ATE239465T1 - Verwendung von 2,7,8-trimethyl-2-( beta- carboxyethyl )-6-hydroxy-chroman (llu-alpha) - Google Patents
Verwendung von 2,7,8-trimethyl-2-( beta- carboxyethyl )-6-hydroxy-chroman (llu-alpha)Info
- Publication number
- ATE239465T1 ATE239465T1 AT95929559T AT95929559T ATE239465T1 AT E239465 T1 ATE239465 T1 AT E239465T1 AT 95929559 T AT95929559 T AT 95929559T AT 95929559 T AT95929559 T AT 95929559T AT E239465 T1 ATE239465 T1 AT E239465T1
- Authority
- AT
- Austria
- Prior art keywords
- chromane
- llu
- carboxyethyl
- trimethyl
- beta
- Prior art date
Links
- VMJQLPNCUPGMNQ-HNNXBMFYSA-N 3-[(2s)-6-hydroxy-2,7,8-trimethyl-3,4-dihydrochromen-2-yl]propanoic acid Chemical compound C1C[C@@](C)(CCC(O)=O)OC2=C(C)C(C)=C(O)C=C21 VMJQLPNCUPGMNQ-HNNXBMFYSA-N 0.000 title 1
- VMJQLPNCUPGMNQ-UHFFFAOYSA-N gamma-CEHC Chemical compound C1CC(C)(CCC(O)=O)OC2=C(C)C(C)=C(O)C=C21 VMJQLPNCUPGMNQ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000002934 diuretic Substances 0.000 abstract 3
- 230000001939 inductive effect Effects 0.000 abstract 3
- 230000001452 natriuretic effect Effects 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 230000029142 excretion Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000012495 positive regulation of renal sodium excretion Effects 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Read Only Memory (AREA)
- For Increasing The Reliability Of Semiconductor Memories (AREA)
- Dram (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/290,430 US6150402A (en) | 1994-08-15 | 1994-08-15 | Natriuretic compounds |
| PCT/US1995/010411 WO1996005191A1 (en) | 1994-08-15 | 1995-08-15 | Natriuretic cyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE239465T1 true ATE239465T1 (de) | 2003-05-15 |
Family
ID=23115959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95929559T ATE239465T1 (de) | 1994-08-15 | 1995-08-15 | Verwendung von 2,7,8-trimethyl-2-( beta- carboxyethyl )-6-hydroxy-chroman (llu-alpha) |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6150402A (de) |
| EP (1) | EP0792270B1 (de) |
| JP (2) | JPH10506383A (de) |
| AT (1) | ATE239465T1 (de) |
| AU (1) | AU3327795A (de) |
| DE (1) | DE69530701D1 (de) |
| WO (1) | WO1996005191A1 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6120432A (en) | 1997-04-23 | 2000-09-19 | Vascular Science Inc. | Medical grafting methods and apparatus |
| AU2474399A (en) | 1998-01-26 | 1999-08-09 | Mitokor | Mitochondria protecting agents for treating mitochondria associated diseases |
| US6048891A (en) * | 1998-12-17 | 2000-04-11 | Loma Linda University Medical Center | Use of γ-tocopherol and its oxidative metabolite LLU-α in the treatment of natriuretic disease |
| US6426362B1 (en) | 1999-10-08 | 2002-07-30 | Galileo Laboratories, Inc. | Formulations of tocopherols and methods of making and using them |
| KR100730338B1 (ko) * | 2000-03-31 | 2007-06-19 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | γ-토코트리에놀 함유 이뇨제 |
| US7034054B2 (en) * | 2000-12-15 | 2006-04-25 | Galileo Pharmaceuticals, Inc. | Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols |
| AU2002352726A1 (en) | 2001-11-15 | 2003-06-10 | Galileo Laboratories, Inc. | Formulations and methods for treatment or amelioration of inflammatory conditions |
| JP4118623B2 (ja) * | 2002-07-23 | 2008-07-16 | 松下電器産業株式会社 | 不揮発性半導体記憶装置 |
| AU2003291012A1 (en) * | 2002-11-15 | 2004-06-15 | Galileo Pharmaceuticals, Inc. | Chroman derivatives for the reduction of inflammation symptoms |
| ITTO20030140U1 (it) * | 2003-09-16 | 2005-03-17 | Interfila Srl | Matita cosmetica |
| CA2580584C (en) * | 2003-09-19 | 2015-07-28 | Galileo Pharmaceuticals, Inc. | Use of alpha-tocotrienol for treatment of mitochondrial diseases |
| US7435837B2 (en) * | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| US20050261347A1 (en) * | 2003-10-24 | 2005-11-24 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| MXPA06012621A (es) * | 2004-05-05 | 2006-12-15 | Hoffmann La Roche | Arilsulfonil benzodioxanos utiles para la modulacion del receptor 5-ht6, el receptor 5-ht2a o ambos. |
| CN101091222A (zh) * | 2004-10-26 | 2007-12-19 | 斯班逊有限公司 | 非易失性存储装置 |
| BRPI0515835A (pt) * | 2004-12-21 | 2008-08-12 | Hoffmann La Roche | derivados de tetralina e de indano e seus usos |
| ES2306275T3 (es) * | 2004-12-21 | 2008-11-01 | F. Hoffmann-La Roche Ag | Derivados de cromano y sus usos como ligandos dde receptores 5-ht. |
| JP4738418B2 (ja) | 2004-12-21 | 2011-08-03 | エフ．ホフマン−ラ ロシュ アーゲー | クロマン誘導体及びｃｎｓ障害の処置におけるその使用 |
| PT1831159E (pt) * | 2004-12-21 | 2010-03-03 | Hoffmann La Roche | Derivados de tetralina e de indano e as suas utilizações |
| CA2591800A1 (en) * | 2004-12-21 | 2006-06-29 | F.Hoffmann-La Roche Ag | Tetralin and indane derivatives and uses thereof as 5-ht antagonists |
| AU2006239897A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Crystal forms of {[(2R)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride |
| CA2604915A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | New therapeutic combinations for the treatment or prevention of depression |
| JP2008538576A (ja) * | 2005-04-22 | 2008-10-30 | ワイス | クロマンおよびクロメン誘導体およびその使用 |
| CA2610152C (en) * | 2005-06-01 | 2018-04-10 | Edison Pharmaceuticals, Inc. | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| ES2823728T3 (es) * | 2005-09-15 | 2021-05-10 | Ptc Therapeutics Inc | Variantes de cola de agentes terapéuticos con actividad redox para el tratamiento de enfermedades mitocondriales y otras afecciones y la modulación de biomarcadores de energía |
| WO2007051735A1 (en) * | 2005-11-03 | 2007-05-10 | F. Hoffmann-La Roche Ag | Arylsulfonylchromans as 5-ht6 inhibitors indolylmaleimide derivatives as protein kinase inhibitors |
| EA019675B1 (ru) | 2006-02-22 | 2014-05-30 | Эдисон Фармасьютикалз, Инк. | Редокс-активные терапевтические средства для лечения митохондриальных заболеваний и модуляции биомаркера коэнзима q |
| US8580746B2 (en) * | 2006-03-30 | 2013-11-12 | Palatin Technologies, Inc. | Amide linkage cyclic natriuretic peptide constructs |
| MX2008012663A (es) * | 2006-03-30 | 2008-10-13 | Palatin Technologies Inc | Constructos ciclicos de peptidos natriureticos. |
| AU2007233123A1 (en) * | 2006-03-30 | 2007-10-11 | Palatin Technologies, Inc. | Linear natriuretic peptide constructs |
| JP2009541248A (ja) * | 2006-06-20 | 2009-11-26 | エフ．ホフマン−ラ ロシュ アーゲー | アリールスルホンアミジルテトラリン誘導体及びそれらの使用 |
| WO2007147763A1 (en) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Arylsulfonyl naphthalene derivatives and uses thereof |
| KR101066306B1 (ko) * | 2006-06-20 | 2011-09-20 | 에프. 호프만-라 로슈 아게 | 테트랄린 및 인데인 유도체 및 이들의 용도 |
| EP3018122B1 (de) | 2007-11-06 | 2018-10-10 | BioElectron Technology Corporation | 4-(p-quinonyl)-2-hydroxybutanamid-derivate zur behandlung von mitochondrialen erkrankungen |
| BRPI0918139B1 (pt) | 2008-09-10 | 2024-04-30 | Ptc Therapeutics, Inc | Composição, alimento medicinal ou funcional, suplemento alimentar ou dietético para tratamento de distúrbios de desenvolvimento pervasivos com terapêuticos redox-ativos |
| EP2678002A2 (de) | 2011-02-25 | 2014-01-01 | Medtronic, Inc. | Therapie für nierenerkrankungen und/oder herzinsuffizienz |
| EP2750697A4 (de) | 2011-09-02 | 2015-03-25 | Medtronic Inc | Chimäre natriuretische peptidzusammensetzungen und verfahren zu ihrer herstellung |
| US20160115141A1 (en) * | 2013-05-31 | 2016-04-28 | Edison Pharmaceuticals, Inc. | Carboxylic acid derivatives for treatment of oxidative stress disorders |
| WO2016100579A1 (en) | 2014-12-16 | 2016-06-23 | Edison Pharmaceuticals, Inc., | Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide |
| CN113024369A (zh) | 2015-12-17 | 2021-06-25 | Ptc医疗公司 | 用于治疗氧化应急障碍的化合物 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL185719B (nl) * | 1954-03-08 | Enichem Elastomers | Werkwijze voor het bereiden van vulcaniseerbare acrylelastomeren. | |
| GB947885A (en) * | 1961-04-12 | 1964-01-29 | Vitamins Ltd | Improvements in or relating to the preparation of chromanols |
| GB949715A (en) * | 1961-04-12 | 1964-02-19 | Vitamins Ltd | Improvements in or relating to chromanols |
| US3726904A (en) * | 1970-11-16 | 1973-04-10 | Ciba Geigy Corp | 2,3-dihydro-5-(2-nitro-1-alkenyl)-benzofuran-2-carboxylic acid and pharmaceutically acceptable salts |
| US3947473A (en) * | 1972-12-22 | 1976-03-30 | Hoffman-La Roche Inc. | Antioxidant chroman compounds |
| US4003919A (en) * | 1973-11-19 | 1977-01-18 | Hoffmann-La Roche Inc. | Antioxidant chroman compounds |
| US4026907A (en) * | 1973-11-19 | 1977-05-31 | Hoffmann-La Roche Inc. | Antioxidant chroman compounds |
| US4018799A (en) * | 1973-11-19 | 1977-04-19 | Hoffmann-La Roche Inc. | Antioxidant chroman compounds |
| US4100294A (en) * | 1976-12-06 | 1978-07-11 | Merck & Co., Inc. | 5-(Hydroxy (substituted) methyl)-2,3-dihydrobenzo furan-2-carboxylic acid and its derivatives |
| US4127608A (en) * | 1977-05-17 | 1978-11-28 | Hoffmann-La Roche Inc. | Synthesis of Vitamin E |
| EP0003484B1 (de) * | 1978-01-30 | 1981-10-14 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Verfahren zur Herstellung von Chromanderivaten |
| US4237130A (en) * | 1979-06-21 | 1980-12-02 | Merck & Co., Inc. | 2,3-Dihydro-6,7-disubstituted-5-(substituted sulfonyl)benzofuran-2-carboxylic acids |
| DE3010504A1 (de) * | 1980-03-19 | 1981-10-01 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von 2-hydroxyalkylchromanen |
| US4321270A (en) * | 1981-01-29 | 1982-03-23 | E. R. Squibb & Sons, Inc. | Substituted chromans |
| JPS57145871A (en) * | 1981-03-05 | 1982-09-09 | Eisai Co Ltd | Chromanolcarboxylic derivative |
| JPS6163671A (ja) * | 1984-09-05 | 1986-04-01 | Shionogi & Co Ltd | ２，３−ジヒドロベンゾフラン−５−スルホンアミド誘導体および降圧利尿剤 |
| US4728650A (en) * | 1985-05-13 | 1988-03-01 | Kuraray Co., Ltd. | 3,4-dihydrobenzopyran derivatives and medicinal uses thereof |
| US4791209A (en) * | 1985-05-22 | 1988-12-13 | Chugai Seiyako Kabushiki Kaisha | Furobenzisoxazole derivatives |
| DK36389A (da) * | 1988-02-05 | 1989-08-06 | Eastman Kodak Co | Praeparat og fremgangsmaade til at forebygge vaevskader ved reperfusion |
| JPH01303467A (ja) * | 1988-05-31 | 1989-12-07 | Mita Ind Co Ltd | 画像形成装置の中間調制御装置 |
| EP0369082A1 (de) * | 1988-11-14 | 1990-05-23 | Merrell Dow Pharmaceuticals Inc. | Herzschutz-Tocopherolanaloge |
| IT1231341B (it) * | 1989-08-18 | 1991-11-28 | Foscama Biomed Chim Farma | 2,3 diidro 5 ossi 4,6,7 trimetilbenzofurani 2 (rs) sostituiti, utili come farmaci antiossidanti con proprieta' mucoregolatrici e antiischemiche. |
| JP3029840B2 (ja) * | 1990-01-18 | 2000-04-10 | 旭電化工業株式会社 | 光学活性なクロマン―２―エタノール誘導体の製造方法およびその中間体 |
| FR2676056B1 (fr) * | 1991-05-03 | 1993-07-16 | Adir | Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| DE4121468A1 (de) * | 1991-06-28 | 1993-01-14 | Deutsches Primatenzentrum Gmbh | Antivirale substanzen und diese enthaltende arzneimittel |
-
1994
- 1994-08-15 US US08/290,430 patent/US6150402A/en not_active Expired - Lifetime
-
1995
- 1995-08-15 AU AU33277/95A patent/AU3327795A/en not_active Abandoned
- 1995-08-15 AT AT95929559T patent/ATE239465T1/de not_active IP Right Cessation
- 1995-08-15 JP JP8507600A patent/JPH10506383A/ja active Pending
- 1995-08-15 EP EP95929559A patent/EP0792270B1/de not_active Expired - Lifetime
- 1995-08-15 DE DE69530701T patent/DE69530701D1/de not_active Expired - Lifetime
- 1995-08-15 WO PCT/US1995/010411 patent/WO1996005191A1/en not_active Ceased
-
1996
- 1996-07-09 JP JP9507600A patent/JPH10510656A/ja active Pending
-
1998
- 1998-04-09 US US09/057,731 patent/US6083982A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10510656A (ja) | 1998-10-13 |
| EP0792270A1 (de) | 1997-09-03 |
| AU3327795A (en) | 1996-03-07 |
| US6150402A (en) | 2000-11-21 |
| EP0792270B1 (de) | 2003-05-07 |
| JPH10506383A (ja) | 1998-06-23 |
| DE69530701D1 (de) | 2003-06-12 |
| US6083982A (en) | 2000-07-04 |
| WO1996005191A1 (en) | 1996-02-22 |
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