sante Rech Med Genetically engineered mice
JPH07500343A (ja) * 1991-10-21 1995-01-12 セル　ジェネシス，インコーポレイティド 結合細胞及び免疫抑制の療法
AU5965294A (en) * 1993-01-08 1994-08-15 Exemplar Corporation An (in vitro)/(in vivo) method for identifying anti-neoplastic drugs
WO1995004064A1 (en) 1993-07-29 1995-02-09 The Regents Of The University Of California Polynucleotide decoys that ihnibit mhc-ii expression and uses thereof
US5859226A (en) * 1993-07-29 1999-01-12 Regents Of The University Of California, The Polynucleotide decoys that inhibit MHC-II expression and uses thereof
WO1995004756A1 (en) * 1993-08-11 1995-02-16 Alexion Pharmaceuticals, Inc. Complement inhibitor proteins of non-human primates
EP0871414B1 (de) * 1994-03-14 2004-04-28 Cryolife, Inc Herstellungsverfahren von gewebe zur implantation
US6156306A (en) * 1994-08-17 2000-12-05 Albert Einstein College Of Medicine Of Yeshiva University Pancreatic β-cells for allogeneic transplantation without immunosuppression
US5629194A (en) * 1994-10-21 1997-05-13 Diacrin, Inc. Isolated porcine pancreatic cells for use in treatment of diseases characterized by insufficient insulin activity
WO1996037602A1 (en) * 1995-05-26 1996-11-28 Diacrin, Inc. Porcine hepatocytes for use in treatment of disorders characterized by insufficient liver function
US5766584A (en) * 1995-06-02 1998-06-16 Massachusetts Institute Of Technology Inhibition of vascular smooth muscle cell proliferation with implanted matrix containing vascular endothelial cells
AU6657996A (en) * 1995-07-18 1997-02-18 Guido Krupp Ribozymes for the selective inhibition of expression by mhc llele genes, and drugs containing such ribozymes
CA2227584A1 (en) * 1995-08-04 1997-02-20 The General Hospital Corporation Transgenic swine and swine cells having human hla genes
US6166288A (en) * 1995-09-27 2000-12-26 Nextran Inc. Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
AU1933897A (en) * 1996-03-22 1997-10-17 Imutran Limited Surfaces which prevent or reduce complement activation
US6022863A (en) * 1996-05-21 2000-02-08 Yale University Regulation of gene expression
ATE313256T1 (de) * 1997-07-14 2006-01-15 Nippon Meat Packers Transgene schweine
US20090087414A1 (en) 2005-04-21 2009-04-02 Pervasis Therapeutics, Inc. Materials and methods for altering an immune response to exogenous and endogenous immunogens, including syngeneic and non-syngeneic cells, tissues or organs
CN101257861B (zh) 2005-06-21 2012-12-05 渗透治疗有限公司 用于增强血管通路的方法和组合物
ES2376131T3 (es) * 2006-09-21 2012-03-09 Tissue Genesis Matrices de administración de células.
JP2011069570A (ja) * 2009-09-28 2011-04-07 Fujitsu General Ltd ヒートポンプサイクル装置
MX373460B (es) * 2014-03-11 2020-04-07 Cellectis Metodo para generar celulas t compatibles para el trasplante alogenico.
WO2017218515A1 (en) 2016-06-14 2017-12-21 Regeneron Pharmaceuticals, Inc. Anti-c5 antibodies and uses thereof
WO2019006127A1 (en) * 2017-06-28 2019-01-03 Rutgers, The State University Of New Jersey ORGANOIDS DERIVED FROM A SINGLE RENAL CELL
WO2019006113A1 (en) * 2017-06-28 2019-01-03 Rutgers, The State University Of New Jersey ORGANOIDS DERIVED FROM A SINGLE CEREBRAL CELL
MX2020006113A (es) 2017-12-13 2020-08-24 Regeneron Pharma Combinaciones de anticuerpos anti-c5 y usos de las mismas.
CA3123408A1 (en) * 2018-12-16 2020-06-25 Figene, Llc Therapeutic uses of gene edited fibroblasts

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL82390A0 (en) * 1986-05-02 1987-10-30 Genentech Inc Nucleic acid and methods for the synthesis of novel daf compositions
US4883755A (en) * 1987-10-28 1989-11-28 Thomas Jefferson University Method of reendothelializing vascular linings
IT1230047B (it) * 1989-07-04 1991-09-27 Giovanni Brotzu Protesi vascolare contenente nella parete microcapsule inglobanti cellule produttrici di ormoni.
JP2750220B2 (ja) * 1989-07-21 1998-05-13 ワシントン ユニバーシティ 組換え産生したヒト細胞膜補助因子タンパク（ｍｃｐ）
JPH04501510A (ja) * 1989-07-25 1992-03-19 セル　ジェネシス，インコーポレイティド 普遍的なドナー細胞及びキメラ性哺乳類宿主のための相同性組換え
WO1991005855A1 (en) * 1989-10-12 1991-05-02 Imutran Limited Modified biological material
EP0537171B1 (de) * 1990-05-11 2002-09-18 The Austin Research Institute CD46 Isoformen
WO1992009688A1 (en) * 1990-11-21 1992-06-11 Massachusetts Institute Of Technology MICE HAVING β2 MICROGLOBULIN GENE DISRUPTION

Also Published As

Publication number Publication date
CA2113089C (en) 2007-11-06
JPH06506604A (ja) 1994-07-28
EP1041142A2 (de) 2000-10-04
EP0591462A1 (de) 1994-04-13
WO1993002188A1 (en) 1993-02-04
JPH1057054A (ja) 1998-03-03
EP0591462B1 (de) 2003-04-16
DE69233010T2 (de) 2004-02-19
DE69233010D1 (de) 2003-05-22
EP1041142A3 (de) 2007-10-24
CA2113089A1 (en) 1993-02-04

Similar Documents

Publication Publication Date Title
DE69233010D1 (de) Universale spenderzellen
DE69020151D1 (de) Genetisch geformte neue pflanzenphenotypen.
NO173741C (no) DNA-sekvens for modifisert protein C, vektor inneholdende denne, patte-dyrceller transfektert med vektorer, og fremgangsmaate for fremstilling av nevnte protein
DK288183D0 (da) Fremgangsmade til fremstilling af et oligonucleotidt terapeutisk middel
DE69229476D1 (de) Ospa proteine von borrelia burgdorferi untergruppen, dafür kodierende gene sowie impfstoffe
FI881185A0 (fi) Human mangan-superoxiddismutas (hmn-sod).
FI971613A7 (fi) Defektiivisiä adenoviruksia, jotka käsittävät terapeuttisen geenin ja immunoprotektiivisen geenin
DE69131321D1 (de) Mutationen in der 5'-3'-exonukleaseaktivität thermostabiler dna-polymerasen
ATE144281T1 (de) Hefezellen der gattung-schwanniomyces
DK0614980T3 (da) Trans-dominante TAT-varianter fra humant immundeficiens-virus
NZ234453A (en) Recombinant dna encoding urate oxidase, and vector, host, protein and pharmaceutical compositions associated therewith
DK0587742T3 (da) Vitaminafhængig carboxylase
DK0630409T3 (da) Defekt-pakkende ikke-onkovirus-vektorer baseret på MPMV
DE50010519D1 (de) Pharmazeutische Zusammensetzungen zur Therapie der Herzinsuffizienz
WO2004035799A3 (de) Virale vektoren und deren verwendung für die gentherapie
WO1994013812A3 (en) Novel entomopoxvirus genes, proteins and methods of use thereof
DK349688D0 (da) Bomologe af humant aprotinin, vaertsstamme samt ekspressionsvektorer til deres fremstilling og deres anvendelse som laegemidler
WO2000071078A3 (fr) Composition destinee a la mise en oeuvre d'un traitement antitumoral ou antiviral chez un mammifere
AU3870195A (en) A novel family of protease inhibitors, and other biologic active substances
DE3789525D1 (de) Das F-Protein vom AIDS-Virus enthaltender Impfstoff.
DK0627004T3 (da) Forbedringer ved eller i forbindelse med malariavaccine
DE3686786D1 (de) Menschliche proteine des chinolinesterase-typs und ihre herstellung.
BR9915970A (pt) Vìrus recombinante expressando dna exógenocodificando cd80 felino, ctla-4 felino ou cd86 felinoe usos do mesmo
CA2002403A1 (en) Injury-stimulated dna-sequence from solanum tuberosum and its use
Meerovitch Effects of cyclosporins on lymphokine gene expression

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties