ATE240969T1 - VERFAHREN ZUR REINIGUNG VON ßBASICß FIBROBLASTEN WACHSTUMSFAKTOR - Google Patents

VERFAHREN ZUR REINIGUNG VON ßBASICß FIBROBLASTEN WACHSTUMSFAKTOR

Info

Publication number
ATE240969T1
ATE240969T1 AT94925093T AT94925093T ATE240969T1 AT E240969 T1 ATE240969 T1 AT E240969T1 AT 94925093 T AT94925093 T AT 94925093T AT 94925093 T AT94925093 T AT 94925093T AT E240969 T1 ATE240969 T1 AT E240969T1
Authority
AT
Austria
Prior art keywords
growth factor
purifying
ßbasicß
fibroblasts growth
cation exchange
Prior art date
Application number
AT94925093T
Other languages
English (en)
Inventor
Paula J Shadle
Kate B Silverness
Robert S King
Original Assignee
Scios Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scios Inc filed Critical Scios Inc
Application granted granted Critical
Publication of ATE240969T1 publication Critical patent/ATE240969T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT94925093T 1994-07-18 1994-07-18 VERFAHREN ZUR REINIGUNG VON ßBASICß FIBROBLASTEN WACHSTUMSFAKTOR ATE240969T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/008016 WO1996002562A1 (en) 1993-04-12 1994-07-18 Process for the purification of basic fibroblast growth factor

Publications (1)

Publication Number Publication Date
ATE240969T1 true ATE240969T1 (de) 2003-06-15

Family

ID=22242753

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94925093T ATE240969T1 (de) 1994-07-18 1994-07-18 VERFAHREN ZUR REINIGUNG VON ßBASICß FIBROBLASTEN WACHSTUMSFAKTOR

Country Status (7)

Country Link
US (1) US5331095A (de)
EP (1) EP0720618B1 (de)
JP (1) JP3509104B2 (de)
AT (1) ATE240969T1 (de)
CA (1) CA2170885C (de)
DE (1) DE69432706T2 (de)
WO (1) WO1996002562A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5331095A (en) * 1993-04-12 1994-07-19 Scios Nova Inc. Process for purification of basic fibroblast growth factor
US6008328A (en) * 1994-10-13 1999-12-28 Amgen Inc. Method for purifying keratinocyte growth factors
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
WO2002057296A1 (en) * 2001-01-16 2002-07-25 Københavns Universitet A method for refolding of proteins
DE102005033250A1 (de) 2005-07-15 2007-01-18 Bioceuticals Arzneimittel Ag Verfahren zur Reinigung von G-CSF
CA2633554C (en) 2005-12-22 2012-11-13 Genetech, Inc. Recombinant production of heparin binding proteins
CA2656835C (en) 2006-07-14 2017-12-19 Genentech, Inc. Refolding of recombinant proteins
IL210162A0 (en) * 2010-12-21 2011-03-31 Omrix Biopharmaceuticals Viral inactivated platelet extract, use and preparation thereof
EP2726496B1 (de) * 2011-07-01 2018-04-04 F.Hoffmann-La Roche Ag Verfahren zum trennen von monomeren polypeptiden von aggregierten polypeptiden
JP6548293B2 (ja) * 2015-09-30 2019-07-24 片山化学工業株式会社 ｂＦＧＦの精製方法およびｂＦＧＦの製造方法
CN115873094A (zh) * 2021-09-30 2023-03-31 温州医科大学 一种高纯度重组人碱性成纤维细胞生长因子的纯化方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444760A (en) * 1983-06-17 1984-04-24 Merck & Co., Inc. Purification and characterization of a protein fibroblast growth factor
US4785079A (en) * 1984-11-09 1988-11-15 The Salk Institute For Biological Studies Isolation of fibroblast growth factor
US5171842A (en) * 1988-01-25 1992-12-15 American Cyanamid Company Heparin-binding brain mitogens
WO1989008117A1 (en) * 1988-02-24 1989-09-08 Yuen Shing Heparin-copper bi-affinity chromatography of fibroblast growth factors
US5120715A (en) * 1988-12-12 1992-06-09 Takeda Chemical Industries, Ltd. Method for purifying fibroblast growth factor protein
US5130418A (en) * 1989-05-02 1992-07-14 California Biotechnology Inc. Method to stabilize basic fibroblast growth factor
CA2020654A1 (en) * 1989-07-07 1991-01-08 Yohko Akiyama Stabilized fgf composition and production thereof
CA2020720A1 (en) * 1989-07-13 1991-01-14 Shigeko Yamazaki Method for the purification of therapeutically active recombinant acidic fibroblast growth factor
US5043431A (en) * 1989-09-11 1991-08-27 Codon Method and apparatus for the production of TGF-β
US5136025A (en) * 1990-04-04 1992-08-04 California Biotechnology Inc. Method to purify basic fibroblast growth factor
US5331095A (en) * 1993-04-12 1994-07-19 Scios Nova Inc. Process for purification of basic fibroblast growth factor

Also Published As

Publication number Publication date
WO1996002562A1 (en) 1996-02-01
JP3509104B2 (ja) 2004-03-22
DE69432706D1 (de) 2003-06-26
DE69432706T2 (de) 2004-03-25
EP0720618A4 (de) 1997-12-03
CA2170885A1 (en) 1996-02-01
EP0720618B1 (de) 2003-05-21
CA2170885C (en) 2004-05-04
US5331095A (en) 1994-07-19
JPH08510762A (ja) 1996-11-12
EP0720618A1 (de) 1996-07-10

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Legal Events

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