ATE241010T1 - Klonierung und expression von biologisch aktiver alpha-n-acetylgalaktosaminidase - Google Patents

Klonierung und expression von biologisch aktiver alpha-n-acetylgalaktosaminidase

Info

Publication number
ATE241010T1
ATE241010T1 AT91920591T AT91920591T ATE241010T1 AT E241010 T1 ATE241010 T1 AT E241010T1 AT 91920591 T AT91920591 T AT 91920591T AT 91920591 T AT91920591 T AT 91920591T AT E241010 T1 ATE241010 T1 AT E241010T1
Authority
AT
Austria
Prior art keywords
cloning
expression
biologically active
active alpha
acetyl galactosaminidase
Prior art date
Application number
AT91920591T
Other languages
English (en)
Inventor
Robert J Desnick
David F Bishop
Yiannis A Ioannou
Anne M Wang
Original Assignee
Sinai School Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinai School Medicine filed Critical Sinai School Medicine
Application granted granted Critical
Publication of ATE241010T1 publication Critical patent/ATE241010T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01049—Alpha-N-acetylgalactosaminidase (3.2.1.49)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT91920591T 1990-10-24 1991-10-23 Klonierung und expression von biologisch aktiver alpha-n-acetylgalaktosaminidase ATE241010T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/602,608 US5382524A (en) 1990-10-24 1990-10-24 Cloning and expression of biologically active α-n-acetylgalactosaminidase
PCT/US1991/007872 WO1992007936A1 (en) 1990-10-24 1991-10-23 Cloning and expression of biologically active alpha-n-acetylgalactosaminidase

Publications (1)

Publication Number Publication Date
ATE241010T1 true ATE241010T1 (de) 2003-06-15

Family

ID=24412043

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91920591T ATE241010T1 (de) 1990-10-24 1991-10-23 Klonierung und expression von biologisch aktiver alpha-n-acetylgalaktosaminidase

Country Status (7)

Country Link
US (2) US5382524A (de)
EP (2) EP0554385B1 (de)
AT (1) ATE241010T1 (de)
AU (1) AU8954791A (de)
CA (1) CA2094922A1 (de)
DE (1) DE69133263T2 (de)
WO (1) WO1992007936A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2042093C (en) * 1990-05-09 2002-12-24 Gyula Hadlaczky Cell line carrying an excess of mammalian centromeres
US5401650A (en) * 1990-10-24 1995-03-28 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-galactosidase A
JPH08503137A (ja) * 1992-11-18 1996-04-09 ジェネンカー インターナショナル，インコーポレイティド Ａ，ａｂ及びｂ型血液をｏ型血液に変換するための方法
WO1994023070A1 (en) * 1993-03-26 1994-10-13 New York Blood Center, Inc. RECOMBINANT α-N-ACETYLGALACTOSAMINIDASE ENZYME AND cDNA ENCODING SAID ENZYME
AU6852296A (en) * 1995-08-22 1997-03-19 Board Of Trustees Of The University Of Arkansas, The Novel liver galnac-1-phosphate kinase
US20020160970A1 (en) * 1996-04-10 2002-10-31 Gyula Hadlaczky Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US20030033617A1 (en) * 1996-04-10 2003-02-13 Gyula Hadlaczky Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6025155A (en) * 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6077697A (en) * 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
RU2141526C1 (ru) * 1998-06-17 1999-11-20 Тихоокеанский институт биоорганической химии Дальневосточного отделения РАН ШТАММ БАКТЕРИЙ FLAVOBACTERIUM SP. - ПРОДУЦЕНТ α-N- АЦЕТИЛГАЛАКТОЗАМИНИДАЗЫ
WO2000050436A1 (en) * 1999-02-23 2000-08-31 Genaissance Pharmaceuticals, Inc. Receptor isogenes: polymorphisms in the tissue necrosis factor receptor
US6534300B1 (en) 1999-09-14 2003-03-18 Genzyme Glycobiology Research Institute, Inc. Methods for producing highly phosphorylated lysosomal hydrolases
US6770468B1 (en) 1999-09-14 2004-08-03 Genzyme Glycobiology Research Institute, Inc. Phosphodiester-α-GlcNAcase of the lysosomal targeting pathway
CN101845446B (zh) * 2000-09-28 2016-01-20 生物源食物及科学公司 脂肪酸去饱和酶家族成员fad4、fad5、fad5-2和fad6及它们的应用
US7767415B2 (en) 2001-09-25 2010-08-03 Velico Medical, Inc. Compositions and methods for modifying blood cell carbohydrates
US20030124652A1 (en) * 2001-12-21 2003-07-03 Novazyme Pharmaceuticals, Inc. Methods of producing high mannose glycoproteins in complex carbohydrate deficient cells
US6905856B2 (en) * 2001-12-21 2005-06-14 Genzyme Glycobiology Research Institute, Inc. Soluble GlcNAc phosphotransferase
WO2003056027A1 (en) * 2001-12-21 2003-07-10 Incyte Genomics, Inc. Carbohydrate-associated proteins
US6800472B2 (en) 2001-12-21 2004-10-05 Genzyme Glycobiology Research Institute, Inc. Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase
US8889127B2 (en) * 2004-07-01 2014-11-18 Icahn School Of Medicine At Mount Sinai Targeted protein replacement for the treatment of lysosomal storage disorders
CA2958259C (en) 2004-10-22 2020-06-30 Revivicor, Inc. Ungulates with genetically modified immune systems
GB0606190D0 (en) 2006-03-28 2006-05-10 Isis Innovation Construct
US8679478B2 (en) 2010-10-04 2014-03-25 Duke University Methods of lysosomal storage disease therapy
LT2753346T (lt) 2011-09-07 2020-08-10 Mount Sinai School Of Medicine Ceramidazė ir ląstelių diferenciacija
ES2897825T3 (es) 2012-06-01 2022-03-02 Icahn School Med Mount Sinai Niveles de ceramida en el tratamiento y prevención de infecciones
PT2968479T (pt) 2013-03-14 2019-08-07 Icahn School Med Mount Sinai Composições terapêuticas de ceramidase ácida e métodos de fabrico e utilização
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2017049157A1 (en) 2015-09-18 2017-03-23 Duke University Methods and compositions for the treatment of steatosis-associated disorders
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
EP4244360A4 (de) * 2020-11-16 2025-05-07 Beijing SoloBio Genetechnology Company Ltd. Rekombinante adeno-assoziierte viren mit erhöhtem lebertropismus und verwendungen davon

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68926569T2 (de) * 1988-12-23 1996-09-26 Genzyme Corp Cho-zellen befähigt enzymatisch aktive rekombinante-glukocerebrosidase zu produzieren
EP0463109A4 (en) * 1989-03-24 1992-11-19 Research Corporation Technologies, Inc. Recombinant alpha-galactosidase, a therapy for fabry disease

Also Published As

Publication number Publication date
DE69133263D1 (de) 2003-06-26
AU8954791A (en) 1992-05-26
EP0554385A4 (en) 1994-08-17
EP0554385A1 (de) 1993-08-11
CA2094922A1 (en) 1992-04-25
EP0554385B1 (de) 2003-05-21
US5491075A (en) 1996-02-13
DE69133263T2 (de) 2004-04-08
US5382524A (en) 1995-01-17
EP1375665A1 (de) 2004-01-02
WO1992007936A1 (en) 1992-05-14

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